ubidecarenone topical (BPM 31510) / BPGbio - LARVOL DELTA

Clinical Evaluation of a Topical Serum Combining Copper Peptides and Coenzyme Q10: Impact on Photodamage and Cutaneous Aging (EADV 2026) - No abstract available

Clinical • Aesthetic Medicine • Dermatology

A dual functional hybrid lipid-polymeric nanoparticle co-loaded coenzyme Q10 and siRNA TNFα for anti-inflammatory skin therapy. (PubMed, Int J Pharm) - "Therapeutic efficacy was validated in LPS-stimulated RAW264.7 macrophages, where HLPN_CoQ10-siTNFα significantly suppressed TNFα (3-6.5-fold), IL-6 (2-2.7-fold), and IL-1β (1.3-3-fold) secretion, while preserving CoQ10's antioxidant capacity and reducing reactive oxygen species (1.3-1.5-fold). Collectively, these findings show that the dual lipid-polymeric nature of HLPNs enables combinatorial delivery of antioxidant and RNAi therapies, offering a promising strategy for complex inflammatory skin disorders."

Journal • Dermatology • Gene Therapies • Immunology • Inflammation • Psoriasis • IL1B • IL6 • TNFA

Next-generation delivery systems for coenzyme Q10: trends in nanovesicles, penetration enhancers, and bioactivity optimization. (PubMed, J Liposome Res) - "Finally, key translational challenges, including formulation stability, biological barriers, manufacturing scalability, and regulatory considerations, are discussed alongside emerging trends such as stimuli-responsive nanocarriers, mitochondria-targeted systems, and computationally guided formulation development. Collectively, these advances highlight the potential of nano-enabled delivery systems to overcome CoQ10 pharmacokinetic limitations and facilitate future clinical translation."

Journal • Review • Cardiovascular • Metabolic Disorders

As Seen on Tiktok: Characterizing Interventions and Attitudes in #PCOS Content (ENDO 2026) - "Of the 22 videos that described conventional therapies, glucagon-like peptide receptor antagonists (GLP1-RA, n=10) and metformin (n=5) were most commonly discussed, often with positive perception (n=10, with phrases such as "life-changing"). Of the 28 videos which described IHM interventions, many described nutrition advice (n=11), particularly a high-protein diet (n=5); followed by supplements (n=8; inositol, CoQ10, multivitamins, and guaifenesin most frequently mentioned); and physical activity (n=6), particularly strength training... TikTok content with #PCOS tends to describe a variety of both IHM and conventional approaches to PCOS management, including GLP1-RA medications, nutritional advice, and supplements. Understanding the information to which patients have been exposed can help providers understand patient needs and preferences and promote patient-centered PCOS care."

Polyendocrine Metabolic Ovarian Syndrome • Women's Health

Comparative evaluation of topical and intramuscular coenzyme Q10 application in non-surgical periodontal disease management: A randomized clinical study. (PubMed, Bioinformation) - "All groups showed significant improvement, but Group 3 (intrasulcular CoQ10 + SRP) demonstrated the greatest reduction in probing pocket depth, from 6.52 ±1.07 mm to 3.67±0.28 mm (p = 0.000). Thus, intrasulcular CoQ10 + SRP is superior for periodontal regeneration opening new adjunctive antioxidant therapy pathways."

Journal • Dental Disorders • Periodontitis

Atypical COQ2-Related Retinopathy in Identical Twins with Nephropathy Mimicking Intermediate Uveitis. (PubMed, Ocul Immunol Inflamm) - "CMO worsened with topical corticosteroids but improved bilaterally after a single unilateral intravitreal bevacizumab injection, suggesting a systemic therapeutic effect. Recognition of this presentation is critical, as early CoQ10 supplementation may stabilize disease progression and prevent systemic complications. Genetic testing should be considered in young patients with CMO resembling intermediate uveitis, particularly when associated with nephropathy."

Journal • Focal Segmental Glomerulosclerosis • Genetic Disorders • Glomerulonephritis • Inherited Retinal Dystrophy • Macular Edema • Metabolic Disorders • Ocular Inflammation • Ophthalmology • Renal Disease • Retinal Disorders • Retinitis Pigmentosa • Uveitis

Pharmacological, Natural and Emerging Therapies for Meibomian Gland Dysfunction: A Review. (PubMed, Drugs) - "Natural therapies that may offer suitable long-term solutions include oral dietary supplements (polyunsaturated fatty acids, astaxanthin, bilberry, Chinese herbal formulations and Korean red ginseng) and naturally derived topical formulations (castor oil, manuka honey, tea tree oil, coenzyme Q10 and green tea extract)...A thorough examination should precede the initiation of treatment to identify underlying pathophysiology and guide targeted interventions. Treatment efficacy, duration and safety profiles must also be considered."

Journal • Review • Dry Eye Disease • Inflammation • Ophthalmology

Ergothioneine: Evaluation of a Novel Antioxidant for Targeting Ocular Oxidative Stress. (PubMed, Curr Eye Res) - "This study evaluated EGT as a novel ocular antioxidant by examining its radical scavenging capacity (DPPH assay compared to glutathione, astaxanthin, and coenzyme Q10), stability (at 40 °C/75% relative humidity for six months using HPLC), ocular tolerance (using a New Zealand rabbit model), and fundus delivery efficiency (topical D9-EGT eye drops quantified by LC-MS/MS)...By overcoming key delivery limitations, EGT presents a promising therapeutic strategy for oxidative stress-related ocular diseases such as age-related macular degeneration and diabetic retinopathy. Further studies are warranted to evaluate its long-term efficacy and clinical translation potential."

Journal • Age-related Macular Degeneration • Diabetic Retinopathy • Macular Degeneration • Ophthalmology • Retinal Disorders

Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment (clinicaltrials.gov) - P=N/A | N=34 | Recruiting | Sponsor: Alexandria University

New trial

In vitro and in vivo study of the inhibition of ubiquinone biosynthesis in Leishmania (Leishmania) amazonensis using the combination of buparvaquone and 4-nitrobenzoate as a strategy for the discovery of new therapeutic targets. (PubMed, Antimicrob Agents Chemother) - "The mechanism of action of 4-nitrobenzoate in promastigote forms suggests a reduction in ubiquinone 6 levels, an alteration in mitochondrial membrane potential, and an increase in reactive oxygen species. In vivo treatment with a topical formulation (buparvaquone 0.1% and 4-nitrobenzoate 0.1%) in infected mice showed a reduction in parasite burden of 57% compared to the control group, suggesting that this combination may represent a promising therapeutic strategy for future treatment of this disease."

Journal • Preclinical • Infectious Disease

Protective Role of Plastoquinone in the Early Stages of Second-Degree Thermal Skin Burn. (PubMed, Biochemistry (Mosc)) - "Plastoquinone in liposomes applied topically or administered intravenously showed a protective effect on erythrocytes comparable to that of ubiquinone, preventing the development of burn-induced erythrocyte shape alterations. However, only plastoquinone administered intravenously completely prevented erythrocyte aggregation, thus eliminating negative effects of the burn injury on the functional activity of erythrocytes, indicating the potential of plant-derived plastoquinone as an effective agent in burn injury management."

Journal • Thermal Injury

Effects of Topical Coenzyme Q10 in Conjunction With Vitamin E on the Pattern Visual Evoked Potential, Visual Field, Retinal Ganglion Cell Layer and Retinal Nerve Fibre Layer Thickness in Patients with Primary Open-angle Glaucoma. (PubMed, Photodiagnosis Photodyn Ther) - "Currently, neuroprotective drug studies in glaucoma are increasing daily.These results suggest that Coqun® administration in POAG had a beneficial effect on the inner retinal layer with consequent enhancement of the visual cortical responses (VEP improvement),visual field (decreased MD) and protect RNFL thickness."

Journal • Glaucoma • Ophthalmology

Clinical Efficacy of a Novel Topical Formulation on Periorbital Dark Circles: An Objective Analysis. (PubMed, J Cosmet Dermatol) - "This novel topical composition offers a safe and effective multi-targeted approach for improving periorbital hyperpigmentation and promoting overall skin rejuvenation. The synergistic action of its active components supports its use in clinical and aesthetic dermatology for the treatment of dark circles and age-related changes."

Journal • Aesthetic Medicine • Dermatology

High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment. (PubMed, Biomedicines) - "This study presents a straightforward and efficient method for the production of NLPUS, thereby offering a promising platform for transdermal delivery of diverse therapeutic agents."

Journal • MMP1

Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review. (PubMed, Eur J Oral Sci) - "Daily oral supplementation (120 mg/day) with CoQ10 resulted in a greater mean reduction of PD by 0.41 mm (95% CI: 0.02-0.80) and a greater mean CAL gain by 0.52 mm (95% CI: 0.26-0.78) than seen in controls. Based on very low certainty of evidence, there was no significant effect of locally delivered Q10 gel on PD/CAL, but daily oral supplementation with CoQ10 resulted in better periodontal health after 12 weeks."

Journal • Review • Dental Disorders • Periodontitis

Effect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics. (PubMed, Redox Biol) - "This confirms AOX's electroneutral redox activity and indicates differences in the proton-translocating capacity of dehydrogenases upstream of the ubiquinone pool...Inhibitor-sensitivity analysis showed that the AOX-induced decrease in H2O2 release is due to the lower contribution of complex I to net ROS production during RET. Overall, our findings provide new insights into the role of temperature as a mechanism to control respiration and highlight the utility of AOX as a genetic tool to characterize both the distinct pathways of oxygen reduction and the role of redox control in RET."

Journal • Preclinical

Comparison of The Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds. (PubMed, J Burn Care Res) - "Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. TQ offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing."

Journal • Fibrosis • Immunology • Inflammation • Thermal Injury

The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review. (PubMed, J Clin Aesthet Dermatol) - "Aging and stressed skin are, in part, the result of alterations in cellular metabolic homeostasis, which can be reversed via the benefits of topical application of CoQ10-enriched formulations that stimulate cutaneous energy metabolism and reduce free radicals via antioxidant function. By restoring physiological homeostasis, topical skincare products with CoQ10 replenish the skin's antioxidant levels, increase cellular (energy) metabolism, and reduce the signs of skin aging."

Journal • Review

Antioxidants for Skin Health. (PubMed, Recent Adv Food Nutr Agric) - "This paper reviews the contributions of key antioxidants, including Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, and Polyphenols, in skin health care...Duplicate publications were excluded to avoid redundancy in the review. Articles with insufficient or incomplete data were excluded to ensure the quality and reliability of the review findings."

Journal • Dermatology • Infectious Disease

Effect of Coenzyme Q10 on early wound healing after recession coverage surgery with the modified coronally advanced tunnel technique and a connective tissue graft: A 6-month, triple-blinded, randomized, placebo-controlled pilot trial. (PubMed, Clin Oral Investig) - "Early wound healing: in young healthy patients with no inflammatory oral conditions topical CoQ10 does not improve early healing."

Clinical • Journal • Metastases • Surgery • Pain

Coenzyme Q10 eyedrops conjugated with vitamin E TPGS alleviate neurodegeneration and mitochondrial dysfunction in the diabetic mouse retina. (PubMed, Front Cell Neurosci) - "Additionally, the CoQ10 treatment significantly alleviated retinal levels of MMP-9 and enhanced mitochondrial function. These findings provide further insight into the role of mitochondrial dysfunction in the development of DR and suggest CoQ10 eyedrops, conjugated with vitamin E TPGS, as a potential complementary therapy for DR-related neuropathy."

Journal • Preclinical • Cardiovascular • Cataract • CNS Disorders • Diabetes • Diabetic Retinopathy • Glaucoma • Hematological Disorders • Inflammation • Metabolic Disorders • Ophthalmology • Pain • Retinal Disorders • Type 2 Diabetes Mellitus • MMP9

Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation. (PubMed, J Transl Med) - "CoQ10@TNPs can precisely deliver CoQ10 to the mitochondria of cold I/R-injured cardiomyocytes to effectively eliminate mitochondrial reactive oxygen species (mtROS), thus reducing oxidative injury and inflammatory reactions in cold I/R-injured graft tissues and finally improving heart graft function. Thus, CoQ10@TNPs offer an effective approach for safeguarding cardiac grafts against extended periods of cold ischaemia, emphasizing the therapeutic potential in mitigating cold I/R injury during HT. These findings present an opportunity to enhance existing results following HT and broaden the range of viable grafts for transplantation."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Inflammation • Metabolic Disorders • Reperfusion Injury • Transplantation

Lipid nanoparticles containing coenzyme Q10 for topical applications: An overview of their characterization. (PubMed, Colloids Surf B Biointerfaces) - "In this context, this article presents a review of the main studies of the coenzyme Q10 encapsulated in lipid nanoparticles for topical use, focusing on the analytic methods used to characterize the systems regarding morphology, zeta potential, release profile, Q10 content, encapsulation efficiency, crystalline organization and structure of the lipid matrix, rheology, antioxidant activity, skin penetration and efficacy, among other aspects. We also describe the main results of the different studies and discuss the critical aspects - the simplest, most reproducible, best, and most relevant - that characterize lipid nanoparticles with encapsulated Q10 for topical use."

Journal • Review

Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial. (PubMed, BMC Oral Health) - P1 | "The topical use of CoQ10 mucoadhesive tablets was as effective as the topical use of triamcinolone acetonide, and its clinical effect was associated with a reduction in the salivary level of MDA."

Clinical • Journal • Dermatology • Dermatopathology • Lichen Planus • Pain

Targeting oxidative stress with systemic antioxidants in vitiligo (WCD 2023) - "More novel systemic antioxidants such as Ginkgo Bilboba demonstrated a statistically significant cessation of depigmentation compared to placebo whereas systemic Silybum Marianum in conjunction with NB-UVB showed superiority over NB-UVB alone.Other systemic treatments which have shown variable effects on repigmentation include minocycline, Munzij and Mushil herbal preparations, turmeric, alpha-lipoic acid, aspirin, Coenzyme Q10 and coffee and sunflower seed preparations. There are limited studies investigating the use of systemic antioxidants in vitiligo treatment, all with heterogeneous study designs and outcomes. Further studies are required to discern the most effective systemic antioxidant and their impacts on vitiligo subtypes"

Late-breaking abstract • Oxidative stress • Dermatology • Immunology • Vitiligo