GM609 / Genervon - LARVOL DELTA

[VIRTUAL] Effect of Peptide-Based Inhibition of DNase II on AAV Transduction and TLR9 Signaling (ASGCT 2021) - "GM16095 human cells were transduced in vitro with AAV8 in the presence or absence of inhibitory peptides targeting DNase II and luciferase transgene expression was detected...Therefore, we studied the modulation of TLR9 signaling with DNase II inhibitory peptide in vitro using the HEK-Blue hTLR9 reporter cells. Although a deeper characterization is needed, our results suggest that peptide-mediated blocking of DNase II activity could be a strategy worth exploring for potentiating the efficacy of AAV-mediated gene delivery."

Gene Therapies

Exploring the Protective Effect of ShenQi Compound on Skeletal Muscle in Diabetic Macrovasculopathy Mice. (PubMed, Endocr Metab Immune Disord Drug Targets) - "All these results indicate that SQC is an effective preventive and protective drug on skeletal muscle of diabetic macrovasculopathy, and could alleviate skeletal muscle tissue damage through affecting biological functions related to cell death and cell adhesion."

Journal • Preclinical