esmolol / Generic mfg. - LARVOL DELTA

Vasopressin role in hypertrophic obstructive cardiomyopathy post-cardiac surgery: A case report. (PubMed, World J Crit Care Med) - "Vasopressin seems to be the preferred vasopressor for managing LVOTO and SAM post-cardiac surgery, because of its absence of inotropic effects. Echocardiography is crucial for early diagnosis and therapeutic management."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Hypertrophic Cardiomyopathy • Hypotension • Obstructive Hypertrophic Cardiomyopathy • Respiratory Diseases

Remimazolam-Based Anesthetic Management in a Patient with Severe Aortic Stenosis and Myelodysplastic Syndrome-Related Thrombocytopenia: A Case Report. (PubMed, J Clin Med) - "Transient systolic hypertension during surgical stimulation was controlled using remifentanil titration and esmolol. Recovery and the postoperative course were uneventful, and the patient was discharged in a stable condition. Remimazolam-based total intravenous anesthesia can provide hemodynamic stability without vasopressors in high-risk patients with severe AS, and a transfusion strategy adjusted step by step according to the patient's response can be effective for optimizing PLTs while minimizing the transfusion-related risks of MDS-associated thrombocytopenia."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Hematological Malignancies • Hypertension • Myelodysplastic Syndrome • Oncology • Thrombocytopenia

Atrial overdrive pacing in drug-refractory postinfarction electrical storm case report. (PubMed, Medicine (Baltimore)) - "AOP demonstrates dual therapeutic efficacy in refractory post-AMI ES: (1) physiological conduction restoration suppressing ectopic triggers and (2) avoidance of ventricular pacing-induced dyssynchrony. Fluoroscopic guidance ensures lead stability, positioning AOP as a hemodynamically favorable intervention in ES management."

Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Hepatology • Hypertension • Liver Failure • Metabolic Disorders • Myocardial Infarction • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Comparison of Esmolol Versus Landiolol on Mortality in Adult Patients With Sepsis: A Systematic Review and Network Meta-Analysis. (PubMed, Crit Care Med) - "Among patients with sepsis treated with β-blockers, esmolol probably improves clinical outcomes compared with SOC. However, the effect of landiolol remains uncertain due to the low certainty of evidence. Esmolol may confer a relative clinical advantage over landiolol, but further studies are needed to confirm this finding and elucidate the underlying mechanisms."

Journal • Retrospective data • Infectious Disease • Septic Shock

Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis. (PubMed, PLoS One) - "Propranolol is often initiated at a target dose and maintained with less titration, while both captopril and esmolol are titrated more often. Younger gestational age patients typically required higher doses of propranolol."

Journal • Retrospective data • Cardiovascular • Hypertension

Refractory ventricular arrhythmia in a patient with suspected immune checkpoint inhibitor-related myocarditis: a case report. (PubMed, Eur Heart J Case Rep) - "We report a 65-year-old male with oesophageal cancer who developed refractory ventricular tachycardia three months after initiating toripalimab, a PD-1 inhibitor...Treatment with high-dose methylprednisolone, immunoglobulin, and anti-arrhythmic drugs (amiodarone, esmolol) yielded limited success, with recurrent arrhythmias requiring multiple cardioversions. Following the family's thoughtful decision to forgo extracorporeal membrane oxygenation, the patient passed away shortly after discharge. This case underscores the diagnostic complexity of suspected ICI-related myocarditis and the critical need for early recognition of immune-mediated cardiac toxicity in immunotherapy patients, emphasizing the role of clinical vigilance when definitive diagnostics are unavailable."

Checkpoint inhibition • Journal • Cardiovascular • Esophageal Cancer • Inflammation • Oncology • Ventricular Tachycardia

The controversies in the clinical management of β-blockers in acute heart failure induced by rapid atrial fibrillation: A narrative review. (PubMed, Am Heart J Plus) - "AF management guidelines generally recommend considering the addition of β-blockers when digoxin-like drugs (such as cedilanid) fail to effectively control the ventricular rate...This article systematically reviews the clinical management strategies under this guideline contradiction, including: (1) Different recommendations on ventricular rate control and the use of β-blockers in domestic and international guidelines for AF and HF; (2) A pooled analysis of relevant research evidence; (3) Application strategies of β-blockers (especially short-acting agents esmolol and landiolol) in the acute phase...Although some studies and consensus articles have focused on the management of rapid AF complicated by HF, there is currently a lack of systematic reviews on this issue. Therefore, the writing of this review has important academic value and clinical guiding significance, providing a reference for treatment decisions in this special population."

Journal • Review • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

Antiarrhythmic drugs for cardiac arrest with a shockable rhythm and their effect on outcomes - A systematic review with meta-analysis. (PubMed, Europace) - "Evidence supporting the use of any antiarrhythmic drugs during CPR remains limited and is partly inconclusive. For the effect on survival to hospital discharge, a statistically significant difference was only found favouring the administration of lidocaine compared to no lidocaine. Further research with improved trial design and into novel drug options should be conducted."

Journal • Retrospective data • Cardiovascular

Polycythemia Vera as an Underrecognized Cause of Aortic Dissection in a Patient Without Traditional Cardiovascular Risk Factors (AHA 2025) - "After receiving aspirin and sublingual nitroglycerin, she was transferred to the ED with persistent back pain (BP 186/110 mmHg)...She was started on IV esmolol and nicardipine and transferred for vascular surgery evaluation...She was started on hydroxyurea, low-dose aspirin, and serial phlebotomy...This underscores the importance of considering myeloproliferative disorders in patients presenting with unexplained erythrocytosis and vascular pathology. Early diagnosis and cytoreductive therapy may reduce the risk of life-threatening cardiovascular events."

Clinical • Atherosclerosis • Back Pain • Cardiovascular • Chronic Eosinophilic Leukemia • Hematological Disorders • Hypertension • Musculoskeletal Pain • Polycythemia Vera • Rheumatology • JAK2

Successful Reversion of Refractory Supraventricular Tachycardia With Neostigmine During Emergent Endoscopic Retrograde Cholangiopancreatography: A Case Report. (PubMed, A A Pract) - "We describe a 69-year-old man in septic shock undergoing an emergent endoscopic retrograde cholangiopancreatography (ERCP) whose narrow-complex supraventricular tachycardia (SVT, 180-200 bpm) persisted despite synchronized cardioversion, vagal maneuvers, adenosine, esmolol, and amiodarone. Noting transient reversion during maneuvers provoking vagal stimulation, when SVT reoccurred we titrated intravenous neostigmine in 0.5 to 1.0 mg increments (3.5 mg total), achieving a stable sinus rhythm at 80 bpm without adverse effects. This case illustrates neostigmine's value as an off-label vagomimetic rescue when guideline-directed therapies fail, and vagal stimulation appears beneficial. ."

Journal • Cardiovascular • Septic Shock • Ventricular Tachycardia

Initial Double Sequential External Defibrillation for Refractory Ventricular Fibrillation in Cardiac Sarcoidosis. (PubMed, JACC Case Rep) - "DSED can be safely and effectively used as initial therapy in patients with refractory VF."

Journal • Cardiovascular • Immunology • Sarcoidosis

A Case Report of Thyroid Storm with Cardiovascular Collapse After Propranolol Administration. (PubMed, Clin Pract Cases Emerg Med) - "Beta-blocker use in the management of thyrotoxicosis can potentially cause cardiovascular collapse. We suggest consideration of shorter acting beta blockers, such as esmolol or landiolol."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Gastroenterology • Gastrointestinal Disorder • Grave’s Disease • Infectious Disease • Myocardial Infarction

Seconds to Save: Recognizing Type A Intramural Hematoma Before It's Too Late (AHA 2025) - "Emergent left heart catheterization revealed mild, non-obstructive coronary artery disease.Diagnostic Evaluation:Given persistent suspicion for acute aortic syndrome, a dedicated CT angiogram of the aorta was performed, revealing an extensive intramural hematoma involving the aortic root, ascending aorta, arch, descending aorta, and abdominal aorta above the renal arteries.Treatment and Management:An esmolol infusion was initiated, and cardiothoracic surgery was urgently consulted...A high index of suspicion is essential to differentiate IMH from ACS. Early, targeted imaging is critical, as interventions such as anticoagulation or invasive catheterization may accelerate disease progression."

Acute Coronary Syndrome • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Diabetes • Hypertension • Hypotension • Metabolic Disorders • Pulmonary Embolism • Respiratory Diseases • Type 2 Diabetes Mellitus

Targeted Therapy Interrupted: Managing Hypertrophic Obstructive Cardiomyopathy in Pregnancy (AHA 2025) - "She was started on IV esmolol and phenylephrine. Mavacamten may reduce the efficacy of combined hormonal contraceptives, contributing to contraceptive failure. This case underscores the need for preconception counseling and multidisciplinary monitoring for women of childbearing age prior to initiating myosin inhibitors."

Acute Coronary Syndrome • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Hypotension • Long-acting Reversible Contraceptives • Obstructive Hypertrophic Cardiomyopathy • Respiratory Diseases

Left Pulmonary vein thrombosis following Lobectomy in a patient with Atrial fibrillation: a unique contraindication to cardioversion (AHA 2025) - "The patient was started on IV digoxin and low-dose esmolol drip for rate control along with a heparin drip for anticoagulation. Therefore, a conservative approach was chosen with rate control and systemic anticoagulation. This case also highlights the value of comprehensive imaging like transesophageal echocardiography for through evaluation of pulmonary vein ostia in addition to left atrial appendage thrombus, especially in the context of recent thoracic surgery."

Clinical • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Non Small Cell Lung Cancer • Respiratory Diseases • Thrombosis

Endovascular Management of Stanford B Aortic Dissection in a Young Patient with a Thoracoabdominal Aneurysm: A Viable Strategy? (AHA 2025) - "Medical management: IV nitroprusside, esmolol, and analgesia. Bicuspid valve anatomy predisposes to aortic disease, requiring close surveillance. Despite ongoing debate, TEVAR proved effective here, especially in experienced hybrid centers."

Clinical • Cardiovascular • Fatigue • Hypertension • Pulmonary Disease • Respiratory Diseases • Thrombosis

An Unusual Etiology of Tamponade: The Role of Solid Pericardial Debris (AHA 2025) - "After starting an esmolol and amiodarone drip, he converted to sinus tachycardia. Patients with pericardial debris up to 2 cm on TTE with risk of developing pericardial effusion should be monitored with follow up TTE. Further studies are necessary to unveil the underlying etiology of large pericardial debris."

Cardiovascular • Immunology • Pulmonary Disease • Respiratory Diseases

To Cath or Not to Cath? A Loeys-Dietz Clinical Dilemma (AHA 2025) - "Blood pressure control with esmolol and clevidipine improved her chest pain...She was already on anticoagulation with coumadin for her history of mechanical MVR, and beta blocker therapy...In this patient population, weighing risks and benefits of making such a diagnosis is important. Here, conservative management was felt to be the best option."

Clinical • Cardiovascular • Coronary Artery Disease • Myocardial Infarction • Rheumatology • SMAD3 • TGFBR2

Late Presentation Myocardial Infarction With Dueling Mechanical Complications: Dynamic Left Ventricular Outflow Tract Obstruction (LVOTO) and Ventricular Septal Rupture (VSR) (AHA 2025) - "She was admitted to the CCU, where shock improved with norepinephrine, milrinone, and IV diuresis.Her course was complicated by new-onset atrial fibrillation with RVR. Despite IV amiodarone, RVR persisted, along with worsening respiratory status and increasing vasopressors needs...Esmolol was considered to reduce the gradient...The presence of dual complications—dynamic LVOTO and VSR—illustrates the clinical complexity. This case also highlights key decision points regarding temporary mechanical circulatory support and the need to weigh aggressive interventions against patient goals in frail, multi-morbid individuals, where benefit to quality of life and survival may be limited."

Atrial Fibrillation • Autoimmune Hepatitis • B Cell Lymphoma • Cardiovascular • Cough • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Lymphoma • Metabolic Disorders • Myocardial Infarction • Non-Hodgkin’s Lymphoma • Palliative care • Pulmonary Disease • Respiratory Diseases

The Effect of Esmolol on Stress Response and Short-term Prognosis in Patients with Acute Type A Aortic Dissectio (ChiCTR) - P=N/A | N=90 | Recruiting | Sponsor: Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University

New trial

A LETHAL ILLUISON: T-CELL LYMPHOMA MASQUERADING AS AORTIC DISSECTION (CHEST 2025) - "Initial imaging(CTA PE) at the OSH demonstrated mediastinal haemorrhage with concerns for aortic rupture, prompting transfer for surgical evaluation while patient was initiated on IV esmolol...The patient was started on DA- EPOCH (etoposide, prednisone, vincristine sulfate, cyclophosphamide, doxorubicin) for chemotherapy... This case highlights the importance of maintaining a broad differential diagnosis when evaluating suspected aortic dissection, especially in the presence of atypical imaging findings. Awareness of this rare but serious mimic can prevent unnecessary surgical intervention and reduce potentially disastrous patient outcomes."

Cardiovascular • Hematological Malignancies • Hypertension • Lymphoma • Oncology • Rare Diseases • Respiratory Diseases • T Cell Non-Hodgkin Lymphoma • Vasculitis

Effect of ultrashort-acting β-blocker on the mortality of patients with sepsis or septic shock: A systematic review and trial sequential meta-analysis of randomized controlled trials. (PubMed, Intensive Crit Care Nurs) - "This study highlights the potential benefits of adjuvant ultrashort-acting β-blocker therapy for the treatment of sepsis or septic shock in terms of enhanced survival and other clinical advantages, including reduced heart rate and cardiovascular biomarkers. Furthermore, such therapy did not appear to impair cardiac function and hemodynamic stability."

Journal • Retrospective data • Review • Cardiomyopathy • Cardiovascular • Infectious Disease • Septic Shock

SYPHILITIC AORTITIS COMPLICATED WITH AORTIC DISSECTION (CHEST 2025) - "He was started on esmolol and diltiazem drip for blood pressure and heart rate control...Infectious disease was consulted and he completed Penicillin G 24,000,000 units as a 4-hour continuous infusion for 10 days... Tertiary syphilis in the United States is extremely rare and syphilitc aortitis complicated with aortic aneurysm is even rarer. This creates a diagnostic challenge for physicians and often goes overlooked."

Cardiovascular • Infectious Disease • Thrombosis

TYPE B AORTIC DISSECTION COMPLICATED BY ESCHERICHIA COLI-INDUCED AORTITIS (CHEST 2025) - "CASE PRESENTATION: A 53-year-old woman with HIV on darunavir/cobicistat/emtricitabine/tenofovir alafenamide presented with chest pain radiating to her back and severe left flank pain...The patient was initially started on ceftriaxone for a suspected urinary tract infection (UTI) and transferred to our facility. Previously acquired blood and urine cultures grew E. coli, leading to escalation to cefepime. Despite initial treatment, including antibiotics and tight blood pressure control with IV clevidipine and esmolol, persistent fevers and leukocytosis prompted further investigation.Subsequent CT imaging revealed new inflammatory changes around the false lumen of the infrarenal aorta, raising concern for E. coli-associated aortitis...After stabilization, she was discharged a six-week oral course of cefdinir due to social barriers preventing home IV antibiotic therapy... This case highlights the importance of recognizing rare infectious complications of aortic dissections...."

Atherosclerosis • Cardiovascular • Chronic Obstructive Pulmonary Disease • Diabetes • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Respiratory Diseases

AORTIC DISSECTION IN AUTOIMMUNE HEPATITIS: THE INFLAMMATORY LINK TO CATASTROPHIC VASCULAR EVENTS (CHEST 2025) - "CASE PRESENTATION: A 69-year-old female with a history of MS and AIH on azathioprine presented to the emergency department (ED) with acute severe headache, confusion, and upper extremity heaviness...An esmolol drip was initiated per protocol and cardiothoracic surgery was consulted, she was then emergently transferred to a tertiary center for surgery...Intraoperative biopsy of the aorta showed hemorrhage with mixed acute and chronic inflammation.Her post-operative course was complicated by new-onset atrial fibrillation requiring amiodarone which was later transitioned to Lopressor and volume overload with hypoxic respiratory failure necessitating BiPAP and heated high-flow oxygen therapy... This case underscores a rare occurrence of aortic dissection in a patient with AIH and MS. While traditional risk factors were absent, underlying autoimmune inflammation may have contributed. Further studies are necessary to clarify the association between autoimmune diseases and..."

Atherosclerosis • Atrial Fibrillation • Autoimmune Hepatitis • Cardiovascular • CNS Disorders • Hematological Disorders • Hepatology • Hypertension • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Multiple Sclerosis • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus