Undisclosed tau degrader / APRINOIA Therap - LARVOL DELTA

TARGETED PROTAIN DEGRADATION OF TAU FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND PRIMARY TAUOPATHIES (ADPD 2025) - "A tau degrader library was generated by combining a di verse collection of tau binders from the APRINOIA tau PET tracer program with different linkers and ligands of CRBN E3 ligase... We have established a platform to identify novel tau aggregate degraders by taking advantage of APRINOIA's rich collection of well -characterized tau binders from its tau PET tracer program. Current effort is focused on further optimization of the drug properties of top tau de grader series as a promising therapy for AD and related tauopathies."

Alzheimer's Disease • CNS Disorders • Dementia • Frontotemporal Lobar Degeneration • Movement Disorders • Progressive Supranuclear Palsy • Targeted Protein Degradation • CRBN

PROTAC tau degrader for the treatment of Alzheimer’s disease and primary tauopathies (AAIC 2023) - "Tau PROTAC degrader generated from proprietary tau warhead can selectively decrease the oligomer/aggregated tau in both in vitro and in vivo models. Current effort is focused on optimization of ADME properties of tau degrader as a promising therapy for AD primary tauopathies."

Alzheimer's Disease • CNS Disorders • Targeted Protein Degradation