trazodone ER / Generic mfg. - LARVOL DELTA

Clinical outcomes in patients with multiple myeloma and antidepressant use: A retrospective cohort study (ASH 2025) - "Adult patients with multiple myeloma since 2010 and prescribed antidepressants (sertraline, escitalopram, citalopram, paroxetine, fluoxetine, fluvoxamine, venlafaxine, duloxetine, trazodone, mirtazapine, or bupropion) were identified using ICD-10 diagnostic and RxNorm codes. While some associations were modest in magnitude, the consistent pattern of increased risk suggests that pre-existing depression and its treatment may identify a more vulnerable subgroup of multiple myeloma patients. Further prospective studies are needed to clarify underlying mechanisms and to evaluate the potential impact of early psychiatric intervention."

Clinical data • Retrospective data • Chronic Kidney Disease • CNS Disorders • Depression • Hematological Malignancies • Infectious Disease • Major Depressive Disorder • Multiple Myeloma • Musculoskeletal Diseases • Nephrology • Renal Disease

Serine/glycine starvation induces metabolic rewiring to uncover ATF4-driven therapeutic vulnerabilities in infant ALL (ASH 2025) - "An FDA-approved drug screencomparing S/G starved and non-starved cells revealed selective sensitivity to drugs targeting upstreampathways of ATF4 activation, such as Trazodone, Metformin and Rapamycin. This was supported by significant sensitivity of the cells to OxPhos inhibitors Metformin,Rotenone and Phenformin.In conclusion, S/G starved KMT2Ar cells rely on the ATF4-mediated ISR for survival. Therefore,repurposing drugs active upstream or downstream of ATF4 could open potential new, more effective, lesstoxic therapeutic windows in the treatment of infant leukaemia."

IO biomarker • Cardiomyopathy • Cardiovascular • Cognitive Disorders • Hematological Malignancies • Leukemia • Solid Tumor • AARS1 • ASNS • ATF4 • DDIT4 • KMT2A • MTHFD2 • SESN2 • SLC7A11 • TRIB3

Case Report: Development of persistent genital arousal disorder due to a possible combination of medications. (PubMed, Front Psychiatry) - "We present a unique case of a menopausal woman who developed PGAD after combined pharmacotherapy with trazodone, pregabalin, vaginal estriol, and depot medroxyprogesterone acetate (DMPA). This case supports the hypothesis that combined modulation of serotonergic, neuronal, and hormonal systems can trigger PGAD in predisposed menopausal women. Recognition of potential pharmacological interactions is crucial for diagnosis and management of PGAD."

Journal • Psychiatry • Sexual Disorders

Sustained-release Drug Delivery System of Trazodone Hydrochloride Based on Electrospray Technology: Preparation, Characterization, In vitro and In vivo Evaluation. (PubMed, AAPS PharmSciTech) - "This study achieved the synergistic goals of drug solubilization, sustained-release delivery, and enhanced bioavailability. It provides new technical references for the development of pH-sensitive drug formulations using electrospray technology and also expands the research on the development of sustained-release formulations of trazodone hydrochloride."

Journal • Preclinical

Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study) (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) | Not yet recruiting ➔ Recruiting | Initiation date: Jun 2025 ➔ Nov 2025

Enrollment open • Trial initiation date • CNS Disorders • Insomnia • Sleep Disorder

Comparison of pharmacist-led outpatient depression management to current prescriber-led depression management. (PubMed, Ment Health Clin) - "Patients were excluded if they were established with a psychiatric specialist, diagnosed with a severe psychiatric disorder or postpartum depression, pregnant, or only prescribed trazodone at doses less than 100 mg...Clinical outcomes were comparable between cohorts at the final assessment. Overall, this shows that pharmacists can provide close follow-up and improve patients' quality of life by providing rapid symptom resolution."

Journal • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Postpartum Depression • Psychiatry

A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer's Disease. (PubMed, Am J Geriatr Psychiatry) - P2 | "Adjunctive dronabinol treatment was safe and effective for treating agitation in AD."

Clinical • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Epilepsy • Psychiatry

Time Course of Serum Dextromethorphan Concentrations in a Case of Serotonin Syndrome After Massive Overdose. (PubMed, Am J Case Rep) - "CASE REPORT A 24-year-old man with bipolar disorder and attention-deficit/hyperactivity disorder, treated with trazodone and methylphenidate, ingested 300 mg of DXM (4.6 mg/kg)...He developed serotonin syndrome with spontaneous clonus and seizures, requiring diazepam, sedation, intubation, and ventilation...CONCLUSIONS Our case report provides a detailed timeline of blood DXM concentrations along with the clinical course in a patient with serotonin syndrome after an acute overdose. The serial measurements support the importance of symptom-focused monitoring to guide treatment decisions."

Journal • ADHD (Impulsive Aggression) • Anesthesia • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry

The impact of antidepressant use on antibiotic treatment outcomes in urinary tract infections and pneumonia: A population-based cohort study. (PubMed, Psychiatry Clin Neurosci) - "Antidepressants are associated with a modest rise in UTI treatment failure risk, possibly due to antibiotic resistance or other mechanisms. Despite this, their essential role in mental health management outweighs the small risk, emphasizing the need for judicious use, particularly in females and older adults. Further research is warranted to clarify underlying mechanisms."

Journal • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

NAP: National Adaptive Trial for PTSD Related Insomnia (clinicaltrials.gov) - P3 | N=673 | Active, not recruiting | Sponsor: VA Office of Research and Development | Recruiting ➔ Active, not recruiting

Enrollment closed • CNS Disorders • Insomnia • Post-traumatic Stress Disorder • Sleep Disorder

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention. (PubMed, Am J Hum Genet) - "Analyzing >3.5 million electronic health records, we conducted analyses of emulated trials for 11 drugs across 290 comparisons and identified three drugs significantly associated with reduced colorectal cancer risk: caffeine vs. paroxetine (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.41-0.64), haloperidol vs. prochlorperazine (HR, 0.47; 95% CI, 0.33-0.68), and trazodone hydrochloride vs. paroxetine (HR, 0.49; 95% CI, 0.38-0.63). Conversely, caffeine was associated with increased cancer risk in comparison with finasteride (colorectal cancer) and fluoxetine (breast cancer). Meta-analysis identified six drugs significantly associated with cancer risk, including acetazolamide, which was associated with reduced colorectal cancer risk (HR, 0.79; 95% CI, 0.72-0.87). This study identifies previously unreported protein biomarkers and candidate drug targets across six major cancer types and highlights several approved drugs with potential chemopreventive effects."

Biomarker • Journal • Breast Cancer • Colorectal Cancer • Genito-urinary Cancer • Oncology • Pancreatic Cancer • Prostate Cancer • Solid Tumor

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea (clinicaltrials.gov) - P4 | N=45 | Completed | Sponsor: China Medical University Hospital | Recruiting ➔ Completed | N=132 ➔ 45

Enrollment change • Trial completion • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Phenobarbital for Refractory Behavioral Disturbances in Anti-NMDAR and HSV Encephalitis: A Case Report. (PubMed, J Pain Palliat Care Pharmacother) - "Disease-modifying therapies, including IV acyclovir, IV immunoglobulin, prednisone, and rituximab, were ineffective. Multiple psychotropic medications, including fluoxetine, quetiapine, olanzapine, and trazodone, failed to relieve behavioral symptoms...No adverse effects were reported. This case suggests that low-dose oral phenobarbital may be a viable option for managing refractory behavioral disturbances in patients and improving quality of life with anti-NMDAR and HSV encephalitis."

Journal • CNS Disorders • Herpes Simplex • Immunology • Insomnia • Mental Retardation • Palliative care • Psychiatry • Sleep Disorder

Venlafaxine-associated priapism: Case report and review of priapism linked to psychotropic medications. (PubMed, Urol Case Rep) - "Priapism is a Urological emergency that manifests as penile erection lasting more than 4 hours and is commonly reported with antipsychotics and a few antidepressants like Trazodone due to their alpha-adrenergic blockade. Here we report a 52-year-old male with a history of Chronic Venlafaxine intake who presented with low-flow ischemic Priapism. In conclusion, clinicians should recognize that venlafaxine, though rarely, can cause ischemic priapism and may present with atypical features."

Journal • CNS Disorders

Comparative gastrointestinal effects of antidepressants for the acute treatment of adults with major depressive disorder: a network and dose‒response meta-analysis. (PubMed, Transl Psychiatry) - "Commonly used antidepressants have different gastrointestinal effects. Duloxetine, levomilnacipran, and vilazodone carry a higher risk of inducing nausea and vomiting, whereas trazodone, amitriptyline, agomelatine, and mirtazapine tend to be better tolerated. Amitriptyline, clomipramine, and reboxetine are more prone to induce constipation. Diarrhoea is more commonly associated with vilazodone, fluvoxamine, and sertraline. Amitriptyline, reboxetine, and duloxetine are more likely to cause anorexia. Amitriptyline, reboxetine, and trazodone are related to causing dry mouth. Compared with the placebo, amitriptyline, fluoxetine, and paroxetine were associated with a greater incidence of dyspepsia."

Journal • Retrospective data • Review • Anorexia • CNS Disorders • Constipation • Depression • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Major Depressive Disorder • Mood Disorders • Psychiatry • Xerostomia

Study of changes in brain dynamics during sleep cycles in dogs under effect of trazodone. (PubMed, PLoS One) - "Furthermore, treated dogs exhibited increased signal entropy and complexity in lower frequency bands across all sleep stages, along with a reduction in brain connectivity in most stages and frequency bands. These results provide new insights into the short-term effects of trazodone on brain activity during sleep, with potential implications for its clinical use as a sleep aid in dogs."

Journal • CNS Disorders • Sleep Disorder

Sodium bicarbonate to the ROSCue: a case report on how sodium bicarbonate successfully resuscitated a patient in cardiac arrest from suspected quetiapine and trazodone overdose. (PubMed, Eur Heart J Case Rep) - "Although the role of SB in cardiac arrest remains limited, SB in SCB toxicity in TCA overdose and in other drug toxicities can be life-saving. SB should be considered in patients with wide QRS and suspected drug overdose."

Journal • Cardiovascular • CNS Disorders • Metabolic Disorders

Effects of chronic trazodone administration on sleep, touchscreen cognitive testing, and neuropathology in the APPNL-Fmouse model of Alzheimer's disease (Neuroscience 2025) - "Touchscreen cognitive testing, novel object recognition, and neuropathology assessment from an extended treatment (120 days) is ongoing. Our results suggest that trazodone should be explored as a potential disease-modifying therapeutic for AD, with potential beneficial effects on sleep, cognition, and neuropathology."

Alzheimer's Disease • CNS Disorders • Sleep Disorder

Examining differences in clinical and demographic characteristics of patients with post-traumatic stress disorder across adult treatment subgroups based on the NeuroBlu database: a non-interventional, retrospective cohort study. (PubMed, BMJ Open) - "In the overall study population, most patients were female, with a high prevalence of psychiatric comorbidities. Demographic and clinical characteristics observed in this study varied across treatment subgroups. These insights may support patient-specific treatment planning and inform health-economic decision models in PTSD."

Journal • Retrospective data • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • Suicidal Ideation

Paralyzed by Relief: A Rare Case of Transient Quadriplegia Following Cervical Epidural Injection (ASRA-FALL 2025) - "•Intralaminar and transforaminal are the most common approaches Case Presentation •Patient: 45-year-old female •Relevant Medical History: •Hypertension, morbid obesity, migraines, myofascial pain syndrome, fibromyalgia •Cervical spinal stenosis with radiculopathy confirmed by EMG and prior ACDF (C5–C6) and posterior discectomy (C6–C7) •Remote CVA at age 15 (thrombotic, no residual deficits) •Psychiatric History: •Acute grief after death of son → panic attacks and insomnia •Medications: trazodone, lorazepam, buspirone •Prior Workup: •Hospitalized for visual changes; lumbar puncture (r/o MS) → post-dural puncture headache treated with blood patch •Presentation: •Persistent cervical radiculopathy with bilateral forearm burning pain and left-hand weakness •Prior treatments (gabapentin, ibuprofen, trigger point injections) minimally effective •Four prior CESIs provided significant improvement •Current Procedure: •CESI at C7–T1 under fluoroscopic guidance using..."

Clinical • Cardiovascular • CNS Disorders • Fibromyalgia • Genetic Disorders • Hypertension • Inflammation • Insomnia • Metabolic Disorders • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Obesity • Orthopedics • Psychiatry • Psychosomatic Disorders • Rheumatology • Sleep Disorder

Lifetime burden of prescription medication for insomnia in middle-aged and older adults in the US: a microsimulation study. (PubMed, Lancet Reg Health Am) - "Prescription sleep medications, including z-drugs, benzodiazepines, and trazodone, are commonly used treatments in older adults for insomnia, but have negative consequences related to injuries, cognitive impairment, and quality of life...Deprescribing efforts may improve quality of life for middle-aged and older Americans. National Heart, Lung & Blood Institute."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Insomnia • Sleep Disorder

Physician Perceptions and Intentions in Response to Unsupportive Data for Off-label Uses: An Experimental Study with Primary Care Providers and Oncologists. (PubMed, Ther Innov Regul Sci) - "Disclosures about unsupportive data for off-label uses are important and useful for prescribing decisions. Physicians who prescribe drugs for off-label uses more frequently or have prescribed the drug previously may discount the importance of the information. Tailoring the specificity of the disclosure to the needs of the audience may increase its effectiveness."

Journal • CNS Disorders • Insomnia • Melanoma • Oncology • Sleep Disorder

Rhabdomyolysis secondary to Influenza A infection in a patient using antipsychotic and serotonergic agents: A case report. (PubMed, SAGE Open Med Case Rep) - "Fluid resuscitation is a mainstay of management; however, iatrogenic fluid overload, such as pulmonary edema, is a possible complication that must be appropriately addressed. This case underscores the importance of maintaining a high index of suspicion for rhabdomyolysis in patients with Influenza A and presents a novel narrative of rhabdomyolysis resulting from a potentially additive interplay of pharmacological (use of trazodone and risperidone) and nonpharmacological predisposing factors."

Journal • Acute Kidney Injury • Cardiovascular • CNS Disorders • Infectious Disease • Inflammation • Influenza • Musculoskeletal Pain • Nephrology • Pain • Psychiatry • Pulmonary Disease • Renal Disease • Respiratory Diseases

Z-drug abuse and dependence: clinical guideline of the Brazilian Academy of Neurology for diagnosis and management. (PubMed, Arq Neuropsiquiatr) - "An advisory committee, consisting of neurologists from the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN, in Portuguese) and psychiatrists specializing in substance-use disorders, contributed to the selection and organization of the scientific literature and took part in the voting process. Key recommendations were established: 1) prior to discontinuation, a comprehensive assessment of mental status, psychiatric and sleep comorbidities, and the degree of pharmacological dependence is essential; 2) gradual tapering is advised; 3) non-pharmacological interventions, such as cognitive behavioral therapy for insomnia, are recommended, and acceptance and commitment therapy, which is optional, may be incorporated; 4) for zolpidem withdrawal, adjunctive pharmacotherapy, which is optional, may include trazodone, other antidepressants, quetiapine or other antipsychotics, alpha-2-delta (α2δ) ligands, or alternative hypnotics (such as ramelteon, zopiclone,..."

Clinical guideline • Journal • Review • CNS Disorders • Insomnia • Psychiatry • Sleep Disorder

A Hidden Threat: Trazodone-Induced Warfarin Failure Leading to Acute Mechanical Aortic Valve Thrombosis (AHA 2025) - "Due to prohibitive surgical risk, thrombolysis with alteplase (25 mg over 6 hours) was administered...He was stabilized on milrinone and extubated by hospital day five.Despite restarting warfarin—at doses up to 30 mg daily (three times his prior regimen)—therapeutic INR was not achieved until 10 days later...While the exact mechanism is unclear, proposed theories include CYP2C9 induction, increased warfarin clearance, or protein-binding displacement. This case highlights the need for close INR monitoring when initiating trazodone in patients on warfarin."

Acute Respiratory Distress Syndrome • Back Pain • Cardiovascular • Cough • Hematological Disorders • Hepatology • Infectious Disease • Liver Failure • Musculoskeletal Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Thrombosis • CYP2C9