betamethasone dipropionate / Generic mfg. - LARVOL DELTA

CD24 Irritant contact dermatitis from Dieffenbachia schott: a case report of a florid reaction to a common household plant. (PubMed, Br J Dermatol) - "Management involved oral flucloxacillin for 1 week, topical betamethasone dipropionate with clotrimazole applied twice daily for 2 weeks, potassium permanganate soaks, Dermol 500 as a soap substitute, and white soft paraffin as a moisturizer. The history of hyacinth bulb allergy may have predisposed her to a lower threshold for a reaction. We present this case for wider acknowledgement of plant eruptions and suggest that gardening gloves are a useful adjunct for handling outdoor as well as indoor plants."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pain • CD24 • CRP

Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat. (clinicaltrials.gov) - P1/2 | N=60 | Not yet recruiting | Sponsor: Jinnah Postgraduate Medical Centre

Intubation • New P1/2 trial • Otorhinolaryngology

Lichen Aureus in a Patient with Prior Methotrexate Therapy: Successful Management with Topical Tacrolimus and Adjunctive Rutin/Vitamin C (ISDS 2025) - "She was started on betamethasone dipropionate 0.05% cream twice daily. While lichen aureus is typically idiopathic, the patient's prior methotrexate use raises the possibility that immune modulation may have contributed to lesion development, though a direct causal link cannot be established. Notably, this case demonstrates successful management using topical tacrolimus as a steroid-sparing agent, combined with adjunctive oral rutin and vitamin C to support vascular integrity, an approach rarely reported in the literature that may provide a useful strategy for persistent or refractory lesions."

Clinical • Dermatitis • Dermatology • Immune Modulation • Immunology • Infectious Disease • Pruritus • Respiratory Diseases • Tuberculosis

Glucocorticoid treatment rescues early lethality in a mouse model of geleophysic dysplasia. (PubMed, Commun Biol) - "Using a cellular model of ADAMTSL2 p.A165T variant, our screening of 2,321 FDA-approved drugs identified several glucocorticoids, particularly betamethasone dipropionate (BMD), which significantly enhance secretion of two crucial proteins for GD, ADAMTSL2 and FBN1 while improving extracellular matrix organization...Notably, BMD administration at birth significantly improved survival rates to 80% and 69%, respectively. These findings suggest that BMD offers a promising therapeutic approach to prevent early mortality in GD patients."

Journal • Preclinical • Genetic Disorders

Design and optimization of phospholipid vesicles for topical betamethasone dipropionate. (PubMed, Eur J Pharm Sci) - "Phospholipid vesicles represent a promising approach for betamethasone dipropionate delivery, as they are characterized by high stability and cytocompatibility. These properties may improve the therapeutic outcomes and minimize the side effects of betamethasone dipropionate, encouraging further investigation to confirm the effective and safe use of betamethasone dipropionate nanoformulations on the skin."

Journal • Dermatology

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Jan 2026 ➔ Aug 2026 | Trial primary completion date: Oct 2025 ➔ Mar 2026

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

An Uncommon Cause of Dysphagia: Bullous Pemphigoid with Esophageal Manifestations (ACG 2025) - "She was started on oral prednisone 40 mg daily, topical betamethasone dipropionate, and loratadine...Management typically involves systemic corticosteroids; immunosuppressants like mycophenolate or rituximab may be used for refractory cases. Adjunctive therapies include acid suppression, diet modification, and cautious endoscopic dilation if strictures develop. Early recognition is key to preventing complications, and interdisciplinary care between dermatology and gastroenterology ensures optimal outcomes.Figure: Endoscopy demonstrating concentric rings"

Bullous Pemphigoid • Dermatology • Dermatopathology • Eosinophilic Esophagitis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology

Addition of Pulsed Radiofrequency to Suprascapular Nerve Block with Glenohumeral Steroid Injection in Patients with Chronic Shoulder Pain. (PubMed, Anesth Pain Med) - "Group A consisted of 30 patients and received a glenohumeral steroid injection of Diprofos® (betamethasone dipropionate 14 mg/2 mL) along with an ultrasound-guided suprascapular nerve (US SSN) block using 10 mL of 0.25% preservative-free bupivacaine...This study showed that the addition of PRF therapy to the SSN significantly improved clinical outcomes compared to the suprascapular nerve block (SSNB) combined with intra-articular corticosteroid injection in patients with chronic shoulder impingement syndrome. The combined modality led to significantly better outcomes in terms of pain alleviation, range of motion, and functional capacity."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

In-office, intra-sinus application of 0.0644% betamethasone dipropionate nasal cream (nasal-BMDP): Phase 2 OT-007b trial results (AAO-HNSF 2025) - "Endoscopic in-office intra-sinus application of nasal-BMDP cream improved symptom control in post-ESS patients with refractory CRS. These promising results support further exploration of nasal-BMDP cream as a potential in-office treatment for refractory CRS symptoms."

Late-breaking abstract • P2 data • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Minimum effective dose of betamethasone for incisional local infiltration for the prevention of postoperative pain after spine surgery: study protocol for a randomised controlled trial. (PubMed, BMJ Open) - P=N/A | "Preliminary evidence suggests that combining diprospan, a mixture of betamethasone disodium phosphate and betamethasone dipropionate, with ropivacaine can significantly reduce analgesic requirements in the immediate postoperative period. The results will be submitted for publication in a peer-reviewed journal. NCT06785350."

Clinical protocol • Journal • Anesthesia • Diabetes • Infectious Disease • Orthopedics • Pain

Polymorphic Eruption and Lichen Planopilaris-Like Hair Loss Induced by Ixekizumab (EADV 2025) - "Case Report: A 57-year-old woman with palmoplantar and large plaque psoriasis (PASI 15.1, DLQI 24) involving feet, groin, axillae, and scalp, was started on ixekizumab in February 2024 after secondary failure on adalimumab. Her background included hypertension and depression (on sertraline)...Clinical findings were interpreted as severe seborrhoeic dermatitis with possible tinea corporis and secondary bacterial infection and was treated with two-week delay in ixekizumab injections, oral itraconazole, doxycycline and antimicrobial washes...Neck, chest, and forearm dermatitis resolved with topical betamethasone dipropionate/clotrimazole. Due to rapid hair loss, she was started on hydroxychloroquine, doxycycline, diprosalic, and clobetasol scalp applications...Psoriasis recurred, prompting initiation of risankizumab (IL-23A inhibitor), which led to psoriasis clearance, rash resolution, and sustained hair regrowth - even after stopping hydroxychloroquine and doxycycline......"

Alopecia • Ankylosing Spondylitis • Atopic Dermatitis • Cardiovascular • CNS Disorders • Depression • Dermatitis • Dermatomyositis • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lichen Planus • Myositis • Otorhinolaryngology • Psoriasis • Psoriatic Arthritis • Psychiatry • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis • IL17A • IL23A

A Case of Cabozantinib-Associated Leukocytoclastic Vasculitis in Metastatic Renal Cell Carcinoma (EADV 2025) - "Several TKIs—such as erlotinib, osimertinib, cabozantinib, and gefitinib— have been implicated in the development of cutaneous vasculitis...Empirical treatment was initiated with oral amoxicillin-clavulanate (1000 mg BID), ciprofloxacin (500 mg BID), and topical Triticum vulgare cream (BID) was initiated...The patient was subsequently started on colchicine (1 mg BID) and topical betamethasone dipropionate (once Daily), resulting in marked clinical improvement of the cutaneous lesions... Cutaneous adverse effects are not uncommon with TKI therapies; however, cases of cabozantinib- associated leukocytoclastic vasculitis have been rarely reported in the literature and may present with a severe clinical course.The underlying pathogenesis of TKI-induced leukocytoclastic vasculitis remains incompletely understood, though dose-dependent mechanism has been proposed. Potential explanations include direct vascular effects resulting from VEGF inhibition, immune complex deposition,..."

Clinical • Metastases • Genito-urinary Cancer • Infectious Disease • Oncology • Pyoderma Gangrenosum • Renal Cell Carcinoma • Respiratory Diseases • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Medullary Carcinoma • Tuberculosis • Vasculitis • CRP • KDR • MET

Juvenile Gangrenous Vasculitis of the Scrotum: A Rare but Important Cause of Genital Ulceration (EADV 2025) - "Scrotal USG was normal.The patient was treated with oral ampicillin-sulbactam and clindamycin for two weeks. For topical treatment betamethasone dipropionate and gentamicin combination were applied for three weeks... The diagnosis of scrotal juvenile gangrenous vasculitis is still debated as to whether it is a separate clinical entity or a variant of pyoderma gangrenosum or the male variant of Lipschütz ulcers."

Infectious Disease • Mood Disorders • Otorhinolaryngology • Pyoderma Gangrenosum • Rare Diseases • Respiratory Diseases • Vasculitis

Small Areas, Big Trouble: Topical Therapy to the Rescue in Psoriasis (EADV 2025) - "Topical treatment with betamethasone dipropionate 50 mg and calcipotriol 50 µg/g cream is an effective and safe option for managing psoriasis in challenging locations. Its versatility allows for use both as a first-line treatment and in combination with systemic therapies, providing a valuable alternative for patients in whom systemic options are contraindicated. Furthermore, its safety profile and ease of application enhance patient autonomy in disease management."

Dermatology • Immunology • Psoriasis • IL17A

Not Just Another Eczema: A Rare Pediatric Case of Sulzberger–Garbe Dermatosis (EADV 2025) - "The patient was treated with potent topical corticosteroids (daily 0.05% betamethasone dipropionate, later switched to 0.05% clobetasol propionate in weekend therapy) and oral antihistamines (10 mg rupatadine 1 x daily). This case highlights a rare pediatric manifestation of Sulzberger–Garbe dermatosis. Although classically described in adult males, the condition should also be considered in adolescents with chronic, pruritic dermatoses unresponsive to conventional treatment. Comprehensive differential diagnosis – including allergy screening and histopathologic evaluation – is essential to exclude other dermatoses that share similar clinical features."

Clinical • Atopic Dermatitis • Dermatology • Eosinophilia • Immunology • Pediatrics • Pruritus • CRP

Papular Variant of Cutaneous Larva Migrans: A Diagnostic Challenge in a Child (EADV 2025) - "A clinical diagnosis was proposed and treatment was initiated with one dose of oral ivermectin at 200 µg/kg, repeated after seven days. On account of impetigo on the face, azithromycin 500 mg was prescribed once daily for five days. Topical betamethasone dipropionate 0.5 mg with gentamicin 1 mg cream was prescribed three times daily... Atypical presentations of cutaneous larva migrans extend beyond the serpiginous linear lesions, including rarely described clinical variants such as the papular form. This case presents exuberant papular lesions which may be explained by a delayed-type hypersensitivity reaction to a high larval burden. Considering its atypical morphology and the nonspecificity of complementary diagnostics tests, the diagnosis is dependent on elements such as epidemiological suspicion and presence of intense pruritus."

Clinical • Dermatology • Immunology • Pediatrics • Pruritus

establishment and clinical application of a transdermal drug delivery sustained-release system based on a nano-microneedle (EADV 2025) - "The cumulative penetration of compound betamethasone in the nano-microneedle group increased by 3.29 times(betamethasone dipropionate) and 4.66 times(betamethasone sodium phosphate) at 24 hours... The nano-microneedle-based transdermal drug delivery sustained-release system enhances the transdermal absorption and sustained-release effects of compound betamethasone, and effectively alleviates immune responses in AD, which provides an innovative solution for the treatment of chronic inflammatory skin diseases."

Clinical • Dermatology • Inflammation • Pruritus • IL13

An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms (EADV 2025) - "Thrice daily topical corticosteroids of methylprednisolone 0.1% fatty ointment and betamethasone dipropionate 0.05% ointment to his face and body under wet wraps were commenced with good symptomatic relief... We report an unusually severe case of shiitake mushroom dermatitis complicated by systemic features compatible with DRESS. Our case highlights that shiitake mushroom dermatitis may not always be a benign, self-limiting disease, and underscores the importance of prompt recognition and management of shiitake dermatitis, which may progress to DRESS and necessitate prolonged oral and topical corticosteroid therapy."

Clinical • Contact Dermatitis • Dermatitis • Dermatology • Eosinophilia • Immunology • Rheumatology

Validation of Dermatophytosis Severity Score(DSS) in steroid modified tinea – A novel method in assessing the severity of dermatophytosis. (EADV 2025) - "also Clobetasol propionate was the most commonly used topical steroid (76 cases), followed by betamethasone dipropionate (13). This study underscores the dangers of unsupervised topical steroid use, which exacerbates disease severity, prolongs treatment duration, and increases resistance. It highlights the need for greater awareness regarding the risks of self-medication with topical steroids. Strict vigilance and implementation of legal interference is required to combat this global threat of steroid misuse."

Atopic Dermatitis • Dermatology • Immunology

Pemphigus foliaceus in adolescent: A case report (ESDR 2025) - "He started prednisone at 0.5 mg/kg/day, later increased to 1 mg/kg/ day due to new lesions, combined with dapsone 1.5 mg/kg/day, topical corticosteroids, and emollients...Afterward, azathioprine 150 mg/day and biweekly intramuscular betamethasone dipropionate with betamethasone disodium phosphate were added, leading to clinical improvement...First-line treatment includes systemic corticosteroids with steroid-sparing immunosuppressants like methotrexate, cyclophosphamide, mycophenolate mofetil, azathioprine, and, more recently, rituximab. Despite its rarity, pemphigus foliaceus should be considered in the differential diagnosis of blistering dermatoses. Early recognition and treatment are vital to avoid complications."

Case report • Clinical • Dermatology • Immunology • Infectious Disease • Pemphigus Vulgaris

Investigation of the Effect of Central Sensitization (CS) on Steroid Injection Response in Rotator Cuff Lesion (clinicaltrials.gov) - P=N/A | N=44 | Completed | Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | Recruiting ➔ Completed

Trial completion • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Mammographic Breast Pseudocalcifications Associated With Topical Betamethasone Dipropionate. (PubMed, Eur J Breast Health) - "Additional clinical history interrogation revealed that due to a diffuse pruritic rash, the patient had been applying topical betamethasone dipropionate daily to her entire body, including her breasts, when she received her initial mammogram. This case illustrates how corticosteroid ointments and lotions may mimic suspicious calcifications on mammography, reinforcing the importance of guidelines recommending avoidance of topical products on the day of imaging."

Journal • Breast Cancer • Oncology • Solid Tumor

Comparison of the Efficacy of Topical Methotrexate 1% gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial. (PubMed, Indian Dermatol Online J) - "Both methotrexate gel and betamethasone lotion are effective and safe treatments for localized alopecia areata, showing comparable overall response rates. However, local side effects are more common with methotrexate gel than with betamethasone lotion. This study suggests that methotrexate gel can be considered one of the topical treatment options for localized alopecia areata."

Journal • Alopecia • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) (clinicaltrials.gov) - P2/3 | N=40 | Enrolling by invitation | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Jul 2025 ➔ Dec 2025

Trial completion date • Trial primary completion date • Dermatology • Immunology • Psoriasis

The Influence of Moisturizer Co-Application Protocols on In Vitro Penetration of Betamethasone in Porcine Skin. (PubMed, Pharmaceutics) - "Hence, this study aimed to evaluate the effects of formulation type, moisturizer composition, application sequence, and mechanical stimulation on betamethasone dipropionate (BET) cutaneous penetration... The results showed pre-hydrating the skin, combined with a 30 s massage, was the best strategy for BET diffusion into the skin following cream administration. The formulation type and the order of application directly influence the effectiveness of drug therapy and the topical absorption of BET."

Journal • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology