ubidecarenone topical (BPM 31510) / BPGbio - LARVOL DELTA

In vitro and in vivo study of the inhibition of ubiquinone biosynthesis in Leishmania (Leishmania) amazonensis using the combination of buparvaquone and 4-nitrobenzoate as a strategy for the discovery of new therapeutic targets. (PubMed, Antimicrob Agents Chemother) - "The mechanism of action of 4-nitrobenzoate in promastigote forms suggests a reduction in ubiquinone 6 levels, an alteration in mitochondrial membrane potential, and an increase in reactive oxygen species. In vivo treatment with a topical formulation (buparvaquone 0.1% and 4-nitrobenzoate 0.1%) in infected mice showed a reduction in parasite burden of 57% compared to the control group, suggesting that this combination may represent a promising therapeutic strategy for future treatment of this disease."

Journal • Preclinical • Infectious Disease

Protective Role of Plastoquinone in the Early Stages of Second-Degree Thermal Skin Burn. (PubMed, Biochemistry (Mosc)) - "Plastoquinone in liposomes applied topically or administered intravenously showed a protective effect on erythrocytes comparable to that of ubiquinone, preventing the development of burn-induced erythrocyte shape alterations. However, only plastoquinone administered intravenously completely prevented erythrocyte aggregation, thus eliminating negative effects of the burn injury on the functional activity of erythrocytes, indicating the potential of plant-derived plastoquinone as an effective agent in burn injury management."

Journal • Thermal Injury

Effects of Topical Coenzyme Q10 in Conjunction With Vitamin E on the Pattern Visual Evoked Potential, Visual Field, Retinal Ganglion Cell Layer and Retinal Nerve Fibre Layer Thickness in Patients with Primary Open-angle Glaucoma. (PubMed, Photodiagnosis Photodyn Ther) - "Currently, neuroprotective drug studies in glaucoma are increasing daily.These results suggest that Coqun® administration in POAG had a beneficial effect on the inner retinal layer with consequent enhancement of the visual cortical responses (VEP improvement),visual field (decreased MD) and protect RNFL thickness."

Journal • Glaucoma • Ophthalmology

Clinical Efficacy of a Novel Topical Formulation on Periorbital Dark Circles: An Objective Analysis. (PubMed, J Cosmet Dermatol) - "This novel topical composition offers a safe and effective multi-targeted approach for improving periorbital hyperpigmentation and promoting overall skin rejuvenation. The synergistic action of its active components supports its use in clinical and aesthetic dermatology for the treatment of dark circles and age-related changes."

Journal • Aesthetic Medicine • Dermatology

High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment. (PubMed, Biomedicines) - "This study presents a straightforward and efficient method for the production of NLPUS, thereby offering a promising platform for transdermal delivery of diverse therapeutic agents."

Journal • MMP1

Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review. (PubMed, Eur J Oral Sci) - "Daily oral supplementation (120 mg/day) with CoQ10 resulted in a greater mean reduction of PD by 0.41 mm (95% CI: 0.02-0.80) and a greater mean CAL gain by 0.52 mm (95% CI: 0.26-0.78) than seen in controls. Based on very low certainty of evidence, there was no significant effect of locally delivered Q10 gel on PD/CAL, but daily oral supplementation with CoQ10 resulted in better periodontal health after 12 weeks."

Journal • Review • Dental Disorders • Periodontitis

Effect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics. (PubMed, Redox Biol) - "This confirms AOX's electroneutral redox activity and indicates differences in the proton-translocating capacity of dehydrogenases upstream of the ubiquinone pool...Inhibitor-sensitivity analysis showed that the AOX-induced decrease in H2O2 release is due to the lower contribution of complex I to net ROS production during RET. Overall, our findings provide new insights into the role of temperature as a mechanism to control respiration and highlight the utility of AOX as a genetic tool to characterize both the distinct pathways of oxygen reduction and the role of redox control in RET."

Journal • Preclinical

Comparison of The Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds. (PubMed, J Burn Care Res) - "Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. TQ offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing."

Journal • Fibrosis • Immunology • Inflammation • Thermal Injury

The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review. (PubMed, J Clin Aesthet Dermatol) - "Aging and stressed skin are, in part, the result of alterations in cellular metabolic homeostasis, which can be reversed via the benefits of topical application of CoQ10-enriched formulations that stimulate cutaneous energy metabolism and reduce free radicals via antioxidant function. By restoring physiological homeostasis, topical skincare products with CoQ10 replenish the skin's antioxidant levels, increase cellular (energy) metabolism, and reduce the signs of skin aging."

Journal • Review

Antioxidants for Skin Health. (PubMed, Recent Adv Food Nutr Agric) - "This paper reviews the contributions of key antioxidants, including Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, and Polyphenols, in skin health care...Duplicate publications were excluded to avoid redundancy in the review. Articles with insufficient or incomplete data were excluded to ensure the quality and reliability of the review findings."

Journal • Dermatology • Infectious Disease

Effect of Coenzyme Q10 on early wound healing after recession coverage surgery with the modified coronally advanced tunnel technique and a connective tissue graft: A 6-month, triple-blinded, randomized, placebo-controlled pilot trial. (PubMed, Clin Oral Investig) - "Early wound healing: in young healthy patients with no inflammatory oral conditions topical CoQ10 does not improve early healing."

Clinical • Journal • Metastases • Surgery • Pain

Coenzyme Q10 eyedrops conjugated with vitamin E TPGS alleviate neurodegeneration and mitochondrial dysfunction in the diabetic mouse retina. (PubMed, Front Cell Neurosci) - "Additionally, the CoQ10 treatment significantly alleviated retinal levels of MMP-9 and enhanced mitochondrial function. These findings provide further insight into the role of mitochondrial dysfunction in the development of DR and suggest CoQ10 eyedrops, conjugated with vitamin E TPGS, as a potential complementary therapy for DR-related neuropathy."

Journal • Preclinical • Cardiovascular • Cataract • CNS Disorders • Diabetes • Diabetic Retinopathy • Glaucoma • Hematological Disorders • Inflammation • Metabolic Disorders • Ophthalmology • Pain • Retinal Disorders • Type 2 Diabetes Mellitus • MMP9

Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation. (PubMed, J Transl Med) - "CoQ10@TNPs can precisely deliver CoQ10 to the mitochondria of cold I/R-injured cardiomyocytes to effectively eliminate mitochondrial reactive oxygen species (mtROS), thus reducing oxidative injury and inflammatory reactions in cold I/R-injured graft tissues and finally improving heart graft function. Thus, CoQ10@TNPs offer an effective approach for safeguarding cardiac grafts against extended periods of cold ischaemia, emphasizing the therapeutic potential in mitigating cold I/R injury during HT. These findings present an opportunity to enhance existing results following HT and broaden the range of viable grafts for transplantation."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Inflammation • Metabolic Disorders • Reperfusion Injury • Transplantation

Lipid nanoparticles containing coenzyme Q10 for topical applications: An overview of their characterization. (PubMed, Colloids Surf B Biointerfaces) - "In this context, this article presents a review of the main studies of the coenzyme Q10 encapsulated in lipid nanoparticles for topical use, focusing on the analytic methods used to characterize the systems regarding morphology, zeta potential, release profile, Q10 content, encapsulation efficiency, crystalline organization and structure of the lipid matrix, rheology, antioxidant activity, skin penetration and efficacy, among other aspects. We also describe the main results of the different studies and discuss the critical aspects - the simplest, most reproducible, best, and most relevant - that characterize lipid nanoparticles with encapsulated Q10 for topical use."

Journal • Review

Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial. (PubMed, BMC Oral Health) - P1 | "The topical use of CoQ10 mucoadhesive tablets was as effective as the topical use of triamcinolone acetonide, and its clinical effect was associated with a reduction in the salivary level of MDA."

Clinical • Journal • Dermatology • Dermatopathology • Lichen Planus • Pain

Targeting oxidative stress with systemic antioxidants in vitiligo (WCD 2023) - "More novel systemic antioxidants such as Ginkgo Bilboba demonstrated a statistically significant cessation of depigmentation compared to placebo whereas systemic Silybum Marianum in conjunction with NB-UVB showed superiority over NB-UVB alone.Other systemic treatments which have shown variable effects on repigmentation include minocycline, Munzij and Mushil herbal preparations, turmeric, alpha-lipoic acid, aspirin, Coenzyme Q10 and coffee and sunflower seed preparations. There are limited studies investigating the use of systemic antioxidants in vitiligo treatment, all with heterogeneous study designs and outcomes. Further studies are required to discern the most effective systemic antioxidant and their impacts on vitiligo subtypes"

Late-breaking abstract • Oxidative stress • Dermatology • Immunology • Vitiligo

BPGbio Announces First Patients Dosed in Phase 2 Trial of AI-Developed BPM 31510 for Glioblastoma Multiforme (Businesswire) - "BPGbio, Inc...announced that patients have been initially dosed in its Phase 2 trial for BPM 31510 for Glioblastoma Multiforme (GBM), a fast-growing and aggressive form of brain cancer...BPM 31510 for GBM is one of the three oncology drug assets in clinical phase that BPGbio developed on its AI-driven Interrogative Biology® platform."

Trial status • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oncology • Solid Tumor

Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases. (PubMed, J Indian Soc Periodontol) - "Adjunctive therapy with coenzyme Q10 provides longer-lasting therapeutic effects and better results when compared with SRP alone. The possibility to use the gel as a sole agent to support standard treatment procedures in periodontitis is also suggested."

Journal • CNS Disorders • Dental Disorders • Immunology • Inflammation • Periodontitis

Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging. (PubMed, Inflammopharmacology) - "This was associated with suppression of the elevated oxidative stress, IL-6, matrix metalloproteinase 1, and caspase, with induction of cathepsin D and subsequent change in anti-LC3 and P62 staining in skin tissue. In addition to metformin antioxidant, anti-inflammatory, and antiapoptotic activities, its anti-photoaging effect is mainly attributed to enhancing autophagic flux by inducing cathepsin D. Its protective effect is boosted by coQ10, which supports their potential use in photoaging."

Journal • Immunology • Inflammation • CTSD • IL6

Tackling Atherosclerosis via Selected Nutrition. (PubMed, Int J Mol Sci) - "Among the substances, those of animal origin are popular: squalene, coenzyme Q10, omega-3...The key factors include weak evidence of the influence of a number of genetic features, the high cost of the approach, and difficulties in the interpretation of the results. Eliminating these deficiencies will contribute to the maintenance of a healthy state of the population through nutrition."

Journal • Review • Atherosclerosis • Cardiovascular • Dyslipidemia • Gastrointestinal Disorder • Metabolic Disorders

THE EFFECT OF COENZYME Q10 ON PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS. (PubMed, J Evid Based Dent Pract) - "Our findings encourage administration of coenzyme Q10 gel in periodontitis based on its meaningful effect on Plaque Index, Bleeding Index, gingival index, clinical attachment level and Pocket Depth. Future studies with better qualities are required for a better conclusion."

Clinical • Journal • Retrospective data • Review • Dental Disorders • Periodontitis

Assessing the Oxidative State of the Skin by Combining Classical Tape Stripping with ORAC Assay. (PubMed, Pharmaceuticals (Basel)) - "The application of coenzyme Q10 resulted in an increase in the iAOC at low doses but decreased the iAOC when doses > 1% were applied on the skin. The results show that the combination of classical tape stripping and ORAC assay is a cost-effective and versatile method to evaluate the skin oxidative state and the pro-oxidate and antioxidative effects of topical skin treatments on the iAOC of the skin. Therefore, the model can be considered to be a valuable tool in skin research."

Journal • Immunology • Oncology

Central Toxic Keratopathy in Siblings After Laser-Assisted Keratomileusis: Case Report and Literature Review. (PubMed, Cornea) - "CTK is a rare, noninflammatory but potentially sight-threatening entity most commonly associated with excimer laser ablation procedures. Its pathophysiology is poorly understood but likely multifactorial. Its isolated presentation in this case of 2 siblings suggests a possible underlying genetic predisposition, which has not been previously described. With careful monitoring and early supportive treatment, patients can have a complete and rapid resolution."

Journal • Review • Immunology • Inflammation • Ophthalmology

Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel. (PubMed, Sci Rep) - "In addition, the 24-h topical application of Protransf-CoQ10 Emulgel showed that no erythema or skin rash was observed during the study. In conclusion, loading CoQ10 into protransfersomal Emulgel successfully enhanced the stability and anti-ageing efficacy enabling its potential use as anti-ageing cosmetics."

Journal • Dermatology

Histopathological effects of topical coenzyme q 10 + Vit E TPGS in experimental ischemic optic neuropathy. (PubMed, Ultrastruct Pathol) - "The number of myelinated axons was significantly increased in the treatment group compared to the experimental group (p = .0028). In the light of the data obtained, the neuroprotective effect of the topically used CoQ10 + Vit E TPGS molecule was found to be histopathologically effective in our experimental study.Abbreviations: NAAION: Nonarteritic anterior ischemic optic neuropathy; CoQ10: Coenzyme q10; CG: Control group; EG: Experimental group; TG: Treatment group."

Journal • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Solid Tumor