Cytovene (ganciclovir) / Roche - LARVOL DELTA

Cytomegalovirus meningoencephalitis in an immunocompetent host with evolution of cystic encephalomalacia. (PubMed, Radiol Case Rep) - "CMV was detected on the repeat CSF sample using PCR on day 11 and he was started on ganciclovir for CMV meningoencephalitis. CMV should be considered as an etiology for viral meningoencephalitis even in immunocompetent patients. Our case also shows the classic imaging evolution of CMV meningoencephalitis."

Journal • CNS Disorders • Cytomegalovirus Infection • Epilepsy • Infectious Disease

Evaluation of the use of Ganciclovir and Letermovir in special patients and optimization of clinical dosing regimens (ChiCTR) - P=N/A | N=150 | Completed | Sponsor: the First Affiliated Hospital of Xian Jiaotong University; the First Affiliated Hospital of Xian Jiaotong University

New trial • Cytomegalovirus Infection • Infectious Disease

Neurological and Endocrine Crossroads: A Rare Case of HHV-6 Encephalitis Inducing Central Diabetes Insipidus (ENDO 2025) - "However, its association with central diabetes insipidus (CDI) is rare.Case Presentation: We report a case of a 33-year-old female with a history of Sjogren's syndrome who presented with altered mental status and was diagnosed with HHV-6 encephalitis via lumbar puncture that was treated with ganciclovir. This case highlights a rare presentation of HHV-6 encephalitis causing CDI, suggesting potential hypothalamic involvement. Clinicians should consider CDI in encephalitis patients with severe hypernatremia and polyuria, as early recognition and treatment are essential for preventing complications."

Clinical • CNS Disorders • Epstein-Barr Virus Infections • Immunology • Metabolic Disorders • Sjogren's Syndrome

A rare case of cytomegalovirus myocarditis complicating rejection after heart transplantation: Case report and review of literature. (PubMed, J Cardiol Cases) - "Aggressive management, including high-dose ganciclovir and intravenous immunoglobulin, resulted in negativization of CMV and rejection markers...To diagnose and treat complications in heart transplantation, such as opportunistic infections and cellular and/or antibody-mediated rejection. To underline role of endomyocardial biopsy in heart transplant monitoring."

Journal • Antibody-mediated Rejection • Cardiomyopathy • Cardiovascular • Cytomegalovirus Infection • Hypertrophic Cardiomyopathy • Infectious Disease • Inflammation • Transplant Rejection • Transplantation

Pharmacokinetics of ganciclovir for prevention of cytomegalovirus infection in a lung transplant recipient on veno-arterial extracorporeal membrane oxygenation: A case report and literature review. (PubMed, J Infect Chemother) - "Compared with lung transplant patients not receiving ECMO, this patient undergoing ECMO exhibited elevated GCV blood trough concentrations, along with acute kidney injury and thrombocytopenia. When GCV is administered during VA-ECMO, therapeutic drug monitoring may be necessary to prevent adverse reactions and account for intra-individual variability."

Journal • PK/PD data • Acute Kidney Injury • Cytomegalovirus Infection • Hematological Disorders • Infectious Disease • Nephrology • Renal Disease • Respiratory Diseases • Thrombocytopenia • Transplantation

Linvoseltamab (LINVO) + bortezomib (BTZ) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): First results from the LINKER-MM2 trial. (ASCO 2025) - P1 | "Dexamethasone premedication was limited to C0–1...One DLT occurred at DL2 (Gr 3 CMV colitis on day 48; resolved with tx delay and ganciclovir)... LINVO + BTZ induced high response rates, with encouraging early DOR and PFS, in a population that was mostly PI-refractory. Safety was consistent with the known profile of each drug, and risk of Gr 3–5 infection was similar to LINVO monotherapy. These data will inform LINVO combination strategies for earlier LoT."

Clinical • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Inflammation • Multiple Myeloma • Neutropenia • Oncology • Pneumonia • Respiratory Diseases • Thrombocytopenia

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. (PubMed, bioRxiv) - "Aortic stiffness (aortic pulse-wave velocity [PWV]), and associated mechanisms were assessed in young adult p16-3MR mice, a model that allows for genetic-based clearance of senescent cells with ganciclovir [GCV]. Young (4-6 month) mice were injected with Doxo and subsequently treated with GCV or the senolytic ABT263...Lastly, we demonstrate the efficacy of senolytic therapy for targeting cellular senescence, the SASP and glycation stress to prevent doxorubicin-induced aortic stiffening. These results offer a novel and clinically actionable approach to preserving vascular health in cancer survivors and mitigating CVD risk."

Journal • Cardiovascular • Oncology

Clinical characteristic and outcome of HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: A study of Infectious Disease Working Party of EBMT. (PubMed, Bone Marrow Transplant) - "Eight-seven patients received treatment mainly with foscarnet or ganciclovir. In conclusion, the incidence of HHV-6 encephalitis was low but associated with high mortality irrespective of antiviral treatment. This confirms the need for further research in this setting."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease • Transplantation

CMV infections after HSCT: prophylaxis and treatment. (PubMed, Blood Res) - "Letermovir, a terminase complex inhibitor, has become the standard of care for primary prophylaxis in CMV-seropositive recipients because of its efficacy and favorable safety profile. PET involves regular monitoring of CMV DNAemia via polymerase chain reaction (PCR) and initiation of antiviral therapy, most commonly ganciclovir or valganciclovir, upon detection of early viral reactivation...Maribavir, a UL97 kinase inhibitor, has demonstrated superior efficacy and improved tolerability compared to conventional therapies in the phase 3 SOLSTICE trial, making it a promising therapy for refractory or resistant CMV. Optimal CMV management requires a risk-adapted, individualized approach that integrates prophylaxis, early detection, and timely intervention to reduce CMV-related complications."

Journal • Review • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Transplantation

Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency. (PubMed, Ann Intern Med Clin Cases) - "Although his initial CMV pharyngitis resolved, the CMV isolated from blood became resistant to ganciclovir and cidofovir and eventually required treatment with foscarnet. After 6 weeks, the patient's viremia resolved and remained undetectable for 6 months after treatment initiation with maribavir. This case demonstrates the feasibility of using maribavir for resistant CMV in a nontransplant, immunocompromised patient."

Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Human Immunodeficiency Virus • Infectious Disease • Primary Immunodeficiency • Transplantation

Clinical and Economic Burden Associated With Anti-Cytomegalovirus (CMV) Prophylaxis Therapies in Adult Kidney Transplant Recipients (LECOCYT): An Observational Study. (PubMed, Transpl Int) - "D+/R- patients with severe leukopenia or neutropenia had a higher rate of outpatient consultations than those without episode (73.9% vs. 57.6%, p = 0.002), and a higher average number of consultations per patient (5.5 ± 4.1 vs. 4.5 ± 3.3, p = 0.042) than D+/R- patients without. Anti-CMV prophylaxis in D+/R- transplant recipients was significantly associated with a higher rate of severe leukopenia or neutropenia compared to no prophylaxis in D-/R- recipients."

Clinical • HEOR • Journal • Observational data • Cytomegalovirus Infection • Hematological Disorders • Leukopenia • Neutropenia • Transplantation

Adenovirus Vasculitis with Necrotising Retinitis and Schisis-Associated Macular Edema (SAME): A Rare Primary Manifestation of HIV-Related Immunodeficiency. (PubMed, Ocul Immunol Inflamm) - "Initial treatment involved topical corticosteroids, intravitreal ganciclovir, and systemic valganciclovir. Due to disease progression, therapy was subsequently escalated to high-dose valacyclovir (2 g TID) with intravitreal ganciclovir and later intravenous cidofovir was introduced...Adenoviral necrotizing retinitis remains an underrecognized entity, particularly in immunocompromised patients. This case underscores the importance of PCR testing for HAdV in atypical necrotizing retinitis and highlights the need for a combined treatment approach, including systemic and intravitreal antiviral therapy."

Journal • Cardiovascular • Genetic Disorders • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Macular Edema • Ocular Inflammation • Ophthalmology • Retinal Disorders • Vasculitis • CD4

Efficacy of Intravitreal Ganciclovir Injection with or without Oral Valganciclovir versus Topical 2% Ganciclovir for Cytomegalovirus Anterior Segment Infection. (PubMed, Ocul Immunol Inflamm) - "In group 1, 39 of 48 patients (81.3%) required adjunctive oral valganciclovir, which was taken for a median duration of 55 days. Despite being a short-term treatment, intravitreal injection of ganciclovir as a loading dose with or without additional oral valganciclovir comparably and effectively prevents recurrence relative to the long-term topical application of 2% ganciclovir."

Journal • Cytomegalovirus Infection • Infectious Disease

An Uncommon Culprit: Cytomegalovirus Colitis Mimicking Malignancy in an Immunocompetent Patient. (PubMed, Cureus) - "This is a rare presentation of CMV colitis, especially in an immunocompetent patient. The rarity of this disease presentation exemplifies the importance of a thorough workup for diagnosis."

Journal • Colorectal Cancer • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Oncology

CMV retinitis in HIV-infected patients: Plasma viral load utility in diagnosis. (PubMed, Diagn Microbiol Infect Dis) - "Plasma viral load testing is a valuable diagnostic tool but cannot replace ophthalmic examination. Quantitative PCR aids in effective virological monitoring and timely treatment initiation."

Journal • Cytomegalovirus Infection • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders

Case Report: Hematopoietic Stem Cell Transplantation to Treat Severe Acquired Aplastic Anemia in a Pediatric Kidney Transplant Recipient. (PubMed, Pediatr Transplant) - "Despite reported favorable outcomes in children who received allogeneic HSCT after kidney transplantation, there is a lack of evidence on how to overcome numerous challenges in these ultrarare cases."

Journal • Absence Seizure Disorder • Acute Graft versus Host Disease • Anemia • Aplastic Anemia • Atypical Hemolytic Uremic Syndrome • Bone Marrow Transplantation • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Epstein-Barr Virus Infections • Graft versus Host Disease • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Nephrology • Pediatrics • Pulmonary Arterial Hypertension • Solid Organ Transplantation • Transplant Rejection • Transplantation

Human Herpesvirus-6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult. (PubMed, Brain Behav) - "This case underscores the need to consider HHV-6 infection in immunocompetent adults presenting with meningitis of unknown etiology. Early detection and targeted antiviral therapy may lead to favorable clinical outcomes."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Human Immunodeficiency Virus • Infectious Disease • Pain • Transplantation

Steroid-responsive Encephalopathy with a Primary CMV Infection Complicated By Enteritis in a Young Woman with Ulcerative Colitis: A Case Report. (PubMed, Intern Med) - "A colon biopsy revealed concurrent CMV enteritis, which improved with ganciclovir. This case shows that steroid-responsive encephalopathy can occur during a primary CMV infection. Additionally, CMV enteritis complicated by a primary CMV infection should be considered in patients with UC."

Journal • CNS Disorders • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pain • Ulcerative Colitis • IL6

Cytomegalovirus infection and drug resistance emergence during letermovir salvage therapy in a pediatric SCID patient. (PubMed, NPJ Antimicrob Resist) - "Sequencing of viral DNA polymerase (DP; UL54), protein kinase (UL97), and terminase (UL51, UL56, UL89) genes identified ganciclovir (GCV) and foscarnet (PFA) resistance mutations in blood, but not cerebrospinal fluid. After treatment was shifted to cidofovir and letermovir (LMV), a LMV resistance mutation rapidly emerged in UL56 (C325F)...This case describes a CMV infection complicated by compartmentalization and the emergence of resistance to GCV, PFA, and LMV. It highlights the need for further investigation into alternative antiviral strategies for the prevention and treatment of CMV."

Journal • Cytomegalovirus Infection • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Primary Immunodeficiency

Use of Letermovir as Secondary Prophylaxis in Cytomegalovirus Resistant Pediatric Heart Transplant Recipients. (PubMed, Clin Transplant) - "In our experience, letermovir was well tolerated and effective in the management of resistant CMV in pediatric heart transplant recipients."

Journal • Cytomegalovirus Infection • Infectious Disease • Pediatrics • Transplantation

Treating Adenovirus Infection in Transplant Populations: Therapeutic Options Beyond Cidofovir? (PubMed, Viruses) - "This led to the development of brincidofovir, which has a better safety profile and great in vitro potency against AdV. The use of ribavirin and ganciclovir has been reported in the literature, but their use is limited due to inconsistent efficacy...This review underscores the need for standardized treatment protocols as well as comparative studies to identify optimal dosing and timing to initiate treatment. Future research should focus on individualized treatment approaches and the development of novel therapeutic agents to address the unmet clinical needs of AdV management."

Journal • Review • Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Infectious Disease • Solid Organ Transplantation • Transplantation

Foscarnet Versus Ganciclovir for Severe Congenital Cytomegalovirus Infection: Short- and Long-Term Follow-Up. (PubMed, Viruses) - "Intravenous ganciclovir and foscarnet were found to be safe at long-term follow-up and appeared to be capable of mitigating the neurological and auditory consequences of congenital CMV disease at the short-term follow-up. However, there was progressive worsening of the symptomatology in all three groups, with a statistically significant increase in the number of deaths (p = 0.035) among 4 of the 24 children in the therapy groups and 6 of the 12 untreated children."

Clinical • Journal • CNS Disorders • Cytomegalovirus Infection • Genetic Disorders • Infectious Disease • Ocular Inflammation • Otorhinolaryngology • Retinal Disorders • Uveitis

Drug Incompatibilities and Complex Assemblies: Let Us Remain Vigilant! (PubMed, Pharmaceuticals (Basel)) - "Case Summary: A 7-week-old preterm infant received ganciclovir at therapeutic dosage for cytomegalovirus (CMV) infection... Multi-lumen infusion devices limit but do not prevent the occurrence of PCIs, particularly in the event of a preparation error. Despite the use of this type of device, great vigilance is still required, particularly with regard to prescription analysis and reconstitution procedures."

Journal • Critical care • Cytomegalovirus Infection • Infectious Disease

Characterization of Pro-Drug Metabolism and Drug Permeability Kinetics in a Microphysiological In Vitro Model of the Human Small Intestinal Barrier Incorporating Mucus-Generating Cells Coupled with LC-MS/MS Analysis. (PubMed, Adv Healthc Mater) - "The established barrier was utilized to assess the absorption kinetics of three selected therapeutic compounds: Doxycycline, Ganciclovir, and its prodrug Valganciclovir, following the implementation of a thorough LC-MS/MS validation protocol. The permeability of ganciclovir following its generation from the prodrug valganciclovir was significantly higher than the permeability of ganciclovir itself, as the active metabolite ganciclovir exhibited an enhanced transport rate compared to when administered without metabolic activation. The developed microfluidic-based intestinal barrier model has demonstrated the capability to reliably simulate drug absorption and prodrug metabolism, and its impact on drug permeation kinetics across the small intestine."

Journal • Preclinical

Anti-MDA5 antibody positive dermatomyositis complicated by interstitial lung disease with an improved outcome: A case report. (PubMed, Medicine (Baltimore)) - "MDA5-DM-ILD poses challenges for clinicians due to its diagnostic difficulty, rapid progression and secondary infection risks. Early immunosuppression combined with infection prevention is the key to a successful treatment of this disease."

Journal • Anorexia • Dermatomyositis • Fatigue • Immunology • Infectious Disease • Interstitial Lung Disease • Melanoma • Musculoskeletal Pain • Myositis • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Solid Tumor • IFIH1