GW493838 / GSK - LARVOL DELTA

Identification of molecular targets from the interactome of primary sclerosing cholangitis and their therapeutic modulation (FFS-AIH 2025) - "In silico screening identified their ligands BGB-283 and RAF-265, which downregulated NF-kB signature expression in PSC organoids. GW-493838 combined with BMS270394 notably downregulated both TGF-beta and Notch signatures. We discovered perspective molecular targets in PSC and showed the impact of their predicted small molecule ligands on transcriptomes of primary PSC cholangiocyte organoids. OP and CF share first authorship MT and TR share senior authorship"

Cholestasis • Fibrosis • Gastroenterology • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Primary Biliary Cholangitis • ABCB4 • CD1C • CD36 • ITGAX • KRT19 • NFKB1 • NRP1 • SCARB1 • SLIT2 • TGFB1 • VEGFA