fluconazole oral / Generic mfg. - LARVOL DELTA

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data. (PubMed, EBioMedicine) - "20 widely used medications may be associated with reduced progression from MCI to ADRD and represent promising candidates for clinical evaluation as repurposed therapies for dementia."

Journal • Real-world evidence • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Pain

Species distribution, antifungal susceptibility pattern and associated factors of Candida blood stream infections in Sri Lanka from 2018 to 2022. (PubMed, Ceylon Med J) - "Candida tropicalis is the commonest species causing candidemia in Sri Lanka. Common Candida species had good susceptibility to antifungals. Long term hospital stay was associated with candidemia in majority of patients."

Journal • Gastrointestinal Disorder • Infectious Disease

Antifungal Activity of Hedychium spicatum Essential Oil Against Candidemia-Causing Candida tropicalis and Candida parapsilosis: In Vitro Evaluation and Computational Identification of Cis-γ-Bisabolene as a Putative CYP51-Binding Constituent. (PubMed, Chem Biodivers) - "MM-PBSA showed favorable binding energies of -6.02 and -8.05 kJ/mol compared to fluconazole (0.98 and 0.66 kJ/mol). DFT showed comparable HOMO-LUMO gaps (6.216 and 6.176 eV) and global hardness (3.108 and 3.088 eV). Overall, HSEO shows promising antifungal potential, with cis-γ-bisabolene as a lead candidate."

Journal • Preclinical • Candidiasis

Podocarpane diterpenoids with various subtypes from Strophioblachia glandulosa Pax var. cordifolia combined with fluconazole activation of the Hog1 pathway demonstrating antifungal activity. (PubMed, Bioorg Chem) - "Compound 8 was therefore selected for further mechanistic investigation. Further mechanistic studies revealed that compound 8 combined with FLC exerts synergistic antifungal activity by activating the Hog1 signaling pathway to suppress hyphal formation and morphological transformation of resistant C. albicans."

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Solid state convergence to fluconazole monohydrate: Mechanochemical hydration, phase transitions, and solvent‑mediated conversion driving solubility. (PubMed, J Pharm Sci) - "PXRD of residual solids demonstrated complete solvent-mediated conversion of FLU-P5 to FLU-MH during equilibration, explaining the similar solubilities of the two starting solid forms. Therefore, this study advances the understanding of relationships among FLU solid phases, establishes a route to obtain phase-pure monohydrate, and provides PXRD evidence that FLU-MH forms at 37°C in water and across the physiological pH range from the pharmaceutically relevant polymorph FLU-P5, thereby governing drug solubility under physiologically relevant conditions even when another solid form is initially present."

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SPONTANEOUS FUNGAL PERITONITIS AS THE INITIAL PRESENTATION OF ALCOHOL-RELATED CIRRHOSIS COMPLICATED BY HEPATOCARDIORENAL SYNDROME: A FATAL CASE (UEGW 2026) - "Diagnostic paracentesis showed >250 polymorphonuclear cells/mm³ and empirical ceftriaxone was initiated for presumed spontaneous bacterial peritonitis.Concurrently, the patient developed acute heart failure...Depletive therapy was initiated; terlipressin was withheld considering the severe cardiac dysfunction and hemodynamic instability.Due to clinical deterioration, computed tomography excluded secondary peritonitis, and antimicrobial therapy was subsequently escalated to piperacillin–tazobactam. However, serial paracentesis demonstrated <25% decline in polymorphonuclear cell count, suggesting resistant or fungal infection, further supported by a positive serum β-D-glucan level (201 pg/mL).Repeated ascitic fluid cultures grew Candida albicans, confirming spontaneous fungal peritonitis (SFP) and prompting initiation of fluconazole...Early suspicion, lack of response to antibiotics and β-D-glucan testing may expedite diagnosis. Concomitant cirrhotic..."

Clinical • Acute Kidney Injury • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Nephrology • Portal Hypertension • Thrombocytopenia • CRP

Esophagitis Dissecans Superficialis in a Patient With Prior Subtotal Gastrectomy and Roux-en-Y Reconstruction: A Case Report. (PubMed, Cureus) - "Because esophageal candidiasis was initially suspected based on the endoscopic appearance, the patient was empirically treated with fluconazole and continued proton pump inhibitor therapy...This case highlights EDS in a patient with extensively altered foregut anatomy and illustrates its potential to mimic infectious esophagitis. Although a causal relationship between prior gastric reconstruction and EDS cannot be established, recognizing this entity and correlating endoscopic and histopathologic findings are important for accurate diagnosis."

Journal • Candidiasis • Gastrointestinal Disorder • Infectious Disease • Pain

Community-Acquired Kodamaea ohmeri Fungemia in an Immunocompetent Host Coexisting With Severe Leptospirosis: A Case Report and Review of Community-Acquired Fungemia Cases. (PubMed, Cureus) - "Antifungal susceptibility testing demonstrated high susceptibility to amphotericin B, voriconazole, and caspofungin, whereas fluconazole showed reduced susceptibility. Due to severe hepatic and renal dysfunction, liposomal amphotericin B was preferred, resulting in rapid clinical improvement and clearance of fungemia...Accurate species identification, repeated blood culture confirmation, and timely antifungal therapy are critical for favourable outcomes. This case expands the clinical spectrum of K. ohmeri infection and suggests that severe leptospirosis may be a possible predisposing condition."

Journal • Infectious Disease • Nephrology • Renal Disease

Clinical and Microbiological Characteristics of Early Candidozyma auris Cases in a Tertiary Hospital in Istanbul, Türkiye: A Retrospective Case Series. (PubMed, Antibiotics (Basel)) - "Early institutional C. auris cases in this tertiary hospital occurred predominantly among elderly, critically ill patients with prolonged healthcare exposure, invasive devices, and extensive antimicrobial use. The findings support the need for early laboratory recognition, cautious interpretation of commercial AFST results, particularly given the propensity of Sensititre YeastOne to overestimate amphotericin B resistance, strengthened infection control practices, and multicenter studies incorporating molecular typing to clarify transmission dynamics and antifungal resistance patterns."

Journal • Retrospective data • Critical care • Infectious Disease

Bioprospecting of Curcuma longa rhizomes reveals a 2.5 kDa antifungal peptide with potent anti-Candida albicans activity and synergistic interaction with nystatin. (PubMed, Nat Prod Res) - "Strong synergistic interactions were observed with nystatin and fluconazole (FIC indices of 0.11 and 0.30, respectively). The peptide also inhibited germ-tube formation at 2 x MIC. These findings highlight a promising plant-derived peptide for antifungal combination therapy."

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Characterization and Chemical Management of Phytophthora palmivora and Fusarium incarnatum-equiseti Species Complex Associated with Durian Root Rot in China. (PubMed, Microorganisms) - "FIESC exhibited sensitivity to tebuconazole, fludioxonil, and pydiflumetofen but was insensitive to difenoconazole, mefentrifluconazole, and phenamacril...Overall, this work clarifies the pathogen complex associated with DRR in China, provides preliminary evidence for enhanced disease severity during co-inoculation of P. palmivora and FIESC, and identifies optimized fungicide combinations and application methods under greenhouse conditions. These results provide a foundation for further field validation and for the development of integrated management strategies."

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Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies. (PubMed, Front Pharmacol) - "Voriconazole's marked DDI variability underscores the necessity of TDM-guided dosing, while fluconazole offers a more predictable antifungal prophylaxis alternative. These results deliver population-specific pharmacokinetic data supporting rational co-administration of venetoclax with azole antifungals in Chinese hematologic malignancy patients."

Journal • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Oncology

Antifungal Susceptibility Patterns in Respiratory Tract Candidiasis and Risk Factors Among HIV-Infected Adults in South West Cameroon. (PubMed, Antibiotics (Basel)) - "In contrast, isolates from HIV patients showed significant resistance to fluconazole and ketoconazole (32.5% each). While these results must be interpreted with care due to the sample size relative to the high national HIV prevalence, they suggest that public health education is needed to improve awareness. These preliminary findings prompt a review by health authorities concerning the use of fluconazole for prophylaxis in HIV-positive patients in Cameroon."

Journal • Candidiasis • Dermatology • Human Immunodeficiency Virus • Infectious Disease

In Silico Structure-Reactivity Analysis of Lignin-Derived Phenolics: O-H Bond Dissociation Enthalpies, Spin Delocalization, and a Propagator/Terminator Framework for Antifungal-Relevant Activity. (PubMed, ACS Omega) - "Docking with Candida albicans sterol 14α-demethylase (CYP51, PDB 5TZ1) revealed phenolic affinities ranging from -5.0 to -7.6 kcal mol-1, which are inferior to the clinical azole fluconazole (-8.4 kcal mol-1) and the native inhibitor VT-1161 (-12.2 kcal mol-1), the affinity correlated with log P (r = -0.76) but not with BDE, suggesting that direct inhibition of CYP51 is at best a secondary factor. The diminished second O-H bond dissociation energies of benzenediols facilitate a quinone redox cascade that, when measured against a peroxyl reference bond, categorizes the phenols into radical-terminating monophenols and redox-cycling propagators. The framework offers a structural justification for the antifungal properties of lignin-derived phenolics at the individual component level and emphasizes the unexploited low-BDE/high-log P area as a focus for enhancement."

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Anti-Fungal and Toxicology Assessment of ISFP10, an Inhibitor of Fungal Phosphoglucomutase (PGM). (PubMed, Drugs R D) - "ISFP10 demonstrates potent antifungal properties against C. albicans and C. glabrata and a favorable safety profile in vivo, supporting its further development as a potential broad-spectrum antifungal agent."

Journal • Oncology • IL6 • TNFA

Consensus recommendations for Trichophyton indotineae: A modified Delphi study. (PubMed, J Eur Acad Dermatol Venereol) - "These consensus statements provide practical interim recommendations. Randomized controlled trials are needed to validate outcomes and optimize regimens."

Journal • Dermatology • Infectious Disease

Clinical management, antifungal susceptibility, and predictors of 28-day mortality in Candidozyma auris candidemia: a single-center cohort study. (PubMed, Med Mycol) - "Resistance rates were 95.1% for fluconazole, 31.2% for amphotericin B, and 1.3% for both anidulafungin and micafungin; multidrug resistance rate was 28.6%, and no isolate met the definition of pandrug resistance. Mortality in C. auris candidemia was mainly associated with baseline comorbidity burden and acute organ dysfunction. Local susceptibility surveillance and early recognition of high-risk patients may support treatment and infection-control strategies."

Journal • Critical care • Infectious Disease

A novel case of Tropicoporus texanus and Aspergillus niger post-traumatic endophthalmitis. (PubMed, Am J Ophthalmol Case Rep) - "Despite a timely initial vitrectomy with injection of intravitreal vancomycin, ceftazidime, and voriconazole as well as initiation of oral fluconazole, her endophthalmitis worsened and she developed a traction retinal detachment within one week of the procedure. The Tropicoporus genus has rarely been implicated in a variety of human infections including keratitis. Ophthalmologists should be aware of Tropicoporus species as a potential cause of aggressive, treatment-resistant fungal endophthalmitis."

Journal • Cataract • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

Portal Venous Gas and Emphysematous Gastritis: An Uncommon Consequence of Upper Endoscopy (ACG 2026) - "She received bowel rest, total parenteral nutrition, PPI therapy, and broad-spectrum antimicrobials (meropenem, vancomycin, fluconazole)...She was discharged on amoxicillin-clavulanate, with complete endoscopic resolution seen at three month follow up...Surgical intervention should be reserved for clinical deterioration, perforation, or confirmed necrosis. Figure: CT images showing emphysematous gastritis (blue arrow) and portal venous gas (orange arrow) Figure: Endoscopic appearance of stomach on presentation, day 3, and at 3 months"

Cardiovascular • Dyspepsia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hypertension • Hypotension • Pulmonary Disease • Respiratory Diseases

Combined Endoscopic OTSC Closure and Percutaneous n-BCA Glue Embolization for a Gastro-Subphrenic Fistula Complicating Crohn's Disease in a Surgically Hostile Abdomen (ACG 2026) - "CD had been controlled on adalimumab then guselkumab, which was held for five months during hospitalizations...He was started on ampicillin-sulbactam and fluconazole...This case highlights the value of a multidisciplinary approach for complicated CD patients at high surgical risk. Figure: Methylene blue was injected via percutaneous drain seen entering the stomach Figure: OTSC clips applied to close the tract"

Cardiovascular • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease • Short Bowel Syndrome

Brewing Trouble: A Rare Complication of Antibiotic-Induced Intestinal Dysbiosis (ACG 2026) - "Further investigation revealed that symptoms including epigastric pain, nausea, emesis, ataxia, dysarthria, and lethargy began after prolonged antibiotic exposure with amoxicillin-clavulanate and ciprofloxacin and were predominant after carbohydrate-rich meals...Our case presents a negative carbohydrate challenge test despite typical presentation, which could be associated with disruption of interactions from ethanol production and phenazines between Candida species and P. aeruginosa biofilm production by fluconazole treatment...Prolonged antibiotic exposure may disrupt normal gut microbiota, leading to intestinal dysbiosis and overgrowth of fermenting organisms, including yeasts such as Saccharomyces and Candida species, as well as bacteria such as Pseudomonas aeruginosa. In this altered microbial environment, dietary carbohydrates are metabolized to glucose and subsequently fermented into ethanol, which is absorbed enterically and can result in endogenous alcohol..."

Dysbiosis • Ataxia • CNS Disorders • Movement Disorders • Otorhinolaryngology • Pancreatitis • Respiratory Diseases • Sinusitis

Candida peritonitis in Advanced HIV/AIDS: Radiologic Clues Prompting Early Diagnostic Paracentesis (ACG 2026) - "Antifungal therapy with fluconazole was initiated and later escalated to caspofungin alongside intensive supportive care...Figure: (A) Axial CECT demonstrates largeâvolume ascites with peripheral rim enhancement. (B) Axial CECT demonstrating splenic infarct and free intraperitoneal air adjacent to the liver (C) Coronal CECT demonstrating peritoneal thickening and enhancement, findings that may coexist with severe infectious"

Metastases • Anal Carcinoma • Chronic Kidney Disease • Fibrosis • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Nephrology • Renal Disease • Septic Shock • Squamous Cell Carcinoma

An Uncommon Cause of Upper Gastrointestinal Hemorrhage: Acute Esophageal Necrosis With Candida glabrata Fungemia (ACG 2026) - "Micafungin was initiated and transitioned to fluconazole based on susceptibility testing...He was discharged on fluconazole and pantoprazole for eight weeks, with no recurrent bleeding at two-week follow-up...Endoscopy was essential not only for diagnosis but for identifying necrosis predisposing to systemic infection. Physicians should suspect AEN in patients with DKA and upper GI bleeding, recognize necrotic mucosa as a potential infectious source, and monitor vigilantly for septic complications."

Acute Kidney Injury • Addiction (Opioid and Alcohol) • Diabetes • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Ocular Infections • Ocular Inflammation • Ophthalmology • Renal Disease • Thrombocytopenia

Necrotic Candida Esophageal Pseudotumor Mimicking Malignancy With Life-Threatening Hemorrhage in a Jehovah's Witness Patient (ACG 2026) - "Case Description/ An 82-year-old man of Jehovahâs Witness faith with coronary artery disease, atrial fibrillation on apixaban, diabetes, and chronic kidney disease was admitted for chest pain and massive hematemesis...He was discharged on oral PPI and fluconazole to complete the planned course...Figure: Figure 2. Lower third of the esophagus shown on the followâup EGD 2 months post-hospitalization, demonstrating resolution of the massâlike lesion and improvement in esophagitis."

Clinical • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Coronary Artery Disease • Diabetes • Esophageal Cancer • Gastrointestinal Disorder • Metabolic Disorders • Nephrology • Oncology • Renal Disease

Seronegative Alpha-1 Antitrypsin Deficiency: The Implications of Acute Illness (ACG 2026) - "Ascitic fungal culture grew Candida albicans , and fluconazole was initiated...Figure: Figure 1: CT abdomen/pelvis demonstrating lobular hepatic contours suggestive of chronic liver disease. Figure: Figure 2: a) Liver biopsy demonstrating periportal AAT globules on PAS-D (arrow) and b) immunohistochemical staining, consistent with AAT accumulation."

Alpha-1 Antitrypsin Deficiency • Chronic Obstructive Pulmonary Disease • CNS Disorders • Fibrosis • Genetic Disorders • Hepatology • Immunology • Inflammation • Obesity • Portal Hypertension • Pulmonary Disease • Respiratory Diseases • SERPINA1