diclofenac/paracetamol tablets / Generic mfg. - LARVOL DELTA

Analysis of Seriousness and Preventability of Adverse Drug Reactions in Patients at a Tertiary Care Teaching Hospital: A Case Series. (PubMed, Cureus) - "The cases included fixed drug eruption associated with paracetamol/amoxicillin exposure, Stevens-Johnson syndrome/toxic epidermal necrolysis following ceftriaxone administration, and acute renal failure after intake of a fixed-dose combination of diclofenac and paracetamol. The cases highlight the contribution of irrational prescribing, inappropriate drug combinations, and delayed recognition to preventable serious ADRs. Early withdrawal of the suspected drug, timely reporting to pharmacovigilance centres, multidisciplinary management, rational prescribing, adherence to clinical protocols, and patient awareness are essential to reduce recurrence and improve medication safety."

Adverse drug reaction • Journal • Acute Kidney Injury • Renal Disease • Steven-Johnson Syndrome

A Comparative Analysis of the Efficacy and Safety of Nimesulide/Paracetamol Fixed-Dose Combination With Other NSAIDs in Acute Pain Management: A Randomized, Prospective, Multicenter, Active-Controlled Study (the SAFE-2 Study). (PubMed, Cureus) - "Conclusions The FDC of nimesulide with paracetamol is superior to ketorolac and non-inferior to the FDC of diclofenac with paracetamol and aceclofenac with paracetamol in the management of pain in patients with acute painful conditions. The tolerability profile of the FDC of nimesulide with paracetamol is similar to that of ketorolac but better than diclofenac with paracetamol and aceclofenac with paracetamol combinations."

Journal • Back Pain • Cardiovascular • CNS Disorders • Gastrointestinal Disorder • Inflammation • Lumbar Back Pain • Migraine • Mood Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Peptic Ulcer