moxifloxacin ophthalmic / Generic mfg. - LARVOL DELTA

A novel anterior segment imaging device for rapid, non-contact examination of conjunctival goblet cells in humans: an investigator-initiated exploratory clinical trial (ARVO 2025) - P=N/A | "Using fluorescence microscopy with a 0.5% moxifloxacin eye drop for labeling, the system produced images identical to PAS histology in mice, rabbits, and non-human primates...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Inflammation • Ophthalmology

The Importance of Recognizing Blepharokeratoconjunctivitis in Children: a Case Series (ARVO 2025) - "She was initially treated for a right corneal ulcer and upon evaluation, in the clinic, she was diagnosed with BKC, ocular rosacea, and symptoms resolved with prednisone, moxifloxacin eyedrops, and oral azithromycin for 3 months...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Conjunctivitis • Dry Eye Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Endophthalmitis After Pars Plana Vitrectomy: Safety and Efficacy of Intraoperative Intraocular Antibiotics (ARVO 2025) - "The impact of prophylactic intraoperative intravitreal or intracameral moxifloxacin on the development of acute infectious postoperative endophthalmitis was examined...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Infections • Ocular Inflammation • Ophthalmology

Clinical Outcomes After Cost-Effective Dropless Cataract Surgery (ARVO 2025) - "Methods A retrospective chart review compared cataract surgeries using a traditional drop protocol (prednisolone acetate 1%, moxifloxacin 0.5%, ketorolac 0.5% dosed four times daily with a 4-week taper) and a dropless protocol (0.2 mL intracameral moxifloxacin 0.5% and 0.5 mL subconjunctival triamcinolone acetate 10 mg/mL). Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Clinical data • Cost effectiveness • HEOR • Surgery • Cataract • Glaucoma • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology

Assessment of Endothelial Cell Loss in Moxifloxacin-Treated Donor Corneal Graft Tissue (ARVO 2025) - "Therefore, we conducted this study to assess the safety of intracameral moxifloxacin in corneal transplantation by analyzing endothelial cell loss in donor corneal grafts...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection. (PubMed, J Control Release) - "The sustained release functionality further led to improved or non-inferior prevention and treatment of Staphylococcus aureus-induced ocular infection in both rats and rabbits compared to gold standard intracameral moxifloxacin and moxifloxacin eye drops. By achieving therapeutically relevant moxifloxacin accumulation, this nanocrystalline moxifloxacin formulation may be a promising alternative to conventional therapies to achieve improved post-surgical infection prevention and bacterial keratitis treatment outcomes."

Journal • Cataract • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Development of sustained-release extemporaneous moxifloxacin loaded commercial soft hydrogel contact lenses. (PubMed, Heliyon) - "Although moxifloxacin eye drops (0.5 % w/v) is accepted for clinical treatments of these infections, the frequent administration is challenging to achieve the adequate dose due to the limitations of low ocular bioavailability and short retention time. Furthermore, both the eye drops brands (Moximac and Zomoxin), the loading pH (6.7 and 6.0), and the loading time (24 h and 2 h) had no significant effects on the loading and release of moxifloxacin, indicating the system versatility. Conclusively, the extemporaneous moxifloxacin loaded contact lenses, with a duration of action of at least 12 h, could be further explored to become a potential treatment for eye infections."

Journal • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

SCUT II: Steroids and Cross-linking for Ulcer Treatment (clinicaltrials.gov) - P3 | N=280 | Completed | Sponsor: Thomas M. Lietman | Active, not recruiting ➔ Completed | Trial primary completion date: Aug 2024 ➔ May 2024

Trial completion • Trial primary completion date • Keratitis • Ocular Inflammation • Ophthalmology

Effects of Bromfenac on Macular Thickness After Phacoemulsification Surgery (clinicaltrials.gov) - P4 | N=87 | Completed | Sponsor: Inas Abd

New P4 trial • Cataract • Macular Edema • Ophthalmology

EFFICACY OF INTRACAMERAL MOXIFLOXACIN VERSUS TOPICAL MOXIFLOXACIN IN PREVENTING ACUTE ENDOPHTHALMITIS AFTER CATARACT SURGERY BY PHACOEMULSIFICATION. (PubMed, J Ayub Med Coll Abbottabad) - "1 ml undiluted intracameral moxifloxacin 0.5% can be given as a last step in cataract surgery by phacoemulsification to prevent postoperative acute endophthalmitis infection. This drug administration is not totally safe as our three cases developed drug reaction with moderate corneal oedema and anterior chamber reaction that resolved in a week time."

Clinical • Journal • Surgery • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Bilateral Corneal Endotheliitis Following Corneal Cross-linking with Riboflavin and Ultraviolet A. (PubMed, Ann Afr Med) - "Treatment with prednisolone acetate and moxifloxacin eye drops was initiated...In our patient, the utilization of loteprednol etabonate gel, cyclosporine eye drops, brimonidine eye drops, and regular follow-up examinations led to improved clinical findings and visual acuity. Further studies are warranted to establish optimal treatment approaches for similar cases of endotheliitis following CXL."

Journal • Achromatopsia • Ophthalmology

Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC. (clinicaltrials.gov) - P1/2 | N=94 | Recruiting | Sponsor: Inder Paul Singh, M.D.

New P1/2 trial • Surgery • Cataract • Ophthalmology

REAGIR II: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II (clinicaltrials.gov) - P3 | N=60 | Recruiting | Sponsor: University of California, San Francisco | Trial completion date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Jul 2025

Trial completion date • Trial primary completion date • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

One-time low concentration betadine eye wash: A novel treatment for epidemic viral conjunctivitis for accelerated recovery. (PubMed, Rom J Ophthalmol) - "Group A (664 patients) underwent a 1% betadine wash in addition to the standard treatment protocol (Eye Lubricant + Moxifloxacin 0.5% eyedrops), while Group B (664 patients) followed the standard protocol alone. A single low-concentration betadine wash expedites recovery and reduces complications in acute infective conjunctivitis. This approach significantly enhances patient outcomes and alleviates the socioeconomic impact of the condition."

Journal • Conjunctivitis • Hematological Disorders • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Intracameral Moxifloxacin Dose for POE Prophylaxis for PCR (AAO 2024) - "The use of dilute ICM is important to prevent drug toxicity. The precise methodology, results and cautions will be presented."

Ocular Infections • Ocular Inflammation • Ophthalmology

A Different Amniotic Membrane Transplantation Technique In Necrotizing Stromal Keratitis (ESCRS 2024) - "In the patient's history, he applied dexamethasone eye drops without consulting a doctor due to redness in his right eye...The patient was initiated on acyclovir tablets 5x400 mg, oral vitamin C preparate 1x1, tetracycline tablets 1x1, moxifloxacin eye drops 4x1, and tropicamide eye drops 3x1...Conclusion/Take home message: Uncontrolled topical steroid use on the background of neurotrophic keratopathy can lead to corneal melting and perforation. Amniotic membrane transplantation techniques are beneficial in the treatment."

Stroma • Cataract • Dry Eye Disease • Keratitis • Ocular Inflammation • Ophthalmology

Role Of Topical Cenegermin In The Management Of Neurosurgically Induced Neurotrophic Keratitis (ESCRS 2024) - "She was treated with moxifloxacin eye drops 4 times, preservative-free artificial tears, cyclosporine 0.05% eye drops, lubricant ointment, autologous serum drops and self-retained amniotic membranes. The safety and efficacy of cenegermin has been successfully tested in clinical trials in patients with moderate and severe NK. This case is the report of our first experience with cenegermin 20 μg/ml in the treatment od NK, which has shown to be effective and well tolerated in the healing of corneal ulcer and improvement of VA and corneal sensitivity in a patient with neurosurgically induced NK."

Keratitis • Ocular Inflammation • Ophthalmology

Ocular Surface Reconstruction With Amniotic Membrane Transplantation For Lyme Keratitis Associated Symblepharon (ESCRS 2024) - "Five days earlier, he was seen at another ophthalmology clinic, where he was commenced on moxifloxacin eye drops, nepafenac eye drops, and oxytetracycline pomade therapy...He was started on topical administration of cefazolin and amikacin empirically and cyclopentolate eye drops, alongside oral tetracycline...In Lyme Disease, symblepharon can occur secondary to conjunctivitis, scleritis, episcleritis, or keratitis. Combining symblepharon removal and AM transplantation is an effective treatment modality for symblepharon linked with infection related inflammatory etiologies."

Conjunctivitis • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Scleritis

Scedosporium Prolificans: The First Case-Report In A Tertiary Hospital In Southern Brazil And A Successful Outcome In A Challenging Keratitis. (ESCRS 2024) - "The patient presented to us using Vigamox® and Hyabak® hourly...prolificans is a rare and multi resistant fungus mostly associated with systemic infections, with few records in medical literature of ophthalmological involvement. The treatment by a route of administration that delivers high concentration on the infection site seems to have been responsible for the success in this case, even though the chosen medication is not the drug of choice for this pathogen."

Case report • Clinical • Astigmatism • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Toxic Anterior Segment Syndrome With Intracameral Moxifloxacin (ESCRS 2024) - "I found the same pic in the 2nd day so I diagnosed the patient as TASS and I decided to do AC wash and started to review literature about the causes of TASS and I found that Intracameral Moxifloxacin can cause this .the patient continued on very high doses of topical steroids The patient started to improve and to took about 4 months until complete resolve of ant seg occurred leaving large areas of iris depigmentation , very week pupillary reaction , dense PCO and high IOP . I continued on anti glaucoma until IOP controlled and did YAG capsulotomy and the final UCVA reached 0.6 that improve by glasses to 0.9 Conclusion/Take home message: High dose of intracameral moxifloxacin can cause TASS even if it is preservative free We should differentiate between endophthmitis and TASS"

Cataract • Glaucoma • Ophthalmology

Intracameral Moxifloxacin: Should We Dilute It? How Much? (ESCRS 2024) - "The study of intracameral antibiotic administration methods and concentration decay can lead to selection of better prophylactic drugs, concentrations and methods, leading to reduction of the incidence of post-operative endophthalmitis."

Ocular Infections • Ocular Inflammation • Ophthalmology

Toxic Anterior Segment Syndrome With Intracameral Moxifloxacin (ESCRS 2024) - "I found the same pic in the 2nd day so I diagnosed the patient as TASS and I decided to do AC wash and started to review literature about the causes of TASS and I found that Intracameral Moxifloxacin can cause this .the patient continued on very high doses of topical steroids The patient started to improve and to took about 4 months until complete resolve of ant seg occurred leaving large areas of iris depigmentation , very week pupillary reaction , dense PCO and high IOP . I continued on anti glaucoma until IOP controlled and did YAG capsulotomy and the final UCVA reached 0.6 that improve by glasses to 0.9 Conclusion/Take home message: High dose of intracameral moxifloxacin can cause TASS even if it is preservative free We should differentiate between endophthmitis and TASS"

Cataract • Glaucoma • Ophthalmology

REAGIR II: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II (clinicaltrials.gov) - P3 | N=60 | Recruiting | Sponsor: University of California, San Francisco | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Cost Analysis of Dropless Cataract Surgery Prophylaxis with Intracameral Antibiotics and Subconjunctival Steroids. (PubMed, J Cataract Refract Surg) - "An evidence-based cataract surgery prophylactic medication regimen of intracameral moxifloxacin and subconjunctival triamcinolone acetonide can reduce healthcare system and patient out-of-pocket costs in comparison to various topical regimens."

Cost-analysis • HEOR • Journal • Surgery • Cataract • Ophthalmology

Bilateral Multiple Herpetic Epithelial Keratitis: A Case Report and Review of the Literature. (PubMed, Cureus) - "The patient was diagnosed as a case of bilateral herpetic epithelial keratitis; he was started on moxifloxacin eye drops four times a day, Artelac (sodium hyaluronate) every two hours, carbomer HS, ganciclovir ointment five times per day. In our case, the presence of bilateral dendritic ulcers in the absence of significant anterior chamber inflammation supported the diagnosis of bilateral herpetic epithelial keratitis Despite the limited literature on bilateral herpetic epithelial keratitis, the principles of management remain consistent with those of unilateral disease. Early recognition, prompt initiation of antiviral therapy, and close follow-up are crucial for successful outcomes."

Journal • Review • Herpes Simplex • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain