fluconazole oral / Generic mfg. - LARVOL DELTA

Infection Characteristics in Patients Treated With Axatilimab for Chronic Graft-Versus-Host Disease in the AGAVE-201 Trial (HOPA 2026) - P2 | "Among 7 patients receiving cyclosporine and 11 receiving tacrolimus, 1 (14.3%) and 3 (27.3%), respectively, completed tapering within 6 cycles. Among 241 randomized patients, 192 (79.7%) had severe cGVHD with a median of 4 prior cGVHD therapies; 130 (53.9%) had ≥4 organs involved. Concomitant medications included antivirals, most commonly acyclovir (60.6%); antibacterials, including sulfamethoxazole/trimethoprim (63.9%) and azithromycin (32.4%); and antifungals, including posaconazole (24.1%) and fluconazole (11.6%). Concomitant corticosteroid use at baseline was reported in 156/239 (65.3%) patients; mean daily dose was 19.4 mg."

Clinical • Chronic Graft versus Host Disease • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Graft versus Host Disease • Immunology • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Multi-Residue Determination and Risk Assessment of EU-Relevant Pharmaceuticals, Pesticides, and UV-Filters in Drinking Water. (PubMed, Pharmaceuticals (Basel)) - "Considering all analyzed samples, 4 (fluconazole, irbesartan, dimoxystrobin, and benzotriazole) of the 23 target compounds were detected. Some MPs were detected, with concentrations indicating no expected human health risks under the conditions evaluated. Further monitoring campaigns should be conducted in the future, with compounds exceeding the limits of the calibration curves requiring special attention."

Journal

Berberine Hydrochloride Enhances the Fluconazole Susceptibility of Candida albicans through Multiple Targets. (PubMed, Curr Microbiol) - No abstract available

Journal

Maternal Allergy to Fluconazole-An Unusual Presentation: Case Report in a Breastfeeding Mother. (PubMed, Children (Basel)) - "With supportive treatment, appropriate therapies and cessation of the medication, these invariably resolve. Where these persist, offering topical antifungal options may minimize the risk of recurrence of the hypersensitivity."

Journal • Allergy • Immunology

A CSA-catalyzed strategy for constructing 1H-pyrazolo[4,3-f]quinoline-8-carboxamide scaffolds as antimicrobial agents. (PubMed, J Mater Chem B) - "Biological screening indicates that compounds 4i and 4k possess strong antibacterial activity, while compounds 4c, 4d, and 4n exhibit enhanced antifungal activity relative to tetracycline and fluconazole. In addition, compounds 4d, 4i, and 4j demonstrate potent anticancer activity against the MCF-7, HepG2, and SiHa cell lines."

Journal • Oncology

The azole-resistance phenotype of a Nakaseomyces glabratus clinical strain encoding a wild-type PDR1 allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis. (PubMed, Microbiol Spectr) - "We found that the azole-resistance phenotype in this strain involves: (i) the expression of the multi-drug resistance transporters Pdh1 and Aus1, whose deletion abolished the fluconazole and voriconazole resistance; (ii) an Aus1-mediated increase in plasma membrane fluidity, especially under fluconazole stress; and (iii) the ability to sustain higher pools of ergosterol and lower accumulation of methylated sterols under fluconazole stress. In this work, we disclose a set of genes that mediate the azole-resistance phenotype of a resistant clinical strain, with one of these players (Cyb5) being also implicated in biosynthesis of ergosterol for the first time. With this, we increase a set of possible therapeutic targets that can be used in future studies to develop new antifungals."

Journal • Infectious Disease • CYB5A

Beyond Candida: Epidemiological Insights into Rare Yeast Fungaemia in Greece from a 15-Year Hospital-Based Study and Literature Review. (PubMed, J Fungi (Basel)) - "Invasive infections attributed to rare yeasts are increasingly recognized and often exhibit resistance to echinocandins or fluconazole...Although infrequent, rare yeast fungaemia at our centre was associated with high breakthrough rates and substantial mortality. Regional epidemiological insight and heightened clinical awareness are key to optimizing outcomes."

Journal • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology

Candidemia in Southern Poland (2017-2022): Multicenter Analysis of Species Distribution and Antifungal Susceptibility. (PubMed, J Fungi (Basel)) - "No C. auris was found. Fluconazole resistance was found in 4.9% of C. albicans strains, 34.7% of N. glabratus strains, and 8.7% of C. parapsilosis complex strains."

Journal • Candidiasis • Dermatology

Evaluation of Antitumor and Antimicrobial Photobiological Activity of Nanocarrier Containing Photosensitizer and Magnetic Nanoparticle. (PubMed, Curr Issues Mol Biol) - "The results of the antifungal photobiological activity against C. albicans were excellent, with IC50 values of 3.75 and 3.5 μg/mL for PNPs-PS and PNPs-PS-MagNPs, respectively, values which were significantly lower with p 30 μg/mL) after irradiation with light and fluconazole (IC50 > 30 μg/mL), the reference antifungal agent. PNPs-PS showed promising results regarding antitumor, antibacterial, and antifungal photobiological activity. However, PNPs-PS-MagNPs showed weak results for antibacterial photobiological activity against MRSA but with promising results for tumor cells and C. albicans."

Journal • Infectious Disease • Oncology

Neonatal Candidemia in Latin America: Trends, Resistance, and Prevention Strategies (2008-2025). (PubMed, J Fungi (Basel)) - "Globally, five species predominate, namely Candida albicans, C. parapsilosis sensu lato (s.I.), Candida tropicalis, Nakaseomyces glabratus, and Pichia kudriavzevii, with a sustained increase in non-albicans species and growing resistance to fluconazole...Mortality remains high, influenced by diagnostic delays and species characteristics. Standardized microbiological surveillance, accurate identification, and strategies tailored to each clinical setting are required to improve outcomes in this vulnerable population."

Journal • Review • Candidiasis • Critical care • Infectious Disease • Septic Shock

Design and Biological Profiling of a Drug-like Chloropyridine Diamine as a Dual Antioxidant-Antimicrobial Lead: In Vitro Evaluation and In Silico Multi-Target Studies. (PubMed, Int J Mol Sci) - "AMZ displayed broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi, with particularly strong effects on Bacillus subtilis (44.5 ± 0.5 mm; MIC/MBC 0.008 mg/mL) and Aspergillus niger (30 mm; MIC/MBC 0.030 mg/mL), in some cases comparable or superior to streptomycin and fluconazole. In silico analysis indicated that AMZ fulfilled major drug-likeness rules, showed high predicted intestinal absorption (91.14%), and was classified as non-AMES toxic, while docking predicted favorable binding to catalase and CYP51, in agreement with the experimental antioxidant and antifungal activities. These findings highlight the potential of AMZ as a multi-target pyridine-based lead compound that warrants further structural optimization and in vivo evaluation for applications in oxidative-stress-related and infectious conditions."

Journal • Preclinical • Infectious Disease • CAT

Trichosporonaceae as (Re-)Emerging Pathogens: A Warning to the Medical Community. (PubMed, J Fungi (Basel)) - "Trichosporonaceae infections, particularly those caused by T. asahii, are associated with critically ill patients and high mortality, highlighting the need for early diagnosis, appropriate therapy, and continuous surveillance."

Journal • Acute Kidney Injury • Critical care • Infectious Disease • Renal Disease • Respiratory Diseases

Clinical features and outcomes of fungal bone and joint infections in Western France. (PubMed, Int J Infect Dis) - "Fungal BJIs represent a wide range of infections associated with a poor prognosis."

Journal • Infectious Disease

Impact of Candida albicans NDT80 and UME6 on biofilm formation and fluconazole susceptibility. (PubMed, mSphere) - "Prior studies in one strain background (SC5314) indicated that Ndt80 controls both biofilm/hypha formation and azole drug susceptibility and that Ume6 controls biofilm/hypha formation. The four new findings here are that (i) Ndt80 effects on fluconazole sensitivity vary considerably with strain background; (ii) Ndt80 is required for filamentation and biofilm formation in multiple clinical isolates; (iii) the Ndt80 target Ume6 contributes to Ndt80 control of filamentation and biofilm formation in multiple clinical isolates; and (iv) Ume6 influences fluconazole vulnerability, the first Ume6 function to our knowledge that is unrelated to filamentation."

Journal • Infectious Disease

Incidence of azole resistance among clinical isolates of Candida parapsilosis: Results from the French nationwide multicenter prospective study "ReCap" 2022-2024. (PubMed, New Microbes New Infect) - "Cross-resistance occurred frequently with voriconazole resistance observed in 62.9% (73/116) of fluconazole-resistant isolates. In France, the frequency of resistance to fluconazole reaches 10% of patients harboring C. parapsilosis, with very significant differences between regions. The Paris area is affected by two epidemic clusters involving many patients."

Clinical • Journal • Infectious Disease

PERSISTING FEVER AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A CASE REPORT OF A RARE INFECTION WITH LOMENTOSPORA PROLIFICANS (EBMT 2026) - "Cytoreductive therapy with hydroxyurea was initiated immediately after diagnosis, with no other prior antineoplastic treatment administered. Conditioning with fludarabine, thiotepa, and melphalan was started 7 months after the initial diagnosis...The patient received an HLA-identical unrelated male donor peripheral blood stem cell graft, with graft-versus-host disease prophylaxis comprising cyclosporine, mycophenolate mofetil, and anti-thymocyte globulin (ATG)...On day −3, the patient developed febrile neutropenia and broad-spectrum antibiotic treatment (piperacillin/tazobactam) was initiated. Recurrent fever on day +1 led to escalation to meropenem and a switch from fluconazole to posaconazole; blood cultures remained negative.Under these measures, the fever persisted...On day +11, increasing somnolence, pathological breathing pattern, and new oxygen requirement prompted sampling of peripheral and central blood cultures and empiric addition of linezolid and..."

Case report • Clinical • Bone Marrow Transplantation • Chronic Myelomonocytic Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Respiratory Diseases • Septic Shock • Transplantation • ASXL1 • NRAS • RUNX1 • SETBP1 • SRSF2

SUBTHERAPEUTIC CYCLOSPORINE CONCENTRATIONS DESPITE STANDARD DOSING IN HSCT PRACTICE (EBMT 2026) - "(p>0.05)Drug–drug interactions were identified in 21 cases receiving concurrent antifungal therapy (6 on voriconazole, 12 on isavuconazole, 3 on fluconazole)...Only 1 case (8.3%) with isavuconazole met target level.Cyclophosphamide was included in the conditioning regimen for 96 patients; the remaining four cases involved second or later transplants, limiting the ability to assess the contribution of cyclophosphamide to cyclosporine clearance... The standard cyclosporine dose of 3 mg/kg/day frequently fails to achieve target therapeutic concentrations in HSCT patients. Despite a wide distribution of BMI in the cohort, no clear association between body size and achieving therapeutic levels was observed when dosing was based on lower body weight. This finding suggests that using lower body weight for dosing is appropriate."

Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Obesity

ANTIFUNGAL PROPHYLAXIS PATTERNS AND INVASIVE FUNGAL INFECTIONS OUTCOMES IN PAEDIATRIC ALLOGENIC HCT: A MULTICENTRE COHORT STUDY (EBMT 2026) - "Choice of antifungal prophylaxis was classified as non–mould-active (fluconazole), mould-active (including micafungin, liposomal amphotericin B, voriconazole and posaconazole), or mixed (both non-mould active and mould active agents). Antifungal prophylaxis in paediatric allogenic HCT was strongly risk-adapted, with increased mould-active use in patients with prior history of IFI. IFIs occurred across all prophylaxis strategies, with all proven IFIs occurring in patients on fluconazole monotherapy. Most IFIs arose post-engraftment, highlighting the need for consistent, risk-based escalation to mould-active prophylaxis in immunosuppressed children."

Clinical • Infectious Disease • Pediatrics

OPEN WIDE: EXPLORING SALIVA AS A NON-INVASIVE TOOL FOR POSACONAZOLE LEVELS IN CHILDREN (EBMT 2026) - "This is the first prospective study assessing salivary detection of posaconazole in children. Our findings indicate that saliva sampling is unsuitable for posaconazole TDM in immunocompromised children. The minimal detection is possibly related to its high protein binding (>98%) similar to itraconazole and in contrast to voriconazole (~58%) and fluconazole (~10%), which have demonstrated reliable salivary penetration."

Clinical • Non-invasive • Infectious Disease • Mucositis • Stomatitis

Case Report: Rare Community-Acquired Pneumonia with Concurrent Methicillin-Resistant Staphylococcus aureus and Cryptococcus neoformans Infection in an Immunocompetent Young Male. (PubMed, Infect Drug Resist) - "The patient showed significant improvement after treatment with oral linezolid (0.6 g twice daily) for 2 weeks and oral fluconazole (400 mg once daily) for 6 months. This case highlights that even immunocompetent individuals can simultaneously contract multiple community-acquired pathogens, while also underscoring the clinical utility of NTS in the early diagnosis of co-infections and detection of resistance genes."

Journal • Cough • Infectious Disease • Pneumonia • Respiratory Diseases

A CASE OF FLUCONAZOLE-INDUCED ARGININE VASOPRESSIN RESISTANCE (ISN-WCN 2026) - "Acquired AVP-R includes drug-induced AVP-R, and typical causative drugs are lithium, demeclocycline, amphotericin B, and rifampicin.Methods We report a rare case of fluconazole drug-induced AVP-R.Results A 52-year-old woman with type I diabetes was admitted to our hospital because of impaired consciousness. The patient had been in her usual state of health until 2 days before the admission, and her diabetic medications included dapagliflozin, insulin, and metformin...Broad spectrum antibiotics, meropenem and daptomycin, were introduced and continued to control the infection...Initially, micafungin 150 mg q12hr was introduced and then stopped due to liver dysfunction...Desmopressin administration did not increase urine osmolality or reduce urine volume, which demonstrated renal unresponsiveness...FCZ has been rarely reported to cause AVP-R, and its mechanistic is unclear. Careful continuous observation of urinary concentration and serum sodium level are important to..."

Clinical • Atherosclerosis • CNS Disorders • Dermatitis • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Obesity • Ocular Infections • Ocular Inflammation • Ophthalmology • Type 1 Diabetes Mellitus

High mortality and amphotericin B-related nephrotoxicity in cerebral cryptococcosis in a low-resource neurology referral center: a prospective cohort study. (PubMed, Front Neurol) - "Amphotericin B (daily regimen) was administered in 74.2% and fluconazole in 82.3%...Cerebral cryptococcosis in this referral setting affects predominantly young, HIV-infected adults and is associated with high mortality and disability. Amphotericin B-related nephrotoxicity and hypokalemia were common and associated with worse outcomes, underscoring the need for nephroprotection protocols and optimized antifungal strategies in resource-limited settings."

Journal • Acute Kidney Injury • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Nephrology • Pain • Renal Disease

Understanding Candidozyma (Candida) auris: genomic evolution, antifungal resistance and the growing challenges in global infection control. (PubMed, J Med Microbiol) - "auris exhibits remarkable persistence on human skin and inanimate surfaces, resistance to multiple antifungals, notably fluconazole, and biofilm formation, which hinders infection control and leads to hospital outbreaks with high mortality rates. Despite ongoing research, key aspects of its reservoir origin, transmission routes and the best way to combat its spread and multidrug resistance remain unclear. Improving genomic surveillance and antifungal strategies is crucial to contain its spread and mitigate the growing public health threat posed by this resilient and potentially fatal fungal pathogen."

Journal • Review • Infectious Disease

Microbiological Profile of Meningoencephalitis Due to Pathogenic Free-Living Amoebae: A Case Series From Kerala, India. (PubMed, Cureus) - " FLA meningoencephalitis often presents with non-specific neurological symptoms, making early recognition challenging. Rapid wet mount microscopy of fresh CSF is a pivotal diagnostic tool in resource-limited settings and facilitated early diagnosis in this series. Early initiation of multidrug therapy upon identification of FLA on wet mount microscopy has improved survival. Although mortality remains high, this outcome exceeds the global data reported for Acanthamoeba infections and reinforces the value of starting treatment promptly."

Journal • CNS Disorders • Infectious Disease • Pain

Variables Associated With Poor Clinical Outcomes in Patients With Serious Fluconazole Non-Susceptible Candida Species Infections. (PubMed, Ann Pharmacother) - "Several host-derived physiological markers and recent exposure to protein synthesis inhibitor antibiotics were independent variables associated with 30-day mortality in patients with non-susceptible serious Candida sp."

Clinical data • Journal • Candidiasis • Hematological Disorders • Infectious Disease • Thrombocytopenia