Organix (pectin/menthol)
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September 30, 2025
IL-17A-driven stromal-immune crosstalk in human vascularized 3D pancreatic cancer models reveals microenvironment reprogramming
(CICON 2025)
- "Functional validation of transcriptomic signatures was supported by proteomic data aligning with transcriptomic findings, flow cytometry-based phenotyping, and 3D assays in OrganiX microfluidic platform, which enable the generation of perfusable vascularized microtumors showing enhanced EC infiltration and increased cancer cell invasion in the four-cell condition...Cytokine analysis from vascularized four-cell PDAC microtumors further revealed that IL-17A inhibition in the presence of T cells shifted the cytokine milieu toward an anti-tumorigenic profile. Our integrated approach demonstrates that targeting stromal-immune crosstalk, particularly via IL-17A, reprograms the PDAC microenvironment and could synergize with immunotherapy, providing a preclinical framework for advancing TME-targeting strategies in pancreatic cancer."
IO biomarker • Preclinical • Stroma • Fibrosis • Immunology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CAFs • IL17A
February 28, 2024
The OrganiX microfluidic system to recreate the complex tumour microenvironment.
(PubMed, Nat Rev Immunol)
- No abstract available
Journal • Tumor microenvironment • Oncology
July 26, 2023
"Tech alert: #OrganixInc has renovated, revamped and reinvigorated our laboratory by upgrading to a 400 MHz @Jeol #NMR and new @Agilent systems including a #UHPLC-CAD for elevated client services and expanded capabilities. Like and follow https://t.co/PAsN9kyk0V"
(@OrganixCRO)
May 27, 2023
Long-Lasting Electret Melt-Blown Nonwoven Functional Filters Made of Organic/Inorganixc Macromolecular Micron Materials: Manufacturing Techniques and Property Evaluations.
(PubMed, Polymers (Basel))
- "Finally, the scanning electron microscopy (SEM) observation suggests that with a spinning die temperature of 240 °C and a spinning die pressure lower than 0.01 MPa, the compound pellets can be successfully formed into melt-blown nonwoven fabrics with a 10-micrometer diameter. The proposed melt-blown nonwoven fabrics can be processed with electret to form long-lasting electret melt-blown nonwoven filters."
Journal
October 14, 2022
"@col_x3q6 @K9xOrganix @VJHemOnc @airdropcuhoca @fammarrnft @Aziz_eth @elchopo35z"
(@IRemmahyc)
July 11, 2022
"A huge thank our #MALSI22 sponsors! @novonordisk, @MassBio, @burnslev, #McDermottWillandEmery, @troutmanpepper, @LabShares, @RegDocs365, #Organix, @JNJNews, and #MassachusettsLifeSciencesCenter. ✅ RSVP 👉 https://t.co/KD3ryRGqam #LifeScience"
(@My_InnoStudio)
April 27, 2022
"#Symeres acquires Massachusetts-based #Organix adding lipids expertise and creating a strategic foothold in the US market https://t.co/dmezIyW0l9"
(@1stOncology)
November 29, 2019
Sampling and degradation of biodegradable plastic and paper mulches in field after tillage incorporation.
(PubMed, Sci Total Environ)
- "2, we applied and tilled four plastic BDMs: BioAgri, Naturecycle, Organix AG, and an experimental mulch; and one paper mulch, WeedGuardPlus, in their respective plots for four consecutive years...The results show that the quartering method reliably estimates the amount of mulch in a field and BDMs degrade over time in the field even with repeated applications, but complete degradation takes >1 year. While a few standards (e.g., ASTM D5988) specify how to determine biodegradation of plastics in soil under controlled laboratory conditions, our sampling method assesses plastic degradation under diverse field conditions."
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