dorsomorphin (Compound C) / EMD Serono - LARVOL DELTA

GDF11 activates AMPK-dependent mitophagy to drive osteogenic differentiation of rat bone marrow mesenchymal stem cells. (PubMed, Am J Stem Cells) - "GDF11 enhances the osteogenic differentiation of rBMMSCs by activating AMPK-dependent mitophagy. These findings identify AMPK-dependent Mitophagy as a pivotal mechanism mediating the osteogenic actions of GDF11, providing new mechanistic insights that may guide the development of novel strategies for bone regeneration."

Journal • Preclinical • GDF11 • RUNX2

Engeletin alleviates doxorubicin-induced cardiotoxicity via the AMPK pathway in mice. (PubMed, Front Pharmacol) - "Moreover, utilization of an AMPK inhibitor CC impeded the protective effect of ENG on DIC. ENG has mitigated DIC through the activation of the AMPK pathway, thereby rendering it a potential drug for the prevention and treatment of DIC."

Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • Oncology

Cardioprotective response of remote ischemic preconditioning: Revealing possible role of cannabinoid type 2 receptor and AMPK-mediated autophagy in rats. (PubMed, J Cardiovasc Thorac Res) - "Pre-administration of AM-630 (selective CB2R antagonist; 0.5 and 1 mg/kg;i.p.) and BML-275 i.e. AMP activated protein kinase (AMPK) mediated autophagy inhibitor; 1.5 and 3 mg/kg;i.p.) substantially abrogated the cardioprotective response of RIPC. The current findings highlight the pivotal role of CB2R activation and AMPK activated autophagy in cardioprotective mechanism of RIPC against MIRI."

Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • Myocardial Ischemia • Oncology • Reperfusion Injury • AMPK • CASP3 • CAT • TGFB1 • TNFA • TNNI3

AdipoRon alleviates cerebral ischemic injury through AMPK-dependent microglial autophagy and phenotypic modulation. (PubMed, Mol Cell Neurosci) - "Collectively, our findings indicate that AdipoRon alleviates ischemic cerebral injury by activating the AdipoR1-AMPK signaling pathway, which subsequently enhances autophagy to promote a microglial phenotypic shift characterized by decreased CD16 and increased CD206 expression. These findings provide novel insights into APR neuroprotective mechanisms and highlight its potential as a therapeutic agent for ischemic stroke."

Journal • Cardiovascular • Inflammation • Ischemic stroke • AMPK • MRC1

Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage. (PubMed, Biology (Basel)) - "Excessive phosphorylation of AMPK may co-activate PGC-1α, jointly contributing to cold-induced uterine dysfunction and exacerbated dysmenorrhea. This study reveals potential signaling pathways underlying cold-induced uterine vascular abnormalities, providing novel theoretical foundations and targeted intervention strategies for the prevention and treatment of primary dysmenorrhea."

IO biomarker • Journal • Women's Health • BAX • BCL2 • CASP3 • PECAM1

Adnp2 promotes neural induction by antagonizing the ved/vent homeobox genes. (PubMed, Development) - "adnp2-deficient larvae display aberrant behavioral alterations, which can be partially rescued by the administration of BMP antagonists Dorsomorphin or dnBmpr1 mRNAs. Our findings in zebrafish model reveal an indirect role of Adnp2 in neuroectoderm formation by antagonizing the activities of BMP-related ventralizing genes, which will be useful for understanding neural disorders caused by ADNP2 dysfunction in human."

Journal

SP1-Induced GLS2 Promotes Hypoxia/Reoxygenation-Induced AC16 Cell Injury by Regulating Ferroptosis Via an AMPK/mTOR Signaling Pathway. (PubMed, J Biochem Mol Toxicol) - "Meanwhile, AMPK inhibitor Dorsomorphin overturned the protective effect of GLS2 downregulation on myocardial cells. GLS2 silencing repressed myocardial damage in vivo. SP1-activated GLS2 could aggravate H/R-induced cardiomyocyte injury and ferroptosis by inactivating the AMPK/mTOR pathway, providing a promising therapeutic target for MIRI treatment in the future."

Journal • Cardiovascular • Myocardial Infarction • Myocardial Ischemia • Oncology • Reperfusion Injury • BCL2 • CASP3 • GLS2 • GPX4 • IL6 • TNFA

The fungistatic mechanism of benzaldehyde against the nematophagous fungus Arthrobotrys oligospora suggests a method for manipulating soil fungistasis. (PubMed, Commun Biol) - "Furthermore, the AMPK activator acadesine bolstered BF resistance in A. oligospora, while the AMPK inhibitor dorsomorphin dihydrochloride or knocking out the AMPK gene had the opposite effect. Finally, we found that the fungistatic mechanism of benzaldehyde similarly underlies SF, with the AMPK activators acadesine or metformin effectively increasing the SF resistance of A. oligospora. This study suggests a mechanism by which soil inhibits fungi and offers a potential method for improving SF resistance of fungal biocontrol agents."

Journal

Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation. (PubMed, Eur J Med Res) - "Sestrin2 inhibits ferroptosis to prevent hypertension by activating the AMPK/Nrf2/GPX4 pathway, suggesting its potential as a therapeutic target for hypertension."

Journal • Cardiovascular • Hypertension • AMPK • CD31 • FTH1 • GPX4 • PECAM1

Disruption of cellular calcium homeostasis by duck Tembusu virus facilitates viral replication via AMPK pathway activation. (PubMed, Front Cell Infect Microbiol) - "To modulate Ca²+ levels and AMP-activated protein kinase (AMPK) activity, we used voltage-gated calcium channel (VGCC) blockers (verapamil, diltiazem hydrochloride), a Ca²+ chelator (BAPTA-AM), and an AMPK inhibitor (Compound C)...DTMUV disrupts host Ca²+ homeostasis to activate AMPK, which promotes viral RNA replication. This study provides novel insights into DTMUV pathogenesis and identifies Ca²+-AMPK signaling as a potential anti-DTMUV target."

Journal • Infectious Disease

RESEARCH NOTE: Effect of inhibition of bone morphogenetic protein signaling pathway by dorsomorphin on the establishment of embryo polarity. (PubMed, Poult Sci) - "Additionally, at higher concentrations, dorsomorphin induces enhanced morphological change in isolated anterior cut-half embryos. Taken together, our results suggest that BMP inhibition by dorsomorphin not only inhibits the formation of the anterior primitive streak but also, at higher concentrations, indirectly inhibits the posterior region, possibly by the ectopic recruitment of cells in the non-posterior areas."

Journal

Corin inhibits microglial inflammatory activation by suppressing mitochondrial dysfunction in intracerebral hemorrhage. (PubMed, BMB Rep) - "Targeting corin offers a promising therapeutic strategy for ICH by reducing neuroinflammation and mitochondrial damage through AMPK activation and modulation of microglial inflammatory phenotype polarization. [BMB Reports 2026; 59(2): 143-150]."

Journal • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Inflammation • Metabolic Disorders • Vascular Neurology • CORIN

Dexmedetomidine regulates fatty acid oxidation through the AMPK/PGC-1α/CPT1A pathway to mitigate renal ischaemia-reperfusion injury. (PubMed, Toxicol Appl Pharmacol) - "Dexmedetomidine alleviates RIRI by reducing oxidative stress and promoting fatty acid oxidation through the AMPK/PGC-1α/CPT1A pathway. This study provides a potential therapeutic mechanism for the use of Dex in mitigating RIRI."

Journal • Reperfusion Injury • CPT1A

Anoctamin 5 mutation leads to abnormal bone homeostasis of GDD by regulating AMPK-dependent glucose metabolism. (PubMed, Front Endocrinol (Lausanne)) - "AMPK inhibitor reversed the bone phenotype of GDD by restraining bone formation and restoring osteoclastogenesis. We highlighted the critical role of glucose metabolic distemperedness mediated by AMPK activation in GDD, which developing a potential therapeutic strategy targeted for treatment of GDD."

Journal • Genetic Disorders • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • AMPK • ANO 5 • PPARGC1A • PPARGC1B

Mitochondrial dysfunction and AMPK-associated metabolic reprogramming in zebrafish exposed to fluorinated liquid crystal monomers. (PubMed, Ecotoxicol Environ Saf) - "Targeted metabolomics and KEGG enrichment further confirmed AMPK- associated rerouting of carbon flux toward amino acid-driven anaplerosis. Overall, these findings identify FLCMs as sublethal mitochondrial toxicants and highlight the AMPK-glutamate-TCA axis as a mechanistic hallmark of metabolic disruption, raising concern that such reprogramming may increase susceptibility to metabolic disorders."

Journal • Metabolic Disorders • AMPK

Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: A study in T2DM rat models and palmitic acid-induced BRL 3 A hepatocytes. (PubMed, Tissue Cell) - "Our findings demonstrate that farrerol ameliorates hepatic IR and associated metabolic dysfunctions by regulating the AMPKα1/mTOR/SREBP-1 pathway. Farrerol may be a promising therapeutic target for the treatment of IR in T2DM."

Journal • Preclinical • Diabetes • Dyslipidemia • Hepatology • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus

Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation. (PubMed, Clin Exp Pharmacol Physiol) - "Myocardial ischemia-reperfusion injury (MIRI) causes severe clinical complications in patients. Further analysis showed that GEM administration prevented the I/R-induced decrease in phospho-AMPK levels in ischemic cardiac tissue, and pharmacological inhibition of AMPK with dorsomorphin (DSMF) abolished all cardioprotective effects of GEM. Taken together, these results suggest that GEM mitigates MIRI-induced cardiac injury by inhibiting apoptosis and oxidative stress via modulation of AMPK, supporting its potential for reducing MIRI-related cardiac damage."

IO biomarker • Journal • Preclinical • Cardiovascular • Inflammation • Metabolic Disorders • Myocardial Ischemia • Oncology • Reperfusion Injury • BCL2 • CASP3 • CASP9 • IL1B • IL6 • TNFA

Icariin regulates osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis, potentially via the AMPK-mTOR-autophagy pathway. (PubMed, Toxicol Appl Pharmacol) - "Ica alleviates PMOP by regulating osteogenic/adipogenic differentiation of BMSCs, which may involve the AMPK-mTOR-autophagy pathway."

Journal • Orthopedics • Osteoporosis • Rheumatology

Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway. (PubMed, J Affect Disord) - "Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine. Our findings indicate that repeated sevoflurane exposure during mid-gestation induces depression-like behaviors in postpartum rats, and that ketamine alleviates these behaviors by reducing microglial neuroinflammation and NLRP3 inflammasome activation via the AMPK/SIRT1 signaling pathway."

Journal • Preclinical • Anesthesia • CNS Disorders • Depression • Inflammation • Mood Disorders • Postpartum Depression • Psychiatry • IL18 • IL1B • NLRP3 • TNFA

Sulforaphane-rich aqueous broccoli seed extract suppresses diet-induced obesity via 5-HT2A/AMPK signaling in mice. (PubMed, Phytomedicine) - "In this study, SFN-rich BSH ameliorated obesity in HFD-fed mice via a peripheral 5-HT2A suppression-AMPK activation axis. However, further mechanistic clarification will require studies to more precisely define the role of 5-HT2A in adipocytes."

Journal • Preclinical • Genetic Disorders • Obesity • HTR2A

Vitamin A-activated PPARγ signaling enhances intramuscular fat accumulation by overriding AMPK-mediated inhibition in late-fattening beef cattle. (PubMed, J Anim Sci Biotechnol) - "Strategic late-fattening VA supplementation enhances marbling development through PPARγ-mediated transcriptional networks, with AMPK serving as a metabolic sensor and negative feedback regulator rather than an absolute inhibitor. This stage-specific intervention achieved superior marbling quality and improved fatty acid composition in Woking black cattle, suggesting potential for optimization of premium beef production. Validation across diverse genetic backgrounds and production systems will be essential for broader industry implementation."

Journal • ACACA • AMPK • FABP4 • FASN • PPARG

Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice. (PubMed, Alzheimers Res Ther) - "These findings unveil a previously unrecognized ADRB2-p-AMPKα-p300 axis that AE utilizes to orchestrate chromatin remodeling, counteracting synaptic degeneration and cognitive decline in AD, providing actionable targets for exercise-mimetic therapies."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • ADRB2

Hair growth enhancement via mitochondrial activation by Mito-activator complex. (PubMed, Int J Cosmet Sci) - "The approach of this study to promote hair growth through mitochondrial activation was successful. In addition, when applied to the human body beyond the in vitro level, a significant increase in hair growth was obtained without any side effects. In conclusion, this study suggested a promising candidate for hair loss treatment."

Journal • Alopecia • AMPK

Ad-VT Oncolytic Adenovirus Suppresses Bladder Cancer via cAMP-Dependent AMPK-Raptor Activation and G2/M Arrest. (PubMed, Tumour Virus Res) - "This was confirmed by pathway inhibitors (Dorsomorphin, ESI-09) and siRNA knockdown, which reversed cell cycle arrest and reduced cytotoxicity...Crucially, AMPK inhibition attenuated Ad-VT's antitumor effects. These results demonstrate that Ad-VT exerts potent, tumor-selective activity against bladder cancer by inducing cAMP-dependent AMPK-Raptor-mTOR signaling and G2/M arrest, supporting its therapeutic potential."

Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • AMPK • CCNB1 • CDK1 • CDKN1A

Integrated bioactivity-guided isolation, network pharmacology, and experimental validation to reveal the key constituents and potential mechanisms of Tectona grandis against diabetes and lipid disorders. (PubMed, J Ethnopharmacol) - "This study demonstrated that TG1 from T. grandis exerted dual mechanisms: Firstly, it directly binds to and activates AMPK, thereby mediating the translocation of GLUT4 to the plasma membrane and enhancing glucose uptake in 3T3-L1 adipocytes; secondly, it acts as a mixed-type inhibitor of PL, effectively suppressing its catalytic activity via a static quenching mechanism. These findings provide a scientific validation for the traditional use of T. grandis in Indian medicine and identify TG1 as a promising multi-target lead candidate for the treatment of diabetes and lipid disorders."

Journal • Diabetes • Dyslipidemia • Metabolic Disorders • SLC2A4