betamethasone dipropionate / Generic mfg. - LARVOL DELTA

Development and evaluation of microemulsion foam formulation for topical delivery of betamethasone dipropionate. (PubMed, J Pharm Sci) - "In vitro permeation studies on normal and exfoliated porcine skin, the ME foam could significantly increase the R/Q (ratio of intradermal retention to permeation) of BDP compared to the two commercial formulations (Diansong cream and Xamiol gel). This further demonstrated the intradermal targeting and sustained-release properties of the ME foam. Overall, the ME foam developed in this study is a promising, safe and effective drug vehicle for the topical delivery of BDP."

Journal • Dermatology • Immunology • Psoriasis

Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular Pain (clinicaltrials.gov) - P4 | N=99 | Not yet recruiting | Sponsor: Benha University

New P4 trial • Musculoskeletal Diseases • Pain

Psoriasiform Dermatitis Following JAK Inhibitor Therapy for Hidradenitis Suppurativa and Crohn's Disease. (PubMed, Cureus) - "Given upadacitinib's established efficacy for both HS and CD, the drug was continued, and topical augmented betamethasone dipropionate was initiated, achieving adequate control at two-week follow-up...Comparable psoriasiform eruptions have been reported with baricitinib and tofacitinib, primarily in rheumatoid arthritis, a comorbidity present in our patient and an important interpretive caveat...Paradoxically, upadacitinib has also resolved psoriasiform eruptions in HS, underscoring the bidirectional and unpredictable nature of JAK1 inhibitor-mediated immune modulation. Psoriasiform dermatitis may represent a paradoxical cutaneous reaction to upadacitinib in patients with HS, warranting vigilant dermatologic monitoring and further investigation into individual susceptibility factors."

Journal • Crohn's disease • Dermatitis • Dermatology • Gastroenterology • Hidradenitis Suppurativa • Immune Modulation • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Lupus • Psoriasis • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus • IFNG • STAT1

Effect Of Intraarticular Triamcinolone Hexacetonide versus Betamethasone on Intraocular Pressure: A Prospective Randomized Study. (PubMed, Orthop Res Rev) - P4 | "In this single-center randomized study, patients receiving IACS were randomized into two groups: Group 1 received betamethasone (Diprospan®, betamethasone dipropionate 6.43 mg + betamethasone sodium phosphate 2.63 mg, equivalent to 7.0 mg betamethasone) and Group 2 received triamcinolone hexacetonide (Artropan®,20 mg triamcinolone hexacetonide)...Triamcinolone hexacetonide may increase IOP after IACS more than betamethasone; caution is warranted in patients with risk factors for glaucoma. The trial was registered at ClinicalTrials.gov retrospectively (No: NCT07242846, Date: 17.11.2025)."

Clinical • Journal • Glaucoma • Ophthalmology

Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) (clinicaltrials.gov) - P2/3 | N=40 | Enrolling by invitation | Sponsor: Wake Forest University Health Sciences | Trial primary completion date: Jul 2026 ➔ Jan 2027 | Trial completion date: Dec 2026 ➔ Dec 2027

Trial completion date • Trial primary completion date • Dermatology • Immunology • Psoriasis

Betamethasone Dipropionate Inhibits NLRP3 Inflammasome Activation by Suppressing Pro-IL-1β Expression. (PubMed, Front Biosci (Landmark Ed)) - "Collectively, our data verify that BD inhibits NLRP3 inflammasome activation by suppressing pro-IL-1β expression. These findings suggest that BD may be a potential therapeutic approach for inflammatory diseases. However, further studies are needed to elucidate its precise role and specific mechanism in clinical practice."

Journal • Inflammation • IL1B • NLRP3 • TNFA

Combined compound betamethasone and 595 nm pulsed dye laser improves hypertrophic scar and is associated with enhanced autophagy in myofibroblasts. (PubMed, Lasers Med Sci) - "In vitro, hypertrophic scar-derived myofibroblasts were treated with betamethasone dipropionate (BD), PDL, or their combination (BD + PDL). Importantly, inhibition of autophagic flux with chloroquine attenuated the collagen-suppressive effect of the combined treatment. Compound betamethasone combined with 595 nm PDL significantly improves hypertrophic scars, an effect associated with enhanced autophagic activity in myofibroblasts which may partly mediate collagen degradation."

Journal

Development and Assessment of Rutin/Betamethasone-Loaded PAN-PVP Nanofibers for Wound Healing Applications. (PubMed, Curr Drug Deliv) - "These findings demonstrate the potential of PAN-PVP nanofibers as a wound dressing platform for localized transdermal delivery."

Journal • Inflammation

Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Pakistan Institute of Medical Sciences

New P4 trial • Dermatology • Immunology • Psoriasis

Impact of Gamma Irradiation and Ethylene Oxide Sterilisation on the Stability of Crystalline and Amorphous Drug Solids. (PubMed, Eur J Pharm Sci) - "In this study, the compatibility of crystalline and amorphous solid forms of five drug substances (betamethasone dipropionate (BMD), estradiol (E2), itraconazole (ITZ), vismodegib (VDG), and zolmitriptan (ZMT)) with sterilising gamma irradiation and ethylene oxide (EtO) cycles was evaluated in terms of chemical and physical stability. Overall, sterilisation compatibility was governed primarily by molecular structure rather than the drug solid-state. These findings provide an insight for selecting sterilisation strategies and facilitate the translation of crystalline and amorphous pharmaceutical solids toward clinical application."

Journal

Rare case of refractory, multiple KOH-negative tinea incognito masquerading as cicatricial alopecia and perifollicular dermatosis, rapidly transforming into giant kerion celsi (EADV-Sp 2026) - "Prior evaluation at another institution, both before treatment and following treatment with topical betamethasone dipropionate and topical chloramphenicol, included multiple negative KOH preparations and Wood’s lamp examination results...Therapy was subsequently modified to topical gentamicin...Despite persistently negative KOH preparations and Wood’s lamp examinations (six times in total), systemic therapy with oral ketoconazole (100 mg twice daily), oral amoxicillin/clavulanic acid, topical miconazole nitrate, and an antifungal shampoo containing ketoconazole was initiated due to strong clinical suspicion of kerion celsi...Although mycological culture remains useful for confirming the diagnosis and identifying the causative species, its utility is limited by prolonged incubation time. This case, characterized by six consecutive negative KOH examinations, highlights the diagnostic limitations of routine mycological testing and underscores the importance of maintaining a..."

Clinical • Alopecia • Dermatology • Immunology • Infectious Disease • Inflammation

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Aug 2026 ➔ Mar 2027 | Trial primary completion date: Mar 2026 ➔ Nov 2026

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

Modified Goeckerman Therapy for Chronic Skin Diseases in a Resource-Limited Setting: A Case Series From Kenya (AAD 2026) - "Each patient completed a minimum 10-day course of therapy consisting of UVB phototherapy administered prior to topical wrap therapy with coal tar and betamethasone dipropionate or clobetasol propionate. To our knowledge, this is the first report of the efficacious use of Goeckerman therapy in mycosis fungoides. Despite decreased utilization of Goeckerman therapy in the U.S., future research is warranted to assess the benefit of Goeckerman therapy for the treatment of chronic skin conditions in resource-limited settings."

Clinical • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Immunology • Mycosis Fungoides • Plaque Psoriasis • Psoriasis

Comparison of Post-Inflammatory Pigment Alteration after Psoriasis Treatment with Topical Tapinarof Versus Betamethasone Dipropionate (AAD 2026) - "This pilot study shows the feasibility of assessing pigmentary and inflammatory outcomes in psoriasis. Observed differences between tapinarof and betamethasone support the need for larger studies to guide treatment strategies for patients at risk of PIPA."

Dermatology • Immunology • Inflammation • Psoriasis

Drugs for atopic dermatitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

OCT-mapping of the scattering coefficient to study the skin hydration process under optical clearing. (PubMed, Skin Pharmacol Physiol) - "We used this approach to quantify the effective skin dehydration depth and rehydration time in rats ex vivo following the topical application of 70% ethanol and an ethanolic solution of the betamethasone dipropionate glucocorticosteroid, both in the presence and absence of ultrasound exposure (1 MHz, 0.5 W/cm², 2 min)...The proposed approach proved to be effective for investigating water diffusion processes in the skin and would facilitate the analysis of dynamic changes in both healthy and pathological tissues, as well as the assessment of the effects of various topical chemical and physical treatments. This work holds significant implications for both basic and practical research at the interface between optics and biomedicine."

Journal

Cushingoid Features and Addisonian Crisis Following Abrupt Withdrawal of Potent Topical Corticosteroids: A Case Report. (PubMed, Cureus) - "He presented with hypotensive septic shock due to community-acquired pneumonia, compounded by adrenal suppression from chronic clobetasol and betamethasone dipropionate use...Management included aggressive intravenous fluids, vasopressor support, broad-spectrum antibiotics, and intravenous hydrocortisone, resulting in progressive recovery...Clinicians should maintain a high index of suspicion for adrenal crisis in any patient presenting with unexplained hypotension, particularly if they have a Cushingoid appearance, recent steroid cessation, or an intercurrent illness. Improving patient education, ensuring supervised tapering, and tightening the regulation of potent topical corticosteroids are essential to prevent such outcomes."

Journal • Cushing’s Disease • Dermatology • Endocrine Disorders • Hypotension • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Psoriasis • Renal Disease • Respiratory Diseases • Septic Shock

Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) (clinicaltrials.gov) - P2/3 | N=40 | Enrolling by invitation | Sponsor: Wake Forest University Health Sciences | Trial primary completion date: Dec 2025 ➔ Jul 2026

Trial primary completion date • Dermatology • Immunology • Psoriasis

CD24 Irritant contact dermatitis from Dieffenbachia schott: a case report of a florid reaction to a common household plant. (PubMed, Br J Dermatol) - "Management involved oral flucloxacillin for 1 week, topical betamethasone dipropionate with clotrimazole applied twice daily for 2 weeks, potassium permanganate soaks, Dermol 500 as a soap substitute, and white soft paraffin as a moisturizer. The history of hyacinth bulb allergy may have predisposed her to a lower threshold for a reaction. We present this case for wider acknowledgement of plant eruptions and suggest that gardening gloves are a useful adjunct for handling outdoor as well as indoor plants."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pain • CD24 • CRP

Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat. (clinicaltrials.gov) - P1/2 | N=60 | Not yet recruiting | Sponsor: Jinnah Postgraduate Medical Centre

Intubation • New P1/2 trial • Otorhinolaryngology

Lichen Aureus in a Patient with Prior Methotrexate Therapy: Successful Management with Topical Tacrolimus and Adjunctive Rutin/Vitamin C (ISDS 2025) - "She was started on betamethasone dipropionate 0.05% cream twice daily. While lichen aureus is typically idiopathic, the patient's prior methotrexate use raises the possibility that immune modulation may have contributed to lesion development, though a direct causal link cannot be established. Notably, this case demonstrates successful management using topical tacrolimus as a steroid-sparing agent, combined with adjunctive oral rutin and vitamin C to support vascular integrity, an approach rarely reported in the literature that may provide a useful strategy for persistent or refractory lesions."

Clinical • Dermatitis • Dermatology • Immune Modulation • Immunology • Infectious Disease • Pruritus • Respiratory Diseases • Tuberculosis

Glucocorticoid treatment rescues early lethality in a mouse model of geleophysic dysplasia. (PubMed, Commun Biol) - "Using a cellular model of ADAMTSL2 p.A165T variant, our screening of 2,321 FDA-approved drugs identified several glucocorticoids, particularly betamethasone dipropionate (BMD), which significantly enhance secretion of two crucial proteins for GD, ADAMTSL2 and FBN1 while improving extracellular matrix organization...Notably, BMD administration at birth significantly improved survival rates to 80% and 69%, respectively. These findings suggest that BMD offers a promising therapeutic approach to prevent early mortality in GD patients."

Journal • Preclinical • Genetic Disorders

Design and optimization of phospholipid vesicles for topical betamethasone dipropionate. (PubMed, Eur J Pharm Sci) - "Phospholipid vesicles represent a promising approach for betamethasone dipropionate delivery, as they are characterized by high stability and cytocompatibility. These properties may improve the therapeutic outcomes and minimize the side effects of betamethasone dipropionate, encouraging further investigation to confirm the effective and safe use of betamethasone dipropionate nanoformulations on the skin."

Journal • Dermatology

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Jan 2026 ➔ Aug 2026 | Trial primary completion date: Oct 2025 ➔ Mar 2026

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

An Uncommon Cause of Dysphagia: Bullous Pemphigoid with Esophageal Manifestations (ACG 2025) - "She was started on oral prednisone 40 mg daily, topical betamethasone dipropionate, and loratadine...Management typically involves systemic corticosteroids; immunosuppressants like mycophenolate or rituximab may be used for refractory cases. Adjunctive therapies include acid suppression, diet modification, and cautious endoscopic dilation if strictures develop. Early recognition is key to preventing complications, and interdisciplinary care between dermatology and gastroenterology ensures optimal outcomes.Figure: Endoscopy demonstrating concentric rings"

Bullous Pemphigoid • Dermatology • Dermatopathology • Eosinophilic Esophagitis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology