phenoxymethylpenicillin / Generic mfg. - LARVOL DELTA

Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort. (PubMed, Environ Health (Wash)) - "In couple-based analyses, sulfaclozine, roxithromycin, sulfamonomethoxine, erythromycin, and penicillin V were positively related to several early IVF reproductive outcomes, while sulfamethoxazole, penicillin G, chlorotetracycline, norfloxacin, florfenicol amine (FFA), sulfadiazine, cyadox, and sulfachloropyridazine were negatively related to early IVF outcomes. The association between parental antibiotic exposure and IVF outcomes requires further validation in a larger cohort of couples. Additionally, the extrapolation of our results to the general childbearing-aged couples requires caution as infertile couples may be more susceptible to antibiotics."

Journal • Preclinical • Gynecology • Infertility

Understanding selective aminopenicillin allergy: findings from a long-term case series. (PubMed, Int Arch Allergy Immunol) - "All patients underwent a standardized work-up including skin prick and intradermal tests, patch tests and/or delayed intradermal testing when indicated, specific IgE measurement in immediate reactions, and drug challenge tests (DCT) with amoxicillin or amoxicillin-clavulanic acid. Notably, all patients tolerated phenoxymethylpenicillin (penicillin V) during DCT, confirming selective sensitization to the aminopenicillin side chain and supporting the safe use of other β-lactams in this population. These findings highlight the clinical relevance of selective aminopenicillin allergy and underscore the importance of comprehensive diagnostic algorithms to optimize antibiotic stewardship and expand therapeutic options for labeled β-lactam-allergic patients."

Journal • Allergy • Cardiovascular • Dermatology • Immunology • Urticaria

Impact of phenoxymethylpenicillin, amoxicillin and amoxicillin/clavulanic acidon the gut microbiome, resistome and mobilome: a randomised clinical trial with healthy adults (ESCMID Global 2026) - No abstract available

Clinical

RHEUMATIC FEVER IS STILL HERE: A CASE OF ACUTE RHEUMATIC FEVER IN A YOUNG ADULT (ACC 2026) - "For his third episode, he was prescribed azithromycin due to reaction to amoxicillin during the prior episode...He was treated for ARF with azithromycin, colchicine, and ibuprofen...While penicillin G benzathine is the first line treatment and would be ideal for secondary prophylaxis, due to frequent shortages in nonendemic regions, azithromycin or penicillin V are acceptable alternatives... In the US, the yearly incidence of ARF remains 10 per 100,000, though adult cases are rare. Generally, timely treatment of GAS pharyngitis prevents development of ARF, but up to one-third of treated patients may still acquire ARF. This case demonstrates the importance of being able to identify and treat ARF, even in an adult treated for GAS in a non-endemic country."

Clinical • Cardiovascular • Eosinophilia • Otorhinolaryngology • CRP

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals. (PubMed, Nat Med) - "Clindamycin, fluoroquinolones and flucloxacillin accounted for most of the associations with the abundance of individual species. Use of these antibiotics 4-8 years earlier was associated with altered abundance of 10-15% of the species studied; penicillin V, extended-spectrum penicillins and nitrofurantoin were associated with only a few species. Similar results were found comparing one antibiotic course 4-8 years before sampling versus none in the past 8 years. These findings indicate that antibiotics may have long-lasting consequences for the gut microbiome."

Journal • Cardiovascular • Metabolic Disorders

Alport Syndrome Unmasked by NSAID- and Antibiotic-Associated Acute Kidney Injury in an Adolescent: A Rare Presentation of Rapidly Progressive Renal Failure (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 19-year-old male with no known medical history presented with fatigue, leg pain, and near-syncope after 10 days of ibuprofen and penicillin V for dental pain. These presentations may mimic AIN, underscoring the importance of recognizing that severe AKI at a young age may reflect an inherited glomerular disorder. Early biopsy, genetic evaluation, and timely planning for long-term renal management are essential to optimize outcomes."

Acute Kidney Injury • Eosinophilia • Fibrosis • Genetic Disorders • Glomerulonephritis • Immunology • Lupus Nephritis • Metabolic Disorders • Nephrology • Renal Disease • COL4A5

Therapy with Targeted-Release Budesonide and Iptacopan in Rapidly Progressive IgA Nephropathy: A Case Report (NKF-SCM 2026) - "Given the acute clinical deterioration, he received three days of intravenous methylprednisolone pulses followed by oral prednisone 40 mg daily (cyclophosphamide withheld)...He received vaccinations against encapsulated bacteria and penicillin V prophylaxis 500 mg twice daily...CONCLUSION This case demonstrates the feasibility and potential efficacy of combining TRF-budesonide and alternative complement pathway inhibition in high-risk, rapidly progressive IgAN. By simultaneously addressing mucosal Gd-IgA1 production (upstream) and complement-mediated glomerular injury (downstream), this dual mechanistic approach may offer superior disease modification compared with traditional nonspecific immunosuppression, supporting its consideration in contemporary management of aggressive IgAN presentations."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Hypertension • IgA Nephropathy • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease

Amoxicillin-induced Erythema Scarlatiniforme Desquamativum Recidivans with cross-reactivity to cefadroxil in a child: A case report and review of literature. (PubMed, Br J Clin Pharmacol) - "This case establishes the first report of generalized ESDR triggered by amoxicillin in a paediatric patient. It emphasizes a unique pattern of drug hypersensitivity, characterized by cross-reactivity to cefadroxil and tolerance to other tested penicillins (phenoxymethylpenicillin and oxacillin). It is essential to conduct a complete allergy work-up, which includes OPTs, to conduct a customized cross-reactivity assessment. This assessment is essential for the safe guidance of future therapeutic decisions in patients with drug-induced ESDR."

Journal • Allergy • Dermatology • Immunology • Pediatrics

A rare presentation of actinomycotic mycetoma of the hand: a case report. (PubMed, BMC Infect Dis) - "This case underscores that mycetoma can present without classic sinus tracts, leading to diagnostic delay. A high index of suspicion and the use of histopathological and molecular methods are essential for diagnosis. Prolonged, targeted antibiotic therapy is the cornerstone of management, though advanced disease may result in a slower response."

Journal • Infectious Disease • Pain

Oral fluoroquinolone use and the risk of aortic and mitral valve regurgitation: a nationwide cohort study. (PubMed, BMJ Open) - "In a nationwide cohort study, there was no statistical support for an increase in the risk of mitral or aortic valve regurgitation associated with oral fluoroquinolone use."

Journal • Cardiovascular

Antibiotic treatment for acute sinusitis and subsequent health care use and work absence: a nationwide registry study from Norway. (PubMed, Fam Pract) - "Acute sinusitis is followed by a short-term increase in health care use and work absence. Initial antibiotic use was associated with modest short-term differences, but no meaningful reduction in overall follow-up. Findings are consistent with recommendations for restrictive prescribing and narrow-spectrum use when appropriate."

Journal • Observational data • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Can the remuneration scheme of general practitioners affect their antibiotic prescription behaviour? (PubMed, Health Econ Rev) - "Remuneration schemes may influence antibiotic prescribing behaviour. FFS/CAP is linked to higher prescription rates and broader-spectrum antibiotic use among regular GPs, likely due to patient retention and time-efficiency incentives. Policy interventions, such as monitoring of prescriptions depending on the remuneration type or adjustments to the remuneration scheme (e.g., antibiotic-related pay-for-performance), could promote prudent prescribing. Further research is needed on prescription appropriateness and quality impacts."

Journal • Infectious Disease • Respiratory Diseases

Validation of an LC-MS/MS multi-residue method for nine antibiotic classes in eggs according to EU regulation 2021/808 and assessment of their occurrence on Croatian poultry farms. (PubMed, Food Addit Contam Part A Chem Anal Control Expo Ri) - "Under Commission Regulation (EU) No 37/2010, only penicillin V, erythromycin A, lincomycin, tylosin A, tylvalosin, tiamulin, tetracycline, oxytetracycline and chlortetracycline are permitted for use in laying hens, with established maximum residue levels (MRL). Three samples were found to be non-compliant, as they contained doxycycline and enrofloxacin residues above the decision limit. Compliance was confirmed for four samples in which residues of tiamulin and enrofloxacin were below the decision limit."

European regulatory • Journal

Antibiotic Prescription Patterns in Poland in the Years 2019-2024 Based on Reimbursement Data from the National Healthcare Fund. (PubMed, Antibiotics (Basel)) - "Although the use of phenoxymethylpenicillin initially decreased after the introduction of "strep-tests" in 2022 (DID 0.18 in 2023 vs. 0.23 in 2022), it increased again to 0.26 in 2024. Our findings demonstrate a slight continuous increase in oral antibiotic use in Poland, despite the current widespread availability of POC testing. The persistent and growing preference for amoxicillin with clavulanic acid, an agent not typically recommended as first-line treatment for most infections, suggests that antibiotic stewardship efforts need to continue in order to curb inappropriate prescription."

Journal • Reimbursement • US reimbursement • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Dual-species biofilm formation of Pseudomonas fluorescens and Hafnia alvei and their susceptibility to penicillin V acylase from Lactiplantibacillus plantarum YP4-1-2. (PubMed, Int J Food Microbiol) - "Additionally, LpPVA down-regulated QS-related genes and biofilm-related genes to inhibit biofilm formation. The study demonstrates that the interactions between P. fluorescens and H. alvei in a dual-species promoted the formation of complex biofilm structures by increasing AHLs, and their sensitivity to LpPVA provides a novel strategy for controlling multi-species contamination in aquatic products."

Journal

Impact of the COVID-19 pandemic on antibiotic treatment for respiratory tract infections in Norwegian primary care. (PubMed, Scand J Prim Health Care) - "During the COVID-19 pandemic, the use of macrolides, specifically azithromycin, for respiratory tract infections (RTIs) in primary care increased in several countries...Over half of all antibiotic treatments for RTIs were phenoxymethylpenicillin, and the distribution of antibiotic types was relatively stable during the study period, except for some temporary changes in the initial months of the pandemic...DGP handled most of the influx of RTIs during the initial phase of the COVID-19 pandemic in primary care. During the pandemic antibiotic treatment for RTIs was reduced, and the distribution of antibiotic types barely changed."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Antibiotic prescriptions to preschool children with respiratory tract infections in primary healthcare. (PubMed, JAC Antimicrob Resist) - "The use of phenoxymethylpenicillin increased in the period from 50% in 2012 to 68% in 2019. There is room for improvement in adherence to guidelines and antibiotic stewardship also in low-prescribing countries. Antibiotic prescribing is closely linked to prescription rates and health-seeking behaviours, offering valuable insights for targeted antibiotic stewardship campaigns."

Journal • Infectious Disease • Otorhinolaryngology • Respiratory Diseases

Improving antibiotic prescribing in LMICs: Insights from an outpatient clinic in Pakistan. (PubMed, New Microbes New Infect) - "Metronidazole was the single most common agent, followed by first-generation cephalosporins, fluoroquinolones, and amoxicillin-clavulanate; phenoxymethylpenicillin and amoxicillin were only minimally prescribed. Antibiotic prescribing was excessive and discordant with recommended first-line therapies, favouring broad-spectrum agents and combination treatments - practices likely influenced by the negligible time available per patient. Our findings highlight the need to adapt antimicrobial stewardship interventions to limited-resource contexts."

Journal

Rumpel-Leede Phenomenon Secondary to Acute Epstein-Barr Virus Infection in a Young Adult. (PubMed, Cureus) - "We report the case of a 20‑year‑old male patient who initially presented with a pruritic widespread maculopapular rash following a course of Penicillin V in the context of an undiagnosed Epstein-Barr virus (EBV) infection and subsequently developed a petechial rash consistent with RLS, following application of a tourniquet prior to venepuncture...EBV serology was consistent with acute EBV infection. No specific treatment was indicated or provided for the Rumpel-Leede phenomenon, which gradually resolved. This case highlights that RLS may occur in the setting of acute EBV infection even in the absence of thrombocytopenia or coagulopathy and underscores the importance of recognition to avoid unnecessary alarm or investigations."

Journal • Epstein-Barr Virus Infections • Hematological Disorders • Infectious Disease • Thrombocytopenia

Beyond the assays: Managing unresolvable TMA and the pharmacokinetic cost of plasma exchange (ASH 2025) - "Case presentation: A 73-year-old man with history of Tetralogy of Fallot with bioprosthetic aortic valve replacement on warfarin and CKD stage IIIb (baseline creatinine 1.7–1.8 mg/dL) presented with two weeks of progressive jaundice, anorexia, and fatigue...Under the suspicion of complement-mediated Hemolytic Uremic Syndrome (HUS), PLEX was held, meningococcal vaccination administered, and penicillin V prophylaxis initiated...PLEX was resumed followed by Rituximab infusion and a 7-day steroid taper...A second dose of Ravulizumab was administered two weeks after the initial dose, at which point PLEX was discontinued...Therefore, beyond emphasizing pre-PLEX sampling to avoid dilutional false negatives, this case highlights the need for rapid, discriminatory biomarkers and protocols that reconcile the competing demands of urgent PLEX and sustained complement inhibition. Finally, elderly patients with limited reserve may sustain permanent organ damage even with optimal..."

PK/PD data • Anorexia • Atypical Hemolytic Uremic Syndrome • Chronic Kidney Disease • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Meningococcal Infections • Nephrology

Availability and Cost of Basic Drugs for Sickle Cell Disease in 13 African Countries (ASH 2023) - "Participants completed questions covering the availability (on a scale from 0 (drug not available) to 10 (no availability concern) and the cost of basic drugs in their centres: HU, penicillin V, folic acid, morphine and vaccines. The high cost of vaccines, beyond the first years of life when a free national program is available in most of African countries, is also a problem. In addition to cost, availability and frequent supply disruptions prevent regular intake of hydroxyurea and, to a lesser extent, of penicillin V. International solidarity and the governments of these countries should work to bring down the cost of hydroxyurea and improve the distribution circuit for these essential medicines."

Genetic Disorders • Hematological Disorders • Infectious Disease • Meningococcal Infections • Pneumococcal Infections • Sickle Cell Disease

Group A Streptococcal Infections—Diagnostic Approaches and Antibiotics Prescriptions in Children and Adolescents in Germany: A Nationwide Representative Claims Data Analysis (ISPOR-EU 2025) - "Phenoxymethylpenicillin remained the most frequently prescribed antibiotic in approx. 40% of GAS infections until 2023, when amoxicillin, cephalosporins, and macrolides became more common (47% of all antibiotic prescriptions)... This real-world evidence highlights evolving patterns in pediatric GAS care and antibiotics prescriptions during a period of unprecedented health system disruption. Most pediatric GAS cases in Germany are managed with appropriate diagnostics and antibiotics, reflecting solid adherence to clinical standards. However, the potential to optimize care is highlighted —particularly in cases without diagnostic confirmation and in varying antibiotic choices."

Clinical • Infectious Disease • Novel Coronavirus Disease • Pediatrics

The first Mpox case in Zambia: a case report. (PubMed, J Med Case Rep) - "Our report emphasizes the transmission risk for Mpox in traditionally nonendemic areas resulting from cross-border movement. This highlights the need for countries to strengthen surveillance systems resulting in increased sensitivity, specificity, and timeliness required for early detection and response to Mpox. A multifaceted collaborative approach is required between countries to ensure formalized cross-border collaboration, strengthening health-seeking behavior through deployment of mobile clinics, and utilization of digital platforms risk communication and community engagement. Improved supply chain management for laboratory reagents, sample collection, and personal protective equipment coupled with training of health workers is crucial for adequate preparedness and successful containment of outbreaks. These initiatives, collectively undertaken, will result in a robust response system safeguarding public health and preventing emerging threats such as Mpox from..."

Journal • Fatigue • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain

Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society. (PubMed, Ger Med Sci) - "The Cochrane network analysis on the treatment of erythema migrans has only shown that, in addition to doxycycline and amoxicillin, oral penicillin V is equally effective. A Slovenian analysis of patients with acrodermatitis chronica atrophicans over the past 30 years has shown a decrease in the incidence of constitutional symptoms and atrophy, likely due to improved early detection. In addition, an information sheet for patients containing recommendations for the prevention of Lyme borreliosis is attached to the guideline."

Clinical guideline • Journal • Dermatitis • Dermatology • Immunology • Inflammatory Arthritis • Lyme Disease • Oncology

Recurrent Erysipelas: Clinical Challenges and Strategies for Prevention-A Narrative Literature Review. (PubMed, Biomedicines) - "Antibiotic prophylaxis, most commonly with oral penicillin V or intramuscular benzathine penicillin, has been shown to lower recurrence rates...While antibiotic prophylaxis is effective, its long-term success depends on simultaneous management of underlying conditions. Further studies are needed to define optimal regimens, treatment duration, and non-antibiotic alternatives."

Journal • Review • Cardiovascular • Dermatology • Diabetes • Genetic Disorders • Metabolic Disorders • Obesity • Tobacco Cessation