CLYM116 / Climb Bio, Beijing Mabworks Biotech - LARVOL DELTA

A Phase 1 Study of CLYM116 in Normal Healthy Volunteers (clinicaltrials.gov) - P1 | N=58 | Not yet recruiting | Sponsor: Climb Bio, Inc.

New P1 trial

Development and Characterization of CLYM116, a Novel Fc-Engineered Anti-APRIL Monoclonal Antibody (mAb) with pH-Dependent Binding for IgAN (KIDNEY WEEK 2025) - "IND-enabling NHP studies are currently underway. CLYM116’s unique profile may provide robust inhibition of APRIL signaling with potential impact on IgAN pathophysiology."

Glomerulonephritis • IgA Nephropathy • Lupus Nephritis • Nephrology • Renal Disease

CLYM116: anti-APRIL monoclonal antibody for IgAN and other B-cell mediated diseases. (GlobeNewswire) - "IND-enabling studies for CLYM116 are ongoing and the Company expects to share initial preclinical data from this program in the second half of 2025."

Preclinical • IgA Nephropathy

Climb Bio Expands Pipeline Through an Exclusive License to Develop and Commercialize an Antibody Targeting the APRIL Pathway for IgA Nephropathy (GlobeNewswire) - "Climb Bio, Inc...today announced it has entered into an exclusive license agreement with Beijing Mabworks Biotech Co., Ltd...for rights to develop and commercialize MIL116 (now CLYM116), an anti-APRIL (A PRoliferation-Inducing Ligand) monoclonal antibody, in the territory outside of Greater China. Climb Bio believes CLYM116 is a potential best-in-class approach to address significant unmet need in patients with IgA nephropathy and other B-cell mediated diseases... CLYM116 is currently in IND-enabling studies, and Climb Bio plans to share data from the ongoing preclinical studies later in 2025...Under the terms of the agreement, Climb Bio will make an upfront cash payment of $9 million to Mabworks, and will be required to make certain additional payments upon the achievement of specified development, regulatory and commercial milestones, and pay low- to mid-single digit tiered royalties on net sales outside of Greater China."

Licensing / partnership • Preclinical • IgA Nephropathy