phenoxymethylpenicillin / Generic mfg. - LARVOL DELTA

Beyond the assays: Managing unresolvable TMA and the pharmacokinetic cost of plasma exchange (ASH 2025) - "Case presentation: A 73-year-old man with history of Tetralogy of Fallot with bioprosthetic aortic valve replacement on warfarin and CKD stage IIIb (baseline creatinine 1.7–1.8 mg/dL) presented with two weeks of progressive jaundice, anorexia, and fatigue...Under the suspicion of complement-mediated Hemolytic Uremic Syndrome (HUS), PLEX was held, meningococcal vaccination administered, and penicillin V prophylaxis initiated...PLEX was resumed followed by Rituximab infusion and a 7-day steroid taper...A second dose of Ravulizumab was administered two weeks after the initial dose, at which point PLEX was discontinued...Therefore, beyond emphasizing pre-PLEX sampling to avoid dilutional false negatives, this case highlights the need for rapid, discriminatory biomarkers and protocols that reconcile the competing demands of urgent PLEX and sustained complement inhibition. Finally, elderly patients with limited reserve may sustain permanent organ damage even with optimal..."

PK/PD data • Anorexia • Atypical Hemolytic Uremic Syndrome • Chronic Kidney Disease • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Meningococcal Infections • Nephrology

Availability and Cost of Basic Drugs for Sickle Cell Disease in 13 African Countries (ASH 2023) - "Participants completed questions covering the availability (on a scale from 0 (drug not available) to 10 (no availability concern) and the cost of basic drugs in their centres: HU, penicillin V, folic acid, morphine and vaccines. The high cost of vaccines, beyond the first years of life when a free national program is available in most of African countries, is also a problem. In addition to cost, availability and frequent supply disruptions prevent regular intake of hydroxyurea and, to a lesser extent, of penicillin V. International solidarity and the governments of these countries should work to bring down the cost of hydroxyurea and improve the distribution circuit for these essential medicines."

Genetic Disorders • Hematological Disorders • Infectious Disease • Meningococcal Infections • Pneumococcal Infections • Sickle Cell Disease

Group A Streptococcal Infections—Diagnostic Approaches and Antibiotics Prescriptions in Children and Adolescents in Germany: A Nationwide Representative Claims Data Analysis (ISPOR-EU 2025) - "Phenoxymethylpenicillin remained the most frequently prescribed antibiotic in approx. 40% of GAS infections until 2023, when amoxicillin, cephalosporins, and macrolides became more common (47% of all antibiotic prescriptions)... This real-world evidence highlights evolving patterns in pediatric GAS care and antibiotics prescriptions during a period of unprecedented health system disruption. Most pediatric GAS cases in Germany are managed with appropriate diagnostics and antibiotics, reflecting solid adherence to clinical standards. However, the potential to optimize care is highlighted —particularly in cases without diagnostic confirmation and in varying antibiotic choices."

Clinical • Infectious Disease • Novel Coronavirus Disease • Pediatrics

The first Mpox case in Zambia: a case report. (PubMed, J Med Case Rep) - "Our report emphasizes the transmission risk for Mpox in traditionally nonendemic areas resulting from cross-border movement. This highlights the need for countries to strengthen surveillance systems resulting in increased sensitivity, specificity, and timeliness required for early detection and response to Mpox. A multifaceted collaborative approach is required between countries to ensure formalized cross-border collaboration, strengthening health-seeking behavior through deployment of mobile clinics, and utilization of digital platforms risk communication and community engagement. Improved supply chain management for laboratory reagents, sample collection, and personal protective equipment coupled with training of health workers is crucial for adequate preparedness and successful containment of outbreaks. These initiatives, collectively undertaken, will result in a robust response system safeguarding public health and preventing emerging threats such as Mpox from..."

Journal • Fatigue • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain

Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society. (PubMed, Ger Med Sci) - "The Cochrane network analysis on the treatment of erythema migrans has only shown that, in addition to doxycycline and amoxicillin, oral penicillin V is equally effective. A Slovenian analysis of patients with acrodermatitis chronica atrophicans over the past 30 years has shown a decrease in the incidence of constitutional symptoms and atrophy, likely due to improved early detection. In addition, an information sheet for patients containing recommendations for the prevention of Lyme borreliosis is attached to the guideline."

Clinical guideline • Journal • Dermatitis • Dermatology • Immunology • Inflammatory Arthritis • Lyme Disease • Oncology

Recurrent Erysipelas: Clinical Challenges and Strategies for Prevention-A Narrative Literature Review. (PubMed, Biomedicines) - "Antibiotic prophylaxis, most commonly with oral penicillin V or intramuscular benzathine penicillin, has been shown to lower recurrence rates...While antibiotic prophylaxis is effective, its long-term success depends on simultaneous management of underlying conditions. Further studies are needed to define optimal regimens, treatment duration, and non-antibiotic alternatives."

Journal • Review • Cardiovascular • Dermatology • Diabetes • Genetic Disorders • Metabolic Disorders • Obesity • Tobacco Cessation

ACTINOMYCES: NOT A MIMIC, BUT A PRECURSOR--A CASE REPORT (CHEST 2025) - "This case report and others highlight that Actinomyces has the potential to not just be a mimicker, but may be a flag to investigate further for current malignancy, and to monitor for future malignancy."

Case report • Clinical • Chronic Obstructive Pulmonary Disease • Cough • Gastrointestinal Disorder • Immunology • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Thoracic Cancer

Effectiveness of a Clinical Decision Support Algorithm on Decreasing Unnecessary Antibiotic Use for Upper Respiratory Tract Infections among HIV-infected Adults in Mozambique: A Cluster Randomized Controlled Trial (ASTMH 2025) - "Amoxicillin (47.8%), azithromycin (21.9%), and phenoxymethylpenicillin (14.1%) were the most prescribed antibiotics. The intervention effectively reduced unnecessary antibiotics by decreasing prescriptions by 33.2%. Expansion of the intervention to other locations, including rural and remote settings, may achieve further reductions in unnecessary antibiotic use and contribute to a reduction in the risks of antimicrobial resistance occurrence."

Clinical • Human Immunodeficiency Virus • Infectious Disease • Respiratory Diseases

Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards. (PubMed, Ann Work Expo Health) - "A widespread environmental contamination of antibiotics was observed in hospital wards that potentially can contribute to the development of antibiotic-resistant bacteria as well as health impacts of exposed personnel. Probable sources include compounding, handling and administration of drug tablets, antibiotic contaminated waste as well as other sources such as excretions from patients and contaminated drug vials. Current surface cleaning routines do not sufficiently reduce spills and leakage regardless of source."

Journal • Immunology • Infectious Disease

Finnish Healthcare Professionals' Online Searches for Paediatric Oral Antibiotics: COVID-19 Impact, 2017-2023. (PubMed, Acta Paediatr) - "Healthcare professionals' online information-seeking for children's oral suspension of antibiotics showed a great decrease in searches after the start of COVID-19 but rapidly increased 2 years later. Information-seeking behaviour may be used to monitor the clinical use of antibiotics in children."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics

OVARIAN ACTINOMYCOSIS WITH NO HISTORY OF INTRA-UTERINE DEVICE USE: A CASE REPORT (FIGO 2025) - "Although diagnosis of pelvic actinomycosis is difficult in patients with no history of IUD use, ovarian actinomycosis should be considered in case of suspecting ovarian malignant tumor with abdominal pain and fever persisting for a long interval."

Case report • Clinical • Gynecology • Long-acting Reversible Contraceptives • Ovarian Cancer • Solid Tumor

Bilateral Breast Involvement by Actinomyces neuii in an Immunocompetent Male Patient: An Exceptional Case. (PubMed, Cureus) - "After failure of penicillin V, he was switched to oral linezolid, which led to resolution of the discharge, though induration remained on follow-up. Recognizing atypical actinomycosis, thorough evaluation, and microbiological confirmation are key to effective treatment and better patient outcomes."

Journal • Infectious Disease

Fast and sustainable active pharmaceutical ingredient (API) screening in over-the-counter and prescription drug products by surface-assisted plasma-based desorption/ionization high-resolution mass spectrometry. (PubMed, Anal Methods) - "Typically, the protonated molecular ion ([M + H]+) was the most abundant species, while some compounds (codeine, metamizole, phenoxymethylpenicillin, and torasemide) did show some degree of fragmentation. Here, SA-FAPA-HRMS with a CN-HPTLC sample substrate yielded the best performance (20.02 ± 0.52 μg mL-1, RSD = 2.6%, and deviation of -1.9% from the theoretical value) compared to RP2-TLC (18.97 ± 1.37 μg mL-1 and RSD = 7.2%, -7.0%), and HPLC-UV (18.51 ± 0.03 μg mL-1 and RSD = 0.2%, -9.3%) results. In conclusion, SA-FAPA-HRMS is considered attractive for rapid and sustainable analysis of pharmaceuticals with potential in non-invasive patient monitoring."

Journal • Anesthesia • Pain

Study of the green microalga Chlorella sorokiniana for the removal of nutrients and of multiple antibiotics in wastewater treatment. (PubMed, Environ Toxicol Chem) - "After 19 days of incubation, the β-lactam class (amoxicillin, penicillin V, cephalexin) showed the highest % of removal (51-85), followed by trimethoprim (24), oxytetracycline (6), metronidazole (6), and sulfamethoxazole (2). In addition, levels of dissolved NH4+, NO3-, PO43-, and COD (chemical oxygen demand), decreased by 88, 22, 100, and 10%, respectively. Our study confirmed the ability of C. sorokiniana to biodegrade antibiotics while also effectively reducing key nutrient loadings."

Journal

Acute generalized exanthematous pustulosis induced by cefazolin: An atypical cross-reactivity involving the "cephem" ring (EADV 2025) - "We performed IDT to ceftriaxone, cefotaxime, ceftazidime, (2 mg/mL), benzylpenicillin, amoxicillin and oxacillin (20 mg/mL)...Subsequently, a sequel gradual oral provocation test (OPT) to amoxicillin and penicillin V were carried out with no incidence... According to the Naranjo Causality Scale, the accountability of both drugs was found to be probable (score of '6'). This patient experienced an AGPE induced by cefazoline and confirmed by a positive IDT. Allergological workup was relevant for a cross-reactivity toward all tested cephalosporins and tolerance to penicillins."

Dermatology • Hematological Disorders • Immunology

Clinical predictors and antibiotics sensitivity of bacterial pathogens of pharyngotonsillitis among children aged 1-17 years in a Tertiary Hospital, Abakaliki, Southeast, Nigeria. (PubMed, Pan Afr Med J) - "Most of the isolated organisms were more susceptible to cephalosporins (ceftriaxone and cefuroxime) than the penicillin (penicillin V and amoxicillin clavulanate). Hence routine throat swab for bacteriology culture should be done for all children presenting with features suggestive of pharyngotonsillitis before commencement of antibiotics. However, where such services are not readily available, the use of cephalosporins empirically is recommended."

Journal • Infectious Disease • Otorhinolaryngology

A low-cost cellulose-based composite as an efficient solid phase extraction sorbent for the determination of antibiotics in water. (PubMed, RSC Adv) - "This study presents a low-cost, cellulose-based solid-phase extraction (SPE) adsorbent (C/PVPP/MDI) for the determination of five antibiotics: tetracycline (TET), ampicillin (AMP), sulfamethoxazole (SMX), penicillin V (PEN V), and chloramphenicol (CAP) in water. Additionally, the C/PVPP/MDI adsorbent was reusable for up to five cycles without significant performance loss and costs approximately 50% less than commercial alternatives. These findings demonstrate the potential of C/PVPP/MDI as a sustainable and affordable SPE material for environmental monitoring of antibiotic contaminants, particularly in developing countries where access to commercial materials is limited."

Journal

Artificial intelligence and health empowerment in rural communities and landslide- or avalanche-isolated contexts: real case at a fictitious location. (PubMed, Front Digit Health) - "A peak CRP of 130 mg/L, combined with otherwise stable vital signs, prompted a remote consultation with a trusted physician in their social network, who confirmed the diagnosis of bacterial tonsillitis and initiated treatment with phenoxymethylpenicillin (Apocillin)...The case illustrates how inexpensive diagnostics and AI-supported reasoning can strengthen health empowerment and temporarily bridge care gaps for residents of geographically isolated Norwegian communities-provided that human clinical oversight and robust digital health governance remain in place. Therefore, all LLM recommendations and technology support were reviewed during an in-person physician examination in a family network, and the final antibiotic prescription came from the clinician, underscoring that AI functioned solely as decision support rather than autonomous care."

Journal • Infectious Disease • Otorhinolaryngology • CRP

Can fluoroquinolones be safely used in patients with immediate hypersensitivity reaction to penicillin? (PubMed, Allergol Immunopathol (Madr)) - "Our study demonstrates a low positive rate (2.6%) for fluoroquinolone oral provocation testing among patients with penicillin allergy. These findings suggest that fluoroquinolones may be a viable and safe alternative in patients with a confirmed penicillin hypersensitivity and no history of multidrug allergy, and may be considered without prior provocation testing in selected cases."

Journal • Retrospective data • Allergy • Cardiovascular • Dermatology • Immunology • Urticaria

Penicillin V as first-line treatment of pneumonia in primary care: a registry-based study. (PubMed, Clin Microbiol Infect) - "No difference was observed in the risk of hospitalisation for LRTI or all-cause mortality when comparing PcV to amoxicillin as pneumonia treatment in primary care. Therefore, PcV may be considered an alternative treatment option in primary care settings with resistance patterns similar to those in Sweden."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

Monensin phase-out in Norwegian turkey production decreases Bifidobacterium spp. abundance while enhancing microbial diversity. (PubMed, Microb Genom) - "In contrast, treatment with phenoxymethylpenicillin (penicillin V) early in the turkey life cycle does not seem to cause long-term changes in the caecal microbiota composition. However, further studies are needed to investigate the effects of a decreased abundance of Bifidobacterium spp. and increased gut microbiota diversity in turkeys in the absence of monensin use."

Journal • Gastrointestinal Disorder

Ornitose. (PubMed, Tidsskr Nor Laegeforen) - "Four days of treatment with phenoxymethylpenicillin had no effect...Ornithosis usually presents primarily with respiratory symptoms in humans. People who have regular contact with birds are considered at risk."

Journal • Cough • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Crystal structure reveals the hydrophilic R1 group impairs NDM-1-ligand binding via water penetration at L3. (PubMed, J Struct Biol X) - "This study resolved the crystal structure of NDM-1 hydrolyzing amoxicillin for the first time, revealed that the hydroxyl group in the R1 moiety of amoxicillin anchors a key water molecule (Wat1) via hydrogen bond, inducing a conformational shift in Met67 (average displacement of 3.8 Å compared to its position in complexes with ampicillin, penicillin G, and penicillin V) and impairing the hydrophobic interaction between the loop 3 and the substrate. Steady-state kinetics showed that amoxicillin exhibited a 2.2-fold higher K m and a 5.2-fold higher k cat compared to ampicillin, demonstrating that hydrophilic R1 groups impair enzyme-substrate binding. This work demonstrates the essential role of hydrophobic interactions in L3-mediated substrate binding and provides a novel strategy for designing L3-targeted NDM-1 inhibitors: maximize hydrophobicity and minimize polar surface area in the L3 contact region to block water penetration, thereby stabilizing the inhibitor-L3..."

Journal

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease: Drug-Wide Trial Emulation. (PubMed, Neurology) - "Our study identified several drugs with potential disease-modifying properties that could be candidates for future clinical trials. It highlights the potential of repurposing existing medications to advance drug development. While these findings are exploratory and, therefore, insufficient to justify immediate clinical application, they warrant further investigation and potential inclusion in clinical trials."

Journal • Observational data • CNS Disorders • Cough • Erectile Dysfunction • Infectious Disease • Movement Disorders • Ophthalmology • Pain • Parkinson's Disease • Respiratory Diseases