betamethasone dipropionate / Generic mfg. - LARVOL DELTA

Efficacy of Steroid Injection in Patients With Bifid Median Nerve Diagnosed Carpal Tunnel Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Yunus Burak Bayır | Not yet recruiting ➔ Recruiting

Enrollment open • Musculoskeletal Pain

MROSF: Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (clinicaltrials.gov) - P1/2 | N=30 | Completed | Sponsor: Ziauddin University | Not yet recruiting ➔ Completed

Trial completion • Fibrosis • Immunology

A comparative study of the efficacy of potent topical corticosteroids per se versus combination of potent topical corticosteroids with fractional CO2 laser in the management of vitiligo vulgaris. (PubMed, J Cutan Aesthet Surg) - "The study aimed to compare the efficacy of two treatment modalities in vitiligo vulgaris that is - potent topical corticosteroid (betamethasone-dipropionate lotion 0.05%) with FrCO2 laser versus Potent topical corticosteroid (PTS) alone, and to observe side effects if any...This suggests that the addition of FrCO2 to steroids may provide superior repigmentation. The addition of FrCO2 laser to topical corticosteroids offers a safe and promising approach and can be considered in patients who are unresponsive to other treatment modalities."

Journal • Dermatology • Immunology • Vitiligo

Enhanced Anti-Inflammatory and Skin Barrier Repair Effects of Nanoemulsions Supplemented with Boesenbergia rotunda for Atopic Dermatitis. (PubMed, ACS Nanosci Au) - "Betamethasone dipropionate (BD) is a potent anti-inflammatory drug for atopic dermatitis (AD); however, it leads to serious adverse effects during prolonged use...The formulation of BD into nanoemulsions also enhanced S. aureus inhibition. Either B. rotunda nanoemulsions loaded with or without BD show promise for the topical treatment and prevention of AD."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • FLG

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Mar 2025 ➔ Jan 2026 | Trial primary completion date: Jan 2025 ➔ Oct 2025

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

Highly Biocompatible Lamellar Liquid Crystals Based on Hempseed or Flaxseed Oil with Incorporated Betamethasone Dipropionate: A Bioinspired Multi-Target Dermal Drug Delivery System for Atopic Dermatitis Treatment. (PubMed, Int J Nanomedicine) - "Moreover, in comparison with the reference medicine, it stood out by providing suitable chemical BD (betamethasone dipropionate) stability, improved 3-fold BD permeation, and excellent biocompatibility with over 85% cell proliferation at all tested concentrations, ensuring keratinocytes' integrity, as well as promoting skin healing with gap closure observed after 36 hours. Unique multi-target drug delivery strategy depicted in newly developed bioinspired lamellar LCCs structurally resembling stratum corneum intercellular lipids, with incorporated BD drug, and composed of multifunctional components that synergistically strengthen skin barrier, was presented here and shows a promising approach for improved AD treatment."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

A Randomized Double-blind Trial of 5% Dextrose Versus Corticosteroid Hydrodissection for Meralgia Paresthetica. (PubMed, Pain Physician) - "Ultrasound-guided perineural injection therapy of D5W is more beneficial than corticosteroid injection for MP at 4 to 6 months posttreatment. Additionally, D5W displays a better safety profile than corticosteroid. Thus, we suggest D5W as a more suitable injectate for patients with MP."

Clinical • Journal • Pain

Glucocorticoids influence on rat hematological parameters and catalase activity. (PubMed, Front Pharmacol) - "The observed hematological shifts suggest an impact of betamethasone dipropionate on the hematopoietic system, reinforcing the need for cautious corticosteroid administration. The findings underline the necessity for judicious corticosteroid treatment, acknowledging both enzymatic and systemic repercussions."

Journal • Preclinical • Hematological Disorders • CAT

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment. (PubMed, J Nanobiotechnology) - "Additionally, this study demonstrated that BD@Zn-MSN-MN could further alleviate itching in psoriasis-afflicted mice by decreasing the excitability of the transient receptor potential vanilloid V1 (TRPV1) ion channel positive neurons and reducing the release of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). These findings offer new insights and effective therapeutic options for the future design of transdermal drug delivery for psoriasis."

Journal • Dermatology • Immunology • Psoriasis

The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS) (clinicaltrials.gov) - P2 | N=24 | Recruiting | Sponsor: Oticara Australia PTY LTD | N=12 ➔ 24 | Trial completion date: Dec 2023 ➔ Jun 2025 | Trial primary completion date: Dec 2023 ➔ Jun 2025

Enrollment change • Surgery • Trial completion date • Trial primary completion date • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Prescribing of clotrimazole-betamethasone dipropionate, a topical combination corticosteroid-antifungal product, for Medicare part D beneficiaries, United States, 2016-2022. (PubMed, Antimicrob Steward Healthc Epidemiol) - "Annual rates were stable (30.9 prescriptions/1,000 beneficiary-years in 2022, enough for one in every 33 beneficiaries). Diagnostic testing was infrequent, particularly among internal medicine, family medicine, and general practitioners, suggesting potential opportunities to improve diagnostic and prescribing practices."

Journal • Medicare • Reimbursement • US reimbursement

Development of 3D printed microneedles of varied needle geometries and lengths, designed to improve the dermal delivery of topically applied psoriasis treatments. (PubMed, Eur J Pharm Biopharm) - "MAPs were characterized for force to fracture, skin penetration, skin damage, as well as their ability to deliver a novel oleogel-based corticosteroid (betamethasone dipropionate (BDP) formulation into ex-vivo porcine skin. We found that the obelisk shaped MAPs are more durable compared to the conical and square pyramidal-shaped MAPs. When the obelisk shaped MAPs were used in combination with the oleogel-based BDP formulation, the amount of BDP penetrating the skin was significantly increased with greater needle lengths."

Journal • Dermatology • Immunology • Musculoskeletal Diseases • Orthopedics • Psoriasis

Treatment Results for Patients with Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2024 ➔ Mar 2025 | Trial primary completion date: Sep 2024 ➔ Jan 2025

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

Multi-omics and Bioinformatics for the Investigation of Therapeutic Mechanism of Roucongrong Pill against Postmenopausal Osteoporosis. (PubMed, J Ethnopharmacol) - "RCRP effectively mitigates OVX-induced bone loss in PMOP rats by modulating GM and associated metabolites, along with their potential targets and key metabolic pathways, including taurine and hypotaurine metabolism, as well as steroid hormone biosynthesis. These findings offer new insights into the therapeutic mechanisms by which RCRP may alleviate PMOP."

Journal • Metabolic Disorders • Osteoporosis • Rheumatology • AR • CTSK • DUSP6 • ER • PTGER4 • TRAP

A newer modality in the treatment of topical steroid damaged face -Pimecrolimus (EADV 2024) - "On enquiring, she gave history of application of betamethasone dipropionate cream twice daily for past 9 months. Since there are no recommended guidelines and practicing dermatologists use their discretion in managing TSDF patients, the treatment mostly becomes symptomatic. In such a scenario, treatment-related side effects are not uncommon .This case is an initiative to highlight the need to bring treatment option for the management of TSDF patients."

Dermatology • Pruritus

Job's Syndrome: Insights from a pediatric case report. (EADV 2024) - "The rash had been treated with topical steroids (betamethasone dipropionate) and oral vitamin C with slight resolution... HIES, also known as Job syndrome, belongs to a group of primary immunodeficiency diseases characterized by elevated serum IgE levels, recurrent infections, and various clinical features. Although most cases are sporadic, two distinct forms are being identified: Autosomal-dominant HIES, which develops due to STAT3 gene mutation and autosomal-recessive HIES caused by DOCK8 gene mutation. Clinical features include recurrent eczema, frequent bacterial pulmonary infections, mucocutaneous candidiasis and cold abscess."

Case report • Clinical • Atopic Dermatitis • Candidiasis • Dermatitis • Dermatology • Dermatopathology • Eosinophilia • Immunology • Infectious Disease • Pediatrics • Primary Immunodeficiency • Respiratory Diseases • DOCK8 • STAT3

Peri-nevoid alopecia: A rare subset of alopecia areata. (EADV 2024) - " He was treated with combination of betamethasone dipropionate (0.5mg) and calcipotriol (50 mcg) , and topical minoxidil spray (5%) . Peri-nevoid alopecia** is an extremely rare subset of AA associated with a central pigmented melanocytic nevus in most instances, in which a cellular auto- inflammatory response is triggered against nevus cells, hair follicles, and melanocytic structures. It is believed that pigmented nevus may cause immune response and inflammatory cell infiltration leading to AA. Due to paucity of reported cases and unawareness of this rare condition, it is imperative that Peri-nevoid alopecia needs to be reported otherwise it might get misdiagnosed as nevi, AA, or other non-scarring alopecia."

Alopecia • Atopic Dermatitis • Immunology • Inflammation

Thermal burn injury keloid scars treated with intralesional steroids and pulsed-dye laser therapy (EADV 2024) - "After discussing the possible treatment options and potential risks with the patient, we decided for a combination therapy approach on the keloid scars of the face, with intralesional triamcinolone acetonide and betamethasone dipropionate injections followed by pulsed-dye laser sessions at monthly intervals. Intralesional corticosteroids have become a cornerstone of both treatment and prophylaxis of hypertrophic and keloid scars. The mechanism of corticosteroid action is related to the suppression of collagen synthesis by decreased gene expression within the scar. Advances in laser technology have made laser therapy one of the most advantageous treatments of scars, targeting the vascular component, but also through collagen fibers remodeling."

CNS Disorders • Dermatology • Fibrosis • Immunology • Thermal Injury

Allergic contact dermatitis to sodium metabisulfite in a rotigotine transdermal therapeutic system (EADV 2024) - "Considering the hypothesis of ACD, applications of TTS were stopped, and he was treated with betamethasone dipropionate cream 0.05% and bilastine 20mg bid, with complete clinical resolution. Sulfites, ubiquitous sulfur-based compounds widely used in cosmetics, pharmaceuticals, and foods, are a common cause of ACD. In medical applications, sulfites are prevalent in topical medications like antifungals, steroids, local anesthetics, and ophthalmic solutions to maintain stability and potency. While skin reactions to rotigotine TTS are generally transient and of mild to moderate severity, discontinuation is necessary in approximately 8% of patients."

Anesthesia • CNS Disorders • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Movement Disorders • Ophthalmology • Parkinson's Disease • Pruritus

Microneedle Transdermal Delivery of Compound Betamethasone in Alopecia Areata - A Randomized Controlled Trial (ChiCTR) - P=N/A | N=80 | Completed | Sponsor: Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College; Hospital for Skin Diseases

New trial • Alopecia • Dermatology • Immunology

Efficacy of Steroid Injection in Patients With Bifid Median Nerve Diagnosed Carpal Tunnel Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: Yunus Burak Bayır

New trial • Musculoskeletal Pain

A unique presentation of lupus tumidus showing improvement with sun exposure (ECP 2024) - "His medications included apalutamide and Lupron...The patient was prescribed betamethasone dipropionate 0.05% and his rash cleared completely... This case represents a unique presentation of lupus tumidus with improvement following sun exposure. UV exposure is thought to be a key environmental trigger in the development of lupus tumidus. The proposed mechanisms primarily implicate UVB in abnormal cytokine release, nuclear damage, and defective removal of apoptotic cells."

Cutaneous Lupus Erythematosus • Dermatology • Genito-urinary Cancer • Immunology • Inflammatory Arthritis • Lupus • Oncology • Prostate Cancer • Solid Tumor

Simultaneous determination of 61 hormones in water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "In this study, we established a rapid and high-throughput continuous online method based on solid phase extraction (SPE) coupled with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the simultaneous determination of 61 hormone components, including 48 glucocorticoids, 1 mineralocorticoid, 4 androgens, and 8 progesterones, in water...Using this method, we successfully detected 10 hormone components (cortisone, fluticasone propionate, ciclesonide, betamethasone dipropionate, clobetasone butyrate, diflucortolone valerate, halobetasol propionate, isoflupredone, difluprednate, and hydroxyprogesterone caproate) in various surface water and groundwater samples collected from the Taihu Basin region...Thus, it exhibits promising potential for tracing targeted hormone residues in water and will be of great value in monitoring and ensuring water safety. Finally, a regional analysis was conducted on the hormone levels in water, and suggestions were..."

Journal

Comparing Intra-articular Betamethasone (Diprospan) and Triamcinolone Acetonide Injection in Knee Osteoarthritis (clinicaltrials.gov) - P4 | N=105 | Completed | Sponsor: Thammasat University | Active, not recruiting ➔ Completed

Trial completion • Immunology • Osteoarthritis • Pain • Rheumatology

Pilot study of a branded (marketed) formulation betamethasone dipropionate called Diprosone® ointment applied to the skin in healthy male and female volunteers to determine the appropriate dose duration (ED50) for use in a pivotal in vivo bioequivalence study. (ANZCTR) - P4 | N=12 | Completed | Sponsor: Zenith Technology Corporation Limited | Not yet recruiting ➔ Completed | Initiation date: Dec 2023

Trial completion • Trial initiation date • Atopic Dermatitis • Dermatology • Immunology • Psoriasis