praziquantel / Generic mfg. - LARVOL DELTA

Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPMPZQ Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni. (PubMed, ACS Infect Dis) - "Molecular modeling studies suggest that the PZQ binding site on Sm.TRPMPZQ may accommodate extended substituents on position 9 of the pyrazinoisoquinoline ring due to a conformational flexibility of the Y1517 side chain. This feature could be explored to design new PZQ analogues with improved drug metabolism and pharmacokinetic properties."

Journal • Infectious Disease

Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits host recognition. (PubMed, PLoS Pathog) - "Although mass drug administration of praziquantel effectively controls the disease in most regions, achieving elimination will require reducing populations of infected snails that shed the human-infective larval stage...Notably, some of these snail peptides can mask the natural gradient of snail cues and inhibit miracidia recognition of snails. This work establishes a scalable behavioral platform for probing parasite-snail interactions and identifies a peptide scaffold that potently blocks snail recognition."

Journal • Infectious Disease

In vitro and in silico schistosomicidal activity of hexane fraction from Copaifera oblongifolia leaves. (PubMed, In Silico Pharmacol) - "While the current treatment with praziquantel is cost-effective, emerging drug resistance underscores the urgency for new therapeutic agents...Further isolation, characterization, and in vivo studies are needed to confirm their potential as natural drug leads. The online version contains supplementary material available at 10.1007/s40203-025-00501-7."

Journal • Preclinical • Infectious Disease

Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs. (PubMed, Parasit Vectors) - "The laboratory studies described herein confirm that a single dose of lotilaner, at the minimum effective dosage of 20 mg/kg, administered as Credelio Quattro, in combination with moxidectin, praziquantel, and pyrantel or Credelio, is effective for the prevention of transmission of B. burgdorferi from infected I. scapularis for a full month in dogs."

Journal • Infectious Disease • Inflammatory Arthritis • Lyme Disease

Exploring drug coverage variability within districts: A CES approach to investigate treatment gaps in Mozambique's schistosomiasis program. (PubMed, PLoS Negl Trop Dis) - "This study highlights how CES can be used to detect heterogeneity of coverage within districts while simultaneously identifying behavioral and operational barriers to participation. Integrating sub-district level spatial analysis with contextual data on reasons for non-uptake can support in the identification of local treatment gaps, which may be integral to tailor approaches to improve MDA participation in future campaigns as national schistosomiasis programs are increasingly urged to conduct MDA at a sub-district level. These findings suggest that more granular data collection within CES could better inform program adjustments and resource allocation."

Journal • Infectious Disease

ADORA-VI: Efficacy and Safety of Ascending Doses of Arpraziquantel in Children Infected With Opisthorchis Viverrini (clinicaltrials.gov) - P2 | N=125 | Not yet recruiting | Sponsor: Jennifer Keiser

New P2 trial • Infectious Disease

Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil. (PubMed, Int J Parasitol Drugs Drug Resist) - "Reduction in S. mansoni burden was observed over time, with the IRR in all groups exceeding the efficacy threshold established by the WHO (>90 %). Cure rates varied according to the diagnostic method used, being overestimated when based on egg quantification, highlighting the importance of using more sensitive tools for the detection of active infections and monitoring the efficacy of PZQ."

Journal • Infectious Disease

Prevalence and associated factors of schistosomiasis among children and adolescents visiting Chitokoloki Mission Hospital of Zambezi District. (PubMed, BMC Infect Dis) - "There is a significant burden of urogenital schistosomiasis among school-aged children and adolescents attending Chitokoloki Mission Hospital in Zambezi District, Zambia. Targeted praziquantel distribution, cost-effective school-based urine screening in high endemic areas, awareness campaigns to sensitize the community on transmission and reinfections and the integration of nutritional and anaemia management strategies are critical components for effective disease control. Strengthening these interventions is essential to advance progress toward achieving the World Health Organization's 2030 schistosomiasis elimination targets in Zambia."

Journal • Hematological Disorders • Infectious Disease • Urology

Unexpected Schistosomiasis Diagnosed After Appendectomy in a Migrant Child. (PubMed, Am J Case Rep) - "She received 2 doses of praziquantel (40 mg/kg) administered 14 days apart...Incidental intraoperative detection of hepatic lesions prompted targeted biopsy, which proved decisive for diagnosis. Early recognition, timely treatment, and heightened clinical awareness can prevent long-term complications and support targeted screening integration into non-endemic healthcare systems."

Journal • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hepatology • Infectious Disease • Inflammation • Oncology • Pain • Pediatrics

Reversible paralysis in pregnancy, thinking beyond malaria: a case report. (PubMed, BMC Infect Dis) - "This case demonstrates the dual burden of malaria and schistosomiasis manifesting as reversible paralysis in pregnancy. Additionally, this case highlights the danger of anchoring bias secondary to a co-existing malaria infection in a low-resource setting where diagnostic evaluation is limited. Public health policies and programmes are needed to eliminate these infectious diseases of poverty to achieve the Sustainable Development Goals."

Journal • Infectious Disease • Malaria • Musculoskeletal Pain • Pain

Zoonotic Schistosomiasis: The Crossroads Between Animal and Human Schistosomiasis in Africa: Narrative Review. (PubMed, Health Sci Rep) - "Although there is less data on the ability of hybrid to cause resistance on praziquantel, experts suggest a possibility. This review calls for researchers, experts, and stakeholders to come together to provide empirical data on this menace especially on the prevailing Schistosoma species in livestock on the African continent."

Journal • Infectious Disease

Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. (PubMed, bioRxiv) - "Chemotherapeutic options for schistosomiasis, a prevalent infectious disease of poverty, are limited to just one drug, praziquantel (PZQ), and alternatives are needed...Finally, to identify potential protein targets, we synthesized a TPP photoaffinity labeling (PAL) probe that labeled several S. mansoni proteins by SDS-PAGE fluorescence analysis, although, notably, not tubulin, suggesting that the antischistosomal activity of 38 is a function of engaging other targets. Future work with the TPP series will aim to decrease toxicity further and improve pharmacokinetic properties to better support in vivo efficacy testing."

Journal • Infectious Disease

Assessment of the trematocidal activity of Citrus aurantium extracts and its major component (limonene) in dogs. (PubMed, Am J Vet Res) - "These outcomes were comparable to those obtained with the standard anthelmintic drug praziquantel, which exhibited 100% efficacy by day 28 of the experiment...The study presents a natural and cost-effective alternative to conventional anthelmintics. However, since safety and toxicity were not evaluated in this study, the conclusions regarding the therapeutic applicability should be considered preliminary."

Journal

Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study. (PubMed, PLoS Negl Trop Dis) - "Women with S. haematobium infection and those with recent parasitological clearance were found to have cervical gene alterations that have been reported in various cancers. Our findings suggest a possible increase in cervical cancer risk and susceptibility to secondary infections shortly after treatment. Further research is necessary to ascertain whether altered gene expression after parasitological clearance of S. haematobium resolves over time."

Journal • Bladder Cancer • Cervical Cancer • Infectious Disease • Oncology • Solid Tumor

Recurrent Granulomatous Mastitis Associated with Breast Sparganosis: A Case Report. (PubMed, Int J Infect Dis) - "The patient underwent surgical excision followed by praziquantel therapy, without recurrence at 12-months of follow-up. This case underscores the need to consider parasitic infection as a cause of granulomatous mastitis in endemic regions and highlights the value of molecular diagnostics when histopathology is inconclusive. Complete surgical excision remains the cornerstone of treatment, making an accurate diagnosis essential, as management differs from other forms of granulomatous mastitis."

Journal • Infectious Disease • Inflammation • Pain

WITHDRAWN Unusual Neurologic Decline in a 28-Year-Old: The Hidden Burden of Schistosomiasis Beyond the Liver in a Patient with End-Organ Vulnerabilities (ASTMH 2025) - "Empiric Praziquantel therapy was initiated based on clinical grounds...The clinical course was further complicated by the dilemma of distinguishing neuroschistosomiasis from other central nervous system infections and neoplastic processes. This highlights the critical role of heightened clinical suspicion and timely empiric therapy in mitigating the risk of irreversible neurological sequelae."

Clinical • Late-breaking abstract • Infectious Disease • Respiratory Diseases • Tuberculosis

WITHDRAWN A Cas13-based assay for detection of circulating microRNAs (miRNAs) associated with schistosomiasis (ASTMH 2025) - "The presence of specific miRNAs in the blood of patients is associated with the degree of fibrosis, as well as clearance of the parasites by praziquantel treatment...These results demonstrate the potential for this assay, which requires no RNA purification, reverse transcription, or amplification, to provide POC detection of miRNAs in patient samples. Next, we will optimize assay sensitivity and specificity and then test in schistosomiasis positive patients across varying disease stages."

Fibrosis • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis

WITHDRAWN Spinal cord schistosomiasis a rare and severe presentation of a common disease A case report and review of literature (ASTMH 2025) - "Treatment-Oral Praziquantel: 680 mg twice daily for five days with oral Prednisolone,15 mg twice daily for 15 days, followed by a taper. Discussion-Spinal cord schistosomiasis, while rare, poses a significant risk if not promptly found and treated. This case illustrates the critical role of early diagnosis and treatment in SCS."

Case report • Clinical • Review • Back Pain • Eosinophilia • Infectious Disease • Muscular Atrophy • Musculoskeletal Pain

Creation and Application of a Health Campaign Integration Optimization Algorithm: Retrospective Analysis of Schistosomiasis Campaigns in Four Countries and Prospective Analysis Across Health Programs in Nigeria (ASTMH 2025) - "In a retrospective analysis, the algorithm identified missed integration opportunities in 2024 for praziquantel (PZQ) campaigns in schistosomiasis-endemic areas of the Democratic Republic of the Congo, Ethiopia, Guinea, and Nigeria...Planned algorithm refinements will add expiration dates, funding sources, and delivery methods. Future work could adapt the algorithm for country-specific use and incorporate projected integration impacts on campaign costs and coverage."

Retrospective data • Infectious Disease

Case Report: Praziquantel-induced flare-up reaction in a rare case of diclofenac-induced probable DRESS comorbid with acute clonorchiasis: diagnostic and therapeutic challenges. (PubMed, Front Med (Lausanne)) - "This case underscores the diagnostic complexity in distinguishing parasitic infections from DRESS through parasitological confirmation, herpesvirus reactivation profiling, validated DRESS criteria, and lesional skin histopathology. Therapeutically, stepwise immunomodulatory prioritization for DRESS control is essential, with PZQ therapy restricted to life-threatening parasitosis only after achieving immune stability, under intensive monitoring for hypersensitivity recrudescence and end-organ damage."

Journal • Chronic Kidney Disease • Dermatopathology • Eosinophilia • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Renal Disease

Hydatid Cyst of the Thigh With Incidental Hepatitis B: A Rare Case. (PubMed, Cureus) - "She was started on albendazole and praziquantel, but treatment was complicated by an incidental finding of hepatitis B and suspected drug-induced hepatotoxicity. Surgical excision was performed, and she remains under regular multidisciplinary follow-up with MRI surveillance. This case highlights the diagnostic difficulty of extrahepatic hydatid disease and the importance of individualised management when liver comorbidities restrict antiparasitic therapy."

Journal • Hepatitis B • Infectious Disease • Inflammation • Musculoskeletal Diseases • Pain

First insight into the role of the host-derived mmu-mir-214 and the parasite-derived sma-bantam as biomarkers of the Egyptian strain of Schistosoma mansoni infection before and after praziquantel treatment. (PubMed, Acta Trop) - "Interestingly, the expression levels of both miRNAs were significantly reduced following treatment. This study uncovers new insights into the role of miR-214 and sma-bantam, especially if combined together, in detecting early cases, assessing the infection intensity, monitoring disease pathology and response to praziquantel treatment of the Egyptian strain of Schistosoma mansoni that have not documented in an earlier work."

Biomarker • Journal • Infectious Disease • Inflammation • MIR214

Delayed schistosomiasis and hypereosinophilic syndrome following remote residence in Japan (ACAAI 2025) - "He was prescribed a 1-week course of prednisone without symptomatic improvement...High-dose steroids were continued and praziquantel was started with symptomatic improvement and resolution of eosinophilia. Discussion This patient developed HES from schistosomiasis 10 years after leaving an endemic region. This case demonstrates the importance of considering parasitic infections in the differential diagnosis of eosinophilia in patients with a remote travel history to endemic regions."

Anorexia • Asthma • Cardiovascular • Eosinophilia • Fatigue • Hematological Malignancies • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Respiratory Diseases • Rheumatology • Thrombosis

Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. (PubMed, ChemMedChem) - "Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available-praziquantel (PZQ)...Two ferrocenyl and one ruthenocenyl derivatives also displayed higher potency against adult schistosomes than niridazole. In conclusion, valuable information could be gained on the structure-activity relationship of the different organometallic modifications, which could be used to design a second generation of derivatives with further improved activity profiles."

Journal • Preclinical • Infectious Disease

Schistosomiasis or Ulcerative Colitis? Unraveling the Overlap Between Parasitic Infection and IBD (ACG 2025) - "He was started on mesalamine and prednisone...Symptom improvement following praziquantel and albendazole may reflect parasite clearance, but concurrent steroid use makes it unclear whether recovery was due to anti-parasitic therapy, immunosuppression, or both...Endoscopic image of the rectum showing continuous moderate inflammation consistent with ulcerative colitis, with loss of vascular pattern, erythema, friability, and superficial ulcerations (Mayo 2).Figure: Figure 2. Left colon biopsy: Colonic mucosa with increased lamina propria eosinophils, eosinophilic microabscess, and parasite ova/larva."

Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis