praziquantel / Generic mfg. - LARVOL DELTA

Incidental Taeniasis During Screening Colonoscopy in an Asymptomatic Urban Patient: Highlighting a Persistent Public Health Concern (ACG 2026) - "The patient also received treatment that differed from current guideline recommendations, which favor praziquantel 10 mg/kg as a single dose or niclosamide 2 g as a single dose. Familiarity with the endoscopic appearance of intestinal helminths may facilitate diagnosis and appropriate treatment. Figure: Endoscopic visualization of a tapeworm within the colonic lumen during screening colonoscopy Figure: Tapeworm identified in the terminal ileum, with clear visualization of the interproglottid segmentation"

Clinical • Colorectal Cancer • Infectious Disease • Solid Tumor

Appendix Under Attack: A Schistosomal Surprise (ACG 2026) - "These pathological features may mimic complicated appendicitis or malignancy, especially in the scenario of persistent inflammation despite appropriate medical therapy. Although acute appendicitis is resolved after appendectomy, definitive management with praziquantel and further assessment for residual pathology or extraintestinal involvement is essential."

Cardiovascular • Coronary Artery Disease • Diabetes • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Metabolic Disorders

Bilharzial Colonic Polyps Mimicking Colorectal Neoplasia: A Diagnostic Pitfall in a Patient With Chronic Hematochezia (ACG 2026) - "The patient underwent endoscopic polypectomy and received praziquantel therapy, with complete symptomatic resolution noted at one-month follow-up...Figure: Figure 1: A ~15 mm pedunculated (Paris Ip) polyp is seen in the sigmoid colon, with a lobulated erythematous head and granular surface pattern. Figure: Figure 2: Histopathological images showing Oval shape eggs with lateral spine which indicate Schistosoma mansoni eggs."

Clinical • Colonic Polyps • Colorectal Cancer • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Metabolic Disorders • Solid Tumor • Type 2 Diabetes Mellitus • Ulcerative Colitis

Atypical Hematochezia: A Case of Chronic Intestinal Schistosoma Mekongi (ACG 2026) - "He was started on praziquantel with notable improvement and eventual clearance of ova in follow up visits...While he has other risk factors for worsening cirrhosis, chronic schistosomiasis likely contributed to an accelerated decompensation and possibly to his readmission for recurrent variceal bleeds despite alcohol abstinence. This case highlights the importance of reviewing travel history as a key feature for a comprehensive differential when evaluating patients with atypical hematochezia."

Clinical • Colon Cancer • Colorectal Cancer • Fibrosis • Gastroenterology • Hepatology • Hypotension • Immunology • Infectious Disease

A Rare Twist: Sigmoid Volvulus Secondary to Schistosomiasis in a Young Male (ACG 2026) - "The patient was treated with oral praziquantel at a dose of 40 mg/kg and was scheduled to receive a second dose, but he was lost to follow up...Paired worms are appreciated with male form on the outside (black triangle), encasing the female form (black star). Figure: Calcified egg form in submucosa (black star), with adjacent lymphoid aggregate (black triangle) (H&E, 100x magnification)"

Constipation • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Inflammation • Inflammatory Bowel Disease

Post-Transplant Presentation of Hepatic Schistosomiasis (ACG 2026) - "He was treated with a course of praziquantel with no residual ova on repeat biopsy...These findings support screening patients for schistosomiasis from endemic areas and with risk factors, even when remote, given risk of reactivation under immunosuppression. Figure: Table 1 Pertinent laboratory value trends during hospitalization including reference ranges"

Post-transplantation • CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Solid Organ Transplantation • Transplantation

A Diagnostic Fluke: An Unexpected Discovery of Cholestatic Liver Disease From Liver Fluke (ACG 2026) - "The patient was treated with praziquantel 25 mg/kg every eight hours for two days...Figure: Figure 1. Hematoxylin and eosin (H&E) stained liver biopsy demonstrating trematode ova (black arrow)."

Autoimmune Hepatitis • Biliary Cancer • Cholangiocarcinoma • Cholestasis • Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Pancreatitis • Solid Tumor

Effects of Three Anthelmintics on the Transcriptome of FHs 74 Int Enterocytes. (PubMed, Trop Med Infect Dis) - "In this study, the three commonly used anthelmintics albendazole, ivermectin, and praziquantel were investigated by transcriptome analysis for their effects on gene activity in the human intestinal cell line FHs 74 Int after 24-h exposure...Analysis of these genes showed that albendazole caused a modest upregulation of cell cycle related processes, especially mitotic spindle formation, and chromosome segregation. The cells showed a stronger response to ivermectin and the data suggested inhibition of cell proliferation through downregulated transcription factors and nuclear receptors and stimulation of cell growth and cell survival mechanisms through upregulated metabolic enzymes."

Journal • Infectious Disease

Raw Whitebait as a Probable Source of Human Diplogonoporus balaenopterae Infection in Non-Coastal Area: A Case Report. (PubMed, J Gen Fam Med) - "Treatment with praziquantel led to complete resolution of symptoms without recurrence...This is likely due to the widespread availability of fresh seafood. This emphasizes the importance of obtaining a dietary history when diagnosing parasitic infections."

Journal • Infectious Disease • Pain

Neuroschistosomiasis Mimicking Spinal Tuberculosis: A Case Report. (PubMed, Niger Med J) - "She received weekly praziquantel (1,200 mg) and tapered prednisolone...Neuroschistosomiasis should be considered in endemic regions, particularly when presumed spinal tuberculosis fails to respond to treatment. Definitive diagnosis requires careful clinicoradiological and histopathological evaluation."

Journal • Back Pain • CNS Disorders • Fibrosis • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Testicular Schistosomiasis Mimicking Testicular Tumour: A Case Report. (PubMed, Niger Med J) - "We report the case of a 34-year-old school teacher from Kano, Nigeria, with a history of freshwater exposure and childhood schistosomiasis treated with praziquantel...Histopathological examination, independently verified by three pathologists, revealed calcified Schistosoma ova within a densely fibrotic, granulomatous background, with no evidence of malignancy. This case underscores testicular schistosomiasis as an important differential diagnosis for testicular masses in endemic regions, and highlights the central role of histopathology in preventing unnecessary orchidectomy."

Journal • Fibrosis • Infectious Disease • Infertility • Oncology • Sexual Disorders • Testicular Cancer

Breaking the cycle: Determinants and opportunities for sustainable control of cystic echinococcosis. (PubMed, Adv Parasitol) - "Effective control requires a One Health approach that combines repeated praziquantel treatment of dogs, safe management of offal and carcasses, inspected slaughter, livestock surveillance, community engagement, and management of owned, semi-owned, and free-roaming dogs...Sardinia and comparable Mediterranean settings are used to illustrate how persistent sheep infection, fertile cysts, working-dog ecology, informal slaughter, incomplete dog prophylaxis, and governance gaps sustain endemic transmission even where the disease is well recognized. The Chapter argues that CE persistence reflects failures of continuity, traceability, and field delivery; durable control therefore depends on the organization of dog management, slaughter systems, surveillance, and community action as much as on parasitology."

Journal • Review • Infectious Disease

Pilot field study to assess efficacy of NexGard Combo®, a topical combination of esafoxolaner + eprinomectin + praziquantel, against natural Lynxacarus radovskyi infestation in cats. (PubMed, Vet Parasitol) - "The topical esafoxolaner treatment demonstrated 100% parasitological efficacy, with all cats free of detectable mites by Day 30 using semi-quantitative counting. Clinical signs improved markedly during the study period, and no adverse events were observed."

Journal • Alopecia • Dermatology • Immunology • Pruritus

Modelling the Transmission Dynamics and Risk of Ovine Cystic Echinococcosis in Argentina Using the CEST Model (Cystic Echinococcosis Stochastic Transmission Model). (PubMed, J Parasitol Res) - "Dog deworming with praziquantel and sheep vaccination with EG95 are simulated at different frequencies and coverage levels...Enhancing CE control requires additional measures, including a deeper understanding of factors contributing to disease persistence despite current control efforts. The CEST model can be extended to simulate additional interventions, making it a valuable tool for policymakers and stakeholders in planning CE control efforts beyond the Sustainable Development Goals."

Journal

Unexpected uterine microhabitat of Schistosoma infection: a migrant case of female genital schistosomiasis in Europe. (PubMed, Infect Dis Poverty) - "This case highlights FGS as a potentially reversible cause of infertility in migrant women from endemic regions. It also underscores the diagnostic limitations of serology and urine microscopy and the importance of histopathological examination in establishing the diagnosis."

Journal • Eosinophilia • Infectious Disease • Infertility • Inflammation • Sexual Disorders • Solid Tumor

Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting. (PubMed, PLoS Negl Trop Dis) - "In China, sustained snail control, environmental management, and mass drug administration with praziquantel reduced schistosomiasis to near-elimination levels, yet re-emergence in Sichuan Province during the early 2000s exposed vulnerabilities in elimination efforts...Together, these findings indicate that parasite persistence in this near-elimination setting was sustained by interacting processes operating across multiple biological scales, including diverse regional parasite populations, localized transmission networks connecting villages, and marked heterogeneity in host-level worm burden. More broadly, this work demonstrates how population genomics can reconstruct otherwise hidden patterns of parasite persistence and transmission, providing a valuable complement to conventional epidemiological surveillance in complex, multi-host parasite systems."

Journal • Infectious Disease

Antibody-mediated functional responses induced by the SchistoShield® schistosomiasis vaccine in disease-naïve and endemic human populations. (PubMed, Vaccine) - "Praziquantel (PZQ) remains the principal standard treatment for schistosomiasis, but concerns about its reduced effectiveness against larval stages, reinfections, and emerging drug resistance reinforces the urgent need for a vaccine. Passive transfer of human total IgG from vaccinated individuals in mice revealed notable reductions in worm burden, egg counts, and egg-hatching ability compared to groups given pre-vaccination sera across all trials. Overall, these findings support that SchistoShield® induces generation of functional antibodies that may play a crucial role in antibody-mediated protection against schistosomiasis."

Journal • Alzheimer's Disease • Cognitive Disorders • Hematological Disorders • Infectious Disease

Screening of candidate antiparasitic drugs against Sparicotyle chrysophrii: A phenotypic drug discovery approach. (PubMed, Vet Parasitol) - "Among the tested compounds, three salicylanilide derivatives exhibited the highest short-term efficacy, showing the lowest lethal doses 50 (LD50): niclosamide (LD50=0.12 µM), closantel (LD50=2.3 µM), and ME1.62 (LD50=0.09 µM). Niclosamide, one of the most potent compounds identified, demonstrated a parasiticidal activity more than 11,000-times greater than praziquantel (LD50=1.43 mM), a reference chemotherapeutic agent commonly used against fish polyopisthocotylean parasites."

Journal • Infectious Disease

Feasibility of paediatric schistosomiasis prevention with praziquantel, Madagascar. (PubMed, Bull World Health Organ) - "Fixed-dose praziquantel preventive chemotherapy using a crushed half tablet with water and sugar was feasible in preschool-aged children and was potentially sustainable. This approach has a strong potential for scaling up in areas where schistosomiasis is highly endemic."

Journal • Infectious Disease • Mood Disorders • Pediatrics • Psychiatry

Postoperative Prophylaxis of Cystic Echinococcosis with Albendazole and Praziquantel: A Retrospective Cohort Study. (PubMed, Biomedicines) - "The results of our study are hypothesis-generating. Further confirmation requires a prospective, multicentre randomized trial with balanced long-term follow-up."

Journal • Retrospective data

How Imported Pathology Becomes Overlooked as Resources Increase: An Example of a Neglected Tropical Disease (NTD). (PubMed, Trop Med Infect Dis) - "Management involved staged antiparasitic therapy with albendazole, ivermectin, praziquantel, and diethylcarbamazine, combined with corticosteroids to mitigate treatment-related reactions...Comprehensive, multidisciplinary approaches are essential, particularly in patients from endemic regions who may harbor multiple co-infections. Strengthening clinical awareness, referral pathways, and appropriate screening for NTDs may help reduce diagnostic delays and improve patient outcomes in increasingly globalized healthcare settings."

Journal • Dermatology • Infectious Disease • Pruritus

Efficacy of five peroral therapeutics against Ichthyophthirius multifiliis infestation in salmonids. (PubMed, Vet Med (Praha)) - "The timing of administration was critical, and prophylactic use of effective compounds via feed may offer a practical strategy for controlling I. multifiliis outbreaks. These findings support the potential of doxycycline and praziquantel as oral chemotherapeutics in aquaculture, warranting further investigation for therapeutic use in advanced infection stages."

Journal • Infectious Disease

Development of synthetic methodologies for 1,2-diamines and their applications in the total synthesis of natural products and drug molecules | Poster Board #1693 (ACS-Fall 2026) - "In another example of the practical application of our methodology, we are executing a new synthetic approach for enantiopure praziquantel, the drug treatment option for the neglected tropical disease, schistosomiasis...However, instead of the expected 1,2-diamine, we obtained two cyclic urea derivatives in 5:1 ratio, which are both potential products of further intramolecular chemical transformations of the expected 1,2-diamine. In the future, we plan to optimize ongoing efforts and also explore milder approaches of hydrogenation to afford the 1,2-diamines from the 1,2,3-triazolidines in this synthetic scheme."

Infectious Disease

Nationwide epidemiology of hospitalized schistosomiasis in Japan: Coexistence of residual Schistosoma japonicum and non-japonicum infections. (PubMed, Parasite Epidemiol Control) - "Praziquantel was administered to 4 patients (4%), consistent with the predominance of chronic sequelae rather than active infection. In conclusion, the current inpatient burden of schistosomiasis in Japan predominantly reflects the long-term clinical legacy of past S. japonicum transmission, underscoring the importance of continued clinical awareness and surveillance despite the elimination of domestic transmission."

Journal • Colorectal Cancer • Fibrosis • Gastroenterology • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Oncology • Solid Tumor

Phytochemical Characterization, Molecular Docking Analysis, and In Vitro Antischistosomal Activity of Capsicum annuum Methanolic Extract. (PubMed, Chem Biodivers) - "Concentrations of C. annuum extract (20-320 µg/mL) and praziquantel (0.2 µg/mL) were evaluated for time-dependent worm mortality at 1, 3, 12, 24, 48, and 72 h post-treatment...Docking analysis suggested apoptosis-related proteases and a Ser/Thr kinase as putative molecular targets that warrant further experimental validation. These findings demonstrate that C. annuum methanolic extract possesses promising antischistosomal activity against S. mansoni."

Journal • Preclinical • Infectious Disease