NAI003 / Nain Biotech - LARVOL DELTA

Development of a first-in-class PDIA6/IRE1 modulator for selectively sensitizing cancer cells to ER stress and regulated cell death (AACR 2025) - "NAI003 is a potential first-in-class small-molecule PDIA6/IRE1 modulator that sensitizes cancer cells to ER stress and RCD by selectively overactivating IRE1 signaling. It holds great promise in treating selected cancers either as a single agent or as a combination therapy with marketed anticancer drugs."

Brain Cancer • Oncology • Pancreatic Cancer • Solid Tumor • ATF6 • ERN1 • PDIA6