nimesulide / Generic mfg. - LARVOL DELTA

Predicting adsorption capacities of pharmaceutical pollutants using chemoinformatics and machine learning techniques. (PubMed, Environ Geochem Health) - "In this work, we developed machine learning models to predict adsorption capacities for Aspirin, Caffeine, Carbamazepine, Ketoprofen, Sulfamethoxazole, Nimesulide, and Paracetamol using chemoinformatics descriptors derived from SMILES strings and experimental inputs, including equilibrium concentration (Ce), initial concentration (C0), temperature, and contact time. SHAP analysis highlighted the influence of charge-partitioned surface areas and nitro functionalities on adsorption outcomes. The best-performing model was deployed in a Streamlit application, enabling predictions of Qe from SMILES and experimental conditions with built-in applicability-domain checks."

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NSAIDs beyond COX: In Silico and In Vitro Insights into Acetylcholinesterase Modulation. (PubMed, ACS Omega) - "Among the compounds that were tested, nimesulide displayed the highest binding affinity (ΔG = -24.2 kcal/mol), followed by dipyrone (-16.0 kcal/mol), ibuprofen (-11.0 kcal/mol), and paracetamol (-9.0 kcal/mol). These findings suggest that NSAIDs, particularly nimesulide, may act as dual modulators with both anti-inflammatory and cholinergic regulatory effects. This work underscores the translational potential of drug repurposing and highlights the importance of combining computational and biochemical methods to uncover novel therapeutic functions of established drugs."

Journal • Preclinical • Inflammation • Metabolic Disorders • Pain

Choline chloride-malic acid Natural Deep Eutectic Solvent containing hydrophobic drugs: Insights into solubility and permeability behavior in digestive tract models. (PubMed, Int J Pharm) - "The selected APIs included weak bases (domperidone, cinnarizine, olanzapine), weak acids (nimesulide, flurbiprofen), and a pH-independent compound (carbamazepine). Nevertheless, its ability to improve bioavailability is highly dependent on the molecular characteristics of each API + NaDES system. Upon dilution in biorelevant media, performance is governed by a delicate interplay of hydrogen bonding, hydrophobic interactions and competition with solubilizing agents present in gastrointestinal fluids."

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Contribution of molecular-modified biomimetic mesoporous silica xerogel in delivering nimesulide with superior anti-inflammatory efficacy. (PubMed, J Mater Sci Mater Med) - "In addition, all these carriers improved drug release by converting the drug crystal form to an amorphous state. The swelling inhibition rate of NMS-loaded LT-MSX and NMS-loaded DT-MSX was the best, owing to their fast drug release and silica degradation, which can be of great value for the application of anti-inflammatory drugs."

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Multi-material integrated 3D-printed electrochemical detection platform for rapid on-site screening of nimesulide in industrial sewage. (PubMed, Mikrochim Acta) - "The detection platform demonstrated high competitive performance in electroanalysis, with excellent reproducibility (RSD = 6.8% by CV, 3.4% by DPV), a recovery of 90 ± 5%, a detection limit of 0.19 μM, and selectivity against most studied interferents. The presented approach serves as a proof-of-concept for a customisable, multi-material integrated 3D-printed electrochemical detection platform that prioritises reproducibility, low cost, and applicability in complex environmental matrices, highlighting its practical potential for sustainable wastewater monitoring."

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Age-Specific Biomarkers TREM1 and KLF4 in Ischemic Stroke: From Transcriptomic Discovery to Therapeutic Drug Screening. (PubMed, FASEB J) - "Molecular docking revealed curcumin's Vina score of -7.0 kcal/mol with TREM1, while calcitriol, nimesulide, and triptonide showed strong interactions with KLF4, scoring -8.2, -7.0, and -7.2 kcal/mol, respectively. This study highlights the importance of age-specific strategies for IS and identifies TREM1 and KLF4 as promising dual-purpose biomarkers for diagnosis and therapy, enhancing prognostic assessments and outcomes for younger patients."

Biomarker • Journal • Preclinical • Cardiovascular • Ischemic stroke • KLF4

Levamisole-Associated Cutaneous Reaction with Atypical Presentation (EADV 2025) - "As soon as the skin lesions began, the patient took nimesulide for one day (two tablets). This case expands the clinical spectrum of cutaneous reactions associated with levamisole exposure. While vasculitic patterns remain typical, alternative presentations such as SDRIFE-like eruptions should be considered. Confirmatory toxicology through GC-MS is essential to establish exposure."

Agranulocytosis • Dermatitis • Dermatology • Granulocytopenia • Immunology • Vasculitis

Sustainable Surfactant-Free Synthesis of MnMoO4/Carbon Nanofiber Composite for Highly Sensitive Detection of Nimesulide in Biological and Pharmaceutical Matrices. (PubMed, ACS Appl Bio Mater) - "Real sample analyses in spiked blood plasma and pharmaceutical tablet extracts yielded satisfactory recoveries, validating the sensor's matrix compatibility and analytical robustness. The synergistic integration of electroactive MnMoO4 and conductive CNF enables efficient electron transfer, high electrocatalytic activity, and structural stability, positioning the MnMoO4/CNF composite as a promising candidate for practical applications in therapeutic drug monitoring and pharmaceutical quality assurance."

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Synthesis and characterization of nanocapsules containing anti-inflammatory drugs: in vitro and in silico biological activity. (PubMed, J Toxicol Environ Health A) - "The aim of this study was to examine the synergic activity of two frequently used anti-inflammatory drugs, dexamethasone acetate (DA), and nimesulide (NIME) in nanoencapsulated form to diminish toxicity but enhance therapeutic effectiveness...Computational results suggested that NIME was more reactive, while DA was more stable. Data suggest that nanocapsules may diminish side effects without reducing the benefits of these drugs against tumors."

Journal • Preclinical • Oncology • MMP13 • TIMP2

Photobiomodulation vs. nonsteroidal anti-inflammatory drugs after diode laser excision of lower lip lesions: a case series. (PubMed, Lasers Med Sci) - "Subjects in G1 reported less pain during follow-ups than those in G2, but with no significant differences between groups in all experimental times (p > 0.05). In the analysis, after seven days, the G1 presented a smaller surgical wound (p = 0.017). PBMT can be an alternative in relation to the use of nimesulide, allowing for less painful symptoms and optimization of the healing process."

Clinical • Journal • Pain

Metabolic activation of nitro-containing drugs by AKR1C enzymes: A focus on flunitrazepam (ACS-Fall 2025) - "While the reduction of NO2 moieties in drugs is known to be catalyzed by NADPH-dependent flavoenzymes (NADPH:P450 oxidoreductase, NAD(P)H-quinone oxidoreductase [NQO1]), P450 enzymes, and oxidases (aldehyde oxidase, xanthine oxidase), information regarding the involvement of aldo-keto reductases in the reduction of nitro-containing drugs is limited.In this study, we screened six nitro-containing drugs (flunitrazepam, clonazepam, nimesulide, nilutamide, flutamide, and chloramphenicol) as substrates against recombinant human AKR1C1, 1C2, 1C3, and 1C4. In addition, flunitrazepam was also identified as an inhibitor of AKR1C2.In conclusion, AKR1C3 can reduce flunitrazepam to reactive nitroso-intemediates that could enhance drug toxicity. Our findings also suggested that AKRs can modulate GABAA receptor activity either by metabolizing benzodiazepines via AKR1C3 or by synthesizing the neuroactive steroid allopregnanolone via AKR1C2."

Addiction (Opioid and Alcohol) • AKR1C1 • AKR1C2 • NQO1

Metabolic activation of flunitrazepam via nitroreduction mediated by aldo-keto reductase 1C3. (PubMed, Drug Metab Dispos) - "We screened 6 nitro-containing drugs (flunitrazepam, clonazepam, nimesulide, nilutamide, flutamide, and chloramphenicol) as substrates against recombinant human AKR1C1, AKR1C2, AKR1C3, and AKR1C4, using discontinuous enzymatic assays. We conclude that both AKR1C3 and AKR1C2 may have an important role in flunitrazepam drug response. SIGNIFICANCE STATEMENT: Aldo-keto reductase (AKR)1C3 reduces flunitrazepam to 7-amino-flunitrazepam through the formation of reactive nitroso and hydroxylamino intermediates, and by inhibiting AKR1C2, flunitrazepam may reduce the formation of the neuroactive steroid allopregnanolone."

Journal • Addiction (Opioid and Alcohol) • Hepatocellular Cancer • Liver Cancer • Solid Tumor • AKR1C1 • AKR1C2

Prospective Real-World Study Comparing the Safety and Effectiveness of Nimesulide with Available Antipyretic and Analgesics for Treatment of Fever or Fever with Pain-ENDEVER. (PubMed, J Assoc Physicians India) - "Nimesulide (100 mg) was superior to ibuprofen (400 mg) + paracetamol (325 mg) and paracetamol (650 mg) in managing fever or fever with pain, with a comparable safety profile."

Clinical • Journal • Observational data • Real-world evidence • Infectious Disease • Inflammation • Pain

Investigation of novel nimesulide derivatives against breast cancer. (PubMed, Bioorg Chem) - "Western blot results showed a dose-dependent decrease in p-ERK levels in both MCF-7 and MDA-MB-231 cells, confirming MAPK pathway inhibition. These findings support that nimesulide-based semicarbazones, particularly compound 5e, exhibit potent antiproliferative and pro-apoptotic activity via MAPK pathway modulation, offering a promising avenue for the development of targeted breast cancer therapies."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • ANXA5 • MAPK12

On the results of a multicenter, open, observational, non-interventional study of the efficacy and safety of nimesulide (Nise) in combination with muscle relaxants in patients with acute back pain (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The use of Nise and Tolperisone in patients with LBP is effective and safe."

Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Inhibition of Bone Resorption and Anti-Inflammatory Effect of 7-Hydroxycoumarin in an Animal Model of Lipopolysaccharide-Induced Periodontal Disease. (PubMed, Int J Dent) - "The mice were randomly assigned to different treatment groups, receiving 7HC at 50 and 100 mg/kg, nimesulide at 25 mg/kg, and a control group that received the vehicle... The bioactive 7HC not only inhibited proinflammatory cytokines but also stimulated the expression of the anti-inflammatory cytokine, thereby preventing bone resorption. This positions 7HC as a promising candidate for periodontal therapy."

Journal • Preclinical • Dental Disorders • Periodontitis • IL10 • IL1B • IL6 • MMP9 • TGFB1 • TIMP1

Exploring the Cardiovascular Safety Profile of Ibuprofen: Insights from EudraVigilance Database. (PubMed, Pharmaceuticals (Basel)) - "Stroke was reported for ibuprofen with a lower probability compared with etoricoxib (ROR: 0.34; 95% CI: 0.21-0.55), celecoxib (ROR: 0.07; 95% CI: 0.06-0.10), meloxicam (ROR: 0.25; 95% CI: 0.14-0.43), acetylsalicylic acid (ROR: 0.07; 95% CI: 0.05-0.09), and ibuprofen/pseudoephedrine (ROR: 0.11; 95% CI: 0.05-0.25). Myocardial infarction was reported as being more probable for ibuprofen than ketoprofen (ROR: 2.31; 95% CI: 1.57-3.40) or nimesulide (ROR: 2.43; 95% CI: 1.25-4.73). Overall, according to our study, the probability of reported cardiovascular adverse reactions is lower than those determined for the rest of the NSAIDs; however, taking into consideration the inherent limitations of the study, further clinical investigations would contribute to a better understanding of the cardiovascular safety of ibuprofen."

Journal • Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Myocardial Infarction • Thrombosis

Identification of Diagnostic Biomarkers and Therapeutic Targets in Sepsis-Associated ARDS via Combining Bioinformatics with Machine Learning Analysis. (PubMed, J Inflamm Res) - "Molecular docking results showed that nimesulide and minocycline were identified as potential therapeutic drugs for sepsis-associated ARDS. LTF and PRTN3 are identified as key NETs genes in sepsis-associated ARDS and show promise as effective molecular markers for disease diagnosis and potential therapeutic targets."

Biomarker • Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock

Nimesulide-induced Erythema Multiforme Major: A Case Report. (PubMed, JNMA J Nepal Med Assoc) - "This case, being the first to identify nimesulide as a possible trigger for EMM, aims to contribute to the growing body of knowledge on this topic. It emphasizes the need for vigilance and swift intervention for unusual drug reactions."

Journal • Dermatology • Immunology • Pain

The regulatory ban on nimesulide in veterinary use in India: A step towards animal welfare and vulture conservation. (PubMed, Environ Sci Pollut Res Int) - No abstract available

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Meloxicam as a Safe Bet: Rethinking the Approach to NSAID Hypersensitivity Alternative Drugs (EAACI 2025) - "No predictive factors for meloxicam reactions were identified. Based on these findings, OCT in hospital setting with nimesulide (considering its lower tolerance) could be considered as a first-line alternative for most patients, except for those with a history of NSAID-anaphylaxis or previous reactions to nimesulide, who should proceed with meloxicam first."

Allergy • Immunology

Assembling the Idiopathic Anaphylaxis Puzzle: Where was the secret key for Idiopathic anaphylaxis's box? (EAACI 2025) - "Initial detailed history failed to identify specific triggers, such as food, drugs, other allergens, or cofactors,e.g., alcohol, exercise, non-steroidal anti-inflammatory drugs (NSAIDs), spices, mammalian meat, latex). Additional information from family members revealed NSAIDs intake prior most of the anaphylactic episodes which the patient failed to recognize as potential trigger. Skin prick testing was not performed due to the acute nature of the episode at the time of evaluation."

Allergy • Immunology • KIT

Nimesulide and sodium hyaluronate ameliorate the inflammatory process and pain severity in traumatic knee osteoarthritis. (PubMed, Inflammopharmacology) - "The combination of nimesulide and intra-articular injection of sodium hyaluronate effectively reduced pain intensity and the severity of arthritis in patients, thereby enhancing clinical efficacy."

Journal • Immunology • Oncology • Osteoarthritis • Pain • Rheumatology • MMP3 • MMP9 • TNFA

The Effects of Non-Steroidal Anti-Inflammatory Drugs Used for Orthodontic Pain Management on Tooth Movement: A Comprehensive Review of the Literature. (PubMed, J Clin Med) - "Evidence shows that NSAIDs such as aspirin, ketorolac, diclofenac, and nimesulide significantly reduce OTM. The results for ibuprofen, meloxicam, and celecoxib were inconsistent with both no influence or a reduction in OTM, depending on dosage, mode, and duration of administration. Conversely, tenoxicam, nabumetone, etoricoxib, and parecoxib appear to have no effect on OTM. Among these, etoricoxib appears particularly promising due to its favorable gastrointestinal profile, high COX-2 selectivity, and negligible influence on OTM in clinical doses. However, the limited number of human trials highlights the need for further research to develop evidence-based guidelines for pain management that preserve treatment efficiency in orthodontics."

Journal • Review • Pain

Multimodal evaluation of lipoxygenase-targeting NSAIDs using integrated in vitro, SAR, in silico, cytotoxicity towards MCF-7 cell line, DNA docking and MD simulation approaches. (PubMed, Int J Biol Macromol) - "We reported earlier that several NSAIDs, including naproxen, aspirin and acetaminophen, inhibited lipoxygenase (LOX) enzyme at sub-micromolar concentrations...Aceclofenac (IC50 0.85 ± 0.06 μM) was the most active drug, followed by indomethacin (IC50 1.13 ± 0.07 μM), meloxicam (IC50 1.94 ± 0.07 μM) and ketorolac (IC50 9.26 ± 0.82 μM). Celecoxib (IC50 15.81 ± 0.71 μM), lornoxicam (IC50 16.54 ± 0.28 μM) and nimesulide (IC50 19.87 ± 0.85 μM) showed excellent inhibitory profiles. Flurbiprofen (IC50 21.73 ± 0.93 μM) and etoricoxib (IC50 24.93 ± 0.64 μM) moderately inhibited the target enzyme...Density functional theory (DFT) and ESP studies, MD simulations and MMPBSA free energy calculations further reiterated the stability of ligand-receptor complexes. Overall, these findings highlight the potential of targeted NSAIDs as dual COX/LOX inhibitors with broader therapeutic relevance in inflammatory disorders."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor