ZP-002 / Zambon - LARVOL DELTA

Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ receptors. (PubMed, Pharmacol Res) - "Moreover, chronically administered in APPswe mice during 2 months, OZP002 prevented learning deficits (in all tests plus place learning in the water-maze) and increased biochemical markers. This study shows that σ PM with high neuropotective potential can be identified, combining pharmacological efficacy, selectivity and therapeutic safety, and identifies a novel promising compound, OZP002."

Journal • Preclinical