moxifloxacin ophthalmic / Generic mfg. - LARVOL DELTA

Acute effects of direct exposure to moxifloxacin on the porcine corneal endothelium: An ex vivo study. (PubMed, Res Vet Sci) - "Direct exposure of the corneal endothelium to moxifloxacin ophthalmic solution at concentrations ≥0.5% may induce endothelial toxicity. Therefore, during intracameral administration, care should be taken to avoid direct contact between moxifloxacin and the corneal endothelium in order to minimize potential endothelial damage."

Journal • Preclinical • Ocular Infections • Ocular Inflammation • Ophthalmology

Reply to 'Comment on: Efficacy of Intracameral Moxifloxacin in Prevention of Post-cataract Surgery Endophthalmitis: A Randomized Control Trial'. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comment on: Efficacy of Intracameral Moxifloxacin in Prevention of Postcataract Surgery Endophthalmitis. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology

Reply to the Comment on: "Efficacy of Intracameral Moxifloxacin in Prevention of Post-Cataract Surgery Endophthalmitis: Randomized Control Trial". (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comment on: Efficacy of intracameral moxifloxacin in prevention of postcataract surgery endophthalmitis: randomized control trial. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology

Reply to "Re: "Efficacy of intracameral moxifloxacin in prevention of post cataract surgery endophthalmitis: randomized control trial". (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comment On: Efficacy of intracameral moxifloxacin in prevention of postcataract surgery endophthalmitis: randomized control trial. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology

Incidence of post-traumatic endophthalmitis following repaired open globe injury: impact of prophylactic intracameral moxifloxacin. (PubMed, Eye (Lond)) - "ICM at the end of surgery reduces the incidence of post-traumatic endophthalmitis after OGI repair, compared with no intracameral antibiotic prophylaxis."

Journal • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Reply to 'Comment on: Efficacy of Intracameral Moxifloxacin in Prevention of Post-cataract Surgery Endophthalmitis: A Randomized Control Trial'. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comment on: Efficacy of Intracameral Moxifloxacin in Prevention of Post-cataract Surgery Endophthalmitis: A Randomized Control Trial. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Intracameral moxifloxacin for endophthalmitis prophylaxis after cataract surgery: a systematic review and meta-analysis. (PubMed, Front Med (Lausanne)) - "This substantial protective benefit is achieved without evidence of compromised endothelial safety; however, safety conclusions are limited by the small number of patients assessed and should be interpreted with caution. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD420251144067), https://www.crd.york.ac.uk/PROSPERO/view/CRD420251144067."

Journal • Retrospective data • Review • Cataract • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

PRO-232 in Patients Subjected to Cataract Surgery (clinicaltrials.gov) - P3 | N=134 | Recruiting | Sponsor: Laboratorios Sophia S.A de C.V.

New P3 trial • Cataract • Ophthalmology

Comment on: Efficacy of intracameral moxifloxacin in prevention of post-cataract surgery endophthalmitis: a randomized controlled trial. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

New evidence for effectiveness of intracameral moxifloxacin for postcataract surgery endophthalmitis prophylaxis. (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology

REAGIR II: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II (clinicaltrials.gov) - P3 | N=60 | Active, not recruiting | Sponsor: University of California, San Francisco | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Reply to letter on "Comment on: Efficacy of intracameral moxifloxacin in prevention of post-cataract surgery endophthalmitis: a randomized controlled trial". (PubMed, J Cataract Refract Surg) - No abstract available

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Efficacy of Intracameral Moxifloxacin in Prevention of Post-cataract Surgery Endophthalmitis: A Randomized Control Trial. (PubMed, J Cataract Refract Surg) - "Intracameral moxifloxacin is safe and effective in preventing post-cataract surgery acute bacterial endophthalmitis."

Journal • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Moxifloxacin-induced insomnia with psychotic episodes in a toddler: a case report. (PubMed, Eur J Hosp Pharm) - "The current case describes the off-label use of moxifloxacin eye drops for nasal administration in a toddler which led to insomnia and symptoms of severe psychosis. Notably, these adverse events resolved completely shortly after discontinuation of treatment. This case highlights a rare and potentially debilitating adverse reaction and underscores the critical importance of clinical judgement when prescribing off-label medicines in the paediatric population."

Journal • CNS Disorders • Insomnia • Mental Retardation • Pediatrics • Psychiatry • Sleep Disorder

Use of Intracameral Antibiotics Prophylaxis in Patients with Posterior Capsular Rupture during Cataract Surgery: a Systematic Review and Meta-analysis. (PubMed, J Cataract Refract Surg) - "Our findings suggest that the use of intracameral antibiotics is efficient in preventing postoperative endophthalmitis in patients who had PCR during cataract surgery."

Journal • Retrospective data • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison of Cataract Surgery Endophthalmitis Rates in Operating Rooms with and without Laminar Air Flow and HEPA Filters. (PubMed, Am J Ophthalmol) - "This large, multicenter, retrospective study found no infection reducing benefit for LAF or HEPA filtration for cataract surgery. This contradicts mandating these more expensive AHU systems for ophthalmic surgery. Recommending or requiring LAF or HEPA unnecessarily imposes additional infrastructural barriers for ophthalmic ORs in resource-limited settings and for office-based surgery in high-income countries."

Journal • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Naturally derived mucoadhesive nanosuspension for treatment of multiple staged ocular infections. (PubMed, J Control Release) - "The MFX-loaded nanosuspension demonstrated around 2.6-fold longer half-life in the cornea compared to commercial MFX drops (Vigamox®), indicating higher drug retention...Histological analysis showed minimal inflammation and a preserved corneal structure, validating the effectiveness of the GelMAP nanosuspension. Currently, no NP formulation has demonstrated dual efficacy in managing both early and established infections, underscoring GelMAP nanosuspension's potential for comprehensive ocular infection management by reducing treatment frequency, minimizing complications, and enhancing patient compliance."

Journal • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

REAGIR: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction (clinicaltrials.gov) - P3 | N=330 | Completed | Sponsor: University of California, San Francisco | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

REAGIR II: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II (clinicaltrials.gov) - P3 | N=60 | Recruiting | Sponsor: University of California, San Francisco | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Jul 2025 ➔ Jun 2026

Trial completion date • Trial primary completion date • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison of Subconjunctival Triamcinolone with Topical Prednisolone for Routine Anti-Inflammatory Prophylaxis in Manual Small Incision Cataract Surgery: A Single-Center, Randomized Controlled Trial Pilot Protocol. (PubMed, Clin Ophthalmol) - P=N/A | "Subconjunctival injection of triamcinolone acetonide (TA) is an effective method to prevent postoperative inflammation in phacoemulsification eyes...Intracameral moxifloxacin 0.15% is injected at the end of surgery in both groups...The objective of this study is to evaluate the safety and efficacy of a single subconjunctival TA injection compared to standard postoperative topical therapy using PA 1% in eyes undergoing MSICS. Clinicaltrials.gov: NCT05248139; Protocol issue date: August 9, 2024; Amendment number: 02."

Journal • Cataract • Inflammation • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis

DVS: Dropless Pars Plana Vitrectomy Study (clinicaltrials.gov) - P4 | N=168 | Recruiting | Sponsor: Massachusetts Eye and Ear Infirmary | Trial completion date: Jan 2026 ➔ Jan 2027 | Trial primary completion date: Jul 2025 ➔ Jul 2026

Trial completion date • Trial primary completion date • Retinal Disorders