Entereg (alvimopan) / Merck (MSD) - LARVOL DELTA

Underutilization of Alvimopan in Radical Cystectomy: A National Perspective on Benefits and Low Adoption Rates (AUA 2025) - "This study provides a nationally representative view of alvimopan use for radical cystectomy, finding that only 39.3% of patients received the medication despite widespread evidence supporting its use. We are able to highlight the median time to alvimopan discontinuation (five doses), suggesting return of bowel function at 60 hours after RC. Further, we associate alvimopan use with decreased antinausea medication need and less GI morbidity to highlight the patient-centered improvement in peri-cystectomy care with alvimopan use."

Bladder Cancer • Gastrointestinal Disorder • Genito-urinary Cancer • Oncology • Solid Tumor

A Prospective Randomized Controlled Trial of the Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery (ASCRS 2025) - "The time required to advance to GI soft diet did not differ between groups (p=0.12). Postoperative complications (p=0.4), reoperation rates (p=0.5), and readmission rates (p=0.6) did not differ between the groups.Conclusion/ These findings indicate that Alvimopan as a rescue therapy may be efficacious in facilitating the restoration of bowel function in patients with POI, although it did not significantly affect the overall hospital LOS."

Clinical • Surgery • Gastrointestinal Disorder

Ileus after colectomy in the modern era: a populationbased analysis (ASCRS 2025) - "Total colectomy is associated with a high rate of ileus compared to segmental colectomy. Increased implementation of minimally-invasive surgery, perioperative alvimopan, and early ambulation might further reduce ileus rates."

Clinical • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Ileus after robotic colectomy: A single institution comparison in enhanced recovery (ASCRS 2025) - "Alvimopan (p=0.107) and TAP blocks (p=0.257) were not associated with decreased ileus. There was no significant difference in ileus between right and left colectomy (p=0.422).Conclusion/ Postoperative opioids were the only modifiable risk factor for ileus after robotic segmental colectomy. Increasing emphasis on opioid-sparing and other targeted enhanced recovery pathway options should focus on further decreasing the incidence of this vexing postoperative complication."

Clinical • Gastrointestinal Disorder • Oncology

ALVIMOPAN ADDITION TO ENHANCED RECOVERY PROGRAM SPEEDS RECOVERY FOLLOWING COLORECTAL SURGERY (DDW 2025) - No abstract available

Surgery

Comparing Rates of Postoperative Complications after Colorectal Surgery with Naloxegol versus Alvimopan (ASHP 2024) - No abstract available

Surgery

Evaluation of Alvimopan in minimally invasive procedures using ERAS (ASHP 2024) - No abstract available

Evaluation of Adherence to Alvimopan Formulary Restriction Criteria to Improve Patient Safety (ASHP 2024) - No abstract available

Adherence • Clinical

Effect of Alvimopan and Naloxegol for PostOperative Ileus in a Community Hospital (ASHP 2024) - No abstract available

Clinical

Alvimopan Medication Use Management Cost Savings Initiative (ASHP 2024) - No abstract available

HEOR

Postoperative ileus and possibilities of pharmacological intervention. (PubMed, Rozhl Chir) - "Postoperative ileus is still recognized as severe complication. Pharmacological treatment options are limited, only a few substances have evident positive impact (neostigmin for treatment and alvimopan - not registered in the Czech Republic for prevention). More evidence is necessary for positive effect of 5-hydroxytryptamine 4 (5HT4) agonists, and the effect of selective COX-2 inhibitors is still controversial."

Journal • Review • Inflammation

A Study of Surgical Techniques During Cystectomy (clinicaltrials.gov) - P3 | N=530 | Recruiting | Sponsor: Memorial Sloan Kettering Cancer Center

New P3 trial • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

Recovery of gastrointestinal functional after surgery for abdominal tumors: A narrative review. (PubMed, Medicine (Baltimore)) - "Interventions that can shorten or prevent such ileus include minimally invasive surgery, early enteral nutrition as well as use of chewing gum, laxatives, and alvimopan. Most of these interventions have been integrated into current guidelines for enhanced recovery of gastrointestinal function after surgery. Future high-quality research is needed in order to clarify our understanding of efficacy and safety."

Journal • Review • Surgery • Gastrointestinal Disorder • Infectious Disease • Oncology • Pain

Alvimopan for postoperative ileus following abdominal surgery: a systematic review. (PubMed, Langenbecks Arch Surg) - "Alvimopan shows promise in reducing POI and hospital stay durations following abdominal surgeries. The incorporation of the recent studies in laparoscopic abdominal procedures further supports these findings. Integrating Alvimopan into perioperative care protocols may enhance patient outcomes and help lower healthcare costs."

Journal • Review • Surgery • Gastrointestinal Disorder • Gynecology

Effect of Alvimopan on Postoperative Ileus and Length of Hospital Stay in Patients Undergoing Bowel Resection: A Systematic Review and Meta-Analysis. (PubMed, Am Surg) - "Robust evidence supports the routine use of alvimopan in patients undergoing open bowel resection as indicated by lower risk of postoperative ileus and shorter length of hospital stay. We support incorporation of alvimopan into enhanced recovery after surgery programs for the procedures involving open bowel resection. The role of alvimopan in minimally invasive bowel resection needs more research."

Journal • Retrospective data • Review

An outline of the management and prevention of postoperative ileus: A review. (PubMed, Medicine (Baltimore)) - "While treatment options such as alvimopan, NSAIDs, and acupuncture have demonstrated efficacy, the use of lidocaine has raised concerns due to associated adverse effects...POI presents a complex challenge in various surgical specialties, necessitating a multifaceted management approach. The integration of preventive and treatment measures within enhanced recovery programs has significantly reduced POI frequency and duration."

Journal • Review

Novel Evaluation of Alvimopan to Prevent Ileus in Live Donor Hepatectomy (ATC 2024) - "There was a trend for lower opiate use postoperatively in the alvimopan group 57.9±39.6 vs. 102.6±107.4mg (oral morphine equivalent) in the control group (p=0.07) and a shorter length of stay 4.5±0.7 vs. 5.1±1.2 days respectively (p=0.06). The novel use of alvimopan in living donor hepatectomy did not accelerate gastrointestinal recovery. Patients who received alvimopan experienced fewer episodes of emesis and there was a trend to lower opiate use and shorter length of hospital stay. Further multicenter work including alvimopan as part of an enhanced recovery pathway are needed to improve donor outcomes."

Gastrointestinal Disorder • Pain • Transplantation

Pharmacologic prevention and therapy of postoperative paralytic ileus after gastrointestinal cancer surgery - systematic review and meta-analysis. (PubMed, Int J Surg) - "Current evidence concerning pharmacological prevention and treatment of POI following gastrointestinal tumor surgery is limited. Opioid-sparing concepts, reduction of sympathetic hyperreactivity, and laxatives should be implemented into multimodal perioperative approaches."

Journal • Retrospective data • Review • Surgery • Gastrointestinal Cancer • Gastrointestinal Disorder • Oncology • Pain • Solid Tumor

Alvimopan as a Rescue Treatment of Postoperative Ileus (clinicaltrials.gov) - P4 | N=58 | Recruiting | Sponsor: Scott Steele | Trial completion date: Feb 2024 ➔ Aug 2024 | Trial primary completion date: Feb 2024 ➔ Aug 2024

Surgery • Trial completion date • Trial primary completion date • Colon Cancer • Gastrointestinal Disorder

Effect of Pharmacoprophylaxis on Postoperative Outcomes in Adult Elective Colorectal Surgery: A Multi-Center Retrospective Cohort Study within an Enhanced Recovery after Surgery Framework. (PubMed, Healthcare (Basel)) - "Significant differences in pharmacotherapy regimens that may improve primary and secondary outcomes in ECRS were identified. In adult ECRS, cefotetan or ertapenem may be better regimens for preventing in-hospital SSI, while ertapenem or C/M may lead to shorter LOS. The value of OA to prevent SSI was not demonstrated. Inpatient enoxaparin, compared to UFH, may reduce VTE rates with a similar LOS. A minority of patients had a documented PONV risk assessment, and a majority used as-needed rather than around-the-clock strategies. Preoperative scopolamine patches continued postoperatively may lower PONV and PDNV severity and shorter LOS. Alvimopan may reduce ileus and shorten LOS. Anesthesia that includes TAP block, ketorolac IV, and pregabalin use may lead to reduced pain rates. Acetaminophen, alvimopan, famotidine, and lidocaine patches may shorten LOS. Given the challenges of pain management and the incidence of PONV/PDNV found in this study, additional studies should be..."

Journal • Retrospective data • Surgery • Anesthesia • Cardiovascular • Infectious Disease • Pain • Venous Thromboembolism

Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus. (PubMed, Biol Pharm Bull) - "These findings suggest that naldemedine is effective for postoperative intestinal hypomotility and adhesions in rodents (i.e., as for alvimopan). Thus, naldemedine may be a useful option for the treatment of POI."

Journal • Preclinical

Strategies to reduce ileus after colorectal surgery: A qualitative umbrella review of the collective evidence. (PubMed, Surgery) - "Early oral feeding, chewing gum, and alvimopan were the most commonly assessed and effective strategies for reducing postoperative ileus after colorectal surgery. Medications used to reduce postoperative ileus included alvimopan, intravenous lidocaine, dexamethasone, probiotics, and oral antibiotics. Intravenous dexamethasone and lidocaine and oral probiotics helped hasten bowel function return. Acupuncture positively impacted the recovery of bowel function."

Journal • Review • Surgery

Alvimopan Use for Postoperative Ileus (ASHP 2023) - No abstract available

Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol (clinicaltrials.gov) - P3 | N=136 | Recruiting | Sponsor: Brigham and Women's Hospital | Trial completion date: Dec 2021 ➔ Jun 2024 | Trial primary completion date: Dec 2021 ➔ Dec 2023

Surgery • Trial completion date • Trial primary completion date • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

Novel kappa opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus (ACS-Fall 2023) - "Finally, an in silico investigation based on a 500-ns molecular dynamics simulation was conducted using the selective agents, JDTic and Alvimopan, the most potent antagonists on kappa and mu opioid receptors, respectively. Also, the most KOP selective derivative MA-8 was subjected to a 100 ns MD simulation to delineate the determinants of selectivity. Discovery of a novel KOP modulator with improved pharmacological profile could represent a new hope for the treatment of addiction and would have a great socio-economic impact worldwide."

Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry