R-(-)-gossypol (AT 101) / Ascentage Pharma - LARVOL DELTA

Steady-state kinetic characterization and mechanistic modeling of human lactate dehydrogenase A as a reference framework for inhibitor screening. (PubMed, Bioorg Chem) - "Based on the determined kinetic parameters, a mechanistic model describing the net reaction rate was developed to simulate the temporal evolution of the enzymatic system. The model captured the main trend of NADH consumption observed experimentally and qualitatively reproduced the distinct kinetic effects associated with competitive and non-competitive inhibition mechanisms."

Journal • Oncology • LDHA

Fermentation-driven degradation of antinutritional factors in plant-based foods. (PubMed, Food Chem) - "However, techno-economic assessments show that although strategies such as sourdough-based phytate reduction and solid-state gossypol detoxification have reached commercial viability, many remain at laboratory scale because of challenges in starter culture stability, batch-to-batch consistency, and cost-effective scale-up. Overall, fermentation is a sustainable approach to improving the safety, digestibility, and functional properties of plant-based foods, although further in vivo validation, process standardization, and techno-economic assessments are still needed."

Journal • Review

Targeting LRPPRC to improve corneal wound healing via augmenting autophagy and suppressing TGF-β/Smad signaling post-alkali burn. (PubMed, J Transl Med) - "LRPPRC inhibition demonstrated efficacy in alleviating pathological corneal fibrosis and neovascularization via suppression of fibroblast activation and ECM deposition post-corneal injury. These findings highlight LRPPRC as a tractable therapeutic target for corneal alkali burns, with GAA as a pharmacological agent offering a clinically translatable intervention."

Journal • Corneal Abrasion • Fibrosis • Immunology • Thermal Injury • CD31 • LRPPRC • PECAM1 • TGFB1

Network Pharmacology and Molecular Docking to Elucidate the Anti-Dermatitic Mechanism of Phytocompounds in Thespesia populnea Flowers. (PubMed, Biotechnol Appl Biochem) - "The network pharmacological study revealed the mechanism of action of the phytocompounds present in Thespesia populnea flowers against potential dermatitis targets and molecular docking analysis highlighted the potent interactions responsible for its anti-dermatitic property. The present study offers valuable insights into the anti-dermatitic property of Thespesia populnea flowers (Supporting information)."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • AKT1 • BCL2 • CREB1 • EGFR • ER • GSK3B • IL2 • KDR • MMP2 • MMP9 • PPARG • STAT3 • TLR2

Single-cell transcriptomics reveals cellular heterogeneity and cell-cell communication networks in free gossypol-induced enteritis in juvenile largemouth bass (Micropterus salmoides). (PubMed, Fish Shellfish Immunol) - "Pseudotime analysis identified branch point 1 as a critical immune-related node in epithelial differentiation. In conclusion, FG impairs growth performance and intestinal health in juvenile largemouth bass, likely by increasing abundance of potential pathogens, disrupting neuroendocrine-immune cell communication; activating macrophages/ B cells, inducing inflammation, inhibiting epithelial repair, and compromising intestinal barrier function."

Heterogeneity • Journal • Gastrointestinal Disorder • Inflammation • CLDN5 • CXCL8 • IL1B • OCLN • TJP1 • TNFA

Chemical insights into cotton materials: from fiber surface chemistry to green cottonseed oil extraction (ACS-Fall 2026) - "Performance metrics including oil yield, free fatty acid content, peroxide value, fatty acid composition, phenolic content, and gossypol levels are being used to assess extraction performance and identify scalable processing pathways. These complementary analytical and green processing approaches support the development of a framework for improving cotton fiber assessment and advancing sustainable cottonseed valorization within renewable material systems."

Advancing cotton material sustainability through fiber surface analysis and green cottonseed oil processing (ACS-Fall 2026) - "Characterization techniques such as 1H NMR and GC-MS are used to evaluate oil molecular profile. These analytical and green processing efforts contribute to the development of an integrated framework for improving cotton fiber evaluation and supporting sustainable cottonseed utilization within renewable material systems."

Current landscape and future perspectives of small-molecule therapeutics for Huntington's disease: From rational design to clinical translation. (PubMed, Eur J Med Chem) - "While currently explored small-molecule therapies have demonstrated preclinical efficacy, further clinical investigation is imperative to expand the chemical space of viable HD therapeutics. This review critically summarizes the design, synthesis, and structural motifs of small-molecule candidates, clinically used agents, and antioxidant natural products, providing a structural framework to guide the rational design and development of next-generation anti-HD compounds."

Journal • Review • Ataxia • CNS Disorders • Huntington's Disease • Immunology • Movement Disorders • Primary Immunodeficiency • ATR

bHLH Family Transcription Factors: Molecular Switches in Plant Specialized Metabolism. (PubMed, Cells) - "We further discuss evidence standards, multi-omics-guided factor discovery, miRNA-mediated post-transcriptional control, and engineering strategies for crop defense, food quality, medicinal-metabolite production, and synthetic biology. Unlike pathway- or MYC2-centered surveys, this review organizes the literature within a direct-cascade-hybrid framework that integrates promoter grammar, spatial competence, storage anatomy, and an explicit evidence hierarchy."

Journal • Review

The study of intestinal toxicity induced by gossypol acetic acid and the mechanism using zebrafish model and network toxicology. (PubMed, Toxicol Appl Pharmacol) - "Furthermore, the mechanism study by network toxicology, molecular docking and RT-qPCR, showed that GAA could affect lipid metabolism, redox balance, apoptosis, inflammation and pyroptosis by regulating PPAR/NLRP3/GSDMD pathways. Taken together, these results will help to deeply understand GAA's harmful effects and underlying mechanisms."

Journal • Metabolic Disorders • Oncology • NLRP3

Physicochemical, structural, and functional properties of dephenolized cottonseed protein meal, concentrate and isolate: A comparative analysis. (PubMed, Food Chem) - "The excellent functional performance of DCPI was attributed to its smaller particle size, higher absolute ζ-potential and richer small-molecular-weight subunits. DCPI is suitable for food use, while DCM and DCPC are more applicable for feed, laying a theoretical foundation for the diversified utilization of cottonseed protein."

Journal

Managing Anti-Nutritional Factors in Plant-Based Feeds: Implications for Herbivore Nutrition and Production. (PubMed, Metabolites) - "Emerging metabolomic and metagenomic evidence shows that certain ANFs confer functional benefits at controlled doses; for example, tannins improve nitrogen retention, saponins reduce methane, and phytic acid scavenges free radicals. This synthesis supports strategic management rather than complete elimination, informing safe and sustainable use of terrestrial feeds under evolving food-security and environmental challenges."

Journal • Review

Sintilimab Plus Gossypol Acetate in Advanced Colorectal Cancer (clinicaltrials.gov) - P2 | N=32 | Not yet recruiting | Sponsor: Peking University People's Hospital

New P2 trial • pMMR • Colorectal Cancer • Oncology • Solid Tumor

Phytotherapeutic potential of Gossypium barbadense L. root as an alternative therapy for colitis: a comprehensive review with network pharmacology insights. (PubMed, Inflammopharmacology) - "Furthermore, this review integrates recent advances in network pharmacology to elucidate the multi-component, multi-target interactions underlying the therapeutic effects of G. barbadense. By consolidating current preclinical evidence and computational pharmacology approaches, this review highlights the potential of G. barbadense root as a prospective source of novel therapeutic agent for IBD while identifying key knowledge gaps that should be addressed before clinical translation."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

A comprehensive review on cottonseed oil: Composition, processing, quality control, and biotechnological innovations. (PubMed, Food Chem) - "Key findings demonstrate that while enzymatic and physical field-based processing, genetic engineering, and smart monitoring enhance CSO value, challenges persist in nutrient retention and comprehensive safety oversight. Future development should prioritize integrated approaches combining nutritional enhancement via biotechnology, smart sustainable processing, and the advancement of a circular bio-economy to fully realize CSO's potential as a high-value functional lipid."

Journal • Review

Discovery of Novel LRPPRC Inhibitors Featuring a Biphenyl-Acylhydrazone Scaffold with Potent Broad-Spectrum Antitumor Activity. (PubMed, J Med Chem) - "In PC9 and HCT116 xenografts, 3o achieved tumor growth inhibition (TGI) rates of 73 and 49% with favorable safety profiles. Overall, we developed novel biphenyl-acylhydrazone LRPPRC inhibitors as potent antitumor agents acting via OXPHOS modulation, providing a valuable lead compound for cancer therapy."

Journal • Oncology • LRPPRC

PdPt bimetallic nanozyme-based colorimetric sensor for sensitive and label-free detection of gossypol. (PubMed, Anal Methods) - "Under optimized conditions, the sensor exhibited a linear response to gossypol in the range of 6.25-62.5 µM, with a detection limit of 1.92 µM, alongside strong anti-interference ability. Satisfactory recoveries of 98.01-109.56% were obtained in spiked egg yolk and milk samples, providing a simple cost-effective tool for rapid gossypol monitoring in food safety."

Journal

Optimizing Broiler Diets: Nutritional and Functional Benefits of Fermented Cottonseed Meal. (PubMed, Food Sci Nutr) - "In conclusion, fermentation enhances the nutritional profile of CSM by improving protein utilization and reducing antinutritional factors. Dietary inclusion of 6%-9% FCSM improves starter-phase growth performance, immune function, and intestinal health in broilers."

Journal

Optimization of the Microbial-Enzymatic Synergistic Treatment of Cottonseed Protein and Evaluation of the Nutritional Value and Antioxidant Activity of Cottonseed Peptides. (PubMed, Foods) - "The peptides also exhibited excellent antioxidant capacity. In conclusion, the microbial-enzymatic synergistic treatment significantly elevated the contents of acid-soluble protein, reducing sugars, and peptides, enhanced antioxidant capacity, and reduced both free gossypol content and pH, thereby effectively improving the nutritional quality of cottonseed protein."

Journal

Exposure to herbivore-induced plant volatiles primes JA-dependent gossypol defenses in cotton. (PubMed, PLoS Pathog) - "The combined results reveal that CBW-induced volatiles prime anti-herbivore resistance in cotton by potentiating the JA signaling pathway, which in turn enhances gossypol biosynthesis upon actual herbivore attack. This new insight into the physio-ecological mechanisms underlying airborne defense priming in cotton also highlights its potential application in sustainable pest management."

Journal

The removal of gossypol from cottonseed oil by Chlorella pyrenoidosa modified with cetyltrimethylammonium bromide. (PubMed, Food Chem) - "The adsorbent maintained a removal efficiency of over 50% after four cycles, with good repeatability. These results suggest that CTAB-ACP is a promising material for gossypol removal from vegetable oils."

Journal

Fluorinated hyperbranched polymers mediate spermatogonia-directed transport across the blood-testis barrier. (PubMed, J Control Release) - "As a functional demonstration, gossypol-loaded Fhb achieved complete contraception in mice after four doses, and fertility recovered after treatment cessation. These findings establish unimolecular Fhb nanoparticles as an effective platform for accessing the seminiferous-tubule compartment and enable testis-targeted therapy and reversible male contraception."

Journal

Scientific Opinion on application (EFSA-GMO-NL-2010-77) for the placing on the market of herbicide-tolerant genetically modified cotton GHB614 × LLCotton25 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Bayer CropScience. (PubMed, EFSA J) - "Environmental risks associated with an unlikely but theoretically possible horizontal gene transfer from cotton GHB614 × LLCotton25 to bacteria have not been identified. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton GHB614 × LLCotton25."

Journal • Gene Therapies

Cardiac Intoxication/Nutritional/Metabolic. (PubMed, Vet Clin North Am Food Anim Pract) - "Since no specific antidotes exist, prompt removal of the toxic source and environmental management are key to improving outcomes. Understanding clinical patterns and implementing herd-wide prevention strategies are vital for reducing morbidity, mortality, and long-term health impacts in affected animals."

Journal • Review

Gossypol Inhibits GLI3-dependent SHH Signaling to Selectively Target SPOP-deficient Breast Cancer Cells. (PubMed, Anticancer Res) - "These findings identify a novel oncogenic role for SPOP loss in promoting breast cancer progression via GLI3-dependent SHH signaling. Furthermore, gossypol is highlighted as a potential targeted therapeutic agent for breast cancers characterized by SPOP deficiency."

Journal • Breast Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • GLI3 • SPOP