albendazole / Generic mfg. - LARVOL DELTA

Central nervous system infection by Angiostrongylus cantonensis in children: experience from Guangdong, China. (PubMed, BMC Infect Dis) - "Pediatric CNS angiostrongyliasis in Guangdong primarily affects rural children during summer-autumn. Clinical signs may be nonspecific. mNGS outperformed serology, especially in early or seronegative cases. Most patients had favorable short-term outcomes."

Journal • CNS Disorders • Eosinophilia • Epilepsy • Infectious Disease • Pediatrics • IL6

In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia. (PubMed, J Genet Eng Biotechnol) - "Giardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole...Target sequence analysis revealed Dextromethorphan and Azathioprine as candidate Rho GTPase inhibitors, and Imatinib, Dasatinib, and Ponatinib as RhoGAP inhibitors...These findings highlight RhoGAP as a promising therapeutic target in G. lamblia, with Dasatinib showing potential as a repurposed treatment for Giardiasis. Proteomic data are publicly available in the MASSIVE database under identifier MSV000097321."

Journal • Preclinical • Gastrointestinal Disorder • Infectious Disease

Developing epigenetic synergistic drug combinations with albendazole in paediatric acute myeloid leukaemia (ASH 2025) - "Similar anthelmintic agents, mebendazole (MBZ) and parbendazole (PBZ), have been reported to have effects on epigenetic regulators that alter C-MYB degradation (Walf-Vorderwülbecke et al...These epigenetic hits represent various target families such as HDAC inhibitors (vorinostat, panobinostat, and CUDC-101), BET inhibitors (OTX-015, PFI-1, and (-)-JQ), aurora kinase inhibitors (MK-8745 and JNJ-7706621), and DNA synthesis inhibitors (cytarabine)...HDAC inhibitors (vorinostat), BET inhibitors (OTX-015) and histone methyltransferase (MS023) were among the most represented epigenetic target families, indicating potential mechanism of action of the novel ABZ+epigenetic combination. The novel drug candidate ABZ was found to have remarkable anti-leukaemia efficacy in murine and human models of childhood AML in vitro and in vivo while having negligible effects in normal cells. Current work is focused on evaluating ABZ+epigenetic synergistic combinations that will be taken..."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Pediatrics • HOXA9 • IL1B • MEIS1

The infectious liver tumour (PubMed, Praxis (Bern 1994)) - "Curative treatment can only be achieved through R0 resection. Suppressive therapy with albendazole can now achieve good long-term survival even in cases where surgery is not possible."

Journal • Review • Liver Cancer • Oncology • Solid Tumor

Anthelminthic Activity of Piper nigrum, Albizia ferruginea, and Guarea cedrata Against Caenorhabditis elegans and Heligmosomoides polygyrus: In Vitro and In Silico Molecular Docking Approach. (PubMed, Scientifica (Cairo)) - "The extracts were screened at varying concentrations, with distilled water being the negative control and albendazole being the positive control...This study has demonstrated in vitro and in silico the effectiveness of Piper nigrum, Albizia ferruginea, and Guarea cedrata toward helminthiasis. To validate this scientific investigation, more research is required, particularly on the acute toxicity and in vivo anthelmintic efficacy."

Journal • Preclinical • Infectious Disease

Loa loa Encephalopathy Following Treatment With Benzimidazole Derivatives: A Systematic Review. (PubMed, Open Forum Infect Dis) - "Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. Due to the limited global use of prolonged benzimidazole regimens for loiasis, the number of encephalopathy cases identified raises significant safety concerns, challenging the rationale of their use. Further research on mechanisms and safer alternative regimens is urgently needed."

Journal • CNS Disorders

Clinical, Diagnostical, and Epidemiological Findings at First Diagnosis of Alveolar Echinococcosis: A Single-Center Cohort Study. (PubMed, Visc Med) - "Albendazole was the initial drug therapy for all patients...Especially in symptomatic patients and in higher WHO stages, AE primarily leads to elevated cholestasis parameters, which reflect a biliary outflow obstruction and correlate with a poorer outcome. In ambulatory patients with unexplained cholestasis, such findings should be a reason to consider an AE."

Journal • Cholestasis • Hepatology • Infectious Disease • Oncology

Activity of antifilarial drugs on microfilaremia in the treatment of loiasis: a systematic review. (PubMed, Parasit Vectors) - "Antifilarial drug efficacy against L. loa microfilaremia varies by dosage and treatment duration, with IVM and DEC demonstrating rapid, high efficacy but presenting safety concerns for hypermicrofilaremic individuals. ALB and MBZ show efficacy with extended treatment but are slower acting. Further research is needed to optimize treatment regimens and assess clinical outcomes beyond microfilaremia reduction."

