clarithromycin / Generic mfg. - LARVOL DELTA

CAR-T cell therapy in multiple myeloma in a front-line setting: A systematic review and meta-analysis (ASH 2025) - "Induction therapy regimen before CAR-T included bortezomib, lenalidomide, and dexamethasone (VRd), or clarithromycin, lenalidomide, and dexamethasone (BiRd), or a combination of VRd and bortezomib, doxorubicin, and dexamethasone (PAD). CAR-T cell therapy showed promising rates of overall response and durable remission in newly diagnosed MM patients in a frontline setting. However, the small sample sizes necessitate further trials with large patient populations to enhance our understanding of these outcomes with CAR-T cell therapy in MM."

CAR T-Cell Therapy • Retrospective data • Review • Hematological Disorders • Hematological Malignancies • Inflammation • Multiple Myeloma • Neutropenia

Toxic Epidermal Necrolysis Induced by First-Line Helicobacter pylori Eradication Therapy: A Case Report. (PubMed, Korean J Helicobacter Up Gastrointest Res) - "Here, we report a fatal case of TEN in an 80-year-old patient who developed diffuse bullous eruptions and multiorgan failure following first-line Helicobacter pylori eradication therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. Despite intensive care, including corticosteroids and supportive treatment, the patient died of sepsis and progressive organ failure. This case highlights the need for early detection of severe cutaneous adverse reactions, particularly in elderly patients receiving H. pylori eradication therapy."

Journal • Critical care • Infectious Disease • Septic Shock • Steven-Johnson Syndrome

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

Estimating macrolide antibiotics use in a typical region of Taihu Lake Basin, China through wastewater-based epidemiology. (PubMed, Environ Geochem Health) - "The concentrations of four MLs-erythromycin, roxithromycin, azithromycin, and clarithromycin-were determined. A significant increase in antibiotic usage was observed in January 2023 that the other sampling months, accompanying with low ambient temperatures. The data set on MLs consumption provides valuable insights for evaluating antibiotic usage patterns under varying temporal and climatic conditions."

Journal

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution. (PubMed, Res Sq) - "Independently, reanalysis of genome-wide CRISPRi screens revealed that the OSR network and high Bayes probability genes are functionally associated with treatment escape and survival with multiple antibiotics, including isoniazid, rifampicin, ethambutol, bedaquiline, vancomycin, clarithromycin, linezolid, and streptomycin. Our findings that host-imposed oxidative stress and inadequate drug penetration may synergistically prime Mtb populations for rapid resistance evolution suggest that targeting pre-resistance mechanisms, such as oxidative stress defenses, could help slow the emergence of antibiotic resistance in tuberculosis."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Clinical characteristics, antimicrobial susceptibility patterns, and treatment outcomes of nontuberculous mycobacterial diseases in eastern China: a retrospective cohort study (2019-2022). (PubMed, Microbiol Spectr) - "Antimicrobial susceptibility testing revealed that Mycobacterium avium complex exhibited relatively favorable sensitivity to clarithromycin, amikacin, ethambutol, rifapentine, rifampicin, and moxifloxacin, while the Mycobacterium chelonae/Mycobacterium abscessus complex showed sensitivity only to amikacin (66.7%). By linking pathogen types, drug resistance, and treatment duration to outcomes, this work equips doctors in Eastern China to diagnose faster, choose effective therapies, and improve patient survival. These findings also urge policymakers to prioritize localized data collection and standardized protocols for NTM management globally."

Journal • Retrospective data • Bronchiectasis • Chronic Cough • Cough • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Eradication Rates of Empiric Helicobacter pylori Treatment Regimens by Race/Ethnicity in a Predominantly Immigrant U.S. Population. (PubMed, Helicobacter) - "Empiric bismuth quadruple therapy had the highest eradication rate while metronidazole and levofloxacin triple therapies had the lowest. Eradication rates may thus serve as a surrogate clinical endpoint when choosing empiric therapies."

Journal • Retrospective data • Infectious Disease

Comparison between optimized bismuth quadruple therapy and standard clarithromycin-based triple therapy for first-line Helicobacter pylori eradication: a double-blind randomized controlled trial. (PubMed, Lancet Reg Health Am) - P4 | "We compared optimized bismuth quadruple therapy: esomeprazole 40 mg three times a day, amoxicillin 1 gr three times a day, metronidazole 500 mg three times a day, and bismuth subsalicylate 369 mg three times a day for 14 days, and standard triple therapy omeprazole 20 mg twice a day, amoxicillin 1 gr twice a day, and clarithromycin 500 mg twice a day for 14 days in a Chilean population. Optimized bismuth quadruple therapy is a reliable and safe empiric eradication therapy, especially in areas with high clarithromycin resistance. FONDECYT (1230504 AR); ANID-FONDAP (152220002 AR); Horizon 2020 program of European Union (825832 AR); ANID-FONDAP (15130011)."

Journal • Gastric Cancer • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Oncology • Peptic Ulcer • Solid Tumor • CYP2C19

Characterization of Methicillin-Resistant Staphylococcus Aureus Resistance and Hematological Profiles in Diabetic Foot Infections. (PubMed, Clin Lab) - "This study examined the characteristics of DFU-associated MRSA infection, particularly its multidrug resistance features. MRSA infection demonstrated 100% sensitivity to vancomycin and linezolid. The findings suggest that combined detection of MCHC, D-dimer, ALB, ALP, Na+, Cl-, and Ca2+ may serve as a valuable reference for the early identification of DFU-associated MRSA infection in clinical settings. Clinicians should be mindful of MRSA infection risks in patients with DFU and develop individualized anti-infection regimens based on drug sensitivity profiles to improve prognosis."

Journal • Retrospective data • Hematological Disorders • Infectious Disease

Study to Evaluate the Efficacy and Safety of DWP14012-based Triple Therapy in Eradication of Helicobacter Pylori (clinicaltrials.gov) - P3 | N=461 | Completed | Sponsor: Daewoong Pharmaceutical Co. LTD. | Recruiting ➔ Completed | Trial completion date: Jun 2026 ➔ Apr 2025 | Trial primary completion date: Jan 2026 ➔ Apr 2025

Trial completion • Trial completion date • Trial primary completion date • Infectious Disease

Quality of different brands of clarithromycin tablets marketed in Ethiopia; implications for the future. (PubMed, JAC Antimicrob Resist) - "As a result, all tested clarithromycin brands conformed with the required quality standards and were of acceptable quality. Consequently, these different brands of clarithromycin can be used to effectively treat patients and support ongoing national efforts to ensure antibiotic quality and strengthen AMR containment strategies."

Journal

Development of an HPLC method for the simultaneous determination of azithromycin, clarithromycin, and erythromycin in wastewater. (PubMed, RSC Adv) - "Application of the validated method to hospital and livestock wastewater samples revealed macrolide concentrations up to 13.36 mg L-1 (CLR), 11.27 mg L-1 (ERY), and 7.80 mg L-1 (AZM). The developed HPLC-PDA method is therefore suitable for routine environmental monitoring, providing a simple and reliable tool for assessing macrolide antibiotic contamination in wastewater."

Journal

Fixed drug eruption induced by clarithromycin and paracetamol in a child. (PubMed, Pediatr Allergy Immunol) - No abstract available

Journal

Targeted detection of Helicobacter pylori resistance to clarithromycin and levofloxacin using single-cell Raman spectroscopy. (PubMed, J Med Microbiol) - "Our results demonstrated that Raman spectroscopy can accurately predict H. pylori antibiotic resistance within 4-6 h, significantly reducing detection time compared with traditional methods.Conclusion. This study provides a promising approach for rapid and accurate detection of H. pylori antibiotic resistance, enabling personalized treatment strategies and improving eradication outcomes."

Journal • Infectious Disease

Impact of macrolide therapy on clinical outcomes in hospitalized pneumonia patients: a retrospective study from Lebanese hospitals. (PubMed, Sci Rep) - "Subgroup analyses revealed fewer ICU admissions with azithromycin compared to clarithromycin, and with intravenous versus oral use, though these findings should be interpreted cautiously given the observational design. Overall, macrolide treatment, particularly azithromycin, may contribute to the improvement in survival of CAP patients, especially those with high inflammatory markers or comorbidities, which suggests potential benefit in using it in the context of a combination therapy. This result supports the rationale for using macrolides in combination therapy and emphasizes prospective studies to investigate their immunomodulatory properties in the management of pneumonia."

Clinical data • Journal • Retrospective data • Critical care • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases

Best Treatment Options for Severe Helicobacter pylori Infections. (PubMed, Turk J Gastroenterol) - "The efficacy of bismuth-containing sequential therapy with clarithromycin (BSTC), bismuth-containing sequential therapy with levofloxacin (BSTL), and bismuth-containing quadruple therapy (BQT) regimens on H. pylori eradication was investigated. It was concluded that BSTL may be the best option for treating H. pylori infections in first-line treatment. This regimen is particularly effective in cases of severe H. pylori colonization."

Journal • Retrospective data • Infectious Disease

Antimicrobial resistance patterns of Nocardia species in clinical isolates from Argentina (2020-2022). (PubMed, Enferm Infecc Microbiol Clin (Engl Ed)) - "This first Argentine nationwide surveillance study confirms trimethoprim-sulfamethoxazole and linezolid as reliable empiric therapy options while highlighting concerning resistance to fluoroquinolones and macrolides. The observed methodological discordance emphasizes the critical need for standardized antimicrobial susceptibility testing protocols for Nocardia species."

Journal • Infectious Disease

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics. (PubMed, Chemistry) - "Selected alkyne-containing exoglycals were further functionalized through cycloaddition with azidothymidine...To contextualize the inhibitory potential of exoglycals, we evaluated three clinically relevant macrolide antibiotics-erythromycin, clarithromycin, and azithromycin...Our results demonstrate exoglycals as tunable scaffolds for glycosidase inhibition of GH3 glycosidases and provide mechanistic distinctions between carbohydrate mimics and macrolide antibiotics. These insights could guide the development of next-generation glycosidase inhibitors with improved specificity."

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Randomized Comparison of Vonoprazan-Amoxicillin Dual Therapy Versus Bismuth Quadruple Therapies for Helicobacter pylori Eradication: A Multicenter Trial Evaluating National Centralized Drug Procurement Antibiotics. (PubMed, J Gastroenterol Hepatol) - "This study confirms that 10-day vonoprazan-amoxicillin dual therapy (using National Centralized Drug Procurement antibiotics) demonstrates noninferior efficacy to bismuth quadruple therapy while offering superior safety, better compliance, and the advantage of shorter treatment duration. These findings support its adoption as a first-line regimen for large-scale H. pylori eradication programs."

Journal • Infectious Disease

Mycobacterium avium Infection in a Domestic Shorthair Cat Following Subdermal Hyaluronic Acid Filler Injection. (PubMed, Vet Ophthalmol) - "Non-tuberculous mycobacterial (NTM) infections are a known and documented complication of subdermal filler injections in human patients. This is the first described case of NTM infection associated with HA injection in a cat. Treatment success with conventional oral antibiotics may be limited, necessitating extended therapeutic courses and alternative drug delivery routes like intralesional injection."

Journal • Aesthetic Medicine • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Antibiotic Susceptibility of Nocardia Clinical Isolates Collected from Chinese Patients - China, 2014-2024. (PubMed, China CDC Wkly) - "Trimethoprim-sulfamethoxazole has long been the first-line treatment for Nocardia infections; however, resistance to this therapy has recently been reported...Nocardia strains generally exhibited high resistance to clarithromycin, clindamycin, and isoniazid. Clinical and reference strains of N. farcinica and N. otitidiscaviarum were susceptible to amikacin and linezolid. Amoxicillin-clavulanate and imipenem were effective against all clinical and reference strains of N. farcinica, whereas gentamicin was effective against all clinical and reference strains of N. otitidiscaviarum...Variability of antimicrobial susceptibility was observed among clinical isolates of the same species and between clinical and reference isolates of the same species. Overall, this study highlights the need for better assessment of the burden of nocardiosis in China and for continuous monitoring of antimicrobial resistance among Nocardia isolates."

Journal • Infectious Disease

Characterization of antibiotic resistance and biofilm formation in clinical Helicobacter pylori isolates from Ningxia, China. (PubMed, Sci Rep) - "Further investigation revealed that high biofilm-forming H. pylori demonstrated a higher proportion of resistance to metronidazole, clarithromycin, and levofloxacin compared to low biofilm-forming H. pylori. Next-generation sequencing data demonstrated low homology among the strains, suggesting that this genetic diversity may drive the strains to evolve along distinct pathways, ultimately resulting in the emergence of more complex drug-resistant isolates within the studied population, despite the limited data size."

Journal • Gastrointestinal Disorder • Infectious Disease

Epidemiology and Drug Susceptibility of Nontuberculous Mycobacteria in the Province of Pavia (Northern Italy): An Overview. (PubMed, Microorganisms) - "Antimicrobial susceptibility testing of 223 isolates from 2016 to 2023 revealed species-specific resistance patterns, with high susceptibility to clarithromycin in MAC (94.7%) and Mycobacterium chelonae (100%), but notable resistance in Mycobacterium abscessus complex (MABC). The increasing incidence of NTM infections underscores the need for improved diagnostic techniques and targeted treatment strategies."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Treatment and Follow-Up of Patients With Helicobacter pylori Infection in Primary Health Care: A Retrospective Multicenter Study. (PubMed, Cureus) - "Primary care physicians in northern Portugal are progressively prescribing guideline-recommended BQ therapy, which demonstrated HP eradication rates above the accepted 90% benchmark. However, CT therapy remains widely used despite high antibiotic resistance and suboptimal eradication rates, and follow-up eradication testing is underutilized, underscoring important gaps in clinical practice. Updating national guidelines, reinforcing antibiotic resistance surveillance, and standardizing follow-up protocols are essential to optimize HP management in primary care."

Clinical • Journal • Retrospective data • Infectious Disease

Challenges and Efficacy of Amikacin Liposome Inhalation in Real-World Refractory Mycobacterium avium Complex Pulmonary Disease. (PubMed, Cureus) - "Prior treatment regimens primarily involved azithromycin- or clarithromycin-based therapies, supplemented with sitafloxacin, with a median treatment duration of five years. These findings highlight the challenges of managing refractory MAC pulmonary disease in a real-world setting and emphasize the importance of considering patient characteristics, including radiographic patterns and baseline health, when initiating ALIS therapy. Adverse events were frequent but manageable with appropriate monitoring and adjustments."

Journal • Real-world evidence • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases