finasteride / Generic mfg. - LARVOL DELTA

Injectable Therapy for Androgenetic Alopecia: A Systematic Review. (PubMed, Dermatol Surg) - "Injectable therapy may provide cosmetic benefit in AGA, particularly with dutasteride, but current evidence is limited by small sample sizes, variable protocols, and short follow-up. Standardized randomized trials are required before injectable therapy can be recommended as routine therapy."

Journal • Alopecia • Dermatitis • Dermatology • Immunology

Dihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking. (PubMed, Addict Biol) - "Future studies are requested to investigate the effects of reduced dihydrotestosterone concentrations over a longer time and to shed light on the molecular mechanisms underlying the here observed effects of finasteride. Trial Registration: DRKS00020569."

Clinical • Journal • Addiction (Opioid and Alcohol)

Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. (PubMed, Front Nutr) - "While standard treatments such as finasteride and minoxidil are effective, their side effects and adherence issues limit long-term use, making the exploration of safe and accessible intervention strategies essential. Future large-scale, high-quality RCTs are needed to verify these findings. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251130173, Identifier CRD420251130173."

Journal • Retrospective data • Review • Alopecia • CNS Disorders • Immunology

Naringin Promotes Hair Regeneration via Wnt/β-catenin Pathway: A Dose-Dependent Study in C57BL/6J Mice. (PubMed, J Ethnopharmacol) - "Naringin promotes hair regeneration through activation of the Wnt/β-catenin signaling pathway, with the 4% concentration showing the best results. This natural compound, particularly at 4% concentration, demonstrates hair growth-promoting efficacy comparable to 5% minoxidil by activating the Wnt/β-catenin pathway, offering a promising alternative for alopecia treatment."

Journal • Preclinical • Alopecia • Immunology

Clinical efficacy and effects on hypothalamic-pituitary-adrenal axis function of proscar combined with selective serotonin reuptake inhibitor in post-stroke depression. (PubMed, World J Psychiatry) - "Combining SSRIs with Free San can enhance therapeutic efficacy, improve depressive symptoms, and regulate HPA axis function in patients with PSD with good safety and clinical application value."

Journal • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry

The Association Between 5α-Reductase Inhibitors and the Presence of Subsequent Dry Eye Disease in Androgenetic Alopecia: A TriNetX Database Study. (PubMed, Cureus) - "In the sensitive analysis, the DED incidences were significantly higher in the 5ARI population than in the non-5ARI population, with several characteristics such as the metabolic syndromes. Conclusions The application of 5ARI is associated with a higher risk of following DED development, which is related to the application time in the androgenetic alopecia population."

Journal • Alopecia • Dry Eye Disease • Immunology • Metabolic Disorders • Ophthalmology

Pregnancy's lasting imprint: Late pregnancy allopregnanolone alters rat fear recall and medial prefrontal cortex activity. (PubMed, Horm Behav) - "To test this, we administered Finasteride, a 5α-reductase inhibitor that blocks allopregnanolone synthesis, during late pregnancy...These findings support a role for pregnancy-related neurosteroids in modulating prefrontal activity and long-term cognitive function. They also highlight the importance of including reproductive experience and individual behavioral phenotypes in neuroscience research to improve translational relevance."

Journal • Preclinical

Ameliorative Potential of Lycopene Against Finasteride-Induced Seminiferous Tubules Damage in Adult Rats: A Histological, Immunohistochemical, and Biochemical Study. (PubMed, Microsc Microanal) - "Interestingly, few changes were detected in rats concomitantly administered lycopene and finasteride. The data suggest that lycopene provides substantial protection against finasteride-induced testicular damage."

IO biomarker • Journal • Preclinical • Alopecia • Immunology • Infertility • Sexual Disorders • BAX • BCL2 • CASP3 • PCNA

Oral finasteride use and sexual adverse events: signal detection from disproportionality analyses of data from the United States Food and Drug Administration Adverse Event Reporting System. (PubMed, J Dermatolog Treat) - "There were more reports with finasteride 1 mg than with dutasteride 0.5 mg; for both, more reporting was observed as of 2012, the year the PFS foundation formally propagated PFS awareness. Our findings support that the disproportionately higher reporting of sexual AEs with finasteride 1 mg than with dutasteride 0.5 mg-even more so after 2012-could be attributed to the nocebo effect."

Adverse events • Journal • Alopecia • Erectile Dysfunction • Immunology

No Elevated Risk for Osteoporosis or Osteopenia among Women with Androgenetic Alopecia or FFA treated with 5-Alpha Reductase Inhibitors: A Retrospective TriNetX Cohort Study. (PubMed, J Am Acad Dermatol) - No abstract available

Journal • Retrospective data • Alopecia • Fibrosis • Immunology • Osteoporosis • Rheumatology

Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis. (PubMed, Int Neurourol J) - "This study found no significant association between the use of alpha-blockers or 5ARIs and increased dementia risk. These findings may assist clinicians in making more informed prescribing decisions, particularly for older male patients with BPH. Further large-scale research with extended follow-up periods is needed to strengthen the evidence across all BPH medications."

Journal • Retrospective data • Alzheimer's Disease • Benign Prostatic Hyperplasia • CNS Disorders • Dementia

Sexual function outcomes of the 5-year treatment with Rezum compared to doxazosin, finasteride and combination drug therapy for men with BPH: cohort data from the Medical Therapy of Prostatic Symptoms (MTOPS) Trial. (EAU 2026) - No abstract available

Benign Prostatic Hyperplasia

Comparative Effects of Finasteride and Dutasteride on Semen Parameters in Young Men with Androgenic Alopecia: A Randomized Controlled Study (EAU 2026) - No abstract available

Clinical • Alopecia • Immunology

Finasteride 1 mg: Silent Impacts on Male Fertility Despite Preserved Hormonal Balance (EAU 2026) - No abstract available

24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: a novel link between brain cholesterol homeostasis and androgen metabolism. (PubMed, Neurochem Int) - "24-Hydroxycholesterol significantly suppressed the conversion of testosterone to DHT and 3α-androstanediol, to a similar degree as the synthetic 5α-reductase inhibitor finasteride...Furthermore, 24-hydroxycholesterol-mediated suppression of DHT formation was also observed in human neuroblastoma SH-SY5Y cells. To summarize, the present data provide information on androgen metabolism in glioblastoma cells and indicate a previously unknown link between cholesterol homeostasis and growth-inducing androgens in glioblastoma and potentially other cell types."

Journal • Preclinical • Brain Cancer • Glioblastoma • Neuroblastoma • Oncology • Solid Tumor

Can we identify a post-Serenoa syndrome (PSS)? A case series on sexual and psychiatric side effects of Serenoa repens. (PubMed, Br J Clin Pharmacol) - "However, emerging reports describe sexual, psychiatric and somatic adverse effects resembling a post-finasteride syndrome...Misbelief in the absolute safety of S. repens likely hinders reporting. Given its widespread, unsupervised use, further pharmacovigilance and clinical studies are warranted."

Adverse events • Journal • Alopecia • Benign Prostatic Hyperplasia • CNS Disorders • Depression • Immunology • Psychiatry

The role of 5-alpha reductase inhibitors in transurethral resection of the prostate: a meta-analysis of randomised controlled trials. (PubMed, BJU Int) - "Preoperative administration of 5ARIs significantly reduces intraoperative blood loss and risk of requiring blood transfusion in patients undergoing TURP for BPH. Even short durations (2 weeks) of 5ARI therapy can significantly reduce prostate vascularity."

Journal • Retrospective data • Review • Benign Prostatic Hyperplasia

Study to Evaluate the Drug-drug Interaction Between IY001 and IY002 in Healthy Adult Male Subjects. (clinicaltrials.gov) - P1 | N=43 | Completed | Sponsor: Il-Yang Pharm. Co., Ltd.

New P1 trial

Curcumin targets miR-21-3p: promising therapeutic strategy for treatment of benign prostatic hyperplasia. (PubMed, Mol Biol Rep) - "The current study demonstrated that curcumin alleviated the inflammatory manifestations of BPH by targeting the pro-inflammatory microRNA miR-21-3p, thereby upregulating SIRT1 and downregulating the pro-inflammatory mediators NF-κB and TNF-α. Furthermore, the anti-proliferative effect of curcumin may be attributed to the inhibition of the β-catenin signaling pathway."

Journal • Benign Prostatic Hyperplasia • Inflammation • MIR21 • MYC • SIRT1 • TNFA

The use of oral dutasteride, minoxidil, and finasteride for treating endocrine therapy-induced hair loss from breast cancer treatment: A case series study. (PubMed, JAAD Case Rep) - No abstract available

Journal • Alopecia • Breast Cancer • Immunology • Oncology • Solid Tumor

Direct-to-Consumer Teledermatology for Male Androgenetic Alopecia: Narrative Review. (PubMed, JMIR Dermatol) - "This narrative review examines the advantages and disadvantages of direct-to-consumer teledermatology for the treatment of male androgenetic alopecia, finding that this treatment modality improves access to care, ensures high adherence rates, and enhances patient satisfaction, while raising concerns about increased drug costs."

Journal • Review • Alopecia • Dermatology • Immunology

ZBTB7B modulates the androgen receptor as an upstream regulator via colocalization and direct binding in LNCaP prostate cancer cells. (PubMed, Transl Cancer Res) - "Furthermore, AR inhibitor finasteride and AR activator dihydrotestosterone (DHT) did not affect ZBTB7B...Notably, N-terminal domain (NTD) of AR is requisite for binding with ZBTB7B in HEK293 cells, not AR-DNA-binding domain (DBD) or AR-ligand-binding domain (LBD) in HEK293 cells. Overall, these findings provide a novel insight that ZBTB7B promotes prostate cancer progression as a potent oncogene via colocalization and binding with AR."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Targeted Protein Degradation • AR • CD8

GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation. (PubMed, Int J Surg) - "This work reveals a causal relationship between EBV infection and ccRCC pathogenesis, establishing GBP1 as a top-priority candidate molecule through a multi-level, multi-dimensional evidence framework. Drug prediction and molecular docking suggest finasteride as a potential inhibitor of GBP1, offering new strategies for the precise prevention and treatment of ccRCC."

Biomarker • Journal • Clear Cell Renal Cell Carcinoma • Epstein-Barr Virus Infections • Genito-urinary Cancer • Infectious Disease • Oncology • Solid Tumor • GBP1 • GBP5 • IFI16 • IL12RB1 • RECQL

Drug-Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance. (PubMed, Mol Pharm) - "Physical stability of the developed coamorphous system evaluated under accelerated as well as long-term stability conditions indicated reasonable stability for potential drug product usage. Considering its industrial applicability due to obvious benefits, viz., single solid phase, improved solubility, dissolution, and better pharmacokinetic parameters leading to higher bioavailability, the developed coamorphous system could prove to be a better therapeutic alternative over the marketed physical mixture."

Journal • Benign Prostatic Hyperplasia

Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics. (PubMed, AAPS J) - "Our results further suggest that the distinct PD profiles of finasteride and dutasteride are attributable to their differing inhibition characteristics against 5αR subtypes (selectivity and affinity). These findings extend our previous work and further support the utility of TMDD-PD modeling for optimizing clinical dose and improving therapeutic outcomes for small-molecule drugs exhibiting TMDD with time-dependent target inhibition."

Journal • PK/PD data