GB1
/ Denali Therap
- LARVOL DELTA
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February 16, 2024
DYSREGULATION OF LYSOSOMAL AND AUTOPHAGIC-ASSOCIATED PROTEINS IN PBMCS AND PLASMA FROM PARKINSON'S DISEASE PATIENTS
(ADPD 2024)
- "Reduced LAMP1 levels in PD patient supports the hypothesis that lysosomes are reduced in PD patients. Additionally, elevated CatB levels in plasma suggests dysregulation in the normal lysosomal pathway in PD patients. We confirmed prior reports of elevated GCase activity in LRRK2 carriers, which may be biologically meaningful considering reduction of GlcSph."
Clinical • CNS Disorders • Movement Disorders • Parkinson's Disease • CTSB • GBA • LAMP1 • LRRK2
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