enalapril / Generic mfg. - LARVOL DELTA

Changes in cardiac structure and function are associated with health-related quality of life in heart failure patients with reduced ejection fraction: Results from the EVALUATE-HF trial. (PubMed, Eur J Heart Fail) - P4 | "In the EVALUATE-HF trial, increases in mitral e' velocities and decreases in septal E/e' ratio and LAVi were associated with improved KCCQ-12 scores over 24 weeks, after adjusting for treatment assignment. These findings suggest that reductions in left ventricular filling pressures and left atrial size are closely coupled with improved physical function and quality of life in HFrEF patients, which may provide insights into the early benefits of sacubitril-valsartan."

HEOR • Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Human pharmaceuticals surface water pollution across urban gradients in the Buenos Aires Metropolitan Region, Argentina. (PubMed, Environ Toxicol Chem) - "Owing to their average annual concentrations and frequencies, acetaminophen, ibuprofen, carbamazepine, atenolol, enalapril, metformin, and sildenafil were the dominant HAPIs. Shifts in HAPIs frequencies and concentrations around the overall medians were a better indicator of seasonal variations than the absolute values affected by hydrological conditions. This study enhances understanding of the relationship between urbanization and HAPIs surface water pollution in a major metropolitan area of South America, offering valuable data for future HAPIs aquatic ecological risk assessments in the region."

Journal

Safety of Drugs in Breastfeeding Women With CKD. (PubMed, Kidney Int Rep) - "Among renin-angiotensin system inhibitors, enalapril and captopril are safe for breastfeeding. Based on limited evidence, quinapril, benazepril, candesartan, and valsartan are likely acceptable for use during breastfeeding. We found no compelling human data regarding the safety of other renin-angiotensin system inhibitors or sodium-glucose cotransporter type 2 (SGLT2) inhibitors, finerenone, sparsentan, or glucagon-like peptide-1 receptor agonists (GLP1RAs) in lactation. Immunosuppressive agents, including azathioprine, cyclosporine, tacrolimus, budesonide, rituximab, and eculizumab are acceptable for use during breastfeeding. Belimumab is most likely safe; however, data are limited...No studies were found on the safety of breastfeeding while on the newer complement inhibitors, including avacopan, ravulizumab, iptacopan, and pegcetacoplan...Human lactation data on the safety of most drugs used in the treatment of CKD are limited, making evidence-based recommendations..."

Journal • Chronic Kidney Disease • Nephrology • Renal Disease

Primary Aldosteronism in a Patient with 20 Years of Uncontrolled Hypertension: A Case of Non-Lateralizing Adrenal Adenoma (ENDO 2025) - "She remained normotensive for nearly 18 years but later developed uncontrolled hypertension despite maximized doses of enalapril, hydrochlorothiazide, amlodipine, and carvedilol...She was started on spironolactone, achieving blood pressure control with spironolactone 400 mg daily and nifedipine 60 mg daily...In non-lateralizing PA, mineralocorticoid receptor antagonists remain the cornerstone of treatment. Through this report, we emphasize the importance for timely involvement of multidisciplinary care to optimize outcomes and mitigate long-term complications associated with PA."

Clinical • Cardiovascular • Chronic Kidney Disease • Endocrine Cancer • Endocrine Disorders • Hypertension • Nephrology • Obstructive Sleep Apnea • Oncology • Renal Disease • Respiratory Diseases • Sleep Disorder • Solid Tumor

Incidental Papillary Thyroid Cancer in Primary Hyperparathyroidism: A Case Series (ENDO 2025) - "Peri-operatively he had hypertension and was managed with Doxazosin and Enalaprilat. It is unclear if factors such as calcium level or the presence of a malignant parathyroid nodule is associated with incidental PTC in patients with PH."

Clinical • Back Pain • Cardiovascular • Endocrine Cancer • Endocrine Disorders • Fatigue • Genetic Disorders • Hypertension • Metabolic Disorders • Musculoskeletal Pain • Oncology • Pain • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma

PARACHUTE-HF: Randomized trial comparing sacubitril/valsartan with enalapril in patients with HFrEF caused by chronic Chagas cardiomyopathy (ESC-WCC 2025) - No abstract available

Clinical • Cardiomyopathy • Cardiovascular

Left Adrenalectomy For Pheochromocytoma, Describing The Technique Step By Step (ACS-CLINCON 2025) - "Her medical history includes hypertension, diagnosed in April 2022, for which she takes enalapril 20 mg twice a day, and a cesarean section at 23 years old...Patient Position (Work Comfortably) Trocar Placement (Ergonomic) Release of the Splenic Flexure of the Colon and the Splenocolic Ligaments (Exposure)Identification of the Left Kidney, Tail of the Pancreas, and Spleen (Continue to Expose) Identify the Left Phrenic Artery (This Will Lead You to the Problem) Identify the Left Adrenal Gland and Dissect the Perirenal Gerota's Fascia (This is Where the Surgery Begins)Open Gerota's fascia from the diaphragm to the renal hilum, and continue opening it just below the adrenal gland. Identification and Ligation of the Adrenal Vessels (First the Artery, Then the Vein) Extraction of the Surgical Specimen Using a Bag Better do not use drainage Make complete hemostasis, review port closure with the camera and finally make a TAP Block"

Cardiovascular • Endocrine Cancer • Hypertension • Oncology • Pain • Solid Tumor

ECHOCARDIOGRAPHIC EVALUATION OF CAPTIVE BORNEAN (PONGO PYGMAEUS), SUMATRAN (PONGO ABELII) AND HYBRID ORANGUTANS (PONGO SPECIES). (PubMed, J Zoo Wildl Med) - "Subjects were anesthetized with either tiletamine/zolazepam intramuscularly or a combination of tiletamine/zolazepam and medetomidine intramuscularly followed by ketamine intravenously. All patients were intubated and maintained on isoflurane gas anesthesia...One adult male Sumatran orangutan was diagnosed with mild left ventricle dysfunction and treated with enalapril 0.1 mg/kg PO SID...Regular cardiac assessment in orangutans allows early detection of heart disease and enables proactive prevention of heart failure. The study also provided preliminary data establishing heart parameters for the two orangutan species and their hybrids."

Journal • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure

Evaluation of the antihypertensive activity of the aqueous extract and the major flavonoid from Boldoa purpurascens Cav. leaves. (PubMed, Fitoterapia) - "Sprague Dawley rats (n = 34) were divided into six groups: normotensive control, hypertensive untreated, hypertensive + enalapril (15 mg/kg/day), hypertensive + B. purpurascens extract (40 or 80 mg/kg/day), and hypertensive + flavonoid (3 mg/kg/day)...The major flavonoid attenuated organ damage, suggesting therapeutic potential. Future studies should assess the presence of other bioactive compounds in the B. purpurascens extract, as well as clarify the mechanism of action."

Journal • Cardiovascular • CNS Disorders • Hypertension

Letter to the Editor Regarding: "The efficacy and safety of enalapril and propranolol on neurological recovery of isolated severe traumatic brain injury, a randomized clinical trial". (PubMed, World Neurosurg) - No abstract available

Clinical • Journal • CNS Disorders • Vascular Neurology

MAMP - triggered immunity and in silico analysis elucidate the nematicidal properties of Bacillus velezensis VB7 against root-knot nematode Meloidogyne incognita infecting tomato. (PubMed, Microb Pathog) - "Molecular docking confirmed that the Enalaprilat biomolecule had the maximum binding energy ranges from -9.4 to -8.4 Kcal/mol with all the five effector proteins of M. incognita...Additionally, the protein-protein interaction confirmed the coordinated expression of various other genes associated with immune response. The present study confirmed the antinemic potential of B. velezensis VB7 against M. incognita and paved the way to explore the potential of bioagents against plant parasitic nematodes."

Journal • Infectious Disease

Efficacy and safety of calcitriol therapy for reduction of proteinuria in children with chronic kidney disease: an open-label randomized controlled trial. (PubMed, Int Urol Nephrol) - "In children with CKD, the combination of calcitriol and enalapril did not result in significant reduction in proteinuria than enalapril alone. Combination therapy was tolerated well. Further studies with a larger sample size and a longer duration of follow-up studies are needed. Trial registration https://ctri.nic.in CTRI/2011/10/002086. Registered in October 21, 2011."

Journal • Chronic Kidney Disease • Endocrine Disorders • Metabolic Disorders • Nephrology • Renal Disease

Effect of losartan on uric acid metabolism in children with proteinuric kidney disease: crossover randomized controlled clinical trial. (PubMed, Pediatr Nephrol) - "Losartan significantly increased UA urinary excretion along with the consequent reduction in its serum levels."

Clinical • Journal • Chronic Kidney Disease • Nephrology • Pediatrics • Renal Disease

Production of Protein Hydrolysates with Antioxidant and Antihypertensive Activity from Edible Larvae of Aegiale hesperiaris and Comadia redtenbacheri. (PubMed, Foods) - "Additionally, they showed significant angiotensin-converting enzyme (ACE) inhibitory activity, reaching IC50 values of 0.35 and 0.017 μg/mL for WWPH and RWPH, respectively-the latter outperforming the commercial drug Enalapril (IC50 = 0.11 μg/mL)...Peptides from RW also showed low Hill coefficients, suggesting a gradual and sustained interaction with ACE. These findings support the use of insect-derived hydrolysates as promising multifunctional ingredients for the development of functional foods targeting cardiovascular health."

Journal • Cardiovascular

Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling. (PubMed, ALTEX) - "As recently shown, enalapril, propranolol, and fluoxetine form NDSRIs under conditions mimicking the acidic environment in the stomach. The long half-life of fluoxetine suggests a risk of bioaccumulation of its nitrosamine with chronic exposure. These findings indicate that PBK modelling could be a valuable tool as part of a weight of evidence approach in contributing to the risk assessment of nitrosamine impurities in pharmaceuticals."

Journal

The impact of ionic excipients on stabilization of enalapril tablets by the formation of alkaline salt "in situ". (PubMed, Eur J Pharm Biopharm) - "This method effectively inhibits the deethylation to DA and provides uniform tablets with minimal DKP content to ensure long-term five-year stability. In general, these tablets show a lower content of degradation products compared to the stability results reported so far in various generics, and the amount of impurities meets the ICH Q3B (R2) requirements."

Journal

PEACE: Postpartum Evaluation of Nifedipine and Enalapril for Hypertension (clinicaltrials.gov) - P4 | N=850 | Not yet recruiting | Sponsor: Nebraska Methodist Health System

New P4 trial • Cardiovascular • Hypertension

NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans. (PubMed, Front Genet) - "We speculate that NOS3 rs3918188A allele may affect NOS3 gene expression, potentially leading to increased amounts of the vasodilator, nitric oxide (NO) and favourable outcomes in individuals taking antihypertensives drugs such as enalapril. NOS3 genetic variation seems important in the susceptibility to RHTN among Africans and requires further studies."

Journal • Cardiovascular • Hypertension • NOS3

INCIDENCE OF NEW-ONSET HYPERTENSION IN ALLOGENEIC PEDIATRIC STEM CELL TRANSPLANT: A SINGLE CENTER STUDY (EHA 2025) - "The most common antihypertensive agents used were Nifedipine (75%), Amlodepine (37.5%), and Enalapril (6.25%) as first-line treatment while Labetolol (12.5%)in second line and Clonidine(12.5%) in 3rd line of therapy...The minimum duration for continuation of anti-HTN therapy was 6 months, and the maximum duration was 2 years, which correlates with the immunosuppressive drugs (Cyclosporine) intake... The incidence of hypertension during the HSCT and early post-HSCT period is high. Younger age at HSCT was significantly associated with hypertension severity. However, further studies are required to confirm the findings."

Clinical • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Cardiovascular • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Hypertension • Leukemia • Neutropenia • Oncology • Pediatrics • Transplantation

Morphological and functional response of Mytilus galloprovincialis exposed to the Enalapril metabolite, Enalaprilat. (PubMed, Environ Toxicol Pharmacol) - "No changes were observed in both DG and gill extracts in the relative transcript abundance of hsp70, neither in the relative protein expression, while a tissue-specific modulation of antioxidant enzymes CAT and SOD was observed in gills and DG. Overall, our data suggest that environmental exposure to Enalaprilat, by activating inflammatory and oxidative stress responses, may potentially affect animal homeostasis."

Journal • Eosinophilia • Inflammation

Crebbp Gene Mutation In A Child With Steroid-Resistant Nephrotic Syndrome: A Rare Association (ERA 2025) - "Initial treatment with oral prednisolone (2 mg/kg/day) failed to induce remission after 6 weeks, classifying him as SRNS...The child was treated with cyclosporine-A (5 mg/kg/day) and enalapril (up to 0.5 mg/kg/day), with steroid tapering... This case highlights a novel association between CREBBP gene mutation and SRNS in the absence of classical RTS features. The role of CREBBP in podocyte function and glomerular integrity warrants further investigation. Genetic testing in early-onset SRNS remains crucial for diagnosis and management, even in the absence of syndromic features."

Clinical • Cardiovascular • Developmental Disorders • Glomerulonephritis • Hypertension • Lupus Nephritis • Mental Retardation • Nephrology • Renal Disease • CREBBP

Normolipidemic lipoprotein glomerulopathy with IgA nephropathy — ApoE Kyoto Mutation: A case report (ERA 2025) - "After 18 months of enalapril treatment without lipid-lowering therapy, the patient's renal function and blood lipid levels were stable and urine protein levels were significantly ameliorated. We presented a rare case of LPG (Kyoto) with IgAN without abnormal blood lipids and other typical clinical manifestations. Therefore, for patients with unremarkable clinical manifestations, renal biopsy is of great value for definite diagnosis of disease."

Case report • Clinical • Dyslipidemia • Glomerulonephritis • IgA Nephropathy • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Renal Disease • APOE

Sex-based differences in glomerular lesions linked to intrarenal lipid accumulation. (ERA 2025) - "Males exhibited more severe glomerular lesions, including mesangial expansion, mesangiolysis, foam cell accumulation, and activated PECs. Enalapril provided renal protection, with more pronounced benefits in females. These findings underscore the importance of considering sex differences in the pathophysiology and treatment of CKD."

Chronic Kidney Disease • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • APOE

Antenatal diagnosis of Antineutrophil Cytoplasmic Antibody (ANCA)- associated vasculitis and latent Tuberculosis (TB) managed with Rituximab during the 2nd trimester: A Case Report of a Successful Pregnancy (UKKW 2025) - "She was also started on enalapril which is safe in breast feeding. This case report highlights a successful pregnancy in a patient with AAV and latent TB diagnosed in the 1st trimester who was treated with Rituximab only to reduce the risk of vasculitis flare. The importance of multidisciplinary involvement for complex pregnancy patients is highlighted to optimise better health outcomes for mother and child."

Case report • Clinical • ANCA Vasculitis • Glomerulonephritis • Gynecology • Infectious Disease • Obstetrics • Pediatrics • Respiratory Diseases • Tuberculosis • Vasculitis • MPO

Evaluation of pharmacotherapy in sickle cell disease in an Afro- Colombian community: A cross-sectional analytical study in San Basilio de Palenque, Bolívar. (PubMed, Intractable Rare Dis Res) - "The most commonly used medications included folic acid, analgesics (paracetamol, tramadol, naproxen, codeine, ibuprofen, morphine), L-glutamine, and enalapril...Notably, 62% of homozygous patients were not receiving baseline treatment with hydroxycarbamide, increasing their risk of complications...In conclusion, this research highlights the need for a multidisciplinary approach to optimize treatment and improve the quality of life of affected patients. Given its genetic significance, San Basilio de Palenque represents a unique setting for further studies on SCD."

Journal • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease