oxapenem (AM-112) / Amura - LARVOL DELTA

Probing the CB1 cannabinoid receptor binding pocket with AM6538, a high-affinity irreversible antagonist. (PubMed, Mol Pharmacol) - "In the present study, we characterize AM6538 as a tight-binding/irreversible antagonist of CB, as well as two derivatives of AM6538 (AM4112 and AM6542) as slowly dissociating CB antagonists across binding simulations and cellular signaling assays...SIGNIFICANCE STATEMENT: AM6538 binds tightly to the CB1 receptor in a wash-resistant manner. It has long lasting antagonist effects in both cellular assays and in vivo."

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