PE-0260 / PharmaEngine - LARVOL DELTA

PE-0260, an oral brain-penetrant MTA-cooperative PRMT5 inhibitor, drives tumor regressions in MTAP-deleted solid tumors (AACR 2025) - "PE-0260 also shows balanced in vitro ADME properties with low risk for drug-drug interactions and the capability to penetrate the blood-brain barrier. In conclusion, PE-0260 is a potential best-in-class MTA-cooperative PRMT5 inhibitor and a strong candidate for further clinical development."

Breast Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pancreatic Cancer • Solid Tumor • MTAP