STMC-103H
/ Siolta Therap
- LARVOL DELTA
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December 10, 2025
Siolta Therapeutics Announces Upcoming Late Breaking Oral Presentation of Results from the Phase 2 ADORED trial at 2026 AAAAI meeting
(PRNewswire)
- "...Abstract describing the one year results from the company's Phase 2 ADORED clinical trial of STMC-103H in infant subjects at-risk for development of atopic diseases (atopic dermatitis, food allergy, allergic asthma, allergic rhinitis/ conjunctivitis) has been accepted..."
Late-breaking abstract • P2 data • Allergic Rhinitis • Asthma • Atopic Dermatitis • Food Hypersensitivity
November 21, 2025
adored: Allergic Disease Onset Prevention Study
(clinicaltrials.gov)
- P1/2 | N=283 | Completed | Sponsor: Siolta Therapeutics, Inc. | Active, not recruiting ➔ Completed
Trial completion • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
November 17, 2025
Siolta Therapeutics Reports Positive Phase 2 Results from the ADORED Study
(PRNewswire)
- "Subjects who completed the full year of treatment with STMC-103H demonstrated a 64% reduction in the risk of developing physician-diagnosed atopic dermatitis compared to placebo at one year after initiation of treatment (23.3% vs. 43.1%; OR = 0.36; 90% CI 0.20-0.66; n=158; p = 0.005). When all randomized infants, including those who received less than 1 year of treatment, were included in the end-of-treatment analysis, the results did not reach statistical significance; STMC-103H showed consistent and clinically meaningful improvements across additional secondary endpoints at one year, including a 77% reduction in the risk of developing physician-diagnosed food allergy (4.7 vs. 16.7%; OR = 0.23; 90% CI 0.09-0.63, p=0.02), prolonged time to development of atopic dermatitis (p=0.01) and reduced total serum IgE (p=0.03) compared to placebo, in those subjects who completed treatment as planned....End of study (Year 2) clinical outcome data will be finalized and reported in Q1 of 2026."
P2 data • Allergic Rhinitis • Allergy • Asthma • Atopic Dermatitis
January 03, 2024
adored: Allergic Disease Onset Prevention Study
(clinicaltrials.gov)
- P1/2 | N=264 | Active, not recruiting | Sponsor: Siolta Therapeutics, Inc. | Recruiting ➔ Active, not recruiting | Phase classification: P1b/2 ➔ P1/2
Enrollment closed • Phase classification • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
August 09, 2023
adored: Allergic Disease Onset Prevention Study
(clinicaltrials.gov)
- P1b/2 | N=264 | Recruiting | Sponsor: Siolta Therapeutics, Inc. | Trial completion date: Dec 2024 ➔ Sep 2025 | Trial primary completion date: Dec 2023 ➔ Sep 2024
Trial completion date • Trial primary completion date • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
July 20, 2022
Siolta Therapeutics Announces First Newborn Dosed in Their Phase 2 ADORED Study Evaluating a Potential First-In-Class Live Biotherapeutic Product for the Prevention of Atopic Diseases
(Businesswire)
- "Siolta Therapeutics...announced that the first newborn subject has been dosed in the adored study, a Phase 1b/2 trial of STMC-103H, a potential first-in-class microbiome-based therapeutic for the prevention of atopic diseases....'The development of STMC-103H allows us to study an innovative and potentially transformative new intervention for newborns at-risk for allergic diseases based on an immediate family history. I am thrilled to lead the investigation of STMC-103H in this Phase 1b/2 trial.'"
Trial status • Atopic Dermatitis • Immunology
September 23, 2021
adored: Allergic Disease Onset Prevention Study
(clinicaltrials.gov)
- P1b/2; N=264; Recruiting; Sponsor: Siolta Therapeutics, Inc.; Not yet recruiting ➔ Recruiting
Enrollment open • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
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