CMHX008 / Chongqing Medical University - LARVOL DELTA

Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes. (PubMed, Front Pharmacol) - "Our findings show that diabetic cardiomyopathy was associated with ectopic overexpression of PPARγ2. The full agonist rosiglitazone prevents cardiac dysfunction at the expense of compensatory hypertrophy, while the partial agonist CMHX008 shared a comparable protective effect without altering the structure of cardiomyocytes."

Journal • Preclinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Hypertrophic Cardiomyopathy • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • PPARG