perindopril arginine / Generic mfg. - LARVOL DELTA

Study of the efficacy and safety of sacubitril-valsartan versus perindopril in the treatment of patients with heart failure (ChiCTR) - P4 | N=220 | Not yet recruiting | Sponsor: The Affiliated Hospital of Yunnan University; The Affiliated Hospital of Yunnan University

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

The effect of Sacubitril/valsartan On Long-term oUtcomes in nonparoxysmal atrial fibrillation paTients wIth adverse left atrial remOdeling after ablatioN (SOLUTION trial) (ChiCTR) - P4 | N=210 | Recruiting | Sponsor: Wujin Hospital Affiliated with Jiangsu University; Wujin Hospital Affiliated with Jiangsu University

New P4 trial • Atrial Fibrillation • Cardiovascular

Myxedema coma following urgent subdural hematoma drainage surgery: a case report (Euroanaesthesia 2025) - "Myxedema coma is a rare and severe cause specially in older adults with thyroid dysfunction.1,2 This report highlights a case of myxedema coma in the postoperative of an urgent subdural hematoma (SDH) drainage.Case Report: A 92-years-old women with medical history of hypertension and hyperthiroidism, medicated with lanzoprazol 15 mg id, furosemide 40 mg id, perindopril 5 mg id, levetiracetam 500mg 3id, atorvastatina 10 mg id and methimazol 5 mg id, presented to the hospital with altered mental status scoring 9 to 14 in the Glasgow Coma Scale (GCS)...The laboratory tests revealed a severe hypothyroidism (free thyroxine 0,11 ng/dl and thyroid-stimulating hormone 109 uU/ml).After urgent endocrinological consultation the patient begun 200 mcg of intravenous levothyroxine followed by 25mcg orally with a rapid and significant improvement...Its diagnosis requires a higher degree of suspicion. Timely intervention and endocrinological collaboration are essential to reduce..."

Case report • Clinical • Surgery • Anesthesia • Cardiovascular • CNS Disorders • Endocrine Disorders • Hypertension

Case Report: VV-ECMO as a bridge to recovery from ACE inhibitor induced post-obstructive negative pressure pulmonary edema. (PubMed, Front Med (Lausanne)) - "This case underscores the critical role of VV-ECMO as a bridge to recovery from severe NPPE. It also highlights the need to raise clinicians' awareness of the potential life-threatening side effects of the commonly used antihypertensive drug perindopril."

Journal • Cardiovascular • Respiratory Diseases

Xinyang Tablets ameliorate ventricular remodeling in heart failure via FTO/m6A signaling pathway (PubMed, Zhongguo Zhong Yao Za Zhi) - "Mice were randomized into sham, model, XYP(low, medium, and high doses), and positive control( perindopril) groups(n= 10)...Furthermore, FTO knockdown reversed the protective effects of XYP-containing serum on Ang Ⅱ-induced cardiomyocyte hypertrophy. In conclusion, XYP may ameliorate ventricular remodeling by regulating the FTO/m6A axis, thereby inhibiting the activation of the PI3K/Akt signaling pathway."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Genetic Disorders • Heart Failure • Immunology • Obesity • FTO

SARTAN-AD: Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients (clinicaltrials.gov) - P2 | N=23 | Terminated | Sponsor: Sunnybrook Health Sciences Centre | N=150 ➔ 23 | Trial completion date: Sep 2023 ➔ Feb 2025 | Recruiting ➔ Terminated | Trial primary completion date: Sep 2023 ➔ Feb 2025; Lack of recruitment.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Alzheimer's Disease • CNS Disorders

Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring. (PubMed, J Transl Med) - "This study established a comprehensive AH proteomic signature of DR progression, offering insights into the pathogenesis of DR and highlighting potential biomarkers and novel therapeutic targets."

Biomarker • Journal • Cataract • Diabetes • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders • Type 2 Diabetes Mellitus • RBP4 • SPP1

Monotherapy Blood Pressure Response and Control-Rates in Treatment-Naïve Patients with Arterial Hypertension: A Randomized Comparison of Four Different Antihypertensive Drug Classes. (PubMed, Kidney Blood Press Res) - "Initial antihypertensive monotherapy failed in most patients (73% uncontrolled, 21%/18% at optimal treatment goal at TP1) even in low-risk patients, with efficacy varying by drug class (inhibitors of the renin-angiotensin-aldosterone system best, HCT least). These findings support guideline-recommended combination therapy."

Journal • Monotherapy • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension

Potential of Combination Pharmacotherapy in Patients with Arterial Hypertension and Prediabetes: Focus on Organ Protection. (PubMed, Kardiologiia) - "The combination including moxonidine was associated with a significant decrease in fasting plasma insulin that was more pronounced than with the diuretic treatment.Conclusion    In patients with AH and prediabetes, the combination therapy including perindopril, metformin and moxonidine provided a significant improvement in the structural and functional state of the LV myocardium and intrarenal vascular resistance comparable to the improvement produced by a combination of perindopril, metformin and sustained-release indapamide. The combination of an ACE inhibitor, biguanide and moxonidine may in some cases be a preferred pharmacotherapy option for patients with AH and early carbohydrate metabolism disorders due to the observed significant metabolic benefits."

Journal • Cardiovascular • Hypertension • Metabolic Disorders • Pulmonary Arterial Hypertension

Repositioning Perindopril for Mitigation of Methotrexate-Induced Hepatotoxicity in Rats. (PubMed, Pharmaceuticals (Basel)) - "These events were reflected in the morphological appearance of the different studied groups. This study presents perindopril as a promising remedy for mitigation of the hepatotoxic effects that occur as a consequence of treatment with methotrexate."

Journal • Preclinical • Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Oncology • AMPK

Preventing Cardiomyopathy in Duchenne Muscular Dystrophy: Long-Term Follow-Up of Patients in the Randomised, Placebo-Controlled Drug-Trial of Perindopril and Bisoprolol. (PubMed, Eur J Neurol) - "While some patients may have benefited from 'early' (active) as opposed to 'delayed' (placebo) initiation of perindopril and bisoprolol, group-mean ventricular function did not differ between study arms after 60 months. Small numbers, absence of a control group, insensitivity of echo-ejection fraction, and additional drug use probably prevented divergence between groups."

Clinical • Journal • Cardiomyopathy • Cardiovascular • Duchenne Muscular Dystrophy • Genetic Disorders • Heart Failure • Muscular Dystrophy

Xinyin tablets affect mitophagy and cardiomyocyte apoptosis to alleviate chronic heart failure by regulating histone deacetylase 3(HDAC3)-mediated PTEN induced putative kinase 1(PINK1)/Parkin signaling pathway. (PubMed, J Ethnopharmacol) - "Xinyin tablets have potential as an intervention for CHF by improving mitophagy and inhibiting cardiomyocyte apoptosis through the HDAC3-mediated PINK1/Parkin signaling pathway."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • BAX • CASP3 • CASP9 • HDAC3 • PINK1

Ramipril, perindopril and trandolapril as potential chemosensitizers in ovarian cancer: considerations for drug repurposing. (PubMed, Drug Discov Today) - "Moreover, clinical data have shown that using ACE-Is with standard chemotherapy prolongs patient survival. Based on this rationale, we discuss the available in vitro models of OC for future studies with ACE-Is and demonstrate an in silico approach that has enabled us to select the most promising molecules: perindopril, ramipril, trandolapril and their diketopiperazine derivatives."

Journal • Review • Oncology • Ovarian Cancer • Solid Tumor

Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways. (PubMed, Immunopharmacol Immunotoxicol) - "Furthermore, the protective combination therapy downregulated NF-κB-p65, P53, Keap-1, and C-FOS, while upregulating Mammalian sirtuin 1 (SIRT1), inhibitor of nuclear factor kappa B (Iκβ), nuclear factor erythroid 2-related factor 2 (Nrf2), and Heme oxygenase-1 (HO-1) levels. The findings reveal the potential clinical application of combining Diosmin and perindopril to reduce AMC-induced nephrotoxicity, which requires further research in clinical settings."

Journal • Preclinical • Inflammation • Renal Disease • CST3 • FOS • HMOX1 • KEAP1 • KIM1 • SIRT1

Dissolving microneedle patch for transdermal delivery of perindopril erbumine. (PubMed, Inflammopharmacology) - "Skin irritation studies confirmed the biocompatibility of the formulation, with no significant adverse effects observed. These findings highlight the potential of Perindopril Erbumine-loaded dissolving microneedles as a promising transdermal delivery system for improved therapeutic outcomes in managing hypertension and inflammation-related vascular conditions, potentially reducing inflammation through enhanced and targeted drug delivery."

Journal • Cardiovascular • Gastrointestinal Disorder • Hypertension • Inflammation

Amlodipine-Associated Angioedema: An Integrated Pharmacovigilance Assessment Using Disproportionality and Interaction Analysis and Case Reviews. (PubMed, J Clin Med) - "Significant safety signals were detected for amlodipine alone and in combination with aliskiren, specific ACE inhibitors (quinapril, benazepril, trandolapril, fosinopril, perindopril), and certain ARBs (candesartan, losartan). While these results should not discourage appropriate clinical use, they emphasize the importance of monitoring for angioedema, particularly during therapy initiation. The findings from this study need to be validated in prospective studies for further elucidation of the underlying mechanisms."

Adverse events • Journal • Cardiovascular • Hypertension

A study combining blood pressure medication with standard treatment in advanced melanoma. ACE-IT-001 (ANZCTR) - P1/2 | N=30 | Recruiting | Sponsor: Calvary Mater Newcastle | Not yet recruiting ➔ Recruiting

Enrollment open • Melanoma • Oncology • Solid Tumor • PD-L1

The role of single-pill ACE inhibitor/ccb combination for hypertension: an Algerian view via the nominal group technique. (PubMed, Future Cardiol) - "The evidence indicated that this combination reduces cardiovascular outcomes and visit-to-visit BP variability, effectively controls 24-hour BP, and is well tolerated. In conclusion, the perindopril/amlodipine SPC provides a valuable new treatment option for hypertension in Algeria."

Journal • Cardiovascular • Hypertension

Application of spectrophotometry in novel simultaneous dissolution profiling of a single pill triple therapy of amlodipine, perindopril and indapamide; whiteness evaluation. (PubMed, BMC Chem) - "Simple, diverse univariate spectrophotometric methods were developed and validated for the determination of amlodipine besylate (AM), perindopril arginine (PE), and indapamide (ID). These methods were successfully applied to determine AM, PE, and ID in bulk powder, as well as in Triplixam® tablets, without interference from excipients and in different used dissolution media. The whiteness of the method was evaluated, demonstrating its excellent environmental, analytical and practical efficiency."

Journal

Perindopril-Induced Collagenous Colitis: Case Report and Literature Review. (PubMed, Gastro Hep Adv) - "The intrinsic imputability of perindopril as the causative agent of microscopic colitis is considered to be reasonable by the French accountability technique. There was no rechallenge test conducted."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology

Simplified Approach to Managing Newly Diagnosed Patients with Mild-to-Moderate Hypertension in Routine Clinical Practice. (PubMed, Adv Ther) - "Data from routine Canadian clinical practice indicate that a perindopril/amlodipine SPC is associated with significant BP reductions from baseline in a broad range of participants with different cardiovascular risk factors and may represent an appropriate first-line treatment for subjects with newly diagnosed hypertension."

Journal • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders

Enhancing the practicality along with greenness sustainability of a high throughput HPLC-MS/MS bioanalytical method for the simultaneous determination of amlodipine, perindopril, and its active metabolite perindoprilat in human plasma: Application to a pharmacokinetic study. (PubMed, J Chromatogr A) - "The developed method is fast, accurate, sensitive, reproducible, ecofriendly, sustainable and suitable for the determination of the concentration of the cited analytes in human plasma. Moreover, it was applied for the bioequivalence study of a generic product to the innovator."

Journal • PK/PD data • Acute Myelogenous Leukemia

Study of the Acidic, Basic, and Thermal Degradation Kinetics of Three Antihypertensive Drugs-Individually and in Combination. (PubMed, Pharmaceutics) - "Great care must be taken when formulating FDCs with these three drugs, as well as solutions or oral suspensions adjusted for geriatric or pediatric populations, since the stability of all three drugs is greatly affected by pH conditions, as well as light or oxidation factors and their interactions."

Journal • Acute Myelogenous Leukemia • Cardiovascular • Hypertension • Pediatrics

Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling. (PubMed, Medicina (Kaunas)) - "These effects had a mitigating impact on VPA-induced histopathological and electron microscopic changes in the hippocampal tissues. Perindopril may emerge as a promising agent for amelioration of the pathologic changes of autism spectrum disorders."

Journal • Preclinical • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Inflammation • Psychiatry • JAK2 • PPARG

Letter to the Editor Regarding "Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril- or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims Database Analysis". (PubMed, Adv Ther) - No abstract available

Claims database • Journal • Real-world • Real-world evidence • Cardiovascular