neublastin (ARTN) / Biogen - LARVOL DELTA

The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers. (PubMed, Cell Prolif) - "ARTN is also referred to as Enovin or Neublastin, and bears structural characteristics of the TGF-β superfamily...The emerging role of ARTN in cancers and therapeutic resistance to cancers is also explored. Further research is necessary to determine the function of ARTN in a tissue-specific manner, including its signalling mechanisms, in order to improve the therapeutic potential of ARTN in human diseases."

Journal • Preclinical • Review • Complement-mediated Rare Disorders • Neuralgia • Oncology • Pain

BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy (clinicaltrials.gov) - P2; N=183; Completed; Sponsor: Biogen Idec; Active, not recruiting -> Completed

Trial completion • Biosimilar • Pain

Tissue distribution of S-metabolically labeled neublastin (BG00010) in rats. (PubMed, J Pharm Biomed Anal) - "Products of degradation are excreted in urine or recycled and utilized for resynthesis. The data we generated for NBN provides a first look at the complex clearance mechanisms for this protein and should aid in the design of ADME studies for other heparin binding proteins."

Journal • Preclinical

Neublastin Challenge in Healthy Subjects and Migraine Patients (clinicaltrialsregister.eu) - P1/2; N=48; Ongoing; Sponsor: Centre for Human Drug Research

Clinical • New P1/2 trial