nimesulide / Generic mfg. - LARVOL DELTA

From Analgesic to Adversary: Toxic Epidermal Necrolysis Caused by Nimesulide (EADV 2026) - No abstract available

Steven-Johnson Syndrome

Organotin-Catalyzed Synthesis, Characterization, Anticancer and Antioxidant Activities, and Molecular Modeling Studies of Nimesulide Ureas as Potential MetAP (Type II) Inhibitors. (PubMed, ACS Omega) - "MD revealed that the drugs bind to the active site of the MetAP2 enzyme, as indicated by stable RMSD and RMSF plots. In conclusion, in silico results and in vitro studies suggest that the nimesulide derivatives may be novel, potential NSAID-based anticancer drug candidates for treating breast, prostate, gastric, and glioblastoma."

Journal • Brain Cancer • Breast Cancer • Glioblastoma • Oncology • Solid Tumor • Triple Negative Breast Cancer • METAP2

Neurobehavioral Effects of Two Distinct Anti-Inflammatory Drugs in a Two-Week Chronic Stress Model in Zebrafish. (PubMed, Brain Sci) - "In contrast, one-week nimesulide treatment during CUS produced an anxiolytic-like effect and normalized the expression of stress-induced pro-inflammatory glial biomarkers cox2 and il1β. Overall, our findings suggest that the two anti-inflammatory drugs tested modulate behavioral and molecular responses to chronic stress in zebrafish, with minocycline demonstrating broader anti-neuroinflammatory and antidepressant-like effects, and nimesulide exhibiting more specific anxiolytic-like properties in this model."

Journal • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry • IL1B • MT-CO2 • NOS2 • S100A10

Design, synthesis, and biological evaluation of a new series of amide-linked chalcone derivatives as selective COX-2 inhibitors. (PubMed, RSC Adv) - "COX isoenzyme inhibition studies identified AS2-2, AS2-5, and AS2-10 as the most potent COX-2 inhibitors, exhibiting low micromolar IC50 values and selectivity indices comparable to that of nimesulide...The enhanced activity of AS2-2 (3-Cl), AS2-5 (2-NO2), and AS2-10 (4-F-benzyl) is attributed to substituent-driven electronic and lipophilic effects, which optimize the COX-2 interaction while limiting COX-1 inhibition. Collectively, the AS2 series represents promising, selective, and biocompatible lead scaffolds with dual analgesic and anti-inflammatory potential for preclinical development."

Journal • Inflammation • Pain

Maternal and Early Developmental Effects of Perinatal Exposure to Therapeutically Relevant Doses of Common Nonsteroidal Anti-Inflammatory Drugs in Rats. (PubMed, Birth Defects Res) - "Perinatal exposure to therapeutically relevant doses of paracetamol/acetaminophen, aspirin, and nimesulide produced little evidence of overt maternal or developmental toxicity during the evaluated period. Although a limited number of drug-specific findings were identified, they were isolated and did not indicate a consistent pattern of reproductive toxicity. These results contribute to the preclinical safety assessment of NSAID exposure during pregnancy and lactation and support further studies to determine the functional relevance of these early observations."

Journal • Preclinical • Hematological Disorders

BET Bromodomain Targeting by NSAIDs: Structural, Biophysical, and Computational Insights. (PubMed, Proteins) - "Herein, we present the crystal structures of the second bromodomain (BD2) of hBRD2 in complex with the FDA-approved drugs, mefenamic acid (ID8) and nimesulide (NIM), and that of the first bromodomain (BD1) of hBRD4 in complex with nimesulide (NIM). Moreover, molecular dynamics simulations were performed on the selected derivatives of ID8 and NIM against these bromodomains and confirmed the stability of these derivatives' binding throughout the simulations. We propose that the derivatives of the aforementioned parent molecules may be potential inhibitors of the function of hBRD2 and hBRD4."

Journal • Oncology

DIC/Oxyma as efficient amide coupling agent for synthesis of amphiphilic hyaluronic acid conjugates in co-solvent systems. (PubMed, Int J Biol Macromol) - "This study aimed to optimize the CE of diisopropylcarbodiimide (DIC)/ethyl 2-cyanohydroxyiminoacetate (Oxyma) in co-solvent system and compare with EDC/NHS and DIC/1-hydroxybenzotriazole (HOBt) in the conjugation of HA with model hydrophobic drugs, nimesulide (NIM), lenalidomide (LEN), and estradiol (E2). In addition, the desirable CE of DIC/Oxyma shown to be consistent across different molecular weight HA. In summary, the observed high CE of DIC/Oxyma in co-solvent systems reiterates its importance in the conjugation of carbohydrate polymers intended to ameliorate the pharmacokinetic properties of hydrophobic drugs."

Journal

Avoiding Mislabeling of Drug Allergy in Patients with Recurrent Cutaneous Symptoms (EAACI 2026) - "In 2007, due to a previous history of suspected nonsteroidal anti-inflammatory drug hypersensitivity, oral provocation test with nimesulide (100 mg) was performed, during which the patient developed bronchospasm...During paracetamol OPT, she developed pruritus and flexural eczema 30 minutes after 250 mg, resolving after intravenous methylprednisolone and intramuscular clemastine...Celecoxib (200 mg) provocation caused mild pruritus after 30 minutes, resolving spontaneously...The occurrence of symptoms after placebo administration and their resolution following reassurance support a non-immunological mechanism. Recognition of stress-related components, appropriate patient counseling, and careful interpretation of provocation tests are essential to prevent misdiagnosis, unnecessary drug avoidance, and inappropriate labeling of drug allergy."

Clinical • Late-breaking abstract • Allergy • Atopic Dermatitis • Immunology

Preemptive Analgesia With Steroidal and Nonsteroidal Anti-Inflammatory Drugs in Dental Implant Surgeries: A Systematic Review. (PubMed, J Oral Implantol) - "Seven RCTs (n = 589 patients) evaluated aceclofenac 100 mg (in combination with acetaminophen), dexamethasone 4 mg, dexketoprofen 25 mg, etoricoxib 90 mg, ibuprofen 600 mg, ketorolac 10 mg, meloxicam 15 mg, nimesulide 100 mg, piroxicam 40 mg, and tenoxicam 20 mg. Owing to the heterogeneity in protocols, drug regimens, and outcome measures, definitive conclusions regarding the most effective and safest preemptive agents could not be drawn. Future trials should emphasize methodological standardization and focus on widely used drugs to support evidence-based decisions in implant dentistry."

Clinical • Journal • Review • Pain

A Descriptive Analysis of Potential Warfarin-NSAID Interactions in Dental Prescribing in Minas Gerais, Brazil, 2011-2021. (PubMed, Healthcare (Basel)) - "Although these PDDIs are low, they are clinically significant and may have important implications for patients and the healthcare system. In conclusion, PDDIs between NSAIDs and warfarin, though low in absolute numbers, have increased over the years, reinforcing the need for greater awareness among dental professionals and for the implementation of clinical decision support strategies to promote safe care."

Journal • Inflammation • Pain

Behavioral, biochemical, and endocrine stress responses in zebrafish exposed to azithromycin, nimesulide, and their combination. (PubMed, Comp Biochem Physiol C Toxicol Pharmacol) - "These findings demonstrate that short-term, repeated exposure to mixtures of commonly detected pharmaceuticals, even at environmentally relevant concentrations, can disrupt behavioral, biochemical, and endocrine homeostasis in aquatic organisms. This highlights the ecological risks posed by multi-compound contamination in aquatic environments."

Journal • Mood Disorders • Pain • Psychiatry • CAT

Blood-Brain Barrier (BBB)-Penetrable Androgen Receptor (AR) Degrader as a Potential Therapeutic Agent for Glioblastoma. (PubMed, ACS Pharmacol Transl Sci) - "Compound A is an analog of the cyclooxygenase-2 (COX-2) inhibitor Nimesulide. Pharmacokinetic studies reveal that compound A has a half-life (t 1/2) of 3.11 h and a BBB penetration of 52%, which is even higher than the standard chemotherapy Temozolomide. These results suggest that the AR degrader has great potential as a novel GBM treatment."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • Targeted Protein Degradation • AR

Synthesis, characterization, biological evaluation, and molecular modeling of novel nimesulide urea derivatives as potential MetAP2 inhibitors. (PubMed, Sci Rep) - No abstract available

Journal • METAP2

Ibuprofen and nimesulide derivatives selectively induce apoptosis in HER2-positive breast cancer via inhibition of the PLA₂-COX-2-NF-κB pathway. (PubMed, Mol Biol Rep) - No abstract available

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • HER-2

Influence of pH, Buffering Capacity, Ionic Strength, Bile Salts, and Model Drugs on Micellization Behaviour of Salcaprozate Sodium in Physiological Range pH Buffers. (PubMed, AAPS PharmSciTech) - "Salcaprozate sodium (SNAC) is an FDA GRAS-listed permeation enhancer used in oral semaglutide and vitamin B12 formulations...Coadministered drugs, including aspirin, metformin, nimesulide, ciprofloxacin, and semaglutide, significantly altered SNAC CMC values. Semaglutide showed a non-monotonic effect, decreasing the CMC at low concentrations but increasing it at higher concentrations due to oligomerisation. These findings provide mechanistic insights into SNAC micellization under physiologically relevant conditions and offer a rational basis for optimising SNAC-based oral drug delivery systems."

Journal • Gastrointestinal Disorder

Chitosan-Stabilized Silver-Nimesulide Coordination Complex with Enhanced Anti-Inflammatory and Redox-Modulating Activity. (PubMed, ACS Omega) - "The biocomposite significantly reduced carrageenan-induced edema, MPO activity, and lipid peroxidation, while modulating thiol-dependent redox responses. These findings demonstrate that coordination-driven polymeric stabilization improves the therapeutic profile of nimesulide and supports further preclinical investigation of this multifunctional biocomposite."

Journal • Inflammation

Sulfonamides as Aromatase Inhibitors: Nimesulide Analogues, N-cyclic- and Aryl-Sulfonamides. (PubMed, Anticancer Agents Med Chem) - "This review aims to describe the most significant structure-activity relationships of nonsteroidal aromatase inhibitors containing a sulfonamide moiety, focusing on (i) biological results related to enzyme inhibition and (ii) interactions with active-site residues of aromatase identified through molecular modeling. Based on their core scaffold, the molecules are classified into (i) analogues of nimesulide, (ii) N-cyclic sulfonamides, and (iii) aryl-sulfonamides."

Journal • Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Solid Tumor

The effect of nimesulide on skeletal muscle hypertrophy and load progression after 8 weeks of resistance training in wistar rats. (PubMed, J Muscle Res Cell Motil) - "Additionally, there were no differences in training load or volume between COMB and TR (p ≥ 0.05). Therefore, based on the results, it is concluded that the administration of nimesulide during eight weeks of training promoted a greater hypertrophic response of the FHL muscle in rats."

Journal • Preclinical • Pain

Development of nimesulide-loaded pH-triggered ocular in situ gels; In vitro characterization, MTT assay and Drazie test. (PubMed, Drug Dev Ind Pharm) - "For this reason, the TB5 formulation may be a good choice when treating ocular inflammation. These findings may be supported by future efficacy studies using this formulation."

Journal • Preclinical • Inflammation • Ocular Inflammation

Drugs in paradise: caffeine, cocaine, and painkillers detected in sharks from The Bahamas. (PubMed, Environ Pollut) - "This study provides the first investigation into the occurrence of selected CECs (acetaminophen, benzoylecgonine, caffeine, carbamazepine, ciprofloxacin, citalopram, clindamycin, cocaine, diclofenac, fipronil, fluoxetine, nimesulide, piroxicam, sertraline, sulfamethoxazole, triclosan, trimethoprim, and tramadol) and their potential associations with physiological systemic health markers (triglycerides, total cholesterol, urea, phosphorus, and lactate) in the serum of five shark species sampled from nearshore habitats in Eleuthera Island, namely Galeocerdo cuvier (Tiger Shark), Carcharhinus limbatus (Blacktip Shark), Carcharhinus perezi (Caribbean Reef Shark), Ginglymostoma cirratum (Atlantic Nurse Shark), and Negaprion brevirostris (Lemon Shark). Furthermore, sharks with detectable CECs exhibited triglyceride, urea, and lactate alterations in comparison to those where these contaminants were not detected. This represents the first report concerning CECs and potentially..."

Journal • Pain

Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report. (PubMed, Cureus) - "This case highlights the diagnostic challenges, the dangers of over-the-counter NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) use, and the importance of pharmacovigilance reporting, given that only three cases of nimesulide-associated GBFDE have been documented to date. Increased awareness among clinicians is essential to prevent morbidity and recognize this rare but potentially life-threatening adverse reaction."

Adverse events • Journal • Steven-Johnson Syndrome

Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation. (PubMed, Front Physiol) - "Electrical Field Stimulation (EFS) (2, 4 and 8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, or guanethidine (10-6 M)...Concentration-response curves to GS-967, GS-6615 or RAN were constructed in rings precontracted with noradrenaline, endothelin-1 or KCl with or without specific inhibitors (L-NAME, nimesulide, SC-560, verapamil, nifedipine, apamin or charybdotoxin)...Taken together, our results indicate that GS-967, GS-6615 and RAN decrease vasoconstrictor responses due to both neural and noradrenaline-induced adrenergic stimuli. We can suggest that the use of GS-967, GS-6615 and Ranolazine may be interesting in clinical procedures involving hyperstimulation of the adrenergic nervous system."

Journal • Preclinical • EDN1

Radiolabeled para-I-nimesulide: an unexpected tracer for imaging peripheral inflammation. (PubMed, Front Nucl Med) - "These findings indicate that while [125I]para-I nimesulide has limited potential for brain-targeted COX-2 imaging, it may serve as a promising tracer for detecting COX-2 expression in peripheral tissues. Importantly, this study also highlighted that the electronic properties of substituents strongly influence metabolic stability, providing valuable insights for the design of future COX-2-targeted molecular imaging agents."

Journal • Inflammation • PTGS2

Design, synthesis, and biological evaluation of novel chalcone derivatives: integrating molecular docking with in vivo anti-inflammatory and antinociceptive studies. (PubMed, RSC Adv) - "Cytotoxicity assessment on 3T3 fibroblasts using the MTT assay revealed no toxicity compared to doxorubicin, while brine shrimp lethality and hemolytic assays further confirmed their safety profile. In vitro COX-1/2 assays demonstrated preferential inhibition of COX-2, with AS1-6 showing a superior selectivity index relative to nimesulide...Collectively, the concordance of in vitro COX-1/2 inhibition, in vivo efficacy, and in silico analyses underscores the potential of these chalcone analogues as selective COX-2 inhibitors. These findings highlight the value of structure-guided design in developing dual-function chalcones with anti-inflammatory and antinociceptive activity, warranting further optimization and preclinical evaluation."

Journal • Preclinical • Inflammation • Pain

An open-label observational study of the efficacy and tolerability of rapidly dissolving forms of aceclofenac and nimesulide for oral use in the treatment of patients with acute non-specific low back pain (ASTRA study) (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The use of aceclofenac and nimesulide in a rapidly dissolving form for the preparation of a suspension for oral administration is an effective and safe option for the treatment of ANLP. Rapid onset of effect, ease of administration, and a favorable safety profile are important advantages of this NSAID formulation for patients. Aceclofenac in the form of a powder for the preparation of a suspension for oral administration is superior to rapidly dissolving nimesulide in the speed of pain relief and can be considered as a first-line treatment for patients with ANLP."

Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain