Organix (pectin/menthol) / ProPhase - LARVOL DELTA

IL-17A-driven stromal-immune crosstalk in human vascularized 3D pancreatic cancer models reveals microenvironment reprogramming (CICON 2025) - "Functional validation of transcriptomic signatures was supported by proteomic data aligning with transcriptomic findings, flow cytometry-based phenotyping, and 3D assays in OrganiX microfluidic platform, which enable the generation of perfusable vascularized microtumors showing enhanced EC infiltration and increased cancer cell invasion in the four-cell condition...Cytokine analysis from vascularized four-cell PDAC microtumors further revealed that IL-17A inhibition in the presence of T cells shifted the cytokine milieu toward an anti-tumorigenic profile. Our integrated approach demonstrates that targeting stromal-immune crosstalk, particularly via IL-17A, reprograms the PDAC microenvironment and could synergize with immunotherapy, providing a preclinical framework for advancing TME-targeting strategies in pancreatic cancer."

IO biomarker • Preclinical • Stroma • Fibrosis • Immunology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CAFs • IL17A

The OrganiX microfluidic system to recreate the complex tumour microenvironment. (PubMed, Nat Rev Immunol) - No abstract available

Journal • Tumor microenvironment • Oncology

"Tech alert: #OrganixInc has renovated, revamped and reinvigorated our laboratory by upgrading to a 400 MHz @Jeol #NMR and new @Agilent systems including a #UHPLC-CAD for elevated client services and expanded capabilities. Like and follow https://t.co/PAsN9kyk0V" (@OrganixCRO)

Long-Lasting Electret Melt-Blown Nonwoven Functional Filters Made of Organic/Inorganixc Macromolecular Micron Materials: Manufacturing Techniques and Property Evaluations. (PubMed, Polymers (Basel)) - "Finally, the scanning electron microscopy (SEM) observation suggests that with a spinning die temperature of 240 °C and a spinning die pressure lower than 0.01 MPa, the compound pellets can be successfully formed into melt-blown nonwoven fabrics with a 10-micrometer diameter. The proposed melt-blown nonwoven fabrics can be processed with electret to form long-lasting electret melt-blown nonwoven filters."

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"@col_x3q6 @K9xOrganix @VJHemOnc @airdropcuhoca @fammarrnft @Aziz_eth @elchopo35z" (@IRemmahyc)

"A huge thank our #MALSI22 sponsors! @novonordisk, @MassBio, @burnslev, #McDermottWillandEmery, @troutmanpepper, @LabShares, @RegDocs365, #Organix, @JNJNews, and #MassachusettsLifeSciencesCenter. ✅ RSVP 👉 https://t.co/KD3ryRGqam #LifeScience" (@My_InnoStudio)

"#Symeres acquires Massachusetts-based #Organix adding lipids expertise and creating a strategic foothold in the US market https://t.co/dmezIyW0l9" (@1stOncology)

Sampling and degradation of biodegradable plastic and paper mulches in field after tillage incorporation. (PubMed, Sci Total Environ) - "2, we applied and tilled four plastic BDMs: BioAgri, Naturecycle, Organix AG, and an experimental mulch; and one paper mulch, WeedGuardPlus, in their respective plots for four consecutive years...The results show that the quartering method reliably estimates the amount of mulch in a field and BDMs degrade over time in the field even with repeated applications, but complete degradation takes >1 year. While a few standards (e.g., ASTM D5988) specify how to determine biodegradation of plastics in soil under controlled laboratory conditions, our sampling method assesses plastic degradation under diverse field conditions."

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