ConZip (tramadol ER) / Cipher, RVL Pharma - LARVOL DELTA

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2 | N=20 | Completed | Sponsor: Medical College of Wisconsin | Active, not recruiting ➔ Completed

Trial completion • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2 | N=20 | Active, not recruiting | Sponsor: Medical College of Wisconsin | Recruiting ➔ Active, not recruiting

Enrollment closed • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2 | N=20 | Recruiting | Sponsor: Medical College of Wisconsin | Trial completion date: Mar 2025 ➔ Sep 2025

Trial completion date • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2 | N=20 | Recruiting | Sponsor: Medical College of Wisconsin | Trial completion date: Aug 2024 ➔ Mar 2025 | Trial primary completion date: Aug 2023 ➔ Mar 2024

Trial completion date • Trial primary completion date • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2 | N=20 | Recruiting | Sponsor: Medical College of Wisconsin | Trial completion date: Dec 2023 ➔ Aug 2024 | Trial primary completion date: Dec 2022 ➔ Aug 2023

Trial completion date • Trial primary completion date • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Opioids for pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Addiction (Opioid and Alcohol) • Pain

Comparison table: Some oral/transdermal opioid analgesics. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2; N=20; Recruiting; Sponsor: Medical College of Wisconsin; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Tramadol oral solution (Qdolo) for pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (clinicaltrials.gov) - P2; N=20; Not yet recruiting; Sponsor: Medical College of Wisconsin

Clinical • New P2 trial • Head and Neck Cancer • Mucositis • Oncology • Pain • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Drugs for osteoarthritis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Immunology • Pain • Rheumatology

Experimental Design to Optimize and Maximize Deterrence Capacity of Deterrent Blends (AAPS 2016) - "Methods: The optimum deterrent blend was determined using a simplex lattice design (Minitab® 17.1.0) with tramadol HCl used as a model drug of abuse. Experimental design was successfully employed to determine an optimized composition of deterrent agents to maximize drug binding in all common extraction solvents. Study showed that XCMC can be used in abuse-deterrent formulations as supplied, however clay and medicinal charcoal need to be coated to avoid undesirable binding under non-abuse conditions before they can be used in such formulations."

Clinical • Biosimilar • Pain

Tramadol - I love you... other than the fuzzy head and lack of cognitive but no pain is gooooooood

“My hips are always in pain. Never a day or minute that these hips are not in pain and tramadol is not doing anything to help today.” (Facebook)

Distribution, pharmacokinetics and primary metabolism model of tramadol in zebrafish. (PubMed) - Mol Med Rep - "However, it took 80 min to fall back to the initial value (1.73 µg) in the high‑dose groups, and tramadol was detectable for up to 4 h. This study developed and validated a simple and high throughput analytical procedure to determine the distribution and pharmacokinetic profiles of tramadol, and its primary metabolites in tissues of zebrafish."

Journal • Biosimilar

The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic. (PubMed) - Int J Nanomedicine - "The optimized selected elastic liposomal formulation followed the Higuchi equation and Fickian diffusion and released the drug for a period of 24 hours. The overall results provide much promise for the continued investigation of deformable vesicles as transdermal drug carriers."

Journal • Biosimilar • Pain

Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: A parallel, double-blind, randomized, placebo-controlled clinical trial. (PubMed) - Med Oral Patol Oral Cir Bucal - "According to the VAS and UAC results, this study suggests that 10 mg of oral ketorolac had superior analgesic effect than 50 mg of tramadol when administered before a mandibular third molar surgery."

Journal • Biosimilar • Demo Pain • Pain

Early neurosyphilis presenting with facial palsy and an oral ulcer in a patient who is human immunodeficiency virus positive: a case report. (PubMed) - J Med Case Rep - "Laboratory diagnosis of neurosyphilis is challenging because to date there is no single laboratory test which is considered sensitive enough for diagnosis of the disease, especially in resource-limited settings. Clinical judgment is still an important part of diagnosis; and neurosyphilis should be considered a diagnostic differential in patients with Human Immunodeficiency Virus presenting with central nervous system involvement and in other high-risk patients."

Journal • Biosimilar • Epilepsy • Gene Therapies • Immunology • Pain

“50mg of tramadol neither makes me high nor significantly reduces the pain.”

Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis. (PubMed) - PLoS One - "Outcome assessments such as kinetics (PVF) and evaluation of central sensitisation (RMTS) are discriminant of OA status. Mobility measured by NMA was not discriminant of OA status, however it increased in OA cats with tramadol treatment. Nociceptive hypersensitivity quantified by RMTS was evident in OA cats and was responsive to tramadol treatment."

Journal • Biosimilar • Immunology • Osteoarthritis • Pain

I'm scripted 100mg tramadol a day (I don't take it) for chronic pain. I'll pop 50mg to 100mg generally and smoke a little bit. I get ridiculously itchy sometimes, especially if I exceed 200mg of Tramadol (plus a wave of nausea at the 4 hour mark). (Bluelight)

"I am now on the start of my second period - just spotting at the moment and the pain is excruciating. I have started back on the tramadol which is serving no purpose than making me feel spaced!" (The Hysterectomy Association)

"I don't think I could handle not having my tramadol. It can be habit forming, but is one of the least addictive of all pain killers." (Fibrotalk)

"I am on lots of meds including lyrica, tramadol and fentanyl patches. I get very fatigued quickly. The pain has been too much to bear." (Ko-kr.facebook.com)

Oral oxycodone/naloxone for pain control in liver cirrhosis: observational study in patients with symptomatic metastatic hepatocellular carcinoma. (PubMed, Liver Int) - "OXN may be considered a safe and effective option in the fragile population of cirrhotic patients."

Journal • Biosimilar • CNS Disorders • Demo Pain • Fibrosis • Gastrointestinal Cancer • Hepatocellular Cancer • Immunology • Oncology • Pain • Solid Tumor