losartan / Generic mfg. - LARVOL DELTA

Losartan Combined with Lenvatinib for Postoperative Adjuvant Therapy in Patients with Tumor Budding-Positive Hepatocellular Carcinoma: A Multicenter, Prospective, Single-Arm Trial. (ChiCTR) - P=N/A | N=56 | Recruiting | Sponsor: Xi'an Jiaotong University Second Affiliated Hospital; Xi'an Jiaotong University Second Affiliated Hospital

New trial • Hepatocellular Cancer • Oncology • Solid Tumor

Early onset radiation-induced leukoencephalopathy in patients treated for a glioblastoma by STUPP protocol and risk factors evaluation, an ancillary study of the phase III ASTER protocol. (PubMed, Rev Neurol (Paris)) - "This study reports a high incidence (29%) of early-onset RIL in glioblastoma patients treated with the Stupp protocol, highlighting the question of individual sensitivity to this severe side effect. While previous research suggests a role for PPARγ in radiation-induced toxicity, this study was underpowered to confirm whether Losartan, as PPARγ agonist, could offer protection against early-onset RIL. The lack of significant results underscores the need for larger, prospective trials to further investigate these factors and develop targeted preventive strategies."

Journal • P3 data • Brain Cancer • Cardiovascular • CNS Disorders • Glioblastoma • Hypertension • Oncology • Solid Tumor

STAR Therapy: Spatiotemporal Antitumor Regimen via a Size-Gated DNA Hydrogel Drug Delivery System. (PubMed, Adv Mater) - "In this system, a small-molecule drug Losartan (Los) and a larger indocyanine green-loaded platelet-mimetic particle (ICG/PLT) are co-encapsulated within the DSH...Notably, this size-gated sequential release strategy significantly enhances the accumulation of ICG/PLT at the tumor site, resulting in superior light-activated photodynamic therapeutic outcomes against tumors. Taken together, this study establishes a novel STAR paradigm based on size-gated DSH, holding promise to advance the therapeutic strategy for solid tumors with dense ECM."

Journal • Oncology • Solid Tumor

Age-Dependent Effects of Losartan and Exercise on Skeletal Muscle Redox Balance and Protein Turnover in Mice. (PubMed, Biomed J) - "While exercise is a robust intervention, losartan's efficacy is critically dependent on the animal's baseline oxidative status. These findings highlight the importance of considering age as a critical factor when designing pharmacological interventions for age-related muscle atrophy."

Journal • Preclinical • Muscular Atrophy • FOXO3 • SMAD2

Angiotensin Receptors as Targets for Protection From Noise-Induced Hearing Loss (ARO 2026) - "Type 1 and Type 2 angiotensin receptors confer opposing effects in our mouse model of noise-induced hearing loss. Availability of AT2Rs for activation may provide endogenous protection against worse hearing outcomes during acoustic trauma. In the absence of AT2R signaling, pharmacologic AT1R inhibition with losartan results in significant levels of protection against severe noise toxicity."

Fibrosis • Immunology • Inflammation • Mood Disorders • Otorhinolaryngology

Drug-Induced Liver Injury Associated With the Angiotensin II Receptor Blocker Losartan in a 59-Year-Old Woman With Hypertension: A Case Report. (PubMed, Am J Case Rep) - "CONCLUSIONS Although rare, losartan-induced hepatotoxicity should be considered in patients with otherwise unexplained liver enzyme elevation. Early recognition, thorough exclusion of other causes, and prompt discontinuation of losartan typically lead to full recovery, emphasizing the need for timely evaluation in patients receiving angiotensin II receptor blocker therapy."

Journal • Back Pain • Cardiovascular • Dyspepsia • Hepatology • Hypertension • Immunology • Inflammation • Liver Failure • Musculoskeletal Pain • Pain

Pharmacological strategies for preventing post-stroke seizures and epilepsy. (PubMed, Front Neurol) - "Although current evidence is limited, we suggest that levetiracetam and lamotrigine may be preferred agents for preventing acute seizure recurrence. Statins, GLP-1 agonists, eslicarbazepine, perampanel, and losartan have not been evaluated yet and need further study on their ability to prevent first-time seizures in stroke patients. While clinical trials of antiseizure medications can be costly, further research into biomarkers of epileptogenesis could facilitate more feasible clinical trials to enhance the evidence base for antiseizure medications in post-stroke seizures and epilepsy."

Journal • Review • Cardiovascular • CNS Disorders • Epilepsy

What's new about angiotensin receptor blocker (ARB) therapy for Marfan syndrome: A narrative review. (PubMed, Vasc Med) - "A key pathological mechanism in MFS is excessive TGF-β signaling, which has been targeted by angiotensin receptor blocker (ARB) therapies such as losartan, demonstrating potential in restoring normal phenotypes in experimental models...Overexpression of NADPH oxidase in MFS contributes to vascular dysfunction, and EXP3179 mitigates aortic vasoconstriction. Given these mechanisms, ongoing research explores the potential of AT1 receptor antagonists as therapeutic agents in MFS, aiming to improve vascular health and long-term patient outcomes."

Journal • Review • Cardiovascular • Genetic Disorders • FBN1 • TGFB1

Elevated homocysteine contributes to the progression of type 1 diabetic nephropathy: Evidence from Mendelian randomization and experimental validation. (PubMed, Medicine (Baltimore)) - "Notably, treatment with losartan and sinomenine alleviated Hcy-induced cytotoxicity, indicating their potential protective effects. The findings of this study suggest that elevated Hcy levels represent an important risk factor contributing to the development of T1DN."

Journal • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus

Shen-Shuai-Ⅱ Recipe ameliorates chronic kidney disease-induced myocardial injury via inhibition of the IL-18/IL-18R1/MyD88 pathway. (PubMed, Phytomedicine) - "SSR ameliorates CKD-induced myocardial injury through suppression of the IL-18/IL-18R1/MyD88 pathway."

Journal • Chronic Kidney Disease • Inflammation • Nephrology • Renal Disease • IL18 • MYD88

The COVID-RASi Trial (COVID-19) (clinicaltrials.gov) - P3 | N=372 | Completed | Sponsor: Ottawa Heart Institute Research Corporation | Active, not recruiting ➔ Completed | N=1155 ➔ 372

Enrollment change • Trial completion • Cardiovascular • Infectious Disease • Novel Coronavirus Disease

Olive Leaf Extract Added to Losartan Treatment Improved Klotho/Wnt/β-Catenin Signaling in Hypertensive Rats with Focal Segmental Glomerulosclerosis. (PubMed, Antioxidants (Basel)) - "The other groups received adriamycin (2 mg/kg, i.v., twice in a 3-week interval) for FSGS induction. The L+O combination reduced proteinuria more efficiently than L and decreased renal injury close to control levels. Although these findings indicate that combined treatment of losartan and olive leaf extract is promising in slowing the progression of the experimental FSGS, further clinical studies are needed to confirm its favorable outcomes and safety in CKD patients."

Journal • Preclinical • Chronic Kidney Disease • Fibrosis • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Immunology • Nephrology • Renal Disease • FN1

Losartan Protects Against Radiation-Induced Testicular Damage by Modulating Oxidative Stress, Testosterone Levels, and Metabolic Profile. (PubMed, Pharmaceuticals (Basel)) - "Long-term, LOS improved sperm quality, reduced oxidative stress, and promoted adaptive metabolic responses. Irradiation-based cancer therapy causes structural and functional testicular damage and changes the testicular metabolome of rats, while LOS has the potential to be used as a radioprotector to mitigate the adverse acute and late effects of radiation on male fertility."

Journal • Oncology

7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways. (PubMed, Pharmaceuticals (Basel)) - "In vivo, unilateral ureteral obstruction (UUO) and adenine (Ade)-induced mouse models were treated with a low/high-dose 7-KLCA or losartan...It upregulated FXR and its downstream genes SHP and FGF15, thereby inhibiting the activation of TGF-β/Smad and Wnt/β-catenin pathways. This is the first study to clarify the molecular mechanism through which 7-KLCA targets FXR and dually suppresses the key pro-fibrotic pathways TGF-β/Smad and Wnt/β-catenin, thereby exerting anti-renal fibrosis effects."

Journal • Fibrosis • Immunology • Inflammation • Renal Disease • IL1B • IL6 • TGFB1

Putative Antianxiety Property of Oral Enalapril Formulation in Mice: a Preclinical and in silico Study. (PubMed, CNS Neurol Disord Drug Targets) - "Enalapril demonstrates anxiolytic-like properties, further insights into the GABAergicrenin- angiotensin-aldosterone mechanistic hypothesis."

Journal • Preclinical • Cardiovascular • CNS Disorders • Hypertension • Mood Disorders • Psychiatry

Benznidazole therapy improves pressure overload and cardiac electrical profile in an experimental model of Angiotensin II infusion-induced hypertension: Mechanistic insights. (PubMed, PLoS One) - "Bz or the AT1R antagonist losartan (Los) were administered from 7 to 28 dps...Bz therapy showed a beneficial effect, tending to restore the IL-6 concentrations and oxidant/antioxidant balance to physiological levels, which was correlated with reversal of the dispersed QTc interval. Altogether, our data support that Bz therapy deserves further evaluation as an anti-inflammatory and antioxidant adjuvant tool to improve BP overload and long-QTc syndrome underlying cardiovascular diseases."

Journal • Cardiomyopathy • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • IL6

Metabolomic Signatures of Physical Function and Functional Trajectories in Older Adults: Insights from the ENRGISE Clinical Trial. (PubMed, Metabolites) - "Participants were randomized to losartan, omega-3 supplementation, both, or placebo... Serum metabolomic signatures were associated with baseline physical function, predicted functional trajectories, and revealed pharmacologic activity of omega-3 supplementation. These findings support the use of metabolomics to uncover biological heterogeneity and inform precision geroscience strategies in aging populations."

Journal • Geriatric Disorders • Inflammation

Ginsenoside Rb1 as a multi-target modulator in heart failure: Mechanistic insights into extracellular remodeling and transcriptional pathways from network pharmacology, molecular dynamics, and binding free energy analyses. (PubMed, Comput Biol Chem) - "This study highlights Ginsenoside Rb1 as a promising polypharmacological candidate for heart failure, showing strong and adaptable binding to multiple Ang II-related targets."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • Inflammation • FGF2 • MMP9 • STAT3

A case of bucillamine-induced membranous nephropathy presenting with acute kidney injury and requiring hemodialysis. (PubMed, CEN Case Rep) - "We present kidney biopsy findings in a 65-year-old male patient with rheumatoid arthritis who developed severe proteinuria 10 months after bucillamine administration and required hemodialysis 14 days later. The following mechanism is speculated as the cause of AKI. Although the arteriosclerotic lesions were mild in the kidney biopsy specimen, the severe hypoalbuminemia caused by severe proteinuria, combined with the drop in blood pressure due to losartan administration, led to an ischemic state, which is thought to have led to the onset of AKI."

Journal • Acute Kidney Injury • Atherosclerosis • Glomerulonephritis • Hypotension • Immunology • Inflammatory Arthritis • Nephrology • Pain • Renal Disease • Rheumatoid Arthritis • Rheumatology • EGF

Retail Sales of Drugs for Diabetes, Dyslipidemia, and Hypertension in Chile Under 2 Health Policies. (PubMed, Value Health Reg Issues) - "Despite public-sector policies, retail sales of these drugs increased over time, although growth slowed during the second decade."

Journal • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders

Fungal keratitis following laser assisted lenticule extraction surgery with use of losartan as an anti-scarring agent - a case report. (PubMed, Am J Ophthalmol Case Rep) - "The subepithelial LALEX pocket was irrigated initially with vancomycin and then voriconazole once the yeast was identified...Two LALEX pocket injections of amphotericin B were then given two days apart as well as intensive topical therapy of amphotericin B, voriconazole and cyclosporine combined with oral voriconazole...parapsilosis secretes hydrolytic enzymes, which may have contributed to the stromal scarring at the interface. Topical losartan is a potential safe new modality for reducing corneal scarring at the LALEX interface, however more evidence is needed to prove its efficacy."

Journal • Corneal Abrasion • Keratitis • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Drug-drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors. (PubMed, Cancer Chemother Pharmacol) - No abstract available

Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

LION: Losartan to Improve Outcomes After Multi-ligament Knee Injury (clinicaltrials.gov) - P2 | N=90 | Recruiting | Sponsor: Brigham and Women's Hospital | Not yet recruiting ➔ Recruiting

Enrollment open

Effects of Losartan on Musculoskeletal Tissues : Basic Science and Clinical Applications. (PubMed, JBJS Rev) - "Losartan offers a mechanistically targeted, clinically familiar antifibrotic therapy with strong potential to improve surgical and rehabilitative outcomes in orthopaedics."

Journal • Review • Fibrosis • Immunology • Musculoskeletal Diseases • Orthopedics • TGFB1

Pharmacokinetic Interaction Among Amlodipine, Losartan, and Chlorthalidone after a Single Oral Administration in Healthy Male Subjects. (PubMed, Clin Pharmacol Drug Dev) - "All the treatments were well tolerated overall. Besides the slight increase in losartan Cmax, the combination therapy did not show clinically significant pharmacokinetic interactions in terms of systemic drug exposure."

Clinical • Journal • PK/PD data