dach-platin polymeric micelle (Debio-0507) / NANO MRNA, Debiopharm - LARVOL DELTA

Low dose aspirin prevents endothelial dysfunction in the aorta and foetal loss in pregnant mice infected with influenza A virus. (PubMed, Front Immunol) - "Influenza A virus (IAV) infection in pregnancy resembles a preeclamptic phenotype characterised by vascular dysfunction and foetal growth retardation. ASA and NCX4016 treatment prevented IAV dissemination and inflammation of the aorta as well as improving the pup placental ratios in utero, survival and growth rates at post-natal day 5. Low dose ASA is safe to use during pregnancy for preeclampsia and this study demonstrates that ASA may prove a promising treatment for averting the significant vascular complications associated with influenza infection during pregnancy."

Journal • Preclinical • Gynecology • Infectious Disease • Inflammation • Influenza • Respiratory Diseases

Mechanisms Underlying the Virulence Regulation of Vibrio alginolyticus ND-01 pstS and pstB with a Transcriptomic Analysis. (PubMed, Microorganisms) - "Therefore, pstS and pstB could regulate the bacterial virulence of V. alginolyticus by affecting its adhesion, biofilm formation ability, and motility. Understanding the relationship between the expressions of pstS and pstB with bacterial virulence could provide new perspectives to prevent bacterial diseases."

Journal • Infectious Disease

Affinities to Oxaliplatin: Vitamins from B Group vs. Nucleobases. (PubMed, Int J Mol Sci) - "Oxaliplatin, similar to Cisplatin, exhibits anticancer activity by interacting with DNA and inducing programmed cell death...In this way, several transient reactive species are formed, including dichloro-, monochloro-, and diaqua-DACH platin, which can complex with DNA and other macromolecules...An application of atoms in molecules (AIM) theory revealed non-covalent interactions present in the complexes studied. The comparison of computed and experimental spectroscopic properties showed a good agreement."

Journal • Colorectal Cancer • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

[VIRTUAL] Injection of oxaliplatin into liver metastases will be required to break immune suppression in colorectal carcinoma patients (AACR-II 2020) - "L-OHP optimally stimulates ICD at 80 microM (32.8 microg/ml) in human CRC while lower and higher concentrations cause non-immunogenic apoptosis. Image-guided intratumoral injection into liver metastases in colorectal carcinoma patients will be required because systemic administration will not deliver enough active L-OHP to cause ICD."

Clinical • Colorectal Cancer • Gastrointestinal Cancer • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • CALR

A Phase 1 Dose-Escalation and Pharmacokinetic Study of NC-4016 in Patients With Advanced Solid Tumors or Lymphoma (clinicaltrials.gov) - P1; N=40; Recruiting; Sponsor: M.D. Anderson Cancer Center; N=30 ➔ 40

Enrollment change • Biosimilar • Hematological Malignancies • Oncology

Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors. (PubMed, J Mol Model) - "...Essentially, the most potent ligand ZINC840169872, which carries a distinct scaffold with a cyclohexane group fused to the furan ring, produced a twofold change in the ligand efficiency of TAM16...Overall, these in silico insights into a low energy benzofuran-based scaffold and an alternative binding mode for the benzofuran ring unravel viable strategies to generate potent anti-tuberculosis drugs, accentuating the applications of virtual screening approaches for exploring large compound libraries that cannot be easily accessed by experimentation. Graphical abstract In silico virtual screening of ZINC15 database for the identification of potential inhibitors targeting PKS13."

Journal