albendazole / Generic mfg. - LARVOL DELTA

Focus on alveolar echinococcosis (PubMed, Rev Med Interne) - "Indeed, drug treatment with albendazole, a parasitostatic molecule sometimes responsible for serious side effects (hepatic cytolysis), remains the main effective and available alternative. In case of imidazole intolerance and impossible surgical access, some patients may be in therapeutic dead end."

Journal • Review • Infectious Disease

GRANULOMATOUS LIVER LESIONS MASKING DIFFUSE LARGE B-CELL LYMPHOMA: A DIAGNOSTIC PITFALL (UEGW 2026) - "Clinical Case Summary: An 85-year-old partially dependent woman with cardiovascular risk factors and rheumatoid arthritis, treated with pantoprazole, carvedilol, prednisolone and apixaban, was admitted with night sweats, weight loss, abdominal pain and fever...Bacterial and parasitic serology was negative, except for Ascaris lumbricoides; albendazole was given without response...A third biopsy revealed poorly differentiated neoplasia, with immunohistochemistry compatible with diffuse large B-cell lymphoma. Clinical deterioration progressed, culminating in death.This case highlights the challenging differential diagnosis of granulomatous liver lesions and the pitfalls of clinical, radiological and histological assessment."

B Cell Lymphoma • Cardiovascular • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Inflammatory Arthritis • Lymphoma • Non-Hodgkin’s Lymphoma • Respiratory Diseases • Rheumatoid Arthritis • Tuberculosis • AFP • B2M

ENTEROBIUS VERMICULARIS PRESENTING AS A SUBEPITHELIAL-APPEARING RECTAL LESION: AN UNUSUAL TISSUE-INVASIVE PRESENTATION (UEGW 2026) - "Following albendazole treatment, the eosinophil count normalised (0.25 × 10⁹/L) and total IgE decreased to 521 IU/mL, with complete symptom resolution.Enterobius vermicularis infection is typically confined to the intestinal lumen, although rare cases of tissue-invasive disease have been reported. In this case, a granulomatous reaction resulted in a subepithelial-appearing rectal lesion mimicking a neoplasm. This report highlights an extremely rare presentation of invasive enterobiasis and the importance of considering this diagnosis in patients with rectal subepithelial lesions and concomitant luminal disease."

Colorectal Cancer • Eosinophilia • Infectious Disease • Pruritus

GASTRIC PERFORATION SECONDARY TO ASCARIS LUMBRICOIDES: A RARE SURGICAL EMERGENCY (UEGW 2026) - "Postoperative management included broad-spectrum antibiotics, proton pump inhibitors, and albendazole... Gastric perforation due to ascariasis is an exceptionally rare surgical emergency. It should be considered in patients presenting with acute abdomen in endemic regions. Early surgical intervention combined with anti-helminthic therapy is essential for favorable outcomes."

Gastrointestinal Disorder • Infectious Disease

Effect of Oral Supplementation of Kratom (Mitragyna speciosa Korth.) on Gastrointestinal Nematodes and Serum Lipid Peroxidation in Crossbred Saanen Goats. (PubMed, Vet Sci) - "The control group received albendazole at a dose of 15 mg/kg on the first day of the experiment...In conclusion, Mitragyna speciosa Korth. supplementation did not significantly reduce fecal egg count compared to conventional anthelmintic treatment but demonstrated a transient effect on oxidative stress, as indicated by changes in serum MDA concentration."

Journal • Hematological Disorders

Disseminated Pulmonary and Hepatic Cystic Echinococcosis Presenting as Suspected Pulmonary Embolism and Mimicking Metastatic Malignancy. (PubMed, Cureus) - "She was treated with albendazole 400 mg twice daily, and five-week follow-up CT showed cavitary transformation of pulmonary nodules consistent with treatment-related cyst degeneration...In patients from endemic regions, discordant FDG PRT/CT findings - hypermetabolic pulmonary lesions with isometabolic hepatic cysts - should prompt consideration of CE. A multidisciplinary approach integrating multimodal imaging and serology is essential for accurate diagnosis and to avoid unnecessary invasive procedures."

Journal • Cardiovascular • Cough • Hepatology • Infectious Disease • Oncology • Pain • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Andrographolide as a Promising Diterpenoid Scaffold Against the Neurotropic Nematode Angiostrongylus cantonensis. (PubMed, Pharmaceuticals (Basel)) - "These EC50 values were similar to those of albendazole, with no statistically significant differences detected for any developmental stage...The in silico analyses predicted compliance with major drug-likeness rules, absence of PAINS alerts, high gastrointestinal absorption, and low probabilities of hepatotoxicity, nephrotoxicity, and neurotoxicity. Andrographolide represents a promising in vitro anthelmintic hit against A. cantonensis and warrants further preclinical investigation."

Journal • CNS Disorders • Infectious Disease • Pain

Worming Yourself to Transplant: A Case of Albendazole Induced Acute Liver Failure (ACG 2026) - "She was treated with N-acetylcysteine without improvement. Portal venule is denoted with asterisk (2A). Central vein (asterisk) with perivenular hemorrhagic necrosis and numerous surrounding necrotic hepatocytes (black arrowheads) with mixed lobular inflammation (2B).?"

Clinical • Autoimmune Hepatitis • Cardiovascular • CNS Disorders • Genetic Disorders • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Obesity • Transplantation

False-Negative Serology as a Diagnostic Pitfall in Hepatic Cystic Echinococcosis: The Value of Repeat Testing (ACG 2026) - "(A) Initial CT demonstrating a large right hepatic cystic lesion. (B) Follow-up CT demonstrating interval reduction in cyst size following albendazole therapy and laparoscopic PAIR-based intervention"

Gastroenterology • Gastroesophageal Reflux Disease • Hepatology

Severe Iron-Deficiency Anemia in the Absence of Overt Gastrointestinal Bleeding: An Unexpected Diagnosis of Polyparasitism (ACG 2026) - "Treatment with albendazole yielded clearance of parasites and sustained improvement in IDA...Parasitic infection should be considered in the differential diagnosis of iron deficiency anemia, especially in patients from endemic regions. Figure: Figure 1: Endoscopic images from colonoscopy showing innumerable white, slender motile organisms throughout the colon from the transverse colon to cecum"

Alzheimer's Disease • Anemia • Cardiovascular • CNS Disorders • Dementia • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypotension • Infectious Disease • Inflammation

Hidden in the Crypts: Strongyloides Hyperinfection Syndrome Overshadowed by Concurrent H. pylori Gastritis (ACG 2026) - "Ivermectin and albendazole were initiated...Figure: (Histology, H&E 200x): Gastric biopsy demonstrating Strongyloides stercoralis larvae within gastric crypts (arrows), with marked active chronic inflammation and reactive epithelial changes. Figure: (EGD): Endoscopic view demonstrating diffuse severe gastritis with mucosal erythema, friability, erosions, and ulceration throughout the gastric body."

Cardiovascular • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Infectious Disease • Inflammation • Metabolic Disorders • Peptic Ulcer • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

Thinking Beyond Simple Hepatic Cysts: Cystic Hepatic Echinococcosis in a Patient With Livestock Exposure (ACG 2026) - "Patient completed a 3-month course of albendazole...(A) Pre-treatment magnetic resonance (MR) abdomen with and without contrast shows a 4.18 centimeter (cm) complex left hepatic lobe lesion. (B) Pre-treatment computed tomography (CT) liver triple phase of cystic hepatic echinococcosis shows approximately 4.2 cm inferior right left lobe nodule with heterogeneous calcification and minimal enhancement"

Clinical • Hepatology • Infectious Disease

Incidental Detection of Trichuris trichiura (Whipworm) During Screening Colonoscopy in an Asymptomatic Patient With HIV (ACG 2026) - "Albendazole and ivermectin are effective, and follow-up stool testing is recommended to confirm eradication...Parasitic infections should be considered during screening colonoscopy in patients with relevant epidemiologic risk factors. Figure: Whipworm visualized on colonoscopy Figure: Whipworm visualized on colonoscopy"

Clinical • Hematological Disorders • Hepatitis B • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Ischemic Colitis With Coexisting Taenia Species on Biopsy (ACG 2026) - "She was treated with albendazole for Taenia spp., along with cefepime and metronidazole for ischemic colitis. Figure: Figure 2: Taenia Spp. eggs in the terminal ileum with increasing magnification from left to right"

Biopsy • Cardiovascular • Chronic Kidney Disease • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Hypotension • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Pancreatitis • Renal Disease • Septic Shock • Thrombosis

Hidden in the Small Bowel: Parasitic Infection Unmasked by Video Capsule Endoscopy in an IgA Deficient Patient (ACG 2026) - "The patient was treated with a one-time dose of albendazole and iron supplementation with overall improvement in symptoms...While current guidelines recommend a trial of iron supplementation over routine use of VCE in asymptomatic patients with IDA and negative bidirectional endoscopy, VCE proved to be a useful tool for this patient with unexplained symptoms, immunodeficiency, and epidemiological risk factors for parasitic infection. Figure: Figure 1: Video capsule endoscopy (VCE) images showing a small intestinal parasite, most likely Ascaris."

Clinical • Video • Constipation • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Mood Disorders

Gut Feeling: Capsule Endoscopy Reveals the Parasitic Puppet Master Behind a Triple-Threat Presentation (ACG 2026) - "He was admitted on IV piperacillin-tazobactam and therapeutic-dose enoxaparin. Figure C: Capsule endoscopy image 2 months after albendazole therapy shows a focal pale, granular mucosal lesion consistent with intestinal lymphangiectasia. Figure D: Follow-up endoscopic image obtained 2 months after albendazole therapy shows residual mucosal erythema, highlighted by the green arrow, without visible worm burden."

Cardiovascular • Eosinophilia • Gastrointestinal Disorder • Infectious Disease • Inflammation • Mucositis • Pulmonary Embolism • Respiratory Diseases

I Coughed up a Worm: An Unusual Presentation of Ascariasis Diagnosed by Video Capsule Endoscopy (ACG 2026) - "The patient was treated with albendazole and remained asymptomatic without further episodes of worm expectoration on follow-up...This case underscores the importance of careful history taking, attention to patient-reported symptoms, and recognition of the limitations of diagnostic testing. Figure: Second Duodenum"

Video • Gastrointestinal Disorder • Infectious Disease

From Liver Abscess to Metastatic Rectal Cancer: A Rare and Confusing Presentation (ACG 2026) - "The patient was empirically treated with ceftriaxone, metronidazole, and albendazole. Well-differentiated neuroendocrine tumor: immunohistochemical workup demonstrates tumor cells positive for synaptophysin (C) and Cam5.2 (D). Liver biopsy showing metastatic well-differentiated neuroendocrine tumor with characteristic features of the tumor cells (E) Higher magnification of liver biopsy highlighting the Ki-67 proliferative index, with a variable rate up to 10%, indicating a G2 grade of the tumor (F)"

Metastases • Colorectal Cancer • Eosinophilia • Gastrointestinal Neuroendocrine Tumor • Hepatocellular Cancer • Hepatology • Infectious Disease • Neuroendocrine Tumor • Oncology • Rectal Cancer • Solid Tumor • NCAM1 • SYP

Effects of Three Anthelmintics on the Transcriptome of FHs 74 Int Enterocytes. (PubMed, Trop Med Infect Dis) - "In this study, the three commonly used anthelmintics albendazole, ivermectin, and praziquantel were investigated by transcriptome analysis for their effects on gene activity in the human intestinal cell line FHs 74 Int after 24-h exposure...Analysis of these genes showed that albendazole caused a modest upregulation of cell cycle related processes, especially mitotic spindle formation, and chromosome segregation. The cells showed a stronger response to ivermectin and the data suggested inhibition of cell proliferation through downregulated transcription factors and nuclear receptors and stimulation of cell growth and cell survival mechanisms through upregulated metabolic enzymes."

Journal • Infectious Disease

Pulmonary Dirofilaria immitis Infection and Concurrent Pleural Lymphangiomatosis in a Young Woman from Costa Rica: A Diagnostic Challenge after 20 Years of Silence. (PubMed, Am J Trop Med Hyg) - "Initial treatment included methylprednisolone, albendazole, and a subsequent course of albendazole plus doxycycline; however, the chylothorax recurred. The patient was discharged with continued treatment but was clinically stable. This case reveals the diagnostic complexity of filariasis and underlying lymphadenopathies coexisting in endemic regions and highlights the value of an integrated clinical, molecular, and histopathological approach."

Journal • Eosinophilia • Immunology • Infectious Disease

Human Neuroangiostrongyliasis Caused by Angiostrongylus cantonensis in Northern Vietnam: a Clinical-Epidemiological Case Series of Eosinophilic Response and Disease Manifestations. (PubMed, Acta Parasitol) - "In 6 of 30 patients (20.0%; 95% CI 9.5-37.3), no CSF eosinophils were recorded on the routine differential at presentation; this should not exclude the diagnosis. The proportion is conditioned on a case definition that admits patients on peripheral eosinophilia with a reactive serology, and on the sensitivity of a routine clinical differential; both are properties of a retrospective case series and are set out in the Limitations. All patients received combined albendazole and methylprednisolone and no serious adverse event was attributed to either drug, but in the absence of a comparator group no inference can be drawn about the independent contribution of either agent. Exposure histories were abstracted retrospectively and cannot identify a transmission route. Cases were referred predominantly from the north-central provinces, indicating where prospective surveillance and molecular diagnostic capacity should be directed."

Journal • Retrospective data • CNS Disorders • Eosinophilia • Infectious Disease • Pain

Albendazole Treatment of Alveolar Echinococcosis in a Trial Based on a Cross Sectional Ultrasound Study in Kyrgyzstan. (PubMed, Trop Med Int Health) - P2 | "In hyperendemic areas of AE, wait and see for small lesions or combined with albendazole therapy is a realistic approach to the management of AE cases. Frequent follow up with imaging every 3-4 months is essential to monitor any disease progression."

Journal

Phytochemical Profiling, Antioxidant, Cytotoxicity, and Anthelmintic Activity of the Bark Extracts of Terminalia superba Against the Murine Intestinal Nematode Heligmosomoides polygyrus: An Integrated In Vitro and In Silico Approach. (PubMed, Scientifica (Cairo)) - "Albendazole served as positive control, and distilled water served as negative control...ProTox-III classified all top compounds at low toxicity levels (class ≥ 4). This study offers preliminary scientific support for the traditional use of T. superba bark extracts in managing intestinal helminthiases, warranting further in vivo validation."

Journal • Preclinical • Hematological Disorders • Infectious Disease

Individual-level agreement between coverage surveys and treatment registers in mass drug administration: A secondary analysis of the multi-country DeWorm3 cluster randomized trial. (PubMed, PLoS Negl Trop Dis) - "Individual-level discordance between coverage surveys and treatment registers was present across all sites and rounds, with surveys consistently estimating higher levels of treatment. Predictors varied by site, suggesting measurement error is driven by site-level programmatic and contextual factors rather than individual demographic characteristics. Programs should implement systematic validation approaches as high aggregate coverage estimates may mask meaningful individual-level measurement error."

Journal

Multiple hepatic artery pseudoaneurysms associated with visceral larva migrans: a rare cause of upper gastrointestinal bleeding in a child. (PubMed, BMJ Case Rep) - "The patient was successfully treated with transarterial embolisation along with albendazole and corticosteroid therapy, resulting in clinical and laboratory improvement. This case highlights the significance of radiological imaging in the diagnosis of visceral larva migrans in children with emphasis on close clinicoradiological integration for accurate identification of the uncommon presentation of this disease and demonstrates the value of CT angiography in identifying life-threatening arterial involvement."

Journal • Cardiovascular • Gastroenterology • Hematological Disorders • Hepatology • Infectious Disease • Oncology • Pain