esmolol / Generic mfg. - LARVOL DELTA

Fragile X and Fatal Rhythms: Electroconvulsive Therapy-Induced Ventricular Tachycardia. (PubMed, JACC Case Rep) - "Patients with FXS may require individualized pre-ECT risk assessment. Antiarrhythmic and sympathetic modulation strategies, including stellate ganglion block, may be essential for arrhythmia prevention in high-risk cases."

Journal • Cardiovascular • CNS Disorders • Fragile X Syndrome • Genetic Disorders • Heart Failure • Mental Retardation • Ventricular Tachycardia

Effect of opioid-free anaesthesia on postoperative delirium in elderly patients undergoing gastrointestinal surgery: study protocol for a single-centre, prospective, randomized controlled trial. (PubMed, BMC Geriatr) - P4 | "The results of this study may shed light on the effects of OFA on POD in elderly patients undergoing gastrointestinal surgery. The study is designed on the basis of the following key hypothesis: the use of opioid drugs for anaesthesia may increase the risk of POD through mechanisms such as blood-brain barrier destruction, neuroinflammatory responses, and central nervous system depression. Through the single-centre and prospective design of this randomized controlled trial, this study will directly analyse differences in the effects of OFA and conventional OBA on the incidence of POD, haemodynamic stability and long-term cognitive function in elderly patients."

Journal • Anesthesia • CNS Disorders • Depression • Geriatric Disorders • Inflammation • Pain • Psychiatry

Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial. (PubMed, Front Med (Lausanne)) - P=N/A | "Results will be disseminated through peer-reviewed journals and scientific conferences. Identifier, ChiCTR2400080160."

Journal • Critical care • Infectious Disease • Pancreatitis • Septic Shock • CRP • IL6

Navigating Hemodynamic Lability: Anesthesia for Bilateral Pheochromocytoma in MEN 2B (ASA 2025) - "Following anesthesia induction in a 25-year-old male with MEN 2B and bilateral pheochromocytomas (right 6.3/1.6cm, left 6.7/5.3cm), a hypertensive crisis (221/107 mmHg) prior to intubation necessitated magnesium, propofol, esmolol, remifentanil, and a clevidipine infusion despite robust pre-operative alpha/beta blockade (phenoxybenzamine, metoprolol). Meticulous intraoperative hemodynamic management with short-acting agents and invasive monitoring (arterial/central line, TEE) was crucial during induction and tumor manipulation. This case underscores the potential for cardiovascular lability in pheochromocytoma resection and the importance of vigilant anesthetic titration even with optimized pre-operative preparation and an asymptomatic patient."

Anesthesia • Cardiovascular • Solid Tumor

Hemodynamic Stability with Methadone During Craniotomy in a Patient with HOCM: A Novel Anesthetic Approach (ASA 2025) - "Following severe hypotension with conventional opioids during a prior attempt, a methadone-based strategy—augmented with esmolol, ketamine, and TEE monitoring—resulted in markedly improved hemodynamic stability and no appreciable SAM on intraoperative TEE. Methadone's long-acting μ-opioid agonism and NMDA antagonism offer advantages in patients with cardiovascular comorbidities. This case supports methadone as a hemodynamically favorable alternative in neurosurgery and warrants further study in high-risk populations."

Clinical • Anesthesia • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Hypotension • Obstructive Hypertrophic Cardiomyopathy

Emergent Management of Type A Aortic Dissection with Chronic Type B Component Using DHCA and RCP (ASA 2025) - "He was taken to the OR on esmolol and nitroglycerin infusions. Induction included fentanyl, midazolam, lidocaine, propofol, and esmolol...The patient was extubated on POD1 without neurologic sequelae with plans for future endovascular intervention of distal dissection. This case highlights successful anesthetic management of a complex aortic dissection."

Anesthesia • Back Pain • Cardiovascular • Chronic Kidney Disease • Dyslipidemia • Hypertension • Musculoskeletal Pain

Bilateral Actively-Secreting Adrenalectomy in a Cardiovascularly Compromised Patient (ASA 2025) - "He developed multiple episodes of ventricular tachycardia requiring esmolol and amiodarone loading, and rapid fluctuations in systolic blood pressure of greater than 100mmHg, requiring clevidipine, epinephrine, norepinephrine, and vasopressin. This case highlights anesthetic strategies to manage acutely fluctuating cardiovascular status in patients with active adrenal tissue with poor cardiorespiratory substrate."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Cushing’s Disease • Endocrine Disorders • Heart Failure • Hypertension • Hypotension • Ventricular Tachycardia

Monitored Anesthesia Care for Endovascular Repair of a Contained Aortic Rupture (ASA 2025) - "After multidisciplinary discussion regarding risks of general anesthesia, emergent endovascular repair was successfully completed under monitored anesthesia care with local anesthetic and esmolol infusion. At his 5-week follow-up appointment, patient had made a full recovery."

Anesthesia • Cardiovascular • Constipation • Fatigue • Gastroenterology • Gastrointestinal Disorder

Supraventricular Tachycardia with Aberrancy vs. Ventricular Tachycardia: Intraoperative Diagnosis and Management (ASA 2025) - "Shortly after induction of general anesthesia, patient developed a wide-complex tachycardia with heart rate in the 130s that terminated with a single administration of 50 mg esmolol. Given patient's baseline underlying bifasciular block, differentials for patient's wide-complex tachycardia included a supraventricular tachycardia with aberrancy versus ventricular tachycardia. We will discuss challenges in differentiating these cardiac arrhythmias and the key differences in intraoperative management."

Anesthesia • Cardiovascular • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Ventricular Tachycardia

Management of C-section in a Patient with Chronic Aortic Dissection (ASA 2025) - "Heart rate and blood pressure control was achieved with esmolol and clevidipine infusions, which prevented extension of the aortic dissection. The case concluded without apparent anesthesia or surgical complications."

Clinical • Anesthesia • Cardiovascular • Gynecology • Hypertension

Anesthetic Management of a Patient with Refractory Ventricular Tachycardia Undergoing Emergency Craniotomy for Traumatic Subdural Hematoma: A Case Report (ASA 2025) - "He received general anesthesia with an endotracheal tube, was induced with etomidate and succinylcholine, and maintained with sevoflurane. He received 360mg amiodarone, 160mg esmolol, 2000mg calcium gluconate, and repletion of potassium and magnesium with no effect. This case highlights the challenge of maintaining hemodynamic stability secondary to VT in a patient with SDH."

Case report • Clinical • Anesthesia • Cardiovascular • CNS Disorders • Ventricular Tachycardia

Undifferentiated Hypoxia and Hypotension following an Extra-Cranial to Intra-Cranial Bypass for Moya-Moya Disease (ASA 2025) - "Eventually, the patient was started on an epinephrine infusion. Subsequently, TEE was performed, and the patient was found to have previously undiagnosed HOCM and MR. The patient was transitioned to esmolol/phenylephrine infusions with improvements in hypotension/hypoxia allowing transfer to the ICU."

Cardiovascular • Genetic Disorders • Hypotension • Obesity • Obstructive Hypertrophic Cardiomyopathy

Intra-operative Management of an Unrecognized Pheochromocytoma (ASA 2025) - "An additional 20 mg of esmolol and 170 mg of propofol were required for stabilization. Surgical pathology revealed a well-differentiated pheochromocytoma, catecholamine type unspecified, chromogranin+, and synaptophysin+."

Cardiovascular • Hypertension • Solid Tumor • SYP

Comparison of the Clinical Efficacy, Adverse Effects, and Patient Satisfaction Between Ciprofol Combined with Etomidate Versus Propofol Combined with Etomidate in Painless Gastrointestinal Endoscopy (ChiCTR) - P4 | N=240 | Completed | Sponsor: Wuxi No.2 People's Hospital, Affiliated Central Hospital of Jiangnan University; Wuxi No.2 People's Hospital, Affiliated Central Hospital of Jiangnan

Adverse events • New P4 trial • Pain

Transcranial Alternative Current Stimulation for postoperative delirium in elderly patients undergoing hip and knee replacement surgery:a randomized controlled trial (ChiCTR) - P=N/A | N=266 | Recruiting | Sponsor: Shanghai Jiaotong University Affiliated Sixth People ’s Hospital; Shanghai Jiaotong University Affiliated Sixth People ’s Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Geriatric Disorders • Musculoskeletal Diseases • Orthopedics

Thyroid storm during the recovery phase after non-thyroid surgery in a hyperthyroid patient: a case report and literature review. (PubMed, Front Surg) - "Intravenous hydrocortisone (100 mg) and continuous esmolol infusion were promptly initiated, leading to gradual heart rate stabilization at 120 bpm. Perioperative management should emphasize: (1) rigorous preoperative optimization of thyroid function to achieve euthyroidism; (2) vigilant postoperative monitoring for early signs of thyroid storm; and 3) prompt diagnosis using the Burch-Wartofsky scale and guideline-based criteria, followed by combined therapy with beta-blockers, corticosteroids, and antithyroid drugs. This case uniquely demonstrates that non-thyroid surgery can precipitate thyroid storm without classic hyperthermia, highlighting the need for standardized monitoring protocols in hyperthyroid surgical patients."

Journal • Anesthesia • Cardiovascular • Endocrine Disorders • Infectious Disease • Musculoskeletal Diseases • Orthopedics

The Effect of Esmolol Versus Dexmedetomidine on Postoperative Pain Control in Endoscopic Sinus Surgery: A Randomized Trial. (PubMed, Anesth Pain Med) - "It was discovered that esmolol and dexmedetomidine both provided superior surgical field, less nasal hemorrhage, and more successful results. Dexmedetomidine caused effective sedation and a reduced need for analgesics."

Journal • Anesthesia • Hematological Disorders • Otorhinolaryngology • Pain

Management of persistent shockable rhythms during cardiac arrest: a national survey from the REVIVE group (REVIVE-2). (PubMed, Resusc Plus) - "This survey investigated current practices amongst UK Helicopter Emergency Medical Services (HEMS) in preparation for a clinical trial of esmolol for persistent VF/pVT...Treatment strategies for managing persistent VF/pVT vary widely between UK HEMS. Further data is required to support an evidence-based pharmacological approach to this cohort."

Journal • Cardiovascular • Ventricular Tachycardia

Challenging the Paradigm: IV Amiodarone in Thyroid Storm Without Worsening Thyrotoxicosis (ENDO 2025) - "He was started on IV esmolol and digoxin. Due to persistent tachycardia and hypotension precluding diltiazem use, an IV amiodarone drip was started as per cardiology recommendation...Hydrocortisone was tapered with the continual improvement of FT4, and methimazole was continued for new-onset hyperthyroidism, with outpatient follow-up planned for further workup.Conclusion This case highlights the potential use of IV amiodarone in thyroid storm for refractory arrhythmia despite maximal conventional management without worsening of thyrotoxicosis, as the patient's thyrotoxic symptoms and thyroid function improved despite IV amiodarone. IV amiodarone inhibits peripheral T4 to T3 conversion which in combination with anti-thyroid medications, preferably started before amiodarone to suppress new hormone synthesis, may help control thyrotoxicosis symptoms in the short term. However, data remain limited due to the absence of randomized controlled trials and their known..."

Ataxia • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Friedreich ataxia • Gastroenterology • Hepatology • Hypotension • Movement Disorders • Pulmonary Embolism • Respiratory Diseases • Septic Shock

Effects of Dexmedetomidine vs Esmolol on Postintubation Hemodynamics: A Meta-Analysis. (PubMed, Anesth Prog) - "The use of dexmedetomidine vs esmolol provided lower heart rates and mean arterial pressures at 1, 3, 5, and 10 minutes and lower systolic and diastolic pressures at 1, 3, and 5 minutes after TI. Dexmedetomidine blunts the hemodynamic response to TI more effectively vs esmolol."

Clinical • Intubation • Journal • Retrospective data • Review • Cardiovascular

Managing Thyrotoxicosis in Acute Heart Failure. (PubMed, JACC Case Rep) - "Suspect thyrotoxic cardiac failure, especially in the setting of normal diastology, and consider starting BB."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Navigating Hemodynamic Lability: Anesthesia for Bilateral Pheochromocytoma in MEN 2B (ASA 2025) - "Following anesthesia induction in a 25-year-old male with MEN 2B and bilateral pheochromocytomas (right 6.3/1.6cm, left 6.7/5.3cm), a hypertensive crisis (221/107 mmHg) prior to intubation necessitated magnesium, propofol, esmolol, remifentanil, and a clevidipine infusion despite robust pre-operative alpha/beta blockade (phenoxybenzamine, metoprolol). Meticulous intraoperative hemodynamic management with short-acting agents and invasive monitoring (arterial/central line, TEE) was crucial during induction and tumor manipulation. This case underscores the potential for cardiovascular lability in pheochromocytoma resection and the importance of vigilant anesthetic titration even with optimized pre-operative preparation and an asymptomatic patient."

Anesthesia • Cardiovascular • Endocrine Cancer • Oncology • Solid Tumor

Hemodynamic Stability with Methadone During Craniotomy in a Patient with HOCM: A Novel Anesthetic Approach (ASA 2025) - "Following severe hypotension with conventional opioids during a prior attempt, a methadone-based strategy—augmented with esmolol, ketamine, and TEE monitoring—resulted in markedly improved hemodynamic stability and no appreciable SAM on intraoperative TEE. Methadone's long-acting μ-opioid agonism and NMDA antagonism offer advantages in patients with cardiovascular comorbidities. This case supports methadone as a hemodynamically favorable alternative in neurosurgery and warrants further study in high-risk populations."

Clinical • Anesthesia • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Hypotension • Obstructive Hypertrophic Cardiomyopathy

Supraventricular Tachycardia with Aberrancy vs. Ventricular Tachycardia: Intraoperative Diagnosis and Management (ASA 2025) - "Shortly after induction of general anesthesia, patient developed a wide-complex tachycardia with heart rate in the 130s that terminated with a single administration of 50 mg esmolol. Given patient's baseline underlying bifasciular block, differentials for patient's wide-complex tachycardia included a supraventricular tachycardia with aberrancy versus ventricular tachycardia. We will discuss challenges in differentiating these cardiac arrhythmias and the key differences in intraoperative management."

Anesthesia • Cardiovascular • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Ventricular Tachycardia

Emergent Management of Type A Aortic Dissection with Chronic Type B Component Using DHCA and RCP (ASA 2025) - "He was taken to the OR on esmolol and nitroglycerin infusions. Induction included fentanyl, midazolam, lidocaine, propofol, and esmolol...The patient was extubated on POD1 without neurologic sequelae with plans for future endovascular intervention of distal dissection. This case highlights successful anesthetic management of a complex aortic dissection."

Anesthesia • Back Pain • Cardiovascular • Chronic Kidney Disease • Dyslipidemia • Hypertension • Musculoskeletal Pain • Pain