Journal • Review

Neuroendoscopic management of a third ventricle hydatid cyst presenting with obstructive hydrocephalus in a 4-year-old female: a case report and review of the literature. (PubMed, J Med Case Rep) - "Hydatid cysts should be considered in the differential diagnosis of intraventricular cystic lesions, although extremely rare. Further studies are necessary to guide standardized protocols for these unusual neurological entities. The surgical intervention is precision-demanding and relies on the neurosurgeon's expertise to prevent intraoperative complications. Histopathological confirmation remains essential for diagnosis in cases of cerebral hydatid cysts."

Journal • CNS Disorders • Ophthalmology • Pain • Strabismus • Ventriculomegaly

Muscular hydatidosis in an exceptional location: Contribution of ultrasound and MRI in diagnosis. (PubMed, Radiol Case Rep) - "The patient underwent open pericystectomy without rupture, preceded and followed by albendazole therapy (400 mg twice daily). Postoperative follow-up showed complete recovery without recurrence at 6 months. Awareness of this rare localization and recognition of its imaging hallmarks are essential to avoid misdiagnosis and ensure appropriate management."

Journal • Oncology • Pain • Sarcoma • Soft Tissue Sarcoma • Solid Tumor

Ascaris lumbricoides infestation of the gallbladder: case report. (PubMed, J Surg Case Rep) - "The patient was treated with albendazole, leading to clinical improvement, and she was advised on prevention...In uncomplicated cases, antihelminthics may suffice. Monitoring is necessary because taking antiparasitic drugs can precipitate the onset of complications by retaining dead worms in the bile duct."

Journal • Pain • CRP

Spinal Hydatidosis in the Lumbar Region: An Unusual Presentation of Echinococcosis. (PubMed, Cureus) - "The patient underwent surgical excision of the cysts and spinal stabilization, along with albendazole therapy administered pre- and postoperatively...This case underscores the importance of including spinal echinococcosis in the differential diagnosis of vertebral lesions, particularly in endemic regions and among patients with risk factors such as close contact with dogs. Early diagnosis through imaging and a combined surgical-medical treatment approach are crucial for favorable outcomes."

Journal • Back Pain • Infectious Disease • Musculoskeletal Pain • Pain

How can Mentha piperita oil affect Trichinella spiralis adults and larvae? In vitro and in vivo studies. (PubMed, Vet Parasitol) - "PEO exhibited a superior activity over albendazole against invasive and encapsulated larvae...The antioxidant capabilities and the anti-inflammatory possessions qualified it to be a promising, safe, therapeutic alternative for trichinosis. However, further studies should be conducted to standardize its dose and duration in human."

Journal • Preclinical • Infectious Disease

Unusual presentation of Enterobius vermicularis infestation of the uterine cervix during pregnancy. (PubMed, BMJ Case Rep) - "The patient was treated with albendazole (400 mg, repeated after 2 weeks), and household contacts received the same treatment...This case highlights E. vermicularis infestation of the uterine cervix as a rare cause of abdominal pain during pregnancy. Clinicians should consider parasitic infections in the differential diagnosis of cervical lesions or unexplained pain, especially in endemic regions."

Journal • Infectious Disease • Pain

Semi-annual and annual mass drug administration of diethylcarbamazine and albendazole are equally effective regimens for eliminating lymphatic filariasis in Papua New Guinea. (PubMed, PLoS Negl Trop Dis) - "Using a generalized estimating equation model that accounted for age, sex, bednet use, and sentinel site, we found no significant difference in the effectiveness of the two treatment approaches (p = 0.845 for Mf and p = 0.332 for CFA). Therefore, annual and semiannual MDA were equally effective in reducing LF prevalence in this high-endemic setting."

Journal • Infectious Disease

When the parasite strikes back: Secondary paraspinal hydatidosis: A case report. (PubMed, Int J Surg Case Rep) - "Hydatid disease should be included in the differential for paravertebral masses, even after treated visceral disease. This case highlights the need for long-term surveillance and a multidisciplinary approach. Early recognition and appropriate therapy are essential to prevent complications and recurrence."

Journal • Infectious Disease • Pain

EMOTI: Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita (clinicaltrials.gov) - P2 | N=100 | Not yet recruiting | Sponsor: Jennifer Keiser

New P2 trial • Infectious Disease

In vitro and in vivo anthelmintic activity of Artemisia absinthium against gastrointestinal nematodes of free-grazing goats from Ayacucho, Peru. (PubMed, J Adv Vet Anim Res) - "Although A. absinthium showed promising in vitro anthelmintic effects, the extract failed to demonstrate significant efficacy in vivo at the tested dose. Additionally, continuous monitoring of drugs in the region of study is strongly recommended based on the results obtained for albendazole."

Journal • Preclinical

Strongyloides stercoralis hyperinfection with thrombosis: A systematic review of case reports. (PubMed, New Microbes New Infect) - "Ivermectin was the mainstay of therapy, alone or with albendazole, although treatment regimens were inconsistently reported...Early empiric antiparasitic therapy, timely investigation for thrombotic complications, and individualized anticoagulation strategies are essential to improving outcomes. Given the reliance on case-level evidence, prospective studies and standardized reporting are urgently needed to characterize better risk factors, optimal management, and prognosis of this neglected but critical complication."

Journal • Review • Cardiovascular • Hematological Disorders • Infectious Disease • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Thrombosis

Early-stage ocular toxocariasis: Progression and histopathologic analysis. (PubMed, Am J Ophthalmol Case Rep) - "Initial 2-week treatment with oral albendazole 15mg/kg/daily lacked response, therefore pars plana vitrectomy, excisional biopsy, laser photocoagulation, silicone oil tamponade and sub-tenon triamcinolone injection was performed for management of retinal detachment and macular lesions...We present a unique case of early-stage ocular toxocariasis in which progression was documented by serial multimodal imaging. The diagnosis was supported by serology and histopathologic analysis."

Journal • Eosinophilia • Eye Cancer • Fibrosis • Immunology • Oncology • Ophthalmology • Retinal Disorders

Isolated Ruptured Pulmonary Hydatid Cyst Mimicking Community-Acquired Pneumonia. (PubMed, Cureus) - "He was treated conservatively with albendazole and antibiotics, leading to rapid clinical and biochemical improvement. This case highlights the need to consider hydatid disease in endemic regions for non-resolving pneumonia and demonstrates the potential role of medical therapy alone in select patients."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Ruptured right atrial hydatid cyst causing anaphylactic shock in a child: a rare and life-threatening case. (PubMed, Cardiol Young) - "Although cardiac hydatid cysts are rare, right atrial localisation is even rarer. The aim of this article is to emphasise the importance of always being alert and prepared for the risk of anaphylaxis developing due to cyst rupture in paediatric patients with isolated cardiac hydatid cysts, to initiate oral albendazole treatment immediately upon diagnosis, to underline the importance of surgical timing, and to discuss the role of clinical assessment and imaging methods in predicting of cyst rupture."

Journal • Infectious Disease • Pediatrics

A Sterically Open Ruthenium-Based Photocage Activated by Red and Far-Red Light for a Wide Range of Drugs. (PubMed, J Am Chem Soc) - "A total of ten active pharmaceutical ingredients (L) have been successfully conjugated to this photocage, including well-known agents such as Albendazole, Gemcitabine, Bosutinib, Neratinib, and Ponatinib. Several of the obtained PACT prodrugs exhibited micro- to nanomolar EC50 values upon red light activation, with photoindexes as high as 7.5. [7]Cl2 showed a photoindex of 6.2 upon far-red light activation (730 nm), which is unprecedented for a ruthenium-based PACT, while the ruthenium cage itself showed very low toxicity in both the dark and light irradiation."

Journal • Oncology

Clinical Presentation, Management and Outcome of Cerebral Echinococcosis in Children: A Systematic Review and Meta-Analysis. (PubMed, Pathogens) - "Advances in non-invasive imaging, refinement of surgical technique, and targeted antiparasitic therapy improved outcomes. Nevertheless, heterogeneous reporting and the prevailing paucity of evidence limit definitive recommendations. Prospective multicenter studies are needed to refine treatment and develop pediatric-specific guidelines."

Clinical • Journal • Retrospective data • Review • Cardiovascular • CNS Disorders • Epilepsy • Hypertension • Pain • Pediatrics

Cardiac and pericardial hydatid cysts: a single center analysis of 22 cases. (PubMed, BMC Cardiovasc Disord) - "Cardiac involvement of hydatid cysts is a life-threatening condition that requires prompt surgical intervention. Postoperative albendazole therapy should be administered to prevent recurrence. In patients who refuse surgery, medical therapy may offer limited prolongation of survival."

Journal • Cardiovascular • Cough • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases