lorazepam / Generic mfg. - LARVOL DELTA

Midazolam in the treatment of catatonia: A case series. (PubMed, Am J Health Syst Pharm) - "Midazolam may be an alternative or adjunctive therapy for the treatment of catatonia in circumstances where IV lorazepam is unavailable. More rigorous studies should be performed to more clearly elucidate the safety and effectiveness of midazolam as monotherapy and when used in combination with ECT early in the treatment of catatonia."

Journal • Cardiovascular • CNS Disorders • Depression • Hypotension • Psychiatry

Proportional Sedation for Persistent Agitated Delirium in Palliative Care: A Randomized Clinical Trial. (PubMed, JAMA Oncol) - P2/3 | "To compare the effect of scheduled haloperidol, lorazepam, haloperidol plus lorazepam, and placebo on patients with advanced cancer and delirium and experiencing restlessness and/or agitation in the palliative care setting. The results of this randomized clinical trial indicate that proactive use of scheduled sedatives, particularly lorazepam-based regimens, may reduce persistent restlessness and/or agitation in patients with advanced cancer and delirium in the palliative care setting. Clinicaltrials.gov Identifier: NCT03743649."

Clinical • Journal • Anesthesia • CNS Disorders • Oncology • Palliative care

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial. (PubMed, JMIR Res Protoc) - "If positive, the results of this RCT may pave the way for international catatonia researchers and clinicians to introduce a new pharmacological treatment option for catatonia. Implementation could potentially benefit patients who endure this severe syndrome and present health care professionals with an additional treatment option."

Journal • Bipolar Disorder • CNS Disorders • Depression • Infectious Disease • Mood Disorders • Pneumonia • Psychiatry • Renal Disease • Respiratory Diseases • NECTIN1

Neurotoxic effects of scorpion envenomation, a video of nystagmus, dysmetria, and tongue fasciculations: a case report. (PubMed, J Med Case Rep) - "Scorpion envenomations can lead to severe neurotoxic effects, even in adults, particularly with multiple stings or enhanced venom absorption. Early recognition of neurotoxic symptoms is crucial for prompt intervention with antivenom and supportive care, significantly improving patient outcomes. This case emphasizes the importance of considering neurotoxic envenomations in adult patients, even when pediatric cases are more common."

Journal • Video • Ataxia • CNS Disorders • Immunology • Infectious Disease • Movement Disorders • Ophthalmology • Pain • Pediatrics • Pertussis • Respiratory Diseases • Tetanus • Xerostomia

Atypical Presentation of Catatonia in an Adolescent With Autism Spectrum Disorder. (PubMed, J Psychiatr Pract) - "We present the case report of an adolescent female with ASD presenting with signs of excited catatonia whose treatment spanned multiple inpatient admissions and trials of medications, including antipsychotics, lorazepam, zolpidem, and eventually electroconvulsive therapy. The complexities of treating catatonia that displays atypical symptomatology and is resistant to oral benzodiazepines are discussed."

Journal • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders

Acute Neuropsychiatric Illness and Catatonia in the Setting of Adrenal Crisis (ENDO 2025) - "Empirical treatment with lorazepam was initiated, with minimal response...However, the causes for atypical presentations remain unclear.Conclusion This case highlights the potential for adrenal insufficiency to manifest with psychiatric symptoms, including catatonia, in the setting of steroid tapering. Prompt recognition and treatment can lead to cognitive recovery without the need for medications."

Cardiovascular • CNS Disorders • Endocrine Disorders • Epilepsy • Heart Failure • Hypoglycemia • Mental Retardation • Nephrology • Pain • Psychiatry • Renal Disease

Diabetic Striatopathy: A Rare Presentation of Non-ketotic Hyperglycemia (ENDO 2025) - "Brain MRI revealed hyperintense T1 signals in the left putamen and caudate head, consistent with diabetic striatopathy.She was started on insulin therapy and lorazepam for symptom relief...However, a relapse occurred during follow-up due to poor adherence to insulin, prompting the addition of risperidone 0.5 mg twice daily.Diabetic striatopathy is the second most common cause of hemichorea/hemiballism...Further research is needed to improve early detection and develop treatment guidelines. Identifying early biomarkers of brain dysfunction in diabetes could enable earlier interventions and reduce the long-term impact on brain health."

Ataxia • Cardiovascular • CNS Disorders • Depression • Diabetes • Hematological Disorders • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Metabolic Disorders • Movement Disorders • Psychiatry

Computational Assessment of GABA Receptor Modulation in PTSD (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: VA Office of Research and Development | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Assessing the safe prescribing of pharmacological detox regimen among patients with liver cirrhosis who have alcohol withdrawal syndrome (BSG 2025) - "Introduction Although chloradiazepoxide remains the drug of choice in alcohol withdrawal syndrome(AWS), lorazepam or Oxazepam is considered a safer option in patients with decompensated liver cirrhosis due to the increased risk of drowsiness and respiratory depression.The aim of this study is to assess the safe prescribing of pharmacological detox regimen among patients with liver cirrhosis in the gastroenterology ward at Leighton hospital.Methodology The patients with AWS who were admitted into gastroenterology ward from June to Decemeber 2024 were recruited in this study. We found that 25% of doctor's answers were incorrect.InterventionThe result of the study was passed to the gastroenterology consultants and the ward manager to correctly implement the trust policy on AWS when reviewing these patients in the ward.There was a presentation of these findings and teaching on AWS in the gastroenterology teaching session(comprising of Consultants, junior doctors and..."

Clinical • CNS Disorders • Depression • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Psychiatry

Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults. (PubMed, Brain Imaging Behav) - "Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Reduced connectivity within higher-order cognitive networks partly supports what has been reported for other benzodiazepines such as midazolam and alprazolam. However, differences across benzodiazepines - possibly due to pharmacokinetics, dosage and receptor selectivity - underscore the need for further research."

Journal • Mood Disorders • Psychiatry

Exparel Interscalene Block & Respiratory Failure (ASA 2025) - "She was given Ativan for presumed anxiety and became unresponsive and hypoxic. Despite reversal with flumazenil, the patient required intubation and mechanical ventilation. With this case, we will discuss patient and surgical considerations for interscalene blocks and alternative regional techniques for shoulder surgeries."

Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Orthopedics • Pain • Psychiatry • Pulmonary Embolism • Respiratory Diseases

Prevalence and factors with potentially inappropriate prescribing among older outpatients with depression: a multicentre study across China. (PubMed, J Glob Health) - "The top five PIM were alprazolam, clonazepam, olanzapine, lorazepam, estazolam. Logistic regression demonstrated that tertiary-level hospital (odds ratio (OR) = 1.215; 95% confidence interval (CI) = 1.100, 1.342, P < 0.001), department of psychiatry (OR = 1.958; 95% CI = 1.855, 2.067, P < 0.001), age ≥80 (OR = 1.069; 95% CI = 1.016, 1.124, P = 0.01), more diseases (OR = 1.209; 95% CI = 1.092, 1.339, P < 0.001), polypharmacy (OR = 1.672; 95% CI = 1.541, 1.814, P < 0.001) exhibited positive links to PIP among older outpatients suffering from depression. This investigation revealed that the occurrence of PIP in older outpatients with depression is high in China."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Association between Dravet syndrome and Catatonia: a case report. (PubMed, Epilepsy Behav Rep) - "Catatonia improved with lorazepam, though seizure frequency increased after zonisamide taper. This case demonstrates an interesting temporal relationship between improved seizure control and emergence of catatonia in a patient with genetic epilepsy. Further research is required to clarify the relationship between catatonia and FN in epilepsy."

Journal • CNS Disorders • Epilepsy • Psychiatry

Is Abrupt Withdrawal of Benzodiazepines a Risk Factor for Neuroleptic Malignant Syndrome? A Case Report With Single-Dose Haloperidol. (PubMed, Clin Case Rep) - "His medical history included long-term use of clonazepam, alprazolam, and methadone maintenance therapy (MMT)...The treatments with bromocriptine and lorazepam further led to gradual improvement, and the patient was discharged after 11 days following the resolution of NMS symptoms...The shared mechanisms between the pathophysiology of NMS and benzodiazepine withdrawal suggest that the abrupt cessation of GABAergic agents may lower dopaminergic activity, contributing to the onset of NMS. Clinicians must be accordingly cautious in distinguishing benzodiazepine withdrawal from other causes of delirium and then option for appropriate treatment approaches to mitigate risks."

Journal • CNS Disorders

Rhabdomyolysis After Risperidone Overdose in a Patient With Schizophrenia: A Case Report. (PubMed, Neuropsychopharmacol Rep) - "A 50-year-old woman with schizophrenia overdosed on risperidone, lormetazepam, and lorazepam and subsequently developed rhabdomyolysis, with elevated creatine kinase (CK) and myoglobin levels. There have been no reports of rhabdomyolysis caused by overdosing on risperidone alone. This case is important for understanding the risk profile of this drug."

Journal • CNS Disorders • Psychiatry • Schizophrenia • AVEN • MB

Predicting the response to Lorazepam in catatonia: a network analysis approach. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "The overall structure of catatonic symptoms appears stable between responders and non-responders. Hypokinetic symptoms, particularly immobility and stupor, serve as strong predictors of Lorazepam response. Given the critical need for early treatment prediction to optimize therapeutic interventions and reduce catatonia-related mortality, further research is needed to refine clinical predictors of Lorazepam response."

Journal

Evaluating health-related quality of life and health resource utilization among Gabapentinoid users with substance use disorder in the US: Trends, co-prescriptions, and cost analysis. (PubMed, Explor Res Clin Soc Pharm) - "Gabapentinoid, including Gabapentin and Pregabalin, are commonly used for approved and off-label health conditions, but their misuse with opioid among individuals with substance use disorder (SUD) increases the risk of respiratory depression and death. Among users with SUD, common co-prescriptions included Tramadol (46.59 %), Oxycodone (35.62 %), and Lorazepam (34.78 %). Our results suggest the critical need to monitor and assess the Gabapentinoid prescription among individuals with SUD, further warrant to develop and implement new policies and guidelines at both federal and state levels in the U.S."

HEOR • Journal • CNS Disorders • Depression • Psychiatry

Evaluation of Prescription Patterns in Management of Agitation in Patients Referred to the Emergency Department. (PubMed, Iran J Psychiatry) - " The findings revealed that 181 patients (71.82%) were given typical antipsychotics, with haloperidol being the most commonly prescribed medication. Atypical antipsychotics were administered to 24 participants (9.52%), primarily olanzapine, and 52 patients (20.63%) received benzodiazepines, predominantly lorazepam. The treatment response was also assessed as appropriate in 224 patients (88.89%) and inappropriate in 28 patients (11.11%). The study recommends providing new-generation medications to developing countries and underscores the importance of updating student educational programs."

Journal • CNS Disorders • Psychiatry • Psychomotor Agitation

Treatment of psychological and behavioral symptoms in dementia with Lewy bodies and Parkinson's disease dementia: Review of the literature and consensus using the Delphi method (PubMed, Geriatr Psychol Neuropsychiatr Vieil) - "The following proposals were made: for pervasive and criticized hallucinations, donepezil or rivastigmine; for delusion, and Capgras syndrome (Delphi), low doses of clozapine; for depression, sertraline, venlafaxine or mirtazapine (Delphi); for RBD, immediate-release melatonin; for frontal syndrome, sertraline or paroxetine first then trazodone (Delphi); for catatonia, lorazepam. Our group's proposals should help to improve the care of DLB and PDD PBS, and thus enhance the quality of life of patients and caregivers."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Depression • Lewy Body Disease • Movement Disorders • Parkinson's Disease • Psychiatry

Metabolic regulation of visual acuity. (PubMed, Sci Adv) - "Our results suggest that the aspartate-malate shuttle in GABAergic amacrine cells metabolizes glucose to γ-aminobutyric acid (GABA), which in turn regulates the ON cone bipolar signal. GABAA receptor agonists such as Ativan are a widely prescribed first-line therapy for seizures initiated by low brain GABA, and we show that Ativan restores ON cone bipolar cell regulation in RP where retinal GABA is diminished, reestablishing luminance and contrast detection."

Journal • CNS Disorders • Epilepsy • Genetic Disorders • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Retinal Disorders • Retinitis Pigmentosa

Pre-post implementation study of a medication-focused order set for management of acute agitation in a pediatric emergency department. (PubMed, Am J Health Syst Pharm) - "Prescribing practices, including medication selection, ordered frequency, ADC overrides, and combination therapy, differed following the implementation of a medication-focused order set for acute agitation. Transitioning to empiric oral and intramuscular olanzapine as first-line therapy, diphenhydramine as second-line therapy, and olanzapine as third-line therapy did not increase the rate of medication administration or utilization of subsequent lines of therapy. Additional studies are needed to better understand individualized response, adverse effects, and the incidence of oversedation with pharmacotherapy for acute agitation management in pediatric patients in the ED setting."

Journal • Anesthesia • Pediatrics • Psychiatry

Valproate-Enhanced Protocols for Alcohol Withdrawal Syndrome: A Brief Review and Retrospective Study of Efficacy and the Ability to Reduce Benzodiazepine Use. (PubMed, Pharmaceuticals (Basel)) - " The median daily benzodiazepine dose was 2.5 mg lorazepam-equivalents (IQR: 2.0-3.81 mg)...IV administration may offer more rapid clinical improvement. Larger prospective trials are warranted to confirm these findings."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • Anesthesia • Mood Disorders • Psychiatry

A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database. (PubMed, Sci Rep) - "In addition, there are gender and age differences in some AEs. These findings provide valuable insights into lorazepam in clinical practice."

Adverse events • Journal • Real-world evidence • Anesthesia • Cardiovascular • CNS Disorders • Depression • Fibrosis • Immunology • Infectious Disease • Mental Retardation • Pneumonia • Psychiatry • Respiratory Diseases

Simultaneous Determination of Buspirone, Alprazolam, Clonazepam, Diazepam, and Lorazepam by LC-MS/MS: Evaluation of Greenness Using AGREE Tool. (PubMed, Biomed Chromatogr) - "Its suitability for therapeutic drug monitoring was demonstrated using the method to determine drug concentration levels in real patients. The developed method has been observed to achieve a high analytical greenness metric approach and software (AGREE) score for the greenness profile."

Journal • CNS Disorders • Mood Disorders • Psychiatry

CIRCADIAN PATTERN OF BREAKTHROUGH RESTLESSNESS IN END-OF-LIFE DELIRIUM: A SECONDARY ANALYSIS OF TWO RANDOMIZED CONTROLLED TRIALS (MASCC-ISOO 2025) - "Methods This was a secondary analysis of two randomized clinical trials that examined the effect of lorazepam (MAD trial, February 2014 – June 2016) and neuroleptics (CHAD trial, July 2017-2019) on restlessness and agitation in end-of-life delirium...Conclusions Peak restlessness was observed in delirious patients between 3-11 pm. This observation of "sundowning" may inform how clinicians can better monitor patients, schedule interventions, and educate caregivers facing this highly distressing syndrome."

Clinical • Anesthesia • CNS Disorders • Oncology • Palliative care • Sleep Disorder