lorazepam / Generic mfg. - LARVOL DELTA

Impact of Beers Criteria Medications in Elderly Patients with Head and Neck Cancer (COSM 2025) - "The three most common medications were Lorazepam, Alprazolam, and Zolpidem. Over half of patients aged 65 and over with head and neck cancer were prescribed one or more Beers Criteria Medications to Avoid and 5.4% were prescribed three or more in the year following their cancer diagnosis. Increased prescription of Beers Criteria medications was associated with inferior overall survival and increased emergency department utilization. Further research regarding how to minimize the use of these medications in elderly patients with head and neck cancer is warranted."

Clinical • Gastrointestinal Disorder • Head and Neck Cancer • Oncology • Pain • Solid Tumor

Utilizing Neonatal Pain and Sedation score (N-PASS) as an objective tool for weaning and escalating sedative medications in neonatal patients. (PAS 2025) - "The process that was implemented included nursing assessment and charting of N-PASS scores on all neonates and infants who are on continuous infusion or scheduled sedative medications (defined as dexmedetomidine, lorazepam, midazolam, or morphine) in the NICU with every hands-on assessment. Within a month of intervention, N-PASS sedation score charting by nurses increased to 74% from 50%. Target sedation scores were documented in progress notes 37% of the time compared to less than 25% prior to intervention. During our 2nd PDSA cycle we were able to further increase nursing charting to 80% and Physician documenting sedation target scores to 50%."

Clinical • Anesthesia • Pain

Utilization of Analgesia, Sedation, and Psychotropic Medications in the Intermountain Health Neonatal Intensive Care Units (PAS 2025) - "Exposure to opioids was most common (25%), followed by sedatives (22%) and psychotropic medications (3%).The largest statistically significant rise in exposure rates was seen with Dexmedetomidine (88% increase), Ketamine (81% increase), and Fentanyl (59% increase), while rates of use of Lorazepam, Midazolam, and Pentobarbital were greatly decreased. Between 2018 and 2023, 17159 infants were admitted to Intermountain Health NICUs. Five thousand sixty-four (30%) were exposed to at least one of the drugs of interest. Any exposure was inversely associated with birthweight and length of stay (p < 0.001) but not with sex, race, or mortality."

Anesthesia • CNS Disorders • Critical care • Pain

Drugs repurposed against morphine and heroin dependence: molecular docking, DFT, MM-GBSA-based MD simulation studies. (PubMed, In Silico Pharmacol) - "We found vilazodone, indinavir, and lorazepam as potential drugs based on their affinity and mechanism of action. We propose that these three drugs have huge potential to reverse the morphine and heroin dependence in diseased subjects near future. The online version contains supplementary material available at 10.1007/s40203-025-00347-z."

Journal • Addiction (Opioid and Alcohol) • Pain • TLR4

Ketamine for Sedation in Severe Traumatic Brain Injury (clinicaltrials.gov) - P4 | N=50 | Suspended | Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine | Recruiting ➔ Suspended

Trial suspension • Anesthesia • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Hypertension • Vascular Neurology

Is My Patient Diverting Their Lorazepam? (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report. (PubMed, Front Psychiatry) - "Therefore, primidone was added and gradually titrated to 50 mg/day...As we gradually replaced diazepam with lorazepam, the patient insisted on discharge...The successful management of tremors with a combination of neuroinhibitory therapies suggested an effective strategy for complex cases. Further studies are needed to better understand the long-term impacts and risks of tiletamine dependence."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Movement Disorders • Psychiatry

Circadian rhythm in end-of-life delirium: a secondary analysis of two randomized controlled trials. (PubMed, J Pain Symptom Manage) - "Delirious patients were more restless between 3 pm and 11 pm. This observation of "sundowning" may help clinicians to better anticipate this symptom, schedule monitoring and treatments, and educate patients and caregivers."

Clinical • Journal • Anesthesia • CNS Disorders • Oncology • Palliative care

"Do We Have to Tell Him He Hasn't Been Getting Ativan?": Truth Telling for a Patient with Nonepileptic Seizures. (PubMed, Narrat Inq Bioeth) - "While most truth telling cases center on navigating cultural differences or worries about emotional harm, this case presented concerns about medical harm in the form of exacerbating the patient's condition. The authors describe the complex patient-family-team dynamic that preceded this ethical dilemma, describe the case, analyze the ethical issue, and describe the outcome."

Biomarker • Clinical • Journal • Observational data • Retrospective data • Review • CNS Disorders • Epilepsy

Psychiatric Emergencies in Children and Adolescents: A Comprehensive Profile and Short-term Outcome Evaluation in a Prospective Follow-up Study. (PubMed, Indian J Psychol Med) - "Lorazepam and clonazepam were the most commonly prescribed medications at first visit (baseline)...Olanzapine was the most common drug prescribed during follow-up visits. The CGI scores decreased, while CGAS scores increased, reflecting improved functioning. The significant improvement in CGI and CGAS scores over follow-ups demonstrates the effectiveness of crisis intervention and pharmacotherapy in stabilizing clinical severity and enhancing functioning in the short term."

Journal • Bipolar Disorder • CNS Disorders • Mental Retardation • Psychiatry

Clinical Efficacy of Sleep Induction Intervention in Conjunction with Lorazepam in Managing Insomnia Disorder. (PubMed, Psychiatry Clin Psychopharmacol) - "Compared to the control group that received only lorazepam treatment, the observation group, who underwent sleep induction intervention, showed a better treatment effectiveness rate, sleep quality, and psychological state regarding the treatment of sleep disorders (P < .05). Sleep induction intervention can improve the overall treatment effectiveness rate of sleep disorders, enhance sleep quality, and alleviate symptoms of anxiety and depression."

Journal • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

NEUROLEPTIC MALIGNANT SYNDROME ASSOCIATED WITH REVERSE TAKOTSUBO CARDIOMYOPATHY - Hossam Albeyoumi Mohammed (ACC 2025) - "During her stay, she required ziprasidone and haloperidol for agitation...Coronary CTA demonstrated normal coronary arteries.Decision-making: The patient was treated with dantrolene and lorazepam every 6 hours, which improved both her NMS and cardiac function... This case highlights the importance of recognizing NMS and its rare association with Takotsubo cardiomyopathy, which can mimic myocardial infarction. Prompt identification and treatment can lead to resolution of cardiomyopathy."

Cardiomyopathy • Cardiovascular • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Movement Disorders • Myocardial Infarction • Psychiatry

The Importance of Accurate Drug Use History in Diagnosing and Managing Cannabinoid Hyperemesis Syndrome: A Case Report. (PubMed, Cureus) - "Upon cessation of cannabis use and symptomatic treatment with mirtazapine, quetiapine, and lorazepam, the patient showed complete resolution of symptoms and remained asymptomatic.This case highlights the diagnostic challenges of CHS and underscores the importance of targeted questioning about cannabis use in patients presenting with cyclical vomiting. Clinicians should maintain a high index of suspicion, especially in cases resistant to conventional antiemetic therapy. Early recognition and patient education regarding cannabis cessation are critical to preventing recurrence and improving long-term outcomes."

Journal • CNS Disorders • Infectious Disease • Mood Disorders • Pain • Psychiatry • Substance Abuse

Guanfacine as an Adjunct Treatment for Complex Post-Traumatic Stress Disorder: A Case Report. (PubMed, J Korean Acad Child Adolesc Psychiatry) - "Initial management with promethazine, melatonin, and lorazepam, and later aripiprazole and fluoxetine provided limited relief. This case underscores the difficulties in treating Complex PTSD with comorbid conditions, and highlights guanfacine as a potential adjunct therapy. However, further research is required to validate its efficacy and safety."

Journal • Autism Spectrum Disorder • CNS Disorders • Cognitive Disorders • Developmental Disorders • Genetic Disorders • Mood Disorders • Pediatrics • Post-traumatic Stress Disorder • Psychiatry • Suicidal Ideation

The Head and the Heart: Ventricular Assist Device and Bipolar Disorder (ISHLT 2025) - "After mood stabilization, he was discharged home 46 days post-VAD on lithium and olanzapine for BP-I, in addition to metoprolol, losartan, dapagliflozin, tadalafil, and anticoagulation with apixaban...After a 39 day admission, he was discharged home on aripiprazole and lorazepam...In the setting of good hemodynamic support, he is not listed for heart transplant while undergoing psychiatric medication optimization.Summary VAD support with concomitant BP-I disorder is a complex decision requiring multi-disciplinary collaboration, individualized care, and reliable mental health resources. We highlight an unmet need for optimal mental healthcare facilities for patients on VAD support."

Bipolar Disorder • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Mood Disorders • Pediatrics • Psychiatry

Azithromycin-induced Adolescent Manic Episode with Psychotic Features: A Case Report. (PubMed, Innov Clin Neurosci) - "At presentation, the patient received an intramuscular injection consisting of haloperidol 10mg and diphenhydramine 50mg, followed by olanzapine 10mg, diazepam 20mg, and lorazepam 5mg orally on account of his severe agitation. The patient demonstrated relative improvement in both the inpatient and outpatient settings, with no relapse despite eventual discontinuation of psychotropic medication. We report, to our knowledge for the first time, that AZT monotherapy might induce a manic episode with psychotic features in adolescent patients with no psychiatric medical history."

Journal • Bipolar Disorder • CNS Disorders • Infectious Disease • Mental Retardation • Mood Disorders • Otorhinolaryngology • Pain • Psychiatry • Vertigo

Computational Assessment of GABA Receptor Modulation in PTSD (clinicaltrials.gov) - P4 | N=150 | Not yet recruiting | Sponsor: VA Office of Research and Development | Trial completion date: Mar 2029 ➔ Jun 2029 | Initiation date: Apr 2025 ➔ Jul 2025 | Trial primary completion date: Mar 2029 ➔ Jun 2029

Trial completion date • Trial initiation date • Trial primary completion date • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Post-Resection Catatonia in a Pediatric Patient with Choroid Plexus Carcinoma (P11-6.014). (PubMed, Neurology) - "Family reported rapid improvement in his responsiveness following lorazepam 3 mg given prior to brain MRI, followed by decline in mental status over several hours...Dr. Risen has nothing to disclose."

Journal • Brain Cancer • CNS Disorders • Oncology • Pediatrics • Psychiatry • Solid Tumor • Ventriculomegaly

SOX1-Positive Encephalitis Presenting as New-Onset Refractory Status Epilepticus (NORSE): A Rare Paraneoplastic Manifestation (P3-8.012). (PubMed, Neurology) - "Despite IV lorazepam, levetiracetam, and phenytoin, her seizures persisted and she required sedation, intubation, and ICU monitoring...She was treated with IV methylprednisolone and IVIG. She again started to have focal seizures and her antiepileptic dose was adjusted and was given IV rituximab...Sharma has nothing to disclose. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff."

Journal • Anesthesia • Brain Cancer • CNS Disorders • Epilepsy • Lung Cancer • Oncology • Solid Tumor

Recurrent Propofol-Induced Seizure-Like Phenomena: Unmasking a Rare Neurological Complication in Anesthesia (P7-2.003). (PubMed, Neurology) - "She was treated with lorazepam and clonazepam, after which the movements slowed, and her neurological symptoms resolved completely over six weeks. The institution of Dr. Shah has received research support from Xenon Pharma."

Journal • Anesthesia • CNS Disorders • Movement Disorders • Orthopedics

Not Meningioma: A Case Report (P9-6.019). (PubMed, Neurology) - "Lorazepam was administered with delayed but good effect and patient was started on levetiracetam. Vienneau has nothing to disclose. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff."

Journal • B Cell Lymphoma • Brain Cancer • CNS Disorders • CNS Tumor • Epilepsy • Follicular Lymphoma • Hematological Malignancies • Lymphoma • Meningioma • Non-Hodgkin’s Lymphoma • Oncology • Solid Tumor

Medically Refractory Nonconvulsive Status Epilepticus in ARIA with Lecanemab (P1-3.017). (PubMed, Neurology) - "Seizures have been reported in aducanumab-induced ARIA...The seizure was treated with lorazepam IV and levetiracetam IV load. Continuous EEG showed focal NCSE in the right temporal region (maximal at P4/T6/O2) corresponding to the known ARIA-E location, which continued after a second dose of lorazepam with loading of lacosamide...Dr. Uhlmann has nothing to disclose."

Journal • Alzheimer's Disease • CNS Disorders • Epilepsy • Hematological Disorders • Pain

Acquired Hepatocerebral Degeneration: The Second Brain (HNS and CNS) (P8-5.029). (PubMed, Neurology) - "Involuntary movements were diagnosed as Tardive Dyskinesia (TD) secondary to SSRI and Metoclopramide, which were discontinued during prior admissions...Low-dose Ativan was trialed, as it is not metabolized by the liver...De Jesus has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Medtronic Inc. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff."

Journal • ADHD (Impulsive Aggression) • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Hepatic Encephalopathy • Hepatology • Liver Cirrhosis • Movement Disorders • Parkinson's Disease • Psychiatry

Appropriate Intervention Techniques and Optimization Programs for Children and Adolescents with Varying Degrees of Emotional Issues (ChiCTR) - P=N/A | N=500 | Not yet recruiting | Sponsor: Shenzhen Kangning Hospital; Shenzhen Kangning Hospital

New trial • CNS Disorders • Depression • Mood Disorders • Psychiatry

SEIZURE-TRIGGERING TAKOTSUBO CARDIOMYOPATHY WITH COEXISTING CORONARY ARTERY DISEASE: A CASE REPORT - Jonida Pjetrushaj (ACC 2025) - "In less than 15% of the cases, CAD coexists with TTS.Case: A 56-year-old female with HIV, Epilepsy, and HTN presented with tonic-clonic seizures for over 20 minutes and controlled with lorazepam... Differential diagnosis can be important to stabilize the treatment approach. It is also essential to keep in mind that CAD and Takotsubo can coexist. To differentiate this and holistically evaluate the case, it is crucial for a successful outcome."

Case report • Clinical • Cardiomyopathy • Cardiovascular • CNS Disorders • Coronary Artery Disease • Depression • Epilepsy • Human Immunodeficiency Virus • Infectious Disease • Psychiatry