phenoxymethylpenicillin / Generic mfg. - LARVOL DELTA

Trends and regional variation in antibiotic prescribing by dentists in Finland, 2012-2025: A register-based study. (PubMed, Eur J Oral Sci) - "Phenoxymethylpenicillin was the most frequently prescribed antibiotic, and its prescribing decreased by 28% in 2012-2019...Prescribing of amoxicillin increased by 41%, whereas prescribing of clindamycin decreased by 74% and that of doxycycline by 79%. There were up to 3- to 4-fold differences between counties in antibiotic prescription rates by dentists. Overall, there was a modest decline in the overall antibiotic prescribing rate by Finnish dentists, but regional variation in antibiotic prescribing was substantial."

Journal

Low-dose amoxicillin as prophylaxis for recurrent erysipelas: Is it the answer? (PubMed, Infect Dis Now) - "This study suggests that at a preventive dose, amoxicillin is well-tolerated, reducing the incidence of erysipelas, possibly representing a viable therapeutic option for patients with contraindication, intolerance, or limited access to first-line prophylaxis (intramuscular or oral penicillin). Given the small sample size and the absence of a comparator arm, comparative studies are needed to confirm the potential equivalence of amoxicillin with penicillin V."

Journal • Allergy • Dermatology • Infectious Disease • Pain

Neoehrlichia mikurensis and Borrelia miyamotoi co-infection in an immunocompromised patient. (PubMed, Diagn Microbiol Infect Dis) - "To our knowledge, this is the first reported human co-infection with B. miyamotoi and N. mikurensis. The case highlights the importance of molecular diagnostics for emerging tick-borne infections in patients receiving anti-CD20 therapy."

Journal • CNS Disorders • Dermatology • Fatigue • Infectious Disease • Lyme Disease • Multiple Sclerosis • Musculoskeletal Pain • Pain

Advances in the diagnosis and management of skin and soft tissue infections. (PubMed, BMJ) - "Management of SSTI includes antibiotics such as penicillin VK, dicloxacillin, or a cephalosporin, while treatment for skin abscess includes incision and drainage, with antibiotics recommended in select patients. While most patients with cellulitis or skin abscess are appropriate for discharge with follow-up, patients with sepsis and those with challenges adhering to therapy, immunosuppression, or failed outpatient therapy should be referred to the emergency department. Novel antibiotics such as tedizolid, delafloxacin, omadacycline, and ceftaroline may be considered in select cases."

Journal • Review • Dermatology • Infectious Disease • Inflammation • Pain • Septic Shock

Current practices in antibiotic prophylaxis for patients on complement inhibitors: a multicenter survey across ERN ERKnet centers. (PubMed, Clin Kidney J) - "Complement inhibitors such as eculizumab and ravulizumab are increasingly used to treat rare complement-mediated diseases...In pediatric settings, phenoxymethylpenicillin and amoxicillin were most commonly used, whereas adult regimens included penicillin or fluoroquinolones for those with allergies...Based on these findings, we propose consensus guidance to support harmonized, risk-adapted prophylaxis strategies across pediatric and adult populations. These guidance statements aim to address an important unmet need in infection prevention among complement-inhibited patients."

Journal • Allergy • Complement-mediated Rare Disorders • Immunology • Infectious Disease • Nephrology • Pediatrics • Rare Diseases • Renal Disease • Transplantation

MEERCATS 2: Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children (clinicaltrials.gov) - P3 | N=9622 | Not yet recruiting | Sponsor: Children's Hospital Medical Center, Cincinnati

New P3 trial • Cardiovascular • Heart Failure

Market landscape of penicillin for syphilis and rheumatic heart disease, WHO South-East Asia Region. (PubMed, Bull World Health Organ) - "Several countries reported supply issues, including shortages of benzathine benzylpenicillin in India, Maldives, Myanmar, Thailand and Timor-Leste; aqueous benzylpenicillin in Sri Lanka during the 2022 economic crisis; and supply disruptions of phenoxymethylpenicillin 250 mg in Maldives and Sri Lanka...Differences in registration, procurement, pricing and forecasting undermine reliable access to penicillin products in the South-East Asia Region. Stronger regional collaboration, improved forecasting, harmonized regulatory approaches and pooled procurement strategies are needed to secure equitable and sustainable access."

Journal • Cardiovascular • Heart Failure • Infectious Disease

Pharmacist test-and-treat authority and empirical antibiotic prescribing: Evidence from state Medicaid data. (PubMed, J Am Pharm Assoc (2003)) - "Pharmacist respiratory test-and-treat authority does appear to shape aggregate prescribing patterns at the state level by reducing the rates of antibiotics frequently prescribed empirically for respiratory illnesses. We found no evidence that UTI test-and-treat authority changed prescription patterns nor that oseltamivir prescriptions were affected by respiratory test-and-treat authority."

Journal • Reimbursement • US reimbursement • Infectious Disease • Nephrology • Respiratory Diseases

Relapse of Steroid-Dependent Nephrotic Syndrome Despite Long-Term Ciclosporin Therapy in an 11-Year-Old Child: A Case Report and Review on the Management of Nephrotic Syndrome in Children. (PubMed, Case Rep Nephrol) - "He had experienced 11 previous relapses and was receiving ciclosporin 50 mg twice daily and enalapril 5 mg once daily with good adherence...Penicillin V was initiated for spontaneous bacterial peritonitis prophylaxis...This case highlights several important therapeutic considerations in relapsing childhood nephrotic syndrome: recognition of SDNS as a subgroup of SSNS, accurate prednisolone dosing during relapse, careful assessment of edema and intravascular volume status before diuretic therapy, and individualized use of steroid-sparing agents and antimicrobial prophylaxis. In children receiving prolonged ciclosporin therapy, treatment should be regularly reviewed with blood pressure, renal function, and therapeutic drug monitoring in view of potential calcineurin inhibitor toxicity, and alternative steroid-sparing options such as levamisole may be considered where clinically appropriate."

Journal • Cough • Glomerulonephritis • Hematological Disorders • Infectious Disease • Nephrology • Renal Disease • Respiratory Diseases • Thrombocytosis

Borrelia as a differential diagnosis to monoarthritis (PubMed, Ugeskr Laeger) - "Treatment with phenoxymethylpenicillin, initiated more than two years after symptom onset, resulted in rapid and near-complete remission. The case underscores the diagnostic challenges of Lyme arthritis and the importance of considering the diagnosis in mono- or oligoarthritis."

Journal • Immunology • Inflammation • Inflammatory Arthritis • Lyme Disease • Orthopedics • Rheumatology

Effectiveness and Limitations of Environmental Risk Assessments to Identify Antibiotics of Greatest Concern in Australia. (PubMed, Regul Toxicol Pharmacol) - "The results from this analysis demonstrate that the environmental risks posed by antibiotics in Australia may be significant with amoxicillin, cefalexin, clindamycin, azithromycin and phenoxymethylpenicillin predicted to exceed environmental risk thresholds. This has implications for the applicability of current environmental risk assessment models both in Australia and overseas. Despite these limitations, this model presents several advantages as a simple method to screen for high-risk antibiotics and is still more effective than the current Australian approach of having no ERA requirements for medicines."

Journal

Integrated Clinical Safety Assessment of Orally Administered Antimicrobials from Different Pharmacological Classes in Nile Tilapia (Oreochromis niloticus). (PubMed, Animals (Basel)) - "Three bioassays were conducted for sulfadimethoxine combined with ormetoprim (SDM-OMP, 50, 100, and 200 mg·kg-1, at a fixed 5:1 SDM:OMP ratio), spiramycin (SPM, 40, 80, and 160 mg·kg-1), and phenoxymethylpenicillin potassium (PMP, 10, 20, and 40 mg·kg-1), including control and treated groups at different dose levels, followed by a drug-free recovery period...Exposure to the antimicrobials resulted only in mild, transient, and reversible physiological alterations, with no evidence of clinically relevant toxicity or structural lesions in the analyzed organs. Collectively, these findings demonstrate that SDM-OMP, SPM, and PMP exhibit a favorable clinical safety profile in Nile tilapia, even at doses up to four times the recommended therapeutic level, supporting their responsible use in aquaculture under controlled conditions."

Journal • Hematological Disorders

A nationwide register study on medicines exiting the reimbursement system in 2010-2022. (PubMed, BMC Health Serv Res) - "APIs, even some classified as critical in the EU, exit the national reimbursement system each year. APIs that remain on the market tend to be older and less expensive than those leaving the market. These findings highlight the importance of monitoring changes in the range of reimbursable medicines and their potential implications for availability and affordability."

Journal • Reimbursement • US reimbursement • Cardiovascular

Efficacy and safety of 24 antibiotics for group A streptococcal pharyngitis: a network meta-analysis of 64 randomized controlled trials. (PubMed, Front Public Health) - "For late bacterial eradication, cefprozil demonstrated greater efficacy compared with penicillin V (OR: 3.12; 95% CI: 1.03-11.25), whereas azithromycin exhibited suboptimal performance (OR: 0.38; 95% CI: 0.25-0.62). For early clinical response, cefdinir (OR: 2.01; 95% CI: 1.28-3.25) and cefuroxime axetil (OR: 2.14; 95% CI: 1.19-3.60) demonstrated significantly greater efficacy compared with penicillin V. For late clinical response, spiramycin showed superior efficacy to penicillin V (OR: 0.17; 95% CI: 0.02-0.94), although evidence was limited to a single small trial...Conversely, azithromycin should be avoided due to inferior efficacy and increased adverse risks. http://www.crd.york.ac.uk/prospero, identifier CRD420251104703."

Clinical • Journal • Retrospective data • Review

BURDEN AND CLINICAL CHARACTERISTICS OF EARLY- AND LATE- ONSET GROUP B STREPTOCOCCAL SEPSIS IN TWO UK TERTIARY NEONATAL CENTRES, 2018–2023 (ESPID 2026) - "Collaborative exploration with maternity services around the reasons for delayed/missed IAP may help reduce the burden risk of EoGBS. Infant prophylaxis with phenoxymethylpenicillin was well tolerated, with insufficient power to assess efficacy versus recurrence."

Clinical • Infectious Disease • Septic Shock

Drug supply shortages and their consequences for the medical profession: a survey in Germany and Austria. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Penicillin V and amoxicillin emerged as the drugs most seriously affected by drug supply shortage although the severity to which physicians were affected by the individual 20 drug shortages varied regionally (Germany/Austria), depending on the place of work (practice/clinic) and the physicians' specialty. Moreover, exact reporting of drug shortages by official authorities is important. Encouraging more judicious prescribing practices may help reduce perceived shortages."

Journal • Hematological Disorders • Nephrology • Oncology • Psychiatry

Complement C5 inhibitors as add-on rescue treatment in severe AQP4-antibody neuromyelitis optica spectrum disorder attacks: a case series and literature review. (PubMed, Ther Adv Neurol Disord) - "Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes...Both patients subsequently transitioned to rituximab within 8 weeks after their fourth weekly eculizumab infusion, while on a moderate dose of prednisolone. Case 2 (left optic neuritis) received ravulizumab, achieving partial visual recovery, and was continued on maintenance ravulizumab. Meningococcal prophylaxis with penicillin V was administered for all three patients...Infections were uncommon with no severe infections reported. In conclusion, emerging evidence supports the use of C5 inhibitors for acute NMOSD attacks, but larger studies are needed to establish robust evidence and inform clinical practice."

Journal • CNS Disorders • Infectious Disease • Meningococcal Infections • Neuromyelitis Optica Spectrum Disorder • Ocular Inflammation • Ophthalmology • Optic Neuritis • Rare Diseases

Systemic Antibiotics in the Surgical Treatment of Peri-Implantitis: Impact on the Salivary Microbiome. (PubMed, J Clin Periodontol) - P4 | "Both adjunctive antibiotic regimens applied in the surgical treatment of peri-implantitis caused comparable ecological disturbances in the salivary microbiome, with no microbiological or clinical evidence supporting the superiority of one regimen over the other."

Journal

An Overview of Evidence-Based Guidelines for Antibiotic Treatment and Prevention in Odontogenic Infections-Current Clinical Perspectives. (PubMed, Infect Disord Drug Targets) - "Combining surgical source control with targeted antibiotics enhances outcomes while mitigating AMR. Prophylaxis is designated for patients at high risk of IE. Dentists should follow local antibiograms, educate patients, and implement stewardship to ensure the sustainable manage-ment of odontogenic infections."

Journal • Allergy • Cardiovascular • Immunology • Infectious Disease

When Cutaneous Sensitization to Polyethylene Glycol (PEG) Goes Beyond Skin Deep: A Case of Anaphylaxis (EADV-Sp 2026) - "He was stabilized in the emergency department where he received IM diphenhydramine and oral prednisolone...Skin prick tests were positive to macrogol 4000 at concentrations of 1:1000, 1:100, 1:10 and methylprednisolone acetate (contains PEG 3350) but negative to methylprednisolone succinate (without PEG). Skin prick and intradermal tests were positive to triamcinolone acetonide (contains polysorbate 80)...Frequently implicated drugs are macrogol laxatives, oral penicillin V, depo-medroxyprogesterone and depo-methylprednisolone2...Conclusions This case depicts a life threatening reaction to PEG following cutaneous sensitization. Awareness of PEG as both a parent compound and an excipient is vital for early recognition to prevent accidental re-exposure."

Clinical • Immunology • Inflammation • Urticaria

Therapy with Targeted-Release Budesonide and Iptacopan in Rapidly Progressive IgA Nephropathy: A Case Report (NKF-SCM 2026) - "Given the acute clinical deterioration, he received three days of intravenous methylprednisolone pulses followed by oral prednisone 40 mg daily (cyclophosphamide withheld)...He received vaccinations against encapsulated bacteria and penicillin V prophylaxis 500 mg twice daily...CONCLUSION This case demonstrates the feasibility and potential efficacy of combining TRF-budesonide and alternative complement pathway inhibition in high-risk, rapidly progressive IgAN. By simultaneously addressing mucosal Gd-IgA1 production (upstream) and complement-mediated glomerular injury (downstream), this dual mechanistic approach may offer superior disease modification compared with traditional nonspecific immunosuppression, supporting its consideration in contemporary management of aggressive IgAN presentations."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Hypertension • IgA Nephropathy • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease

Alport Syndrome Unmasked by NSAID- and Antibiotic-Associated Acute Kidney Injury in an Adolescent: A Rare Presentation of Rapidly Progressive Renal Failure (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 19-year-old male with no known medical history presented with fatigue, leg pain, and near-syncope after 10 days of ibuprofen and penicillin V for dental pain. These presentations may mimic AIN, underscoring the importance of recognizing that severe AKI at a young age may reflect an inherited glomerular disorder. Early biopsy, genetic evaluation, and timely planning for long-term renal management are essential to optimize outcomes."

Acute Kidney Injury • Eosinophilia • Fibrosis • Genetic Disorders • Glomerulonephritis • Immunology • Lupus Nephritis • Metabolic Disorders • Nephrology • Renal Disease • COL4A5

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians. (PubMed, Eur J Clin Pharmacol) - "Supply shortages can foster antimicrobial resistance through the use of antibacterials with a higher potential for resistance. The success of alternative treatments was not always considered to be very good in comparison to the original medication."

Journal • Infectious Disease • Novel Coronavirus Disease • Pain

Alternative enzymatic pathways to penicillin antibiotics. (PubMed, Nat Commun) - "In this paper, we describe an alternative pathway to penicillins that uses stand-alone ligase and epimerase enzymes to generate peptide precursors, which can be transformed to penicillin derivatives using an engineered IPNS enzyme. Unlike the native NRPS assembly line, the ligase pathway provides direct access to therapeutically relevant penicillin G, penicillin V and ampicillin, which are currently produced by semi-synthesis."

Journal

Ibuprofen-Induced Pemphigus Vulgaris: A Case Report. (PubMed, Hosp Pharm) - "We report a case of a 41-year-old Myanmar female who developed generalized bullous eruptions, oral ulcers, and ocular pain after the concurrent use of ibuprofen and penicillin V. She presented with extensive cutaneous erosions complicated by sepsis and malnutrition. Importantly, the exclusion of penicillin allergy allowed the use of piperacillin/tazobactam to effectively treat sepsis. This rare case of ibuprofen-induced PV highlights the critical role of pharmacists in performing adverse drug reaction assessments to accurately identify the causative agent, thereby enabling safe and effective therapeutic decision-making."

Journal • Allergy • Dermatology • Immunology • Infectious Disease • Pain • Pemphigus Vulgaris • Septic Shock