XmAb143
/ Xencor
- LARVOL DELTA
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October 06, 2022
XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP
(SITC 2022)
- "Conversely, XmAb143 pharmacodynamics in cynomolgus monkey pilot tox studies was observed only at higher doses, and serum half-life improved from hours to days over WT IL18-Fc. Conclusions XmAb143, our engineered monovalent IL18-Fc fusion demonstrates insensitivity to IL18BP inhibition, robust inflammation activity in vivo, and improved pharmacokinetics in mice and cynomolgus monkeys."
Oncology • IFNG • IL15 • IL18BP • PD-L1
October 05, 2022
Xencor to Present Seven Posters on Multiple Clinical Trials and Research-stage Programs at the SITC Annual Meeting
(Businesswire)
- "Xencor, Inc... today announced seven poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer, being held in Boston, November 10-12, 2022....Data from the first patients enrolled in a Phase 2 study of vudalimab, Xencor’s selective PD-1 x CTLA-4 bispecific antibody, plus chemotherapy in patients with metastatic castration-resistant prostate cancer, will be presented in abstract 668."
P1 data • P2 data • Preclinical • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Kidney Cancer • Oncology • Prostate Cancer • Renal Cell Carcinoma • Solid Tumor • Urothelial Cancer
March 09, 2022
Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP
(AACR 2022)
- "Analysis of serum from the study revealed up to 100-fold increases in IFNγ levels. Our engineered, reduced-potency IL18-Fc cytokines demonstrate robust inflammation activity in vivo, improved pharmacokinetics in mice, and insensitivity to IL18BP inhibition."
IO biomarker • Oncology • IFNG • IL15 • IL18BP • PD-L1
March 08, 2022
Xencor to Present Preclinical Data from XmAb Cytokine Programs at the American Association for Cancer Research (AACR) Annual Meeting 2022
(Businesswire)
- "Xencor...today announced it will present preclinical data on two novel XmAb® cytokine programs...'We look forward to sharing our first preclinical data from two additional wholly owned cytokine programs, a decoy-resistant and potency-reduced IL18-Fc fusion protein, and a LAG-3 targeted IL15/IL15α-Fc fusion protein, which is biased toward binding and activating checkpoint-upregulated lymphocytes that are more likely to be tumor-reactive.'"
Preclinical • Oncology
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