Undisclosed tau degrader
/ APRINOIA Therap
- LARVOL DELTA
Home
Next
Prev
1 to 2
Of
2
Go to page
1
March 11, 2025
TARGETED PROTAIN DEGRADATION OF TAU FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND PRIMARY TAUOPATHIES
(ADPD 2025)
- "A tau degrader library was generated by combining a di verse collection of tau binders from the APRINOIA tau PET tracer program with different linkers and ligands of CRBN E3 ligase... We have established a platform to identify novel tau aggregate degraders by taking advantage of APRINOIA's rich collection of well -characterized tau binders from its tau PET tracer program. Current effort is focused on further optimization of the drug properties of top tau de grader series as a promising therapy for AD and related tauopathies."
Alzheimer's Disease • CNS Disorders • Dementia • Frontotemporal Lobar Degeneration • Movement Disorders • Progressive Supranuclear Palsy • Targeted Protein Degradation • CRBN
July 07, 2023
PROTAC tau degrader for the treatment of Alzheimer’s disease and primary tauopathies
(AAIC 2023)
- "Tau PROTAC degrader generated from proprietary tau warhead can selectively decrease the oligomer/aggregated tau in both in vitro and in vivo models. Current effort is focused on optimization of ADME properties of tau degrader as a promising therapy for AD primary tauopathies."
Alzheimer's Disease • CNS Disorders • Targeted Protein Degradation
1 to 2
Of
2
Go to page
1