TA-NIC / Celtic Pharma - LARVOL DELTA

Anti-amnesic effects of Terminalia chebula extract on scopolamine-induced learning deficits in mice (Neuroscience 2016) - "The major components of TCE such as tannic acid and chebulagic acid have anti-oxidant, anti-mutagenic, and anti-inflammatory properties. Mice was orally administered with TCE (200 mg/kg) or donepezil (5 mg/kg) for 14 days (days 1-14), and scopolamine (1 mg/kg) was injected intraperitoneally for 7 days (days 8-14), 30 min before the Morris water maze task (MWM) which was used to examine cognitive status. Supported by the National Research Council of Science & Technology (NST) grant by the Korean government (MSIP) (No. G15120 and CRC-15-04-KIST)."

Preclinical • Alzheimer's Disease • Biosimilar • Colorectal Cancer • Gastrointestinal Cancer • Oncology

High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis. (PubMed) - Chem Commun (Camb) - "Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced phospholipidosis. Chemical fixation using tannic acid effectively seals cellular membranes aiding intracellular retention of diffusible drugs."

Journal • Biosimilar

Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation. (PubMed) - "The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors."

Journal • Alzheimer's Disease • Biosimilar

The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds. (PubMed) - Biomed Res Int - "Resveratrol and caffeic acid prevented malondialdehyde accumulation and preserved glutathione, glutathione peroxidase, and catalase activities in erythrocytes. We demonstrated that resveratrol, caffeic acid, and tannic acid in stored blood could decrease the sensitivity to oxidation of erythrocytes in vitro but did not exhibit such effects on CA activity."

Journal • Biosimilar

Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae. (PubMed) - PLoS One - "Functional studies, performed using mouse ileal loops and Ussing chamber experiments, corroborate biophysical data, all pointing to the fact that tannic acid destabilizes Ace, inhibiting its function, whereas DGA stabilizes the toxin with enhanced fluid accumulation in mouse ileal loop. The efficacy of tannic acid in mouse model suggests that the targeted modulation of Ace structure may be of therapeutic benefit for gastrointestinal disorders."

Journal • Biosimilar

Tannic acid Attenuates TGF-β1-induced Epithelial-to-mesenchymal Transition by Effectively Intervening TGF-β Signaling in Lung Epithelial Cells. (PubMed, J Cell Physiol) - "Finally, we conclude that TA might directly interact with TGF-β1, thereby repressing TGF-β signaling and subsequent EMT process in lung epithelial cells. Further animal studies are needed to clarify its potential therapeutic benefit in pulmonary fibrosis."

Journal • Biosimilar • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Respiratory Diseases

HER2(+) breast cancer cells undergo apoptosis upon exposure to tannic acid released from remodeled crosslinked collagen type I. (PubMed, J Biomed Mater Res A) - "HER2(+) breast cancer cells underwent caspase-mediated apoptosis in response to TA exposure. TA induced apoptosis in a concentration- and time-dependent manner, with HER2(+) breast cancer cells demonstrating an increased sensitivity to the TA effects."

Journal • Biosimilar • Breast Cancer • HER2 Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

Toxicity of tannic acid-modified silver nanoparticles in keratinocytes: potential for immunomodulatory applications. (PubMed) - Toxicol In Vitro - "Tannic acid-modified but not unmodified AgNPs down-regulated TNF-α and LPS-triggered production of IL-8 in VK2-E6/E7 but not in HaCaT cells. In summary, tannic acid-modified AgNPs sized above 30nm show good toxicological profile both in vitro and possess immunomodulatory properties useful for potential dermal applications in humans."

Journal • Biosimilar • Complement-mediated Rare Disorders

Phytochemical Screening: Antioxidant and Antibacterial Properties of Potamogeton Species in Order to Obtain Valuable Feed Additives. (PubMed) - "Antibacterial efficiency of methanolic extracts was notably demonstrated against Gram negative (Escherichia coli, Enterobacter hormaechei) and Gram positive bacteria (Enterococcus casseliflavus). The data reported for the first time for Romanian Potamogeton species, provides extensive support for the chemical investigations of these plants of the aquatic anthropogene ecosystems in order to obtain valuable bioadditives for animal feed and/or pharmaceutical/food industry."

Journal • Biosimilar

Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids. (PubMed, World J Gastroenterol) - "Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa, from the rectum to the anus, and this is the first description of a case that developed a severe liver disorder after this treatment; hence, an analysis of future cases as they accumulate is desirable."

Journal • Biosimilar • Oncology • Solid Tumor

Efficacy and safety of gelatine tannate for the treatment of acute gastroenteritis in children: protocol of a randomised controlled trial. (PubMed) - BMJ Open - "Abstracts will be submitted to relevant national and international conferences. NCT02280759; Pre-results."

Journal • Biosimilar • Immunology

The effect of three different antioxidants on the dentinal tubular penetration of Resilon and Real Seal SE on sodium hypochlorite-treated root canal dentin: An in vitro study. (PubMed) - J Conserv Dent - "10% gallic acid was superior among the antioxidant irrigants that enabled the increased dentinal tubular penetration of Resilon and Real Seal SE."

Journal • Biosimilar

Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time-Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell Screening. (PubMed) - "Consequentially, RT-QuIC enabled the more specific classification of compounds according to action (i.e., inhibition of prion propagation versus reduction of amplified aggregates). RT-QuIC addresses the limitations of cell-based screening methods and can be used to further aid our understanding of the mechanisms of action of anti-prion compounds."

Journal • Biosimilar

Secondary metabolites constituents and antioxidant, anticancer and antibacterial activities of Etlingera elatior (Jack) R.M.Sm grown in different locations of Malaysia. (PubMed) - "In general, therefore, based on the potent antioxidant and anticancer activity of flower extracts, it appears that E. elatior grown in the North-east of Malaysia (Kelantan) is a potential source of therapeutic compounds with anti-cancer activity."

Journal • Biosimilar • Oncology

Tailoring stimuli-responsive delivery system driven by metal-ligand coordination bonding. (PubMed) - "In this study, a novel coordination bonding system based on metal-tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery...In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal-TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations...Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery."

Journal • Biosimilar

Tannic acid alleviates bulk and nanoparticle Nd2O3 toxicity in pumpkin: A physiological and molecular response. (PubMed) - Nanotoxicology - "In addition, TA promotes antioxidant enzymatic activity by elevating the transcript levels of genes involved in ROS scavenging. Our results shed light on the mechanisms underlying the influence of DOM on the bioavailability and toxicity of NPs to terrestrial plants."

Journal • Biosimilar

Artificial Spores: Cytocompatible Coating of Living Cells with Plant-Derived Pyrogallol. (PubMed) - Chem Asian J - "Three different cell types (anucleate, microbial, and mammalian cells) are coated with pyrogallol without noticeable decrease in cell viability. The protocol developed in this work could be applied to other polyphenolic compounds, and, considering many polyphenols identified as a coating material, provides an advanced chemical tool in cell-surface engineering."

Journal • Biosimilar

Biodegradable thin films of UCST-type micelles: Film stability, degradation and biocompatibility (ACS-Fall 2017) - "...These micelles were assembled on the silicon wafer substrate with tannic acid (TA) via the layer-by-layer (LbL) assembly technique...Culture of human dermal fibroblasts and epidermal keratinocytes on the UCST-type micellar films showed negligible cytotoxicity, confirming their biocompatibility. Taken together, these results suggest that these micelle-containing, degradable LbL films demonstrate robust temperature response and therefore have the potential to provide on-demand release of biofunctional compounds."

Preclinical • Biosimilar • Ophthalmology

Doubly Dynamic Self-Healing Materials Based on Oxime Click Chemistry and Boronic Acids. (PubMed) - Macromol Rapid Commun - "The addition of a polyphenol (tannic acid) proves a facile means to incorporate a second, dynamic covalent cross-linking network through boronate ester formation which, owing to the increase in the degree of cross-linking, is found to be nearly double the hydrogel strength (storage modulus increased from 4.6 to 8.5 kPa). Finally, the tannic acid cross-linking network is selectively degraded returning the hydrogel storage modulus to its initial value and providing a means for the synthesis of materials with tunable mechanical properties."

Journal • Biosimilar

Assessing the effect of different natural dissolved organic matters on the cytotoxicity of titanium dioxide nanoparticles with bacteria. (PubMed) - J Environ Sci (China) - "In this study, the effects of terrestrial humic acid (HA) and tannic acid (TA), two major members of the collective: dissolved organic matter (DOM), on the cytotoxicity of TiO2 NPs to Escherichia coli were investigated in the presence and absence of natural sunlight. The inhibition of bacterial viability in the light treatment groups, with respective treatment organics at concentrations of 10 ppm, was less in TA than in terrestrial HA. SAS was used to analyze the treatment effect of individual factors of light irradiation, DOM, and concentration of TiO2 NPs."

Journal • Biosimilar

Facile loading of Ag nanoparticles onto magnetic microsphere by the aid of a tannic acid-Metal polymer layer to synthesize magnetic disinfectant with high antibacterial activity. (PubMed, J Hazard Mater) - "As a result, the magnetic composite can be synthesized simply with less cost. Moreover, the composite has a high magnetic saturation value of 55.47emug(-1) owing to the Fe3O4 core and the magnetic separation ability can play an important role in the recovery of the disinfectant."

Journal • Biosimilar • Immunology

Interaction between natural antioxidants derived from cinnamon and cocoa in binary and complex mixtures. (PubMed) - Food Chem - "...Two representative active compounds of chocolate (epicatechin, catechin) were combined with seven of cinnamon (gallic acid, tannic acid, quercetin, sinapic acid, cinnamic acid, eugenol and cinnamaldehyde) in multilevel ratios...The interaction of their constituents substantially influenced the antioxidant activity of the mixture and was dependent on the ratio. The kinetics' study could elucidate how the polyphenols work in a mixture."

Journal • Biosimilar

Variability among strains of Aspergillus section Nigri with capacity to degrade tannic acid isolated from extreme environments. (PubMed) - Arch Microbiol - "In the last location, the major diversity and specific richness were found. But in "Ojo Caliente," tannase allele conservations were observed."

Journal • Biosimilar