Humalog Mix75/25 Kwikpen (lispro protamine/ lispro) / Eli Lilly - LARVOL DELTA

[VIRTUAL] Difference in estimated glomerular filtration rate (eGFR) amongst different races: two case reports (ASHP 2020) - "Her A1C was 7.4 percent on a regimen consisting of aspirin 81 mg DR once daily, atorvastatin (Lipitor) 40 mg once daily, dapagliflozin (Farxiga) 10 mg once daily, glipizide (Glucotrol) 10 mg twice daily before meals, lisinopril (Prinivil, Zestril) 20 mg once daily, atenolol (Tenormin) 50 mg once daily, and metformin (Glucophage) 1,000 mg twice daily with meals...During the visit, the patient’s dapagliflozin had to be discontinued as her eGFR trended downwards below 45 mL/min overtime and unfortunately the patient’s insurance would not cover for canagliflozin...In June, her A1C was 6.5 percent on a regimen consisting of 6 units injected daily of insulin lispro protamin-lispro (Humalog Mix 75-25 Kwikpen, U-100), metformin (Glucophage-XR) 500 mg 24 hr tablet twice daily with meals, semaglutide (Ozempic) 0.5 mg (2 mg/1.5 mL) weekly, valsartan (Diovan) 160 mg once daily, and atorvastatin (Lipitor) 40 mg once daily...Although more studies are needed to further elucidate this..."

Clinical • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hypoglycemia • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Renal Disease • Type 2 Diabetes Mellitus • ERBB3

[VIRTUAL] Evaluation of premixed insulin safety and efficacy within a large community teaching hospital (ASHP 2020) - "On average patients who received Humalog Mix 75/25 were not more controlled than patients who received Humulin Mix 70/30. By extrapolating the collected data, we can determine if all Humalog Mix 75/25 orders are interchanged to Humulin mix 70/30 it would result in significant cost savings with little to no effect on the management of patients’ blood glucose. Additionally, removing Humalog Mix 75/25 would help prevent medication errors."

Clinical • Acute Kidney Injury • Chronic Kidney Disease • Diabetes • Hypoglycemia • Metabolic Disorders • Nephrology • Renal Disease

Comparison of analog insulin mix 50:50 with human insulin mix 30:70 in persons with type 2 diabetes during Ramadan. (PubMed, Int J Clin Pract) - "Switching from human insulin mix 30:70 to analog insulin mix 50:50 results in better post main meal control in Ramadan, without affecting HbA1c, or increasing the incidence of hypoglycaemia."

Journal

"Does this also apply to the humalog mix 75/25 kwikpen?" (@DustinG2018123)