Aerospan (flunisolide HFA) / Viatris, AbbVie - LARVOL DELTA

Treatment of allergic rhinitis and allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison table: Some nasal sprays for seasonal allergic rhinitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation

Enhanced host protection and survival to Listeria monocytogenes infection after small molecule innate training (IMMUNOLOGY 2024) - "Here, we aim to show the protective potential of flunisolide (FN) using live infection model...Furthermore, FN mice showed improved survival up to d7. We showed FN can induce innate training, altering BM landscape at homeostasis and after infection, with improved response to L. monocytogenes."

Hematological Disorders • Infectious Disease • Inflammation

Identifying the predictive role and the related drugs of oxidative stress genes in the hepatocellular carcinoma. (PubMed, Cancer Rep (Hoboken)) - "Our findings indicate that OS related-genes have a favorable prognostic value for HCC, which sheds new light on the relationship between oxidative stress and HCC, and suggests potential therapeutic strategies for HCC patients."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor

Identification of potential biomarkers in the peripheral blood of neonates with bronchopulmonary dysplasia using WGCNA and machine learning algorithms. (PubMed, Medicine (Baltimore)) - "Moreover, we predicted flunisolide, budesonide, and beclomethasone as potential anti-BPD drugs. The genes CYYR1, GALNT14, and OLAH have the potential to serve as diagnostic biomarkers for BPD. This may prove beneficial in clinical diagnosis and prevention of BPD."

Biomarker • Journal • Machine learning • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

The Rising Cost of Rhinologic Medications. (PubMed, Ann Allergy Asthma Immunol) - "The rising cost of highly utilized medications contribute to increased patient acquisition costs and may pose barriers of drug adherence to particularly vulnerable populations."

Journal • Allergy • Immunology • Otorhinolaryngology

In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data. (PubMed, Int J Mol Sci) - "Using genes from top-activated pathways, we detected several promising small molecules to reverse MS immune cells' transcriptomic signatures, including AG14361, FGIN-1-27, CA-074, ARP 101, Flunisolide, and JAK3 Inhibitor VI. Among these molecules, we also detected an FDA-approved MS drug Mitoxantrone, supporting the reliability of our approach."

Journal • Cardiovascular • CNS Disorders • Hypertension • Immunology • Multiple Sclerosis • JAK3

Targeted glucocorticoid analysis using ion mobility-mass spectrometry (IM-MS). (PubMed, J Mass Spectrom Adv Clin Lab) - "LC-IM-MS was used to characterize 16 glucocorticoids including three isomer pairs: cortisone/prednisolone, betamethasone/dexamethasone, and flunisolide/triamcinolone acetonide. Despite the relatively modest resolution of isomer pairs under standard conditions (i.e., nitrogen drift gas, sodiated ions, etc.), improvements were observed for alkaline earth and transition metals (notable barium adducts) and in carbon dioxide drift gas. In summary, LC-IM-MS offers potential as a clinical method due to its ease of coupling with traditional LC-MS methods and its promise for tuning separations to better resolve targeted and/or global isomers in complex biological samples."

Journal

Drugs for allergic rhinitis and allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology

Supercritical CO Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate. (PubMed, Pharmaceutics) - "In particular, in the range investigated, optimal pressure and temperature conditions for the extraction of residual organic solvents were found working at 200 bar and 40 °C, which corresponds to a CO density of 0.840 g/cm. Operating in this way, total organic solvent residues were reduced from 13,671 ppm and 326 ppm to 12 ppm and 10 ppm for Fluni and Fluti, respectively."

Journal

Comparison table: Some nasal sprays for allergic rhinitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Immunology

What makes flunisolide different among inhaled corticosteroids used for nebulization: a close look at the role of aqueous solubility. (PubMed, Multidiscip Respir Med) - "Furthermore, in vivo simulation studies demonstrate that the intersubject variability of the inhaled dose among asthmatic children was much greater for suspensions of fluticasone propionate and beclomethasone dipropionate than for those of flunisolide. The physicochemical properties and pharmacokinetic profile of flunisolide favor its employment in nebulization."

Journal • Asthma • Immunology • Respiratory Diseases

Expanded table: Correct use of inhalers for asthma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Immunology • Respiratory Diseases

Network perturbation analysis in human bronchial epithelial cells following SARS-CoV2 infection. (PubMed, Exp Cell Res) - "Overall, lung involvement and RDS could be generated by the activation and down regulation of diverse gene pathway involving respiratory cilia and muscle contraction, apoptotic phenomena, matrix destructuration, collagen deposition, neutrophil and macrophages recruitment."

Journal • Acute Respiratory Distress Syndrome • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases

Table: Correct Use of inhalers for COPD. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Chronic Obstructive Pulmonary Disease • Respiratory Diseases

Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. (PubMed, Front Endocrinol (Lausanne)) - "Additionally, flunisolide effectively suppressed the responses of proliferation and MCP-1/CCL-2 production from IL-13 stimulated lung fibroblasts from silica- or saline-challenged mice. In conclusion, we report that intranasal treatment with the corticosteroid flunisolide showed protective properties on pathological features triggered by silica particles in mice, suggesting that the compound may constitute a promising strategy for the treatment of silicosis."

Journal • Preclinical • Fibrosis • Immunology • CCL2 • CCL3 • CXCL1 • IL13 • MIP-2

UPLC-MS based urine untargeted metabolomic analyses to differentiate bladder cancer from renal cell carcinoma. (PubMed, BMC Cancer) - "UPLC-MS urine metabolomic analyses could not only differentiate cancers from HCs but also discriminate BC from RCC. In addition, pathway analyses demonstrated a deeper metabolic mechanism of BC and RCC."

Journal

Molecular Dissection of an Inhibitor Targeting the Hiv Integrase Dependent Pre-Integration Complex Nuclear Import. (PubMed, Cell Microbiol) - "Significantly, Budesonide or its analogue Flunisolide, were able to effect a significant reduction in the presence of specific nuclear forms of the HIV DNA (2-LTR circles), suggesting that the inhibitors work though blocking IN, and potentially PIC, nuclear import. The work presented here represents a platform for further development of these specific inhibitors of HIV replication with therapeutic and prophylactic potential."

Journal

Epistaxis Risk Associated with Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis. (PubMed, Otolaryngol Head Neck Surg) - "While a differential effect on epistaxis among INCS agents is not clearly demonstrated, this meta-analysis does confirm an increased risk of epistaxis for patients using INCSs as compared with placebo for treatment of allergic rhinitis."

Journal • Retrospective data • Review

Quality by design (QbD) approach for design and development of drug-device combination products: A case study on flunisolide nasal spray. (PubMed, Pharm Dev Technol) - "A design space plot within which the CQAs remained unchanged was established at laboratory scale. In conclusion, this study demonstrated how QbD based development approach can be applied to the development of drug device combination products with enhanced understanding of impact of formulation, process and device variables on CQAs of drug device combination products."

Clinical • Journal

In Vivo-Relevant Transwell Dish-Based Dissolution Testing for Orally Inhaled Corticosteroid Products. (PubMed, Pharm Res) - "The in vivo-relevant Transwell dish-based "respirable" aerosol dissolution test system was developed, kinetically discriminative in accordance with the ICS solubility, but indistinguishable for a given ICS between the marketed products."

Journal • Preclinical

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. (PubMed, Am J Physiol Lung Cell Mol Physiol) - "...All transcriptomes revealed agents beneficial for mitigating AHR; however, only the vagal ganglia transcriptome identified agents used clinically to treat asthma (flunisolide, isoetarine). We also tested one compound identified by vagal ganglia transcriptome profiling that had not previously been linked to asthma and found that it had bronchodilator effects in both mouse and pig airways. These data suggest that transcriptome profiling of the vagal ganglia might be a novel strategy to identify potential asthma therapeutics."

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