OvaSave (ovalbumin) / Sangamo Therap - LARVOL DELTA

Yanghe Pingchuan granule promotes BMSCs homing in asthmatic rats by upregulating miR-139-5p and downregulating Notch1/Hes1 pathway (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "YHPC granule can enhance the inhibitory effect of BMSCs homing on Th2 inflammatory response in asthmatic rats by up-regulating miR-139-5p and down-regulating Notch1/Hes1 pathway."

Journal • Asthma • Immunology • Inflammation • Respiratory Diseases • Transplantation • CXCR4 • HES1 • IFNG • IL4 • MIR139 • NOTCH1

Exploring the Potentialities of Photoinduced Glycation to Steer Protein Functionalities: The Study Case of Freeze-Dried Egg White Proteins/Carbohydrates Mixtures. (PubMed, Foods) - "Samples were then analyzed for selected physical (critical concentration, particle size and viscosity), chemical (ovalbumin content) and technofunctional properties (gelling temperature and foaming capacity)...Photoinduced glycation was associated to a decrease in viscosity, a tendency to form gel at temperature lower by up to 8 °C and a better capacity of foam stabilization. The intensity of these changes seems to be affected by the nature of the carbohydrates reacting with proteins, with longer carbohydrates able to produce systems with higher foam stability capacity."

Clinical • Journal

Repeated allergic asthma in early versus late pregnancy differentially impacts offspring brain and behavior development. (PubMed, Brain Behav Immun) - "The inflammatory responses from maternal allergic asthma in early gestation and resulting increases in anxiety-like behavior in males support a link between the timing of prenatal insults and sex-specific developmental outcomes. Moreover, the heightened stress responses in late gestation and concomitant dampened inflammatory response to allergic asthma suggest that interactions between the maternal immune and stress-response systems shape early life fetal programming."

Journal • Asthma • Autism Spectrum Disorder • Genetic Disorders • Immunology • Inflammation • Mood Disorders • Psychiatry • Respiratory Diseases • CSF3 • IFNG • IL4 • IL7 • TNFA

Mouse models of atopic dermatitis: a critical reappraisal. (PubMed, Exp Dermatol) - "We suggest that valid AD models should at least meet the following criteria: a) an AD-like epidermal barrier defect with reduced filaggrin expression along with hyperproliferation, hyperplasia; b) increased epidermal expression of thymic stromal lymphopoietin (TSLP), periostin and/or chemokines such as TARC (CCL17); c) a characteristic dermal immune cell infiltrate with overexpression of some key cytokines such as IL-4, IL-13, IL-31 and IL-33; d) distinctive "neurodermatitis" features (sensory skin hyperinnervation, defective beta-adrenergic signaling, neurogenic skin inflammation and triggering or aggravation of AD-like skin lesions by perceived stress); and e) response of experimentally induced skin lesions to standard AD therapy. Finally, we delineate why humanized AD mouse models (human skin xenotransplants on SCID mice) offer a particularly promising preclinical research alternative to the currently available "AD" mouse models."

Journal • Preclinical • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Transplantation • IL13 • IL4 • POSTN

Anti-Inflammatory Effect of Mangiferin on an Experimental Model of Allergic Rhinitis through the Inhibition of NF-κB Signaling Pathways. (PubMed, J Environ Pathol Toxicol Oncol) - "In this investigation, we used ovalbumin-provoked AR to examine the antiallergic, anti-inflammation activities of mangiferin...Moreover, mangiferin reduced signs of ciliary loss, vascular congestion in the lamina, goblet cell elevation, and eosinophil filtration in the AR model. Hence, our findings suggest that mangiferin is a promising approach for immunotherapy in AR disease."

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation • Oncology • Otorhinolaryngology • STAT3

Protective Effects of Korean Herbal Remedy against Airway Inflammation in an Allergic Asthma by Suppressing Eosinophil Recruitment and Infiltration in Lung. (PubMed, Antioxidants (Basel)) - "The PGT mixture was orally gavaged to mice (PM group, 20 mg/mouse/day) from 7 days before sensitization with ovalbumin (OVA) (day -7)...When treating PGT on murine lung epithelial cells stimulated by papain, there was a significant reduction in IL-33 mRNA expression levels. Taken together, oral delivery of PGT successfully alleviated asthmatic responses provoked by OVA in a mouse model and could lead to novel therapies for allergic asthma."

Journal • Asthma • Immunology • Inflammation • Respiratory Diseases • IL13 • IL5

Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a guinea pig model of cough variant asthma. (PubMed, J Ethnopharmacol) - "HCZP ameliorated the symptoms of guinea pigs with CVA induced by OVA by regulating the Th1/Th2 imbalance and TLR4 receptors."

IO biomarker • Journal • Asthma • Immunology • Inflammation • Respiratory Diseases • GATA3 • IFNG • IL4 • IL5 • TNFA

Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis. (PubMed, Pharmaceuticals (Basel)) - "The MEO (0.1 v/v %) was aerosolized by a nebulizer to ovalbumin and PM10-induced asthmatic mice...PM10-induced phosphorylation of JAK2 and STAT3 was significantly decreased by MEO. Collectively, MEO may have an inhibitory effect on asthma under the condition of PM10 exposure through the IL-6/JAK2/STAT3 signaling pathway."

Journal • Asthma • Fibrosis • Immunology • Pain • Respiratory Diseases • IL6

Influence of the Treatment Used in Inflammatory Bowel Disease on the Protease Activities. (PubMed, Int J Gen Med) - "Among the 20 CD patients, 17 were treated with aminosalicylates, 14 with azathioprine, and 4 with corticosteroids, while 8 patients were undergoing biological treatment...Proteolytic activities were determined against different substrates (gelatine, haemoglobin, ovalbumin, albumin, cytochrome C, and casein), and haemoglobin was the optimal substrate...2. The decrease of protease activities in patients with CD and UC in remission may be a marker suggesting the patients' response to the treatment."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immune Modulation • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway. (PubMed, Biochem Pharmacol) - "The therapeutic effect of IMP on asthma was evaluated by a lung inflammation mouse model which was induced by ovalbumin (OVA)...Furthermore, IMP binds well to MRGPRX2 protein. The binding constant (K) is 4.48 ± 0.49 ×10 M. The data suggeste that IMP is a novel inhibitor of MRGPRX2 to treat allergic asthma."

Journal • Allergy • Asthma • Immunology • Inflammation • Pneumonia • Respiratory Diseases • MIP-2 • TNFA

Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation. (PubMed, Allergy) - "Our data indicate that STC1 deficiency in asthmatic airways promotes STIM1 hyperactivity, enhanced ASM contraction and AHR. STC1 may be a candidate EpDRF."

Journal • Asthma • Immunology • Inflammation • Respiratory Diseases • IL13 • STC

A mouse allergic asthma model induced by shrimp tropomyosin. (PubMed, Int Immunopharmacol) - "This study aims to develop an alternative murine model induced by shrimp tropomyosin (ST) instead of ovalbumin (OVA)...We find severe structural changes in animals upon prolonged exposure to ST, including goblet cell hyperplasia, collagen deposition, and smooth muscle thickening. In conclusion, ST-induced asthma is a simple murine model for studying pathogenesis of asthma and evaluating new therapeutic drugs."

Journal • Allergy • Asthma • Immunology • Inflammation • Respiratory Diseases • IL4 • IL5

CD8 T-lymphocyte driven limbic encephalitis results in temporal lobe epilepsy. (PubMed, Ann Neurol) - "These data indicate that a CD8 T-cell initiated attack of distinct hippocampal neurons is sufficient to induce LE converting into TLE-HS. Intriguingly, the role of CD8 T-cells exceeds neurotoxic effects and points to their major pathogenic role in TLE following LE."

Journal • CNS Disorders • Epilepsy • Immunology • CD8 • MRI

Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation. (PubMed, Ther Adv Respir Dis) - "Sixty-four BALB/c mice, with pulmonary inflammation induced by ovalbumin were treated with anti-IL17A (7.5/µg per dose, intraperitoneal) and/or Rho-kinase inhibitor (Y-27632-10 mg/kg, intranasal), 1 h before each ovalbumin challenge (22, 24, 26, and 28/days)...We observed no difference in angiogenesis after treatment with Rho-kinase inhibitor and anti-IL17. Although the treatments did not show differences in angiogenesis, they showed differences in the markers involved in the angiogenesis process contributing to inflammation control and vascular remodeling.The reviews of this paper are available via the supplemental material section."

Journal • Asthma • Immunology • Inflammation • Pneumonia • Respiratory Diseases

Astragalus Polysaccharides Attenuate Ovalbumin-Induced Allergic Rhinitis in Rats by Inhibiting NLRP3 Inflammasome Activation and NOD2-Mediated NF-κB Activation. (PubMed, J Med Food) - "In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. These findings indicate that APS has the potential to be used as a therapeutic agent for AR."

Journal • Allergic Rhinitis • CNS Disorders • Immunology • Inflammation • Mood Disorders • Psychiatry • Sleep Disorder

The effect of polyunsaturated fatty acid deficiency on allergic response in ovalbumin-immunized mice. (PubMed, Prostaglandins Leukot Essent Fatty Acids) - "However, levels of VLC-PUFAs in the small intestine increased after OVA-sensitization and did not decrease during EFAD diet administration, showing that small intestinal VLC-PUFAs levels were strongly preserved in the food-allergy model mice. Further studies are required to elucidate the mechanisms by which small intestinal VLC-PUFAs are retained in food-allergy model mice."

Journal • Allergy • Food Hypersensitivity • Immunology

TxCell and Ferring International Center sign collaboration, option, development and license agreement for TxCell’s lead product Ovasave for the treatment of IBD (TxCell Press Release) - TxCell SA...and Ferring International Center SA...announces the signing of a collaboration, option, development and license agreement potentially worth up to €76 million plus royalties subject to the achievement of milestones."; Anticipated new P2 b trial in H2 2014.

Anticipated new P2 trial • Licensing / partnership • Inflammatory Bowel Disease

TxCell re-acquires full rights to its lead product Ovasave (TxCell Press Release) - "TxCell SA...today announces that it has agreed with Trizell Holding SA (Trizell)...to terminate the collaboration, option, development and license agreement concerning TxCell’s lead product Ovasave...TxCell has now regained full rights to Ovasave...TxCell now proposes to amend the CATS29 phase IIb trial for Ovasave, currently underway in refractory Crohn ’s disease patients...TxCell intends to recommence the trial in Q2 2016, with the drug product manufactured by MaSTherCell...TxCell expects to complete recruitment in CATS29 at the end of 2017 and announce topline data by Q4 2017 or Q1 2018."

Anticipated enrollment status • Anticipated P2 data • Licensing / partnership • Inflammatory Bowel Disease

TxCell to lead POSITIVE project to automate first production step of Ovasave(R), its lead personalised cellular immunotherapy (The Wall Street Journal) - "TxCell SA...announces today the launch of, and funding awarded to, the POSITIVE project in collaboration with the Gene and Cell therapy Unit (UTCG)...The POSITIVE project will focus on the development and establishment of a procedure to automate the first step of manufacturing of Ovasave...TxCell will receive a grant of EUR 250,000 and UTCG will receive EUR 167,000. Both grants will be for the performance of experiments by TxCell and UTCG and the optimization of the resulting new automated and standardized procedure."

Clinical • Financing • Inflammatory Bowel Disease

TxCell financial results for the first half of 2014 (TxCell Press Release) - "The increase of operating expenses can be explained mainly by the launch of Col-Treg development, the upcoming start of the phase IIb clinical study with Ovasave® and employer contributions on stock-option subscriptions granted during the first half of 2014."

Commercial • Inflammatory Bowel Disease