VB-08 / Vincere Biosci - LARVOL DELTA

ENCHANCEMENT OF MITOPHAGY VIA USP30 INHIBITION AS A THERAPEUTIC STRATEGY FOR ACUTE KIDNEY INJURY (ISN-WCN 2024) - "These findings highlight Vincere's USP30 inhibitor molecules potential in AKI treatment and as a prophylactic measure against CKD progression. The mitophagy-enhancing ability, coupled with selectivity and favorable pharmacological profile present a promising therapeutic approach in AKI management and CKD prevention."

Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Renal Disease • Targeted Protein Degradation

VB-08: A SMALL MOLECULE INHIBITOR OF USP30 THAT ENHANCES MITOPHAGY (ADPD 2023) - "Here, we report a novel USP30 inhibitor, VB - 08... VB-08 presents a useful tool to test the effect of increased mitophag y in rodent models of neurodegeneration and sets the stage for translational development of a new and promising class of compounds for PD."

CNS Disorders • Movement Disorders • Parkinson's Disease • Targeted Protein Degradation