Sivextro (tedizolid) / Merck (MSD), Nabriva Therap - LARVOL DELTA

Development, Validation, and Clinical Application of a Simultaneous Quantification Method of Seventeen Antituberculosis Drugs in Plasma, Serum, or Saliva Using LC-MS/MS. (PubMed, Ther Drug Monit) - "This validated LC-MS/MS method allows simultaneous analysis of multiple anti-TB drugs in plasma, serum, and saliva, facilitating clinical and research applications. The method has been successfully applied in clinical practice."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Advances in the diagnosis and management of skin and soft tissue infections. (PubMed, BMJ) - "Management of SSTI includes antibiotics such as penicillin VK, dicloxacillin, or a cephalosporin, while treatment for skin abscess includes incision and drainage, with antibiotics recommended in select patients. While most patients with cellulitis or skin abscess are appropriate for discharge with follow-up, patients with sepsis and those with challenges adhering to therapy, immunosuppression, or failed outpatient therapy should be referred to the emergency department. Novel antibiotics such as tedizolid, delafloxacin, omadacycline, and ceftaroline may be considered in select cases."

Journal • Review • Dermatology • Infectious Disease • Inflammation • Pain • Septic Shock

Nitric oxide enhances antimicrobial effects of clofazimine against Mycobacterium abscessus (NACFC 2026) - "We also performed 3-D checkerboard assays in one laboratory strain (ATCC 19977) combining CFZ + dNO with seven antibiotics (amikacin, cefoxitin, linezolid, tedizolid, bedaquiline, omadacycline, and imipenem). Inhaled NO is a promising adjunctive therapy for MAB, particularly when combined with CFZ. However, NO-antibiotic interactions are complex, and further research is needed to guide the selection of optimal antibiotic regimens."

Cardiovascular • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Synergy and mechanism of tedizolid in combination with fluconazole against resistant Candida albicans. (PubMed, Future Microbiol) - "Mechanistic studies revealed that synergistic inhibition was associated with ROS accumulation, impaired filamentous development, metacaspase activation, and disruption of Ca2+ homeostasis, but was independent of drug uptake and efflux pathways. The TDZ and FLC combination demonstrates the significant cooperative antimycotic potential against resistant C. albicans, providing a foundation for developing novel therapeutic strategies against resistant candidiasis and offering valuable insights into new antifungal agent development."

Journal • Candidiasis • Infectious Disease

Clinical improvement of methicillin-resistant Staphylococcus epidermidis prosthetic knee joint infection after changing therapy from tedizolid to linezolid: A case report. (PubMed, J Infect Chemother) - "The patient achieved sustained clinical improvement without severe thrombocytopenia. This case suggests that switching from TZD to LZD may be an effective therapeutic strategy when TZD fails to control MRSE PKJI and that therapeutic drug monitoring-guided dose adjustment may facilitate prolonged LZD therapy while minimizing hematological toxicity."

Journal • Hematological Disorders • Infectious Disease • Orthopedics • Thrombocytopenia

A rare invader on a cardiac stent: Mycobacterium abscessus mediastinitis managed with tedizolid after linezolid intolerance. (PubMed, IDCases) - "The patient received a multidrug regimen anchored by amikacin and an oxazolidinone...Because of early hematologic intolerance to linezolid, therapy was transitioned to tedizolid 200 mg once daily, with clofazimine later used as the companion oral agent after intolerance to minocycline...Serial imaging showed substantial regression of the mediastinal lesion without clinically significant FDG uptake at end of therapy. This case highlights three clinically relevant lessons: first, post-PCI M. abscesses stent-associated mediastinitis demands aggressive source control; second, tedizolid can serve as a viable salvage therapy after linezolid intolerance; third, serial cardiac PET-CT can assist treatment monitoring when repeat deep tissue sampling is impractical; and fourth, advanced multimodal imaging plays a critical role in diagnosis, surgical planning, and monitoring of complex post-cardiac surgical infections."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nontuberculous Mycobacterial Disease • Pain • Respiratory Diseases

Green stability-indicating RP-HPLC method for simultaneous bioanalysis of tedizolid phosphate and ciprofloxacin in human plasma. (PubMed, Sci Rep) - "The environmental impact of the method was comprehensively evaluated using multiple established greenness and blueness assessment tools, confirming its favorable environmental profile. Overall, the developed approach presents a rapid, highly accurate, and environmentally sustainable strategy for the simultaneous bioanalysis of TP and CIP in bulk drugs, pharmaceutical formulations, and human plasma."

Journal • Infectious Disease

Design and synthesis of neomycin-oxazolidinone hybrid antibiotics: exhibiting synergistic activity against Pseudomonas aeruginosa via outer membrane disruption. (PubMed, Bioorg Chem) - "In this study, we designed and synthesized 14 neomycin-oxazolidinone hybrid antibiotics, comprising one direct neomycin-tedizolid hybrid, nine tedizolid-neomycin hybrids with alkyl linkers of varying lengths, and four linezolid-neomycin hybrids with different linker lengths...In addition, the representative hybrids exhibited low cytotoxicity toward mammalian cells. These findings identify neomycin-oxazolidinone hybrids as promising antibiotic adjuvants for potentiating the activity of existing antibiotics against Gram-negative pathogens and provide a useful strategy for combating multidrug-resistant bacterial infections."

Journal • Infectious Disease

UFL1-Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression. (PubMed, Adv Sci (Weinh)) - "Notably, pharmacological enhancement of the UFL1-ENO1 interaction using the FDA-approved antibiotic torezolid significantly potentiates the antitumor efficacy of 5-fluorouracil (5-FU) across multiple preclinical models, including CRC patient-derived organoids and xenografts, without detectable toxicity. Collectively, these findings identify ENO1 as a direct substrate of UFMylation, establish UFMylation as a previously unrecognized regulator of cancer metabolic reprogramming, and highlight the UFL1-ENO1 axis as a promising therapeutic target for colorectal cancer."

Journal • Colorectal Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • ENO1

Impact of Elexacaftor/Tezacaftor/Ivacaftor on Systemic Antibiotic Utilization in Pediatric Patients With Cystic Fibrosis. (PubMed, Pediatr Pulmonol) - "ETI therapy was associated with decreased antibiotic days for many therapeutic classes of both enteral and IV antibiotics."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • CFTR

Mycobacterium abscessus subsp. abscessus Pulmonary Disease: Fatal Case in an Immunocompetent Patient. (PubMed, New Microbiol) - "Guideline-based multidrug therapy with intravenous amikacin, tedizolid, clofazimine, and moxifloxacin was initiated. Nephrotoxicity required substitution of intravenous amikacin with an inhaled formulation, followed by ototoxicity and further modification with tigecycline...This case shows that MABC infection may follow an aggressive, life-threatening course even in immunocompetent individuals. Antimicrobial resistance combined with treatment-limiting toxicity underscores the urgent need for more effective, better-tolerated therapies and early multidisciplinary management."

Journal • Cachexia • Infectious Disease • Nontuberculous Mycobacterial Disease • Novel Coronavirus Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Nocardia antimicrobial susceptibility testing by microdilution: evaluation of ready-to-use plate including tedizolid and meropenem. (PubMed, Eur J Clin Microbiol Infect Dis) - "For the antimicrobials common to both plates, the FRNOCAR1 demonstrated good agreement compared with RAPMYCOI. FRNOCAR1 includes tedizolid and meropenem, for which MIC could be reported upon justified request, with a comment indicating that these results are pending further validation."

Journal • Infectious Disease

Study of Tedizolid susceptibility among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections, eastern India. (PubMed, Indian J Med Microbiol) - No abstract available

Journal • Infectious Disease

Tedizolid Targets AQP9-JAK/STAT Axis to Suppress Metastatic Progression in Clear Cell Renal Cell Carcinoma: Mechanism and Therapeutic Implications. (PubMed, Int J Mol Sci) - "In conclusion, AQP9 promotes ccRCC metastasis through the JAK/STAT-EMT axis and represents a potential prognostic biomarker and therapeutic target. Tedizolid, identified as a novel AQP9 inhibitor, offers a promising repurposed strategy for ccRCC treatment."

Journal • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Oncology • Solid Tumor

Septic Pulmonary Embolism due to Methicillin-Resistant Staphylococcus aureus Bacteremia during Adjuvant Chemotherapy for Breast Cancer: A Case Report. (PubMed, Case Rep Oncol) - "A woman in her 50s with a history of atopic dermatitis underwent left mastectomy and sentinel lymph node biopsy for hormone receptor-positive, HER2-negative breast cancer, followed by weekly adjuvant paclitaxel chemotherapy...Empirical intravenous antibiotic therapy was initiated and later deescalated to oral tedizolid after methicillin-resistant Staphylococcus aureus was confirmed...SPE should be considered in patients with breast cancer who develop fever and new pulmonary nodules during adjuvant chemotherapy, particularly in those with underlying skin conditions or chemotherapy-induced immunosuppression. Prompt recognition and targeted antibiotic therapy are essential for achieving favorable clinical outcomes."

Journal • Atopic Dermatitis • Breast Cancer • Cardiovascular • Dermatitis • Dermatology • Hematological Disorders • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Immunology • Infectious Disease • Leukopenia • Musculoskeletal Pain • Oncology • Pain • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • CRP • HER-2

Antibiotic Tolerability in Nocardia Infection Among Kidney Transplant Recipients: A Multicenter Cohort Study. (PubMed, Transpl Infect Dis) - "This is the largest series of Nocardia infection in KT recipients in Spain and the first to specifically evaluate antibiotic tolerability. TMP-SMX and linezolid were poorly tolerated, reinforcing the need for alternative strategies. Tedizolid showed a favorable safety profile and may be considered a promising first-line option in high-risk patients. Further prospective studies are needed to confirm these findings and support guideline development."

Journal • Acute Kidney Injury • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Solid Organ Transplantation • Transplantation

Retrospective comparative study of myelosuppression associated with linezolid and tedizolid therapy. (PubMed, J Infect Chemother) - "TZD demonstrated a lower risk of myelosuppression than LZD, particularly in patients undergoing hemodialysis."

Journal • Retrospective data • CNS Disorders • Hematological Disorders • Infectious Disease • Respiratory Diseases • Thrombocytopenia

New Lungs, Old Foes: The Challenges of Resistant Infections Pre - and Post-Transplant in a Patient with Cystic Fibrosis (ISHLT 2026) - "The patient was initiated on intravenous (IV) imipenem-cilastatin-relebactam and IV colistin based on clinical improvement with this regimen during a prior exacerbation...Sputum cultures grew methicillin-susceptible Staphylococcus aureus and P. aeruginosa susceptible to cefiderocol...He was started on empiric therapy for rapid growing NTM infection with tedizolid, azithromycin, ethambutol, imipenem, moxifloxacin, and inhaled amikacin...Following availability of susceptibilities, the patient was discharged on IV amikacin, oral azithromycin, and oral omadacycline. Donor investigation revealed a healthy 19-year-old man who drowned in a chlorinated pool.Summary This case highlights a successful lung transplant in a CF patient with ongoing pan-drug-resistant Pseudomonas infection, complicated by a donor-derived polymicrobial NTM infection. Although rare, such infections can be effectively managed with thoughtfully selected antimicrobial therapy."

Clinical • Post-transplantation • Bronchiectasis • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

Between a Heart and a Hard Node: A Difficult Case of Lymphadenopathy (ISHLT 2026) - "For immunosuppression, he was on belatacept, tacrolimus, mycophenolate, and prednisone...He was started on empiric mycobacterial treatment with intravenous amikacin, imipenem, linezolid, ethambutol, and rifabutin...He completed 4 weeks of ertapenem, and has continued on isavuconazole, azithromycin, ethambutol, rifabutin, and tedizolid.Summary This case highlights a challenging presentation of lymphadenopathy with B-symptoms initially concerning for PTLD but was found to have multiple infections. In immunosuppressed patients, overlapping infectious and noninfectious processes can complicate diagnosis. Obtaining comprehensive diagnostic evaluation is essential to identify the cause and initiate appropriate therapy for optimal outcomes."

Clinical • Cardiomyopathy • Cardiovascular • Infectious Disease • Pneumonia

Post-marketing pharmacovigilance of tedizolid: emerging safety signals. (PubMed, Expert Opin Drug Metab Toxicol) - "Post-marketing data confirm TED's hematologic risks and reveal additional potential hepatic, neuropsychiatric, and gastrointestinal signals. These findings merit further evaluation and prospective studies to clarify clinical significance, establish causality, and optimize monitoring strategies."

Adverse events • Journal • P4 data • Hematological Disorders • Psychiatry

Investigating tedizolid analogues as a new class of herbicides. (PubMed, Org Biomol Chem) - "Here we use tedizolid, a known antibiotic, as a scaffold for herbicide development. Tedizolid analogues have been prepared with herbicidal activity and diminished antibacterial activity, as demonstrated using model systems."

Journal

Antibiotic dose-response curves can measure antibiotic activity against Mycobacterium abscessus and Mycobacterium peregrinum. (PubMed, Antimicrob Agents Chemother) - "We used Clinical and Laboratory Standards Institute growth conditions for rapidly growing nontuberculous mycobacteria AST to generate 990 dose-response curves across three time points (72 h, 96 h, and 120 h) for six guideline-recommended (clarithromycin, amikacin, cefoxitin, linezolid, tigecycline, and clofazimine) and five new (omadacycline, tedizolid, SPR719, SQ109, and bedaquiline) antibiotics against Mycobacterium abscessus subspecies abscessus ATCC 19977 and Mycobacterium peregrinum ATCC 700686. We identified time-dependent changes in dose-response curve metrics that allow the detection of inducible clarithromycin resistance with only 5 days of incubation. This study demonstrates the potential of dose-response curves in measuring antibiotic activity against Mycobacterium abscessus."

Journal • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Current Status and Perspectives of Antibacterial Agents Belonging to 2-Oxazolidinones. (PubMed, Pharmaceuticals (Basel)) - "Tedizolid phosphate was the second commercially available oxazolidinone antibiotic approved, followed by other oxazolidinones (contezolid, radezolid, ranbezolid, sutezolid, delpazolid, cadazolid, TBI-233 and MK-7762) that are in clinical study. Three literature databases, i.e., PubMed/MEDLINE, Google Scholar and Scopus, were used for the literature search, particularly focusing on the last five years, and screened using different keywords. The design of new drugs belonging to this class may be of considerable interest to researchers and clinicians, contributing to the discovery of new antibiotics that retain antibacterial activity but have fewer side effects."

Journal • Review • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Investigation of In vitro Efficacy of New Generation Drugs Tedizolid and Omadacycline against Nontuberculous Mycobacteria. (PubMed, Int J Mycobacteriol) - "The findings demonstrated that TZD exhibits strong in vitro activity against NTM isolates, whereas OMC showed a variable activity profile, particularly among rapidly growing species. These results support the necessity of basing antibiotic selection for the treatment of NTM infections on species-specific susceptibility testing."

Journal • Preclinical • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Advances in Therapeutic Drug Monitoring and Pharmacokinetic Researches of Oxazolidinone Antibacterial Agents in the Elderly Patients. (PubMed, Clin Interv Aging) - "Therefore, this article comprehensively reviews the progress in therapeutic drug monitoring (TDM) and pharmacokinetic (PK) studies of linezolid, contezolid and tedizolid in the elderly population, to inform individualized dosing strategies...The PK characteristics of oxazolidinone antibiotics may be altered in the elderly population. TDM and model-informed precision dosing (MIPD) are crucial approaches for achieving individualized dosing strategies."

Journal • PK/PD data • Review • Infectious Disease