SAB01 / Santa Ana Bio - LARVOL DELTA

Santa Ana Bio Announces First Subjects Dosed in Phase 1 Study of SAB01 to Treat Autoimmune Inflammatory Diseases (GlobeNewswire) - "The Phase 1 clinical trial is a randomized, double-blind, placebo-controlled, single ascending dose trial evaluating subcutaneous and intravenous SAB01 in healthy adult participants. Fifty-six participants will be enrolled across six subcutaneous cohorts and one intravenous cohort of eight participants each, randomized 6:2 to SAB01 or placebo."

Trial status • Immunology • Inflammation

Phase 1 Study Involving SAB01 and Healthy Participants (clinicaltrials.gov) - P1 | N=88 | Recruiting | Sponsor: Santa Ana Bio

First-in-human • New P1 trial

Pseudovitamin B12 producing Loigolactobacillus coryniformis enhances soy milk fermentation by Lactobacillus delbrueckii subsp. bulgaricus. (PubMed, J Sci Food Agric) - "Our findings in this study indicate that the growth of Lb. delbrueckii subsp. bulgaricus NBRC 13953 was promoted by the pseudovitamin B12 produced by Loigolactobacillus coryniformis SAB01, thereby suggesting a novel symbiotic relationship between these two lactic acid bacteria in soy milk."

Journal

Santa Ana Bio Launches With $168 Million to Advance Precision Medicines for Inflammatory Diseases (Businesswire) - "Santa Ana Bio...today emerged from stealth with $168 million in combined Series A and B funding. Founding investor Versant Ventures led the Series A round and was joined by TPG’s Life Science Innovations fund and GV. The $125 million Series B round was led by GV, with participation from all existing investors as well as new investors Access Biotechnology, Andreessen Horowitz (a16z) Bio + Health and RTW...The vast majority of biologics for autoimmune disease target cytokines, which are the messengers but not the causal agents. Nor do these treatments discriminate diseased from healthy tissue....SAB01 has been named as a development candidate, with Phase I testing expected to start next year in chronic inducible urticaria."

Financing • New P1 trial • Chronic Spontaneous Urticaria • Immunology • Inflammation • Inflammatory Bowel Disease