CKD-M808 / Chong Kun Dang - LARVOL DELTA

[VIRTUAL] The role of CT Thorax scans in triaging suspected cases of Covid-19 (ERS 2021) - "BMJ 2020; 369:m1808)...Our data also supports its use in select situations to triage patients to appropriate wards, where there is clinical and microbiological diagnostic uncertainty. However, radiation exposure to the patient must be considered."

Clinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis. (PubMed, Arthritis Res Ther) - "Inhibiting HDAC6 dampens the inflammatory and destructive activity of RA-FLS and reduces the severity of arthritis. Thus, targeting HDAC6 has therapeutic potential."

Epigenetic controller • Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • CCL2 • CXCL10 • CXCL8 • ICAM1 • IL1B • IL6 • MMP1 • MMP3 • VCAM1

First report of pearl millet bacterial leaf blight caused by Pantoea stewartii subspecies indologenes in India. (PubMed, Plant Dis) - "The partial sequence of 16S rRNA gene (primers: 27F/1492R) of the isolate PPi-M1 was amplified, sequenced, and curated sequence submitted to NCBI GenBank (accession number: MN808555)...This study will supplement future pearl millet breeding programs, and to our knowledge, this is the first report of P. s. subsp. indologenes inciting pearl millet leaf blight disease in India."

Journal • Infectious Disease • CAT

First report of leaf spot caused by Colletotrichum siamense on Salix matsudana in China. (PubMed, Plant Dis) - "MW784679 and MW808959 to MW808964 for NHY1-1; MW784726 and MW808965 to MW808970 for NHY1-2; MW784729 and MW808971 to MW808976 for NHY1-3]...This is the first report of C. siamense causing leaf spot of S. matsudana in China and the world. These data will help to develop effective strategies for managing this newly emerging disease."

Journal • Infectious Disease • G3PD • GAPDH • SOD2

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity. (PubMed, J Med Chem) - "Determination of the co-crystal structure of M-808 in complex with menin provides a structural basis for their high-affinity, covalent interactions. M-808 represents a promising, covalent menin inhibitor for further optimization and evaluation toward developing a new therapy for the treatment of MLL leukemia."

Journal • Preclinical • Hematological Malignancies • Leukemia • Oncology