MT-104 / MabTics - LARVOL DELTA

Analysis of antigenic gene characteristics and drug resistance of Bordetella pertussis in Liaoning Province from 2018 to 2024 (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "Multilocus variable-number tandem-repeat (MLVA) analysis combined with antigenic genotype analysis revealed that two isolates carried the ptxP1-MT104 genotype and eight carried the ptxP3-MT28 genotype...All isolates were resistant to macrolides (erythromycin, azithromycin, clarithromycin) but susceptible to levofloxacin, ampicillin, ciprofloxacin, trimethoprim-sulfamethoxazole, and ceftriaxone. Non-vaccine-type ptxP3-MT28 strains, accounting for 8/10 of all isolates in this study, showed resistance to macrolides, and all strains isolated since 2023 belonged to this genotype. Pertussis isolates in Liaoning Province have universally undergone antigenic drift and developed resistance to macrolides, among which non-vaccine-type ptxP3-MT28 strains have become the predominant circulating strains."

Journal • Infectious Disease • Pertussis • Respiratory Diseases • PTX3

Drug Development. (PubMed, Alzheimers Dement) - "MT104 improved memory performance and global cognition in patients with MCI without safety concerns. These findings support the potential of dietary therapeutic strategies to reduce the risk of progression from MCI to AD dementia. Further studies are needed to confirm these results and explore the long-term benefits of MT104."

Clinical • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia

Efficacy and Safety of MT104, A Dietary Supplement Based on Cuscuta Seeds and Heat-Killed Probiotics, on Cognitive Function in Patients with Mild Cognitive Impairment: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. (PubMed, J Med Food) - "In addition, no significant findings were identified. This study highlighted the potential of dietary therapeutic strategies focused on reducing the risk of progression from MCI to AD."

Clinical • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders