perindopril arginine / Generic mfg. - LARVOL DELTA

CHARACTERISTICS OF CARDIOHEMODYNAMICS AND THE EFFECTIVENESS OF PHARMACOTHERAPY IN PATIENTS WITH COPD COMBINED WITH PULMONARY AND ARTERIAL HYPERTENSION (ERS 2026) - "Patients were divided into two subgroups: the 1st group (n=35) received standard therapy (ACE inhibitor (perindopril)), the second group (n=31) received standard therapy and perindopril with L-carnitine...In both groups, a reduction in right ventricular end-diastolic dimension by 5.6% and 8.5% (44.3±0.13 cm and 43.01±0.10 cm) and a decrease in right ventricular end-systolic dimension by 14.3% and 19.4% were observed, accompanied by an increase in right ventricular stroke volume by 13.61% and 22.83%, respectively. The cardiac output (1.69±0.2 L/min and 1.76±0.4 L/min) and an ejection fraction increased by 4% and 6% were noted."

Clinical • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Arterial Hypertension • Respiratory Diseases

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson's Disease in Swiss Albino Mice. (PubMed, Ann Afr Med) - "RAS modulators demonstrated significant neurobehavioral protection in MPTP-induced Parkinsonism, suggesting their potential as adjunct therapeutic agents in PD."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • RAS

Clinical analyses of angiotensin-converting enzyme inhibitor users presenting with cough to a chest diseases outpatient clinic: A single-center retrospective study. (PubMed, J Int Med Res) - "Perindopril use was more common in the non-pulmonary group, whereas ramipril use was more common among patients with pulmonary cough (p = 0.015). C-reactive protein levels were higher in the pulmonary group (10.87 vs. 5.67 mg/L, p = 0.010), whereas other hematological parameters did not differ significantly.ConclusionsIn the angiotensin-converting enzyme inhibitor-treated patients presenting with cough, shorter symptom duration, absence of dyspnea, and lower C-reactive protein levels may be more compatible with non-pulmonary or presumed angiotensin-converting enzyme inhibitor-related cough, whereas prolonged cough, dyspnea, and elevated C-reactive protein levels may support the consideration of a pulmonary pathology. These findings are hypothesis-generating and require prospective validation."

Journal • Retrospective data • Cardiovascular • Cough • Hematological Disorders • Pulmonary Disease • Respiratory Diseases • CRP

Metabolic and Inflammatory Adverse Drug Reactions Associated with Amlodipine: A Descriptive and Disproportionality Analysis of EudraVigilance Reports. (PubMed, Pharmaceuticals (Basel)) - " "Hyperglycaemia" could be considered a safety signal for amlodipine, compared to beta-blockers (e.g., bisoprolol-ROR: 2.56), ACE inhibitors (e.g., ramipril-ROR: 2.82), and sartans (e.g., candesartan-ROR: 3.85). "Metabolic syndrome" was reported for amlodipine with a lower probability than for hydrochlorothiazide (ROR: 0.35). Inflammatory signals (e.g., increased C-reactive protein) appeared less frequently for amlodipine than for certain renin-angiotensin-aldosterone system inhibitors (e.g., perindopril-ROR: 0.53)...Reports of inflammation likely reflect patient comorbidities rather than a direct drug effect. These findings demonstrate that post-marketing surveillance remains essential, even when accounting for the methodological limitations of spontaneous reporting."

Adverse drug reaction • Journal • Cardiovascular • Diabetes • Genetic Disorders • Hypertension • Inflammation • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • CRP

A Retrospective, Observational Study of Adherence, Persistence and Clinical Outcomes with Perindopril-Based Single-Pill or Free-Pill Antihypertensive Treatments in Italy. (PubMed, Adv Ther) - "SPCs are associated with sustained, better adherence and persistence to antihypertensive pharmacological treatments compared with FPCs, which may contribute to real-world clinical benefits. Graphical abstract available for this article."

Clinical data • Journal • Observational data • Retrospective data • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypertension

EFFICACY OF PERINDOPRIL IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION. (PubMed, Georgian Med News) - "Perindopril therapy is associated with significant clinical improvement, LVEF recovery, and positive reverse cardiac remodeling in patients with HFrEF. Both perindopril and sacubitril/valsartan demonstrate comparable efficacy in reducing cardiac dimensions and optimizing NYHA functional status. Furthermore, perindopril maintains a favorable safety profile with low nephrotoxicity, confirming its potential as an effective therapeutic option in HFrEF management."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

Liver sinusoidal endothelial cell (LSEC) defenestration in chronic heart failure is primarily dependent on cardiac diastolic dysfunction and is reversed by sodium-glucose cotransporter 2 inhibitor but not by angiotensin-converting enzyme inhibitor. (PubMed, Cardiovasc Res) - "LSEC defenestration was primarily driven by cardiac diastolic dysfunction, not by impaired liver perfusion or hepatocyte function, and was independent of biomarkers of congestive hepatopathy in the murine model of CHF in Tgαq*44 mice. As fully reversed by SGLT2-I, but not by ACE-I, LSEC defenestration arises as a target in the treatment of the cardiohepatic axis in CHF, which is not uniformly improved by CHF pharmacotherapy."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology

Digital pharmacoepidemiology of angiotensin-converting enzyme inhibitors in Russia. (PubMed, Front Pharmacol) - "Search queries were analyzed for six major ACE inhibitors (captopril, enalapril, lisinopril, perindopril, ramipril, fosinopril), as well as for their brand names (21 drugs in total). The identified digital patterns may indirectly reflect medication-related information needs and potential gaps in the population's health literacy. The infodemiological approach represents a promising tool for monitoring patients' information needs and optimizing clinical communication and preventive programs."

Journal • Cardiovascular • Hypertension

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence. (PubMed, Am J Cardiovasc Drugs) - "In this long-term, real-world study, SPC use was associated with better adherence, reduced HCRU, and lower healthcare costs compared with FPC regimens. These economic benefits were evident within 1 year and may yield substantial long-term savings for national health systems, given the high prevalence and chronic nature of hypertension."

HEOR • Journal • Real-world evidence • Cardiovascular • Hypertension

Nebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices. (PubMed, J Hypertens) - "Nebivolol was the most effective at reducing the factors, associated with HT induced cellular senescence of endothelium, through reducing TGF-β1."

Journal • Cardiovascular • Hypertension • Oncology • ANGPT1 • CCL2 • FGF • HIF1A • IGF1 • TGFB1 • TNFA • TP53BP1

Cardiac function assessment using GLS in breast cancer chemotherapy: A study of representative cases where GLS measurement was useful. (JBCS 2026) - "She underwent epirubicin + cyclophosphamide therapy and trastuzumab + pertuzumab + docetaxel therapy as neoadjuvant therapy, followed by breast-conserving surgery...Although the decrease in EF was mild, the decrease in GLS was considered an early sign of cardiac dysfunction, and perindopril 2 mg was initiated for cardioprotective purposes...This case is representative of cases where cardiac dysfunction could be detected early through GLS measurement, enabling treatment intervention and continuation of chemotherapy. GLS measurement is considered a useful indicator in cardiac function management during breast cancer chemotherapy, and this case is reported with a brief literature review."

Clinical • Breast Cancer • Congestive Heart Failure • Heart Failure • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor

Behavioral Effects of Renin-Angiotensin System Modulators in a Rotenone-Induced Model of Parkinson's Disease in Wistar Albino Rats. (PubMed, Cureus) - "RAS modulation using angiotensin-converting enzyme inhibitors and angiotensin receptor blockers demonstrated significant improvement in motor and behavioral parameters in a rotenone-induced PD model. These findings suggest the potential therapeutic utility of these agents in mitigating both motor and non-motor manifestations associated with PD. However, further biochemical, histopathological, mechanistic, and clinical investigations are required to establish their potential neuroprotective role."

Journal • Preclinical • CNS Disorders • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Facilitatory effects of LY404187, a positive allosteric modulator of AMPA receptors, on swallowing initiation in anesthetized male rats. (PubMed, Arch Oral Biol) - "These results suggest that LY404187 facilitates the initiation of mechanically induced swallows via AMPAR activation."

Journal • Preclinical • Anesthesia

Peripheral endothelial and coronary microvascular responses to lipophilic versus hydrophilic ACE inhibitors in newly diagnosed hypertension. (PubMed, J Hypertens) - "In patients with newly diagnosed hypertension, both lipophilic and hydrophilic ACE inhibitors improve peripheral endothelial and coronary microvascular function. The absence of a significant differential effect, particularly for CFR, supports a predominant class effect. While quinapril showed numerically greater improvements in FMD, this did not reach statistical significance, highlighting heterogeneity across vascular beds and warranting caution in interpreting surrogate markers."

Journal • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Hypertension

Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial. (PubMed, Am J Hypertens) - "Besides mean SBP, higher variability, cumulative load, slope and last measures of diastolic BP, PP and MAP were associated with increased risk of cognitive decline/dementia."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Hypertension

Hypertension and myocardial fibrosis: A systematic review and meta-analysis. (PubMed, Clin Radiol) - "The extent of MF is closely associated with various factors, underscoring the importance of its identification in hypertensive patients. Histology and T1 mapping parameters are effective for quantifying MF. Due to the variable effects of antihypertensive medications on MF, the use of specific agents to mitigate MF in hypertensive patients is recommended."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hypertension • Immunology

Efficacy of primary cardioprotection with perindopril, bisoprolol, and trimetazidine in high-risk patients with breast and gastric cancer receiving anthracycline- and trastuzumab-containing therapy. (ASCO 2026) - "AC (doxorubicin/cyclophosphamide) regimen was administered in 54 BC patients, AC followed by T in 30 BC pts, T – in 8 GC pts. In high-risk pts with BC and GC receiving anthracycline- and trastuzumab-containing therapy, primary CPT with perindopril, bisoprolol, and trimetazidine effectively prevents adverse cardiac remodeling, preserves myocardial systolic function, reduces the incidence of cardiovascular complications, and is associated with a significant reduction in one-year all-cause mortality."

Clinical • Breast Cancer • Congestive Heart Failure • Coronary Artery Disease • Gastric Cancer • Heart Failure • Oncology • Solid Tumor

AIFA-CARDIO-129: Pharmacological optimization in prevention in Heart Failure: A Sex-gap? (clinicaltrialsregister.eu) - P4 | N=368 | Recruiting | Sponsor: Policlinico San Donato S.p.A. | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Congestive Heart Failure • Heart Failure

Yiqi Huoxue Formula Promotes Post-Myocardial Infarction Angiogenesis by Modulating Mitochondria-Associated Membranes (MAMs) and Calcium Homeostasis via the cGMP/PKG Signaling Pathway. (PubMed, J Ethnopharmacol) - "This study demonstrates that MI/hypoxia impairs endothelial function by disrupting the structural and functional integrity of MAMs. YQHX effectively preserves MAMs architecture and restores intracellular Ca2+ signaling via the cGMP/PKG signaling axis, thereby promoting post-MI angiogenesis and improving cardiac performance. These findings identify a novel therapeutic target for MI and highlight the unique advantages of traditional Chinese medicine formulas in modulating subcellular organelle interactions.However, given the inherent variability of botanical materials, these mechanistic findings are based on a single validated batch, and future multi-batch standardizations are warranted."

Journal • Cardiovascular • Myocardial Infarction • Myocardial Ischemia • CD31 • HSPA9 • PECAM1 • VDAC1

Patterns and determinants of drug-drug interactions among community-dwelling older adults in Saudi Arabia: a cross-sectional study. (PubMed, Front Pharmacol) - "Amlodipine, aspirin, and insulin were the most commonly implicated medications, while atorvastatin, perindopril, and gliclazide were frequently involved in severe interactions. Although many interactions were classified as moderate or severe, most required monitoring rather than therapy modification, and their clinical relevance may vary depending on dosage and treatment context. Routine DDI screening and pharmacist-led medication review may enhance medication safety."

Journal • Observational data • Cardiovascular • Hypertension

Blood pressure lowering for the prevention of REcurrent stroke and Cardiovascular outcomes After acute intracerebral haemorrhage: protocol for an individual Participant data meta-analysis of randomised controlled trials (RECAP-ICH). (PubMed, Cerebrovasc Dis) - "We will undertake an IPD meta-analysis, with TRIDENT (Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial) serving as our anchor study, and three other major RCTs of BP lowering treatment for secondary prevention with a subgroup of at least 100 ICH patients: ESPRIT (Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing Risk of Vascular Events) trial, PROGRESS (Perindopril Protection Against Recurrent Stroke Study), and RESPECT (Recurrent Stroke Prevention Clinical Outcome) Study...A sensitivity analysis will treat death as a competing risk. The time to benefit of BP lowering will also be estimated according to specific absolute risk reduction thresholds."

Journal • Retrospective data • Cardiovascular • Cerebral Hemorrhage • Diabetes • Hematological Disorders • Hypertension • Metabolic Disorders • Myocardial Infarction

Serelaxin has greater anti-fibrotic potential than perindopril but maintains its anti-fibrotic efficacy in the presence of perindopril in normotensive mouse models of heart disease. (PubMed, Life Sci) - "These findings confirmed that RLX had greater anti-fibrotic potential than perindopril, but could be applied as a rapidly-acting adjunct therapy to ACEi."

Journal • Preclinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hypotension • Immunology • Myocardial Infarction

A flavour of death: perindopril induced thick melanoma and bcc of the back: the special link to the drug mediated nitroso photo carcinogenicity (EADV-Sp 2026) - "Following alert checks confirming their post-existence in diabetes drugs, anti- smoking drugs, a number of antibiotics, ACE inhibitors, Sartans, thiazide diuretics, ranitidine, but probably a number of others, the decision has been taken to give the green light to their permissible availability...Initial ten courses of immunotherapy with pembrolizumab were started...Conclusions The potential pro-carcinogenic effects of both nitrosamines and the generic substance of perindopril are discussed. Special attention is drawn to the Nitroso Photocarcinogenicity, triggered via the permanent drug intake."

Basal Cell Carcinoma • Diabetes • Melanoma • Metabolic Disorders • Non-melanoma Skin Cancer • Skin Cancer • Skin Nodular Basal Cell Carcinoma • Solid Tumor • BRAF

The Nitrosamine contamination in Beta blockers , ACE inhibitors , thiazides diuretics , calcium channel blockers, sartans and the subsequent skin cancer development and progression: Apocalypse now (EADV-Sp 2026) - "In practice, mankind faces the problem of certainly over 1 billion patients taking nitrosamine-contaminated drugs: 280 million patients with depression (antidepressants), over 1 billion patients with arterial hypertension (antihypertensive drugs), over half a billion patients with type 2 diabetes mellitus (oral antidiabetic drugs/metformin/ sitagliptin), over 4 billion patients with gastritis (ranitidine), over 5 million with tuberculosis (rifampicin), and probably a number of others...Figure.1a-e: 1a: 4 patients 1a: Drug-induced basal cell carcinoma (Bisoprolol/ Lisinopril) in the area under the left eyelid and immediately above the nasolabial fold. 1b: Drug-induced (Hydrochlorothiazide/ Felodipine) basal cell carcinoma in the medial orbital angle...Nitrosamine contamination in beta blockers seems to have the same procarcionogenic effect as Perindopril and Candesartan preparations. Results For the first time in the scientific literature, the contributory..."

Acute Lymphocytic Leukemia • Basal Cell Carcinoma • Brain Cancer • CNS Disorders • Colorectal Cancer • Depression • Diabetes • Gastrointestinal Cancer • Gastrointestinal Disorder • Genetic Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Melanoma • Metabolic Disorders • Neuroblastoma • Non-melanoma Skin Cancer • Oncology • Pulmonary Arterial Hypertension • Rectal Cancer • Respiratory Diseases • Skin Cancer • Solid Tumor • Tuberculosis • Type 2 Diabetes Mellitus

Profound Asymptomatic Hyponatremia Associated With Anuric Acute Kidney Injury: Successful Controlled Correction Using Short Intermittent Hemodialysis. (PubMed, Cureus) - "We describe the case of a 66-year-old hypertensive woman receiving hydrochlorothiazide and perindopril who presented 10 days after cataract surgery with severe anuric AKI, profound asymptomatic hyponatremia (104 mmol/L), hyperkalemia (6.6 mmol/L), elevated creatinine (143 mg/L), and urea (2.6 g/L). This approach enabled progressive correction of serum sodium to 126 mmol/L over four consecutive sessions without exceeding recommended safety thresholds and without neurological complications. This case highlights that meticulously tailored short-duration intermittent hemodialysis can achieve safe sodium correction while addressing life-threatening metabolic indications, suggesting a potential alternative when continuous renal replacement therapy is unavailable."

Journal • Acute Kidney Injury • Cardiovascular • Cataract • Heart Failure • Nephrology • Ophthalmology • Renal Disease