NAI003 / Nain Biotech - LARVOL DELTA

A first-in-class ER stress modulator selectively induces regulated cell death of STK11/TP53-deficient cancer cells (AACR 2026) - "PDIA6/IRE1-regulated ER stress is a target of vulnerability in STK11/TP53-deficient cancers, and NAI003 is a potential first-in-class small-molecule ER stress modulator that can specifically treat cancer patients harboring STK11/TP53 genetic and functional defects. This compound holds great promise in tackling hard-to-treat cancers such as pancreatic cancer, and in overcoming cancer drug resistance by various mechanisms."

IO biomarker • Oncology • Pancreatic Cancer • Solid Tumor • ERN1 • KRAS • PDIA6 • STK11

Development of a first-in-class PDIA6/IRE1 modulator for selectively sensitizing cancer cells to ER stress and regulated cell death (AACR 2025) - "NAI003 is a potential first-in-class small-molecule PDIA6/IRE1 modulator that sensitizes cancer cells to ER stress and RCD by selectively overactivating IRE1 signaling. It holds great promise in treating selected cancers either as a single agent or as a combination therapy with marketed anticancer drugs."

Brain Cancer • Oncology • Solid Tumor • ATF6 • ERN1 • PDIA6