DFV890
/ Novartis
- LARVOL DELTA
Home
Next
Prev
1 to 25
Of
34
Go to page
1
2
February 21, 2024
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 and MAS825 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
(clinicaltrials.gov)
- P2 | N=28 | Recruiting | Sponsor: Novartis Pharmaceuticals | Not yet recruiting ➔ Recruiting
Enrollment open • Cardiovascular • Coronary Artery Disease • Heart Failure • Hematological Disorders • DNMT3A • IL18 • IL6 • TET2
January 09, 2024
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
(clinicaltrials.gov)
- P1 | N=80 | Recruiting | Sponsor: Novartis Pharmaceuticals | Trial completion date: Jun 2025 ➔ Jun 2026 | Trial primary completion date: Jun 2025 ➔ Jun 2026
Trial completion date • Trial primary completion date • Myelodysplastic Syndrome
December 14, 2023
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 and MAS825 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
(clinicaltrials.gov)
- P2 | N=28 | Not yet recruiting | Sponsor: Novartis Pharmaceuticals | Phase classification: P2a ➔ P2
Phase classification • Cardiovascular • Coronary Artery Disease • Heart Failure • Hematological Disorders • DNMT3A • IL18 • IL6 • TET2
November 03, 2023
Safety and Preliminary Efficacy of DFV890 in Adult Patients with Myeloid Diseases: A Phase 1b Study
(ASH 2023)
- P1 | "Eligible pts must be 18 years of age, with an Eastern Cooperative Oncology Group performance status ≤2, candidates for serial bone marrow assessments who are willing to undergo a bone marrow aspirate/biopsy during the trial, and meet one of the following: (a) IPSS-R–defined LR-MDS who failed to respond to or did not tolerate erythropoiesis-stimulating agents (ESAs) or luspatercept or hypomethylating agents (HMAs) and pts with del 5q who failed to respond to or did not tolerate lenalidomide; (b) CPSS–defined LR-CMML who failed to respond to or did not tolerate hydroxyurea or HMAs. The study is currently enrolling in Singapore, Hong Kong, and the USA with plans to treat approximately 80 pts. The first patient first visit was achieved on May 8, 2023."
Clinical • P1 data • Chronic Myelomonocytic Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • Transplantation • IL18 • IL1B • NLRP3
November 30, 2023
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease
(clinicaltrials.gov)
- P2 | N=24 | Recruiting | Sponsor: Novartis Pharmaceuticals | Phase classification: P2a ➔ P2
Phase classification • Cardiovascular • Coronary Artery Disease • Heart Failure • CRP • IL18 • IL6
November 13, 2023
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
(clinicaltrials.gov)
- P1 | N=80 | Recruiting | Sponsor: Novartis Pharmaceuticals | Phase classification: P1b ➔ P1
Phase classification • Myelodysplastic Syndrome
October 25, 2023
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease
(clinicaltrials.gov)
- P2a | N=24 | Recruiting | Sponsor: Novartis Pharmaceuticals | Not yet recruiting ➔ Recruiting
Enrollment open • Cardiovascular • Coronary Artery Disease • Heart Failure • CRP • IL18 • IL6
October 24, 2023
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 and MAS825 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
(clinicaltrials.gov)
- P2a | N=28 | Not yet recruiting | Sponsor: Novartis Pharmaceuticals
New P2a trial • Cardiovascular • Coronary Artery Disease • Heart Failure • Hematological Disorders • DNMT3A • IL18 • IL6 • TET2
September 11, 2023
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease
(clinicaltrials.gov)
- P2a | N=24 | Not yet recruiting | Sponsor: Novartis Pharmaceuticals
New P2a trial • Cardiovascular • Coronary Artery Disease • Heart Failure • CRP • IL18 • IL6
July 27, 2023
Research progress of NLRP3 inflammasome and its inhibitors with aging diseases.
(PubMed, Eur J Pharmacol)
- "At present, the only clinical approach to the treatment of NLRP3 inflammasome-related diseases is to use anti-IL-1β antibodies, but NLRP3-specific inhibitors may be better than the IL-1β antibodies. This article reviews the relationship between NLRP3 inflammasome and aging diseases: summarizes some of the relevant experimental results reported in recent years, and introduces the biological signals or pathways closely related to the NLRP3 inflammasome in a variety of aging diseases, and also introduces some promising small molecule inhibitors of NLRP3 inflammasome for clinical treatment, such as: ZYIL1, DFV890 and OLT1177, they have excellent pharmacological effects and good pharmacokinetics."
Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • IL1B • NLRP3
May 23, 2023
DFV890-FCAS: Study of Safety, Tolerability and Efficacy of DFV890 in Participants With Familial Cold Auto-inflammatory Syndrome (FCAS)
(clinicaltrials.gov)
- P2 | N=4 | Completed | Sponsor: Novartis Pharmaceuticals | Recruiting ➔ Completed | Trial primary completion date: May 2023 ➔ Dec 2022
Trial completion • Trial primary completion date • Genetic Disorders • Inflammation
April 06, 2023
"Inflammasome inhibitors in development: - RRx-001 in cancer, ALS, parkinsons - OLT1177 in OA knee, gout, Schnitzlers - DFV890 in CAPs, knee OA - IZD174/334 in CAPS - ZYIL1 CAPS https://t.co/7E2jdx9TPA"
(@RheumNow)
CNS Disorders • Gout • Inflammatory Arthritis • Movement Disorders • Oncology • Parkinson's Disease • Rheumatology
April 18, 2023
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
(clinicaltrials.gov)
- P2 | N=108 | Recruiting | Sponsor: Novartis Pharmaceuticals | Trial completion date: Apr 2024 ➔ Apr 2025 | Trial primary completion date: Mar 2024 ➔ Mar 2025
Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology • CRP
April 06, 2023
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
(clinicaltrials.gov)
- P1b | N=80 | Recruiting | Sponsor: Novartis Pharmaceuticals | Not yet recruiting ➔ Recruiting
Enrollment open • Myelodysplastic Syndrome
April 03, 2023
"March 2023 WRAP of compounds I uncovered on Molecular Sherlock! ✨STARRING✨ DFV890: NLRP3i @Novartis in ph2 for osteoarthritis BI 1015550 ✅: PDE4i @Boehringer in ph3 for IPF MK-0616 ✅: PCSK9i @Merck in ph3 for hypercholesterolemia $MRK $NVS https://t.co/zeOO090cND"
(@victoriacyanide)
Dyslipidemia • Immunology • Metabolic Disorders • Osteoarthritis • Pain • Rheumatology • NLRP3
March 21, 2023
"DFV890: an NLRP3 inhibitor by @Novartis currently in ph2 for the tx of osteoarthritis! $NVS How did I figure out the structure? A thread! 🧵1/13 PS - subscribe to my substack, Molecular Sherlock, for more small molecule detective work!👇 https://t.co/Pmu7MlMaz9"
(@victoriacyanide)
Immunology • Osteoarthritis • Pain • Rheumatology • NLRP3
September 23, 2022
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
(clinicaltrials.gov)
- P1b | N=80 | Not yet recruiting | Sponsor: Novartis Pharmaceuticals
New P1 trial • Myelodysplastic Syndrome
September 20, 2022
DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function.
(PubMed, Infection)
- P2 | "DFV890 did not meet statistical significance for superiority vs. SoC in primary endpoint of combined APACHE II score at Day 14. However, early SARS-CoV-2 clearance, improved clinical status and in-hospital outcomes, and fewer fatal events occurred with DFV890 vs. SoC, and it may be considered as a protective therapy for CARDS."
Journal • P2a data • Acute Respiratory Distress Syndrome • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • CRP • NLRP3
July 05, 2022
DFV890-FCAS: Study of Safety, Tolerability and Efficacy of DFV890 in Participants With Familial Cold Auto-inflammatory Syndrome (FCAS)
(clinicaltrials.gov)
- P2 | N=6 | Recruiting | Sponsor: Novartis Pharmaceuticals | Trial completion date: Aug 2022 ➔ Feb 2023 | Trial primary completion date: Aug 2022 ➔ Jan 2023
Trial completion date • Trial primary completion date • Genetic Disorders • Inflammation
May 19, 2022
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
(clinicaltrials.gov)
- P2 | N=108 | Recruiting | Sponsor: Novartis Pharmaceuticals | Trial completion date: Sep 2023 ➔ Apr 2024 | Trial primary completion date: Sep 2023 ➔ Apr 2024
Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology • CRP
February 15, 2022
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
(clinicaltrials.gov)
- P2 | N=108 | Recruiting | Sponsor: Novartis Pharmaceuticals | Trial completion date: Mar 2023 ➔ Sep 2023 | Trial primary completion date: Mar 2023 ➔ Sep 2023
Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology • CRP
December 07, 2021
DFV890-FCAS: Study of Safety, Tolerability and Efficacy of DFV890 in Participants With Familial Cold Auto-inflammatory Syndrome (FCAS)
(clinicaltrials.gov)
- P2; N=6; Recruiting; Sponsor: Novartis Pharmaceuticals; Trial completion date: Feb 2022 ➔ Aug 2022; Trial primary completion date: Feb 2022 ➔ Aug 2022
Clinical • Trial completion date • Trial primary completion date • Genetic Disorders • Inflammation
October 25, 2021
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
(clinicaltrials.gov)
- P2; N=108; Recruiting; Sponsor: Novartis Pharmaceuticals; Trial completion date: Oct 2022 ➔ Feb 2023; Trial primary completion date: Oct 2022 ➔ Jan 2023
Clinical • Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology • CRP • MRI
October 05, 2021
The role and transformative potential of IL-19 in atherosclerosis.
(PubMed, Cytokine Growth Factor Rev)
- "Most antiatherosclerotic drugs in current clinical use, including atorvastatin and alirocumab, target hyperlipidemia. Several other drugs have also been investigated in clinical trials as anti-inflammatory agents; the development of some of these agents has been terminated (canakinumab, darapladib, varespladib, losmapimod, atreleuton, setileuton, PF-04191834, veliflapon, and methotrexate), but others remain in development (ziltivekimab, tocilizumab, Somalix, IFM-2427, anakinra, mesenchymal stem cells (MSCs), colchicine, everolimus, allopurinol, and montelukast)...We propose that IL-19 is a promising biomarker and target for the diagnosis and treatment of atherosclerosis. This review considers the role and mechanism of action of IL-19 in atherosclerosis and discusses whether IL-19 is a potential therapeutic target for this condition."
Journal • Review • Atherosclerosis • Cardiovascular • CNS Disorders • Dyslipidemia • Immunology • Inflammation • Multiple Sclerosis • Orthopedics
September 29, 2021
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
(clinicaltrials.gov)
- P2; N=108; Recruiting; Sponsor: Novartis Pharmaceuticals; Not yet recruiting ➔ Recruiting
Clinical • Enrollment open • Immunology • Osteoarthritis • Pain • Rheumatology • CRP • MRI
1 to 25
Of
34
Go to page
1
2