esmolol / Generic mfg. - LARVOL DELTA

Comparison of Efficacy and Safety Between Landiolol and Esmolol in Critically Ill Patients with Tachycardia (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First Affiliated Hospital with Nanjing Medical University; The First Affiliated Hospital with Nanjing Medical University

New trial • Cardiovascular

Effects of low-dose dexmedetomidine combined with esketamine infusion on sleep in non-mechanical ventilation patients with sepsis in ICU: a multicenter, randomized, double-blind, placebo-controlled study (ChiCTR) - P1 | N=376 | Recruiting | Sponsor: Peking University First Hospital; Peking University First Hospital

New P1 trial • Infectious Disease • Septic Shock

The impact of intraoperative esmolol on postoperative cardiovascular adverse events in patients with coronary artery disease undergoing non-cardiac surgery: A single-center, bidirectional cohort study (ChiCTR) - P=N/A | N=1096 | Recruiting | Sponsor: Shandong Provincal Hospital; Shandong Provincial Hospital Affiliated to Shandong First Medical University

New trial • Cardiovascular • Coronary Artery Disease

The Effect of Esmolol on Postoperative Pain in Patients Undergoing Bariatric Surgery: A Randomized Controlled Study (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, China; Sir Run Run Shaw Hospital, School of Medicine, Zhejiang

New trial • Pain

Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery: A Systematic Review and Network Meta-Analysis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Randomized clinical trials of patients undergoing ESS and receiving dexmedetomidine, clonidine, esmolol, labetalol, bisoprolol, metoprolol, diltiazem, nifedipine, or verapamil vs placebo. In this systematic review and network meta-analysis, controlled hypotension improved surgical field quality in ESS with comparable safety. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine was associated with reduced MAP the most, and esmolol favored recovery."

Clinical • Journal • Retrospective data • Hypotension • Otorhinolaryngology

Systematic Identification and Recognition Analysis of Beta1-Adrenergic Receptor Targeting Material Basis in Tibetan Medicine Formula Bawei Chenxiang Powder. (PubMed, J Mol Recognit) - "So, in this work, we engineered a fusion protein by linking the kinase domain of epidermal growth factor receptor (EGFR) to the C-terminus of β1-AR, which was subsequently immobilized onto the ibrutinib-modified silica gels. Following column preparation by packing the β1-AR immobilized silica into a stainless-steel column, the specificity and stability of β1-AR column were evaluated through the retention behavior analysis of atenolol, esmolol, and metoprolol for characterization...These confirmed the reliability of the screened compounds by the immobilized β1-AR. To our knowledge, this work establishes the first systematic identification of BWCP's bioactive components targeting β1-AR, providing a pharmacological foundation for developing novel cardiovascular therapeutics derived from this traditional formulation."

Journal • Cardiovascular • EGFR

Research progress on beta-blockers in the treatment of sepsis-induced cardiomyopathy: A mini review. (PubMed, SAGE Open Med) - "Short-acting β₁-blockers (esmolol, landiolol) offer a targeted therapeutic approach by reducing heart rate (target: 80-95 bpm), myocardial oxygen demand, and proinflammatory cytokines while improving diastolic perfusion-leveraging ultra-short half-lives (t₁/₂ = 4-9 min) for rapid reversibility during instability. Current limitations include heterogeneous trial designs, small samples, and undefined benefiting phenotypes. Thus, cautious short-acting β-blockade is supported only for selected SCM patients with hemodynamic stability (MAP ⩾65 mmHg, normalized lactate, LVEF >35%), necessitating future precision trials with AI phenotyping to guide mechanism-targeted application."

Journal • Review • Cardiomyopathy • Cardiovascular • Heart Failure • Infectious Disease • Inflammation • Septic Shock

Mutation of a Cysteine Residue in LAMP2 Affecting a Disulfide Bridge in a Patient with Danon Disease (ACMG 2026) - "Treatment and Management The patient was started on esmolol, then achieved arrhythmia control after transition to metoprolol...Immunoflorescence demonstrated normal expression of LAMP1 with reduced expression of LAMP2. These features were noted to be consistent with Danon Disease."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology • Hypertrophic Cardiomyopathy • Ophthalmology • Ventricular Tachycardia • LAMP1 • LAMP2

Atypical negative pressure pulmonary edema with myocardial injury post-appendectomy: A case report. (PubMed, Medicine (Baltimore)) - "This case highlights that NPPE can present with occult myocardial injury without respiratory signs, necessitating serial cardiac biomarker monitoring in hemodynamically unstable patients. The underlying mechanism, while not directly proven here, may involve catecholamine surge, inflammatory cascades, and hypoperfusion."

Journal • Cardiovascular • Hypertension • Hypotension • Inflammation • Pulmonary Disease • Respiratory Diseases

Epic-Beta: POCUS-Guided Esmolol in Septic Shock: A Pilot RCT (clinicaltrials.gov) - P1/2 | N=100 | Not yet recruiting | Sponsor: John Basmaji

New P1/2 trial • Septic Shock

Tachyarrhythmia-induced cardiomyopathy in a neonate. (PubMed, BMJ Case Rep) - "The baby required synchronised cardioversion along with non-invasive respiratory support, adenosine and esmolol infusions. TIC responded to oral supplementation of furosemide and enalapril at discharge. The baby had improved cardiac function with normal-sized cardiac chambers in follow-up."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Pediatrics

Nutritional support contributes to improving cardiac function and nutritional status in atrial fibrillation patients receiving treatment with esmolol hydrochloride. (PubMed, Front Cardiovasc Med) - "Furthermore, the combined intervention group demonstrated markedly improved nursing satisfaction and quality of life. Nutritional care administered alongside treatment with esmolol hydrochloride demonstrates superior efficacy in improving cardiac function, nutritional status, and quality of life among patients with AF."

Journal • Atrial Fibrillation • Cardiovascular

Editorial: Esmolol as a Part of Perioperative Multimodal Analgesia Regimen: A Pretender or the Real McCoy? (PubMed, Anesth Analg) - No abstract available

Journal

Merging Lignin and Glycerol Carbonate Valorization Toward the Green Synthesis of β-Adrenergic Blocker Esmolol. (PubMed, ChemSusChem) - "Here, we describe a novel synthetic/catalytic route toward the production of the highly valuable β-adrenergic blocker esmolol. Our strategy consists of: 1) Reductive Catalytic Fractionation (RCF) of sugarcane lignocellulose mediated by copper porous metal oxides (Cu20PMO) in MeOH, leading to the in situ formation of methyl 3-(4-hydroxyphenyl) propionate (1H) with good selectivity (>70%), followed by 2) the selective catalytic amination of glycerol carbonate (GlyC) with isopropyl amine via the borrowing hydrogen strategy, and 3) the subsequent utilization of the obtained amine intermediate as a phenol alkylating agent in combination with 1H to afford the desired β-adrenergic blocker esmolol (1Ha)."

Journal

Vasopressin role in hypertrophic obstructive cardiomyopathy post-cardiac surgery: A case report. (PubMed, World J Crit Care Med) - "Vasopressin seems to be the preferred vasopressor for managing LVOTO and SAM post-cardiac surgery, because of its absence of inotropic effects. Echocardiography is crucial for early diagnosis and therapeutic management."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Hypertrophic Cardiomyopathy • Hypotension • Obstructive Hypertrophic Cardiomyopathy • Respiratory Diseases

Remimazolam-Based Anesthetic Management in a Patient with Severe Aortic Stenosis and Myelodysplastic Syndrome-Related Thrombocytopenia: A Case Report. (PubMed, J Clin Med) - "Transient systolic hypertension during surgical stimulation was controlled using remifentanil titration and esmolol. Recovery and the postoperative course were uneventful, and the patient was discharged in a stable condition. Remimazolam-based total intravenous anesthesia can provide hemodynamic stability without vasopressors in high-risk patients with severe AS, and a transfusion strategy adjusted step by step according to the patient's response can be effective for optimizing PLTs while minimizing the transfusion-related risks of MDS-associated thrombocytopenia."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Hematological Malignancies • Hypertension • Myelodysplastic Syndrome • Oncology • Thrombocytopenia

Atrial overdrive pacing in drug-refractory postinfarction electrical storm case report. (PubMed, Medicine (Baltimore)) - "AOP demonstrates dual therapeutic efficacy in refractory post-AMI ES: (1) physiological conduction restoration suppressing ectopic triggers and (2) avoidance of ventricular pacing-induced dyssynchrony. Fluoroscopic guidance ensures lead stability, positioning AOP as a hemodynamically favorable intervention in ES management."

Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Hepatology • Hypertension • Liver Failure • Metabolic Disorders • Myocardial Infarction • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Comparison of Esmolol Versus Landiolol on Mortality in Adult Patients With Sepsis: A Systematic Review and Network Meta-Analysis. (PubMed, Crit Care Med) - "Among patients with sepsis treated with β-blockers, esmolol probably improves clinical outcomes compared with SOC. However, the effect of landiolol remains uncertain due to the low certainty of evidence. Esmolol may confer a relative clinical advantage over landiolol, but further studies are needed to confirm this finding and elucidate the underlying mechanisms."

Journal • Retrospective data • Infectious Disease • Septic Shock

Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis. (PubMed, PLoS One) - "Propranolol is often initiated at a target dose and maintained with less titration, while both captopril and esmolol are titrated more often. Younger gestational age patients typically required higher doses of propranolol."

Journal • Retrospective data • Cardiovascular • Hypertension

Refractory ventricular arrhythmia in a patient with suspected immune checkpoint inhibitor-related myocarditis: a case report. (PubMed, Eur Heart J Case Rep) - "We report a 65-year-old male with oesophageal cancer who developed refractory ventricular tachycardia three months after initiating toripalimab, a PD-1 inhibitor...Treatment with high-dose methylprednisolone, immunoglobulin, and anti-arrhythmic drugs (amiodarone, esmolol) yielded limited success, with recurrent arrhythmias requiring multiple cardioversions. Following the family's thoughtful decision to forgo extracorporeal membrane oxygenation, the patient passed away shortly after discharge. This case underscores the diagnostic complexity of suspected ICI-related myocarditis and the critical need for early recognition of immune-mediated cardiac toxicity in immunotherapy patients, emphasizing the role of clinical vigilance when definitive diagnostics are unavailable."

Checkpoint inhibition • Journal • Cardiovascular • Esophageal Cancer • Inflammation • Oncology • Ventricular Tachycardia

The controversies in the clinical management of β-blockers in acute heart failure induced by rapid atrial fibrillation: A narrative review. (PubMed, Am Heart J Plus) - "AF management guidelines generally recommend considering the addition of β-blockers when digoxin-like drugs (such as cedilanid) fail to effectively control the ventricular rate...This article systematically reviews the clinical management strategies under this guideline contradiction, including: (1) Different recommendations on ventricular rate control and the use of β-blockers in domestic and international guidelines for AF and HF; (2) A pooled analysis of relevant research evidence; (3) Application strategies of β-blockers (especially short-acting agents esmolol and landiolol) in the acute phase...Although some studies and consensus articles have focused on the management of rapid AF complicated by HF, there is currently a lack of systematic reviews on this issue. Therefore, the writing of this review has important academic value and clinical guiding significance, providing a reference for treatment decisions in this special population."

Journal • Review • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

Antiarrhythmic drugs for cardiac arrest with a shockable rhythm and their effect on outcomes - A systematic review with meta-analysis. (PubMed, Europace) - "Evidence supporting the use of any antiarrhythmic drugs during CPR remains limited and is partly inconclusive. For the effect on survival to hospital discharge, a statistically significant difference was only found favouring the administration of lidocaine compared to no lidocaine. Further research with improved trial design and into novel drug options should be conducted."

Journal • Retrospective data • Cardiovascular

Polycythemia Vera as an Underrecognized Cause of Aortic Dissection in a Patient Without Traditional Cardiovascular Risk Factors (AHA 2025) - "After receiving aspirin and sublingual nitroglycerin, she was transferred to the ED with persistent back pain (BP 186/110 mmHg)...She was started on IV esmolol and nicardipine and transferred for vascular surgery evaluation...She was started on hydroxyurea, low-dose aspirin, and serial phlebotomy...This underscores the importance of considering myeloproliferative disorders in patients presenting with unexplained erythrocytosis and vascular pathology. Early diagnosis and cytoreductive therapy may reduce the risk of life-threatening cardiovascular events."

Clinical • Atherosclerosis • Back Pain • Cardiovascular • Chronic Eosinophilic Leukemia • Hematological Disorders • Hypertension • Musculoskeletal Pain • Polycythemia Vera • Rheumatology • JAK2

Successful Reversion of Refractory Supraventricular Tachycardia With Neostigmine During Emergent Endoscopic Retrograde Cholangiopancreatography: A Case Report. (PubMed, A A Pract) - "We describe a 69-year-old man in septic shock undergoing an emergent endoscopic retrograde cholangiopancreatography (ERCP) whose narrow-complex supraventricular tachycardia (SVT, 180-200 bpm) persisted despite synchronized cardioversion, vagal maneuvers, adenosine, esmolol, and amiodarone. Noting transient reversion during maneuvers provoking vagal stimulation, when SVT reoccurred we titrated intravenous neostigmine in 0.5 to 1.0 mg increments (3.5 mg total), achieving a stable sinus rhythm at 80 bpm without adverse effects. This case illustrates neostigmine's value as an off-label vagomimetic rescue when guideline-directed therapies fail, and vagal stimulation appears beneficial. ."

Journal • Cardiovascular • Septic Shock • Ventricular Tachycardia

Initial Double Sequential External Defibrillation for Refractory Ventricular Fibrillation in Cardiac Sarcoidosis. (PubMed, JACC Case Rep) - "DSED can be safely and effectively used as initial therapy in patients with refractory VF."

Journal • Cardiovascular • Immunology • Sarcoidosis