OncoHist (recombinant human histone H1.3) / Pharmsynthez, Xenetic Biosci - LARVOL DELTA

Polycomb dysregulation by oncohistones (AACR 2018) - "We are currently using a combination of biochemical and genomic approaches to investigate how oncohistone-driven changes in histone H3 K27 methylation lead to altered chromatin states that profoundly influence gene expression patterns. I will discuss some of our recent mechanistic and functional work on various oncohistone mutations."

Oncology

Oncohistones in cancer: How to turn a cells symphony into non harmonic rap? (AACR 2018) - "Here, we describe these epigenetic misfits and our knowledge of their effects, along with novel tools needed to study them. We will also discuss how we are harnessing synergies between the approaches of cancer genomics and chemical biology to help make sense of the pathogenesis of oncohistones and describe how oncohistones are promoting global redistribution of important epigenetic marks, seemingly hijacking our epigenome."

Head and Neck Cancer • Sarcoma