Merional (menotropin) / IBSA Institute Biochemical SA - LARVOL DELTA

Vaginal micronized progesterone on preventing luteinizing hormone untimely surge in ART cycles: A prospective proof-of-concept study. (PubMed, JBRA Assist Reprod) - "Progestin-Primed Ovarian Stimulation with micronized vaginal progesterone seems to be a compelling choice for preventing premature ovulation without compromising oocyte quality in women undergoing ovarian stimulation."

Journal

The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles (clinicaltrials.gov) - P4 | N=600 | Recruiting | Sponsor: Cairo University | Trial completion date: Aug 2022 ➔ Aug 2024 | Trial primary completion date: Jul 2022 ➔ Jul 2024

Trial completion date • Trial primary completion date • Infertility • Sexual Disorders

YouTube as a source of information on gonadotropin self-injections. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Our analysis revealed that there were a significant number of English-language YouTube videos, with high quality, rich content, and reliability that could be sources of information on the accurate technique of gonadotropin self-injections. However, some misleading information videos may lead to negative outcomes. Therefore, physicians should ensure that online sources are comprehensive and reliable for the use of their patients with infertility. Also, YouTube health videos should be checked for both reliability and ethical standards."

Journal • Infertility • Sexual Disorders

Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance (clinicaltrials.gov) - P2/3; N=161; Completed; Sponsor: Saudi German Hospital - Madinah

New P2/3 trial • Polycystic Ovary Syndrome

The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles (clinicaltrials.gov) - P4; N=600; Recruiting; Sponsor: Cairo University; Trial completion date: Aug 2020 ➔ Aug 2022; Trial primary completion date: Jul 2020 ➔ Jul 2022

Trial completion date • Trial primary completion date • Infertility • Sexual Disorders

Qualitative risk assessment of follicle stimulating hormone injectable products. (PubMed, Expert Opin Drug Deliv) - "The study identifies differences in the risks for both sharps injuries and dosing errors between FSH delivery options that practitioners should consider when making a treatment choice."

Journal

AIPRICSI: Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI (clinicaltrials.gov) - P4; N=20; Recruiting; Sponsor: Minia University; Not yet recruiting ➔ Recruiting

Enrollment open • Biosimilar

Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis (clinicaltrials.gov) - P3; N=450; Recruiting; Sponsor: Cairo University; Not yet recruiting -> Recruiting

Enrollment open • Biosimilar • Endometriosis

TEMPER: Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal Responders (clinicaltrials.gov) - P4; N=32; Completed; Sponsor: D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology; Recruiting ➔ Completed

Trial completion

The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles (clinicaltrials.gov) - P4; N=600; Recruiting; Sponsor: Cairo University; Trial completion date: Aug 2019 ➔ Aug 2020; Trial primary completion date: Jul 2019 ➔ Jul 2020

Trial completion date • Trial primary completion date

Is there a difference in the efficacy of recombinant and urinary purified FSH hormones in patients with different FSHR genotype? A study on 3268 cycles (ESHRE 2019) - "In women ≥38 years the delivery rate was slightly increased using the HP-FSH: 16% with HP-FSH versus 12% with rFSH, but this difference was not statistically significant (p=0.24) Limitations, reasons for caution: Despite the high number of patients and cycles, it is a retrospective study where different stimulation protocols have been used. Prospective and randomized studies should be performed Wider implications of the findings: No major differences in efficacy of hormonal ovary stimulation was observed between HP-FSH and rFSH in a large, 10 year retrospective study"

Clinical

TEMPER: Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal Responders (clinicaltrials.gov) - P4; N=40; Recruiting; Sponsor: D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology; Trial completion date: Sep 2018 ➔ Dec 2019; Trial primary completion date: Jun 2018 ➔ Jun 2019

Clinical • Combination therapy • Trial completion date • Trial primary completion date