lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma - LARVOL DELTA

The neuroprotective effect of submicron and blended Lycium barbarum for experiment retinal ischemia and reperfusion injury in rats. (PubMed, J Vet Med Sci) - "Generally better antioxidative effects were observed in the submicron LB than blended LB among treated groups, especially the 250 mg/kg submicron LB, providing good retinal neuroprotection by preserving retinal structure and function with improved antioxidative capacity. The submicron LB may have clinical implication as an adjuvant therapy of oxidative stress and retinal damage caused by HIOP induced retinal ischemia and reperfusion injury."

Journal • Preclinical • Glaucoma • Ophthalmology • Pain • Reperfusion Injury • CAT

[VIRTUAL] Lycium barbarum extracts preserve retinal function by rescuing synaptic loss in 3xTg mouse model of Alzheimer's disease (AAIC 2020) - "Our results indicated that at early- and mid-stage of AD, presynaptic changes in IPL contributed to b-wave decline and LBE gavage could rescue the retinal functional deterioration in 3xTg AD mice by preventing the synapse loss in IPL through inhibiting oxidative stress and lowering Ca2+ in retinas."

Preclinical • Alzheimer's Disease • CNS Disorders • Synaptophysin

Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract. (PubMed, J Ethnopharmacol) - "Our findings showed that diabetes caused cataract is associated with suppression of SIRT1 and Bcl-2 and activation of other cell death related genes. LBP prevented diabetic cataract in animals by upregulating Sirt1 and Bcl-2 and suppressing cell death related genes."

IO Biomarker • Journal • Cataract • Diabetes • Metabolic Disorders • Ophthalmology • BCL2 • CASP3 • FOXO1 • SIRT1

Lycium barbarum (Wolfberry) Increases Retinal Ganglion Cell Survival and Affects both Microglia/Macrophage Polarization and Autophagy after Rat Partial Optic Nerve Transection. (PubMed, Cell Transplant) - "We find that LBP can delay secondary degeneration of RGCs after temporal injury of optic nerves, promote the M2 polarization of microglia/macrophages, and down-regulate the level of autophagy after PONT. In conclusion, we find that the polarization of microglia/macrophages and the autophagy level change after PONT; LBP treatment delays secondary degeneration of RGCs; and the polarization of microglia/macrophages and the level of autophagy are also altered after LBP treatment."

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The Effect of Lycium barbarum Polysaccharides on Pyroptosis-Associated Amyloid β Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage. (PubMed, Int J Mol Sci) - "Furthermore, Aβ oligomers up-regulated the cellular immunoreactivity of pyroptosis markers including NOD-like receptors protein 3 (NLRP3), caspase-1, and membrane N-terminal cleavage product of GSDMD (GSDMD-N), which could be reversed by LBP treatment. Taken together, this study showed that LBP effectively protects the Aβ oligomers-induced pyroptotic ARPE-19 cell damages by its anti-Aβ oligomerization properties and its anti-pyroptotic effects."

Clinical • Journal • Age-related Macular Degeneration • Complement-mediated Rare Disorders • Gene Therapies • Ophthalmology • Retinal Disorders • IL18

Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier. (PubMed, Neural Regen Res) - "This study was approved by the Committee for the Use of Live Animals in Teaching and Research (approval No. CULTRA-#1664-08)."

Journal • Glaucoma • Hypertension • AGER • APP • Glial Fibrillary Acidic Protein

Posttreatment Intervention With Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension. (PubMed, Invest Ophthalmol Vis Sci) - "However, both LBP treatments preserved the retinal ganglion cells (RGC) and retinal functions up to week 15, which were significantly reduced in vehicle control. LBP posttreatment arrested the subsequent neuronal degeneration after treatment commencement and preserved RGC density and retinal functions in a chronic OHT model, which was comparable with pretreatment outcomes."

Journal • Preclinical

Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury. (PubMed, Neural Regen Res) - "The results of flow cytometric analysis showed LBP could effectively reduce the CoCl-induced retinal ganglion cell apoptosis, inhibited the generation of reactive oxygen species and the reduction of mitochondrial membrane potential. These findings suggested that LBP could protect retinal ganglion cells from CoCl-induced apoptosis by reducing mitochondrial membrane potential and reactive oxygen species."

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The Ocular Protective Effects of Nano/Submicron Particles Prepared from Lycium barbarum Fruits Against Oxidative Stress in an Animal Model. (PubMed, J Ocul Pharmacol Ther) - "Milled LB fruits demonstrated superior protection against oxidative threats than blended fruits. Thus, these fruits could be an inexpensive supplement for many oxidative stress-related ocular diseases."

Journal • Preclinical • GSR • PCR

Protective effects of lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats. (PubMed, Am J Transl Res) - "In addition, the decreased expression of P-Occludin and increased expression of RhoA-associated protein kinase (ROCK) or phosphorylated myosin light chain (P-MLC) were observed in retinal tissue of diabetic rats and high glucose induced by RF/6A cells, which could be rescued by LBP and/or Fasudil. LBP has the protective effects on blood-retinal barrier by regulating the Rho/ROCK signaling pathway in diabetic rats. LBP may be served as a Rho/ROCK inhibitor for the treatment of DR."

Journal • Preclinical

Lycium Barbarum Polysaccharides Rescue Neurodegeneration in an Acute Ocular Hypertension Rat Model Under Pre- and Posttreatment Conditions. (PubMed, Invest Ophthalmol Vis Sci) - "GCL density was reduced in vehicle control (P = 0.0001), but did not differ between sham and pre- and posttreated AOH groups. The rescue effect of LBP posttreatment was observed later, which arrested the secondary degeneration and improved the retinal function."

Journal • Preclinical

The protective effects of lycium barbarum polysaccharides on retinal neurons in diabetic rats and its mechanism (PubMed, Zhongguo Ying Yong Sheng Li Xue Za Zhi) - "LBP can improve retinal oxidative stress and exert beneficial neuroprotective effects in diabetic rats, and its mechanism may be associated with the activation of the Nrf2/HO-1 antioxidant pathway."

Journal • Preclinical

Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. (PubMed, J Ethnopharmacol) - P=N/A; "LB supplement provides a neuroprotective effect for the retina and could help delay or minimize cone degeneration in RP."

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Protective Effects of Lycium barbarum Extracts on UVB-Induced Damage in Human Retinal Pigment Epithelial Cells Accompanied by Attenuating ROS and DNA Damage. (PubMed, Oxid Med Cell Longev) - "Collectively, the ethanol extract exerts a superior effect on rescuing UVB-induced growth arrest of ARPE-19 compared to the aqueous extract, which might be associated with the activation of TLR signaling. Our present work will benefit the preventive strategy of herbal medicine-based vision protection for treating eye diseases such as age-related macular degeneration in the future."

